Rfwd3 (ring finger and WD repeat domain 3)

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Gene: Rfwd3 (ring finger and WD repeat domain 3) Rattus norvegicus

Analyze

Symbol:

Rfwd3

Name:

ring finger and WD repeat domain 3

RGD ID:

1305243

Description:

Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; programmed DNA elimination by chromosome breakage; and regulation of cell cycle phase transition. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3); INTERACTS WITH bisphenol A; cobalt dichloride; ochratoxin A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase RFWD3-like; LOC361409; NEWGENE_1305243; RGD1305243; similar to hypothetical protein FLJ34389

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	39,235,883 - 39,268,536 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	39,236,787 - 39,268,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	46,040,108 - 46,073,335 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	46,693,440 - 46,726,667 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	48,993,968 - 49,026,584 (-)	NCBI	Rnor_WKY
Rnor_6.0	19	43,477,121 - 43,499,068 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	42,964,586 - 42,972,101 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	54,289,116 - 54,310,716 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	19	53,787,638 - 53,798,031 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	41,190,144 - 41,222,888 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	41,195,928 - 41,258,147 (-)	NCBI
Celera	19	38,624,795 - 38,656,471 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Fanconi Anemia Complementation Group W (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

paraplegia (ISO)

Testicular Germ Cell Tumor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

dioxygen (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

topotecan (EXP)

trimellitic anhydride (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (ISO)

double-strand break repair via homologous recombination (ISO)

interstrand cross-link repair (ISO)

mitotic G1 DNA damage checkpoint signaling (ISO)

protein ubiquitination (ISO)

regulation of DNA damage checkpoint (ISO)

replication fork processing (ISO)

response to ionizing radiation (ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (ISO)

site of DNA damage (ISO)

site of double-strand break (ISO)

Molecular Function

MDM2/MDM4 family protein binding (ISO)

metal ion binding (IEA)

p53 binding (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20173098	PMID:21504906	PMID:26474068	PMID:28575657	PMID:28575658	PMID:28691929

Genomics

Comparative Map Data

Rfwd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	39,235,883 - 39,268,536 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	39,236,787 - 39,268,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	46,040,108 - 46,073,335 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	46,693,440 - 46,726,667 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	48,993,968 - 49,026,584 (-)	NCBI	Rnor_WKY
Rnor_6.0	19	43,477,121 - 43,499,068 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	42,964,586 - 42,972,101 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	54,289,116 - 54,310,716 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	19	53,787,638 - 53,798,031 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	41,190,144 - 41,222,888 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	41,195,928 - 41,258,147 (-)	NCBI
Celera	19	38,624,795 - 38,656,471 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

RFWD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	74,621,399 - 74,666,877 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	74,621,399 - 74,666,877 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	74,655,297 - 74,700,775 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	73,212,798 - 73,258,280 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	58,948,218 - 58,993,367 (-)	NCBI		Celera
Cytogenetic Map	16	q23.1	NCBI
HuRef	16	60,404,913 - 60,450,359 (-)	NCBI		HuRef
CHM1_1	16	76,067,246 - 76,112,724 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	80,668,129 - 80,713,619 (-)	NCBI		T2T-CHM13v2.0

Rfwd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	111,997,576 - 112,026,854 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	111,997,576 - 112,026,854 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	111,270,944 - 111,300,222 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	111,270,944 - 111,300,222 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	113,794,844 - 113,824,122 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	114,157,617 - 114,186,895 (-)	NCBI		MGSCv36	mm8
Celera	8	115,495,609 - 115,526,062 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI

Rfwd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	2,824,422 - 2,858,283 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	2,824,057 - 2,857,321 (+)	NCBI	ChiLan1.0	ChiLan1.0

RFWD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	74,541,448 - 74,586,951 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	74,541,450 - 74,586,951 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	16	55,187,178 - 55,233,265 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RFWD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	75,960,909 - 76,001,088 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	75,960,955 - 76,000,467 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	75,936,552 - 75,976,729 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	76,317,468 - 76,357,876 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	76,317,515 - 76,357,874 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	76,220,089 - 76,259,587 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	76,042,941 - 76,083,200 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	76,535,192 - 76,575,417 (+)	NCBI		UU_Cfam_GSD_1.0

Rfwd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	36,002,371 - 36,042,495 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	23,544,953 - 23,586,740 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936475	23,544,974 - 23,586,716 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RFWD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	12,952,253 - 12,994,052 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	12,952,243 - 12,994,053 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	12,883,190 - 12,925,878 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RFWD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	53,045,408 - 53,092,214 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	53,045,465 - 53,092,494 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666323	32,173 - 78,985 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rfwd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	12,225,293 - 12,253,246 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	12,217,287 - 12,252,183 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rfwd3
263 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589102	Slep13	Serum leptin concentration QTL 13	4.63	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	19	569374	45569374	Rat
8694186	Bw152	Body weight QTL 152	3.34	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	569374	45569374	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2187927	46708701	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	2316121	47316121	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	3204777	48204777	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	7457249	42983518	Rat
724565	Tcas5	Tongue tumor susceptibility QTL 5	10.04		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	19	9977753	39654489	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10827970	43544039	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	15605023	46559041	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	24817978	39654489	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat

Markers in Region

RH130976

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	39,236,824 - 39,237,042 (-)	MAPPER	mRatBN7.2
Rnor_6.0	19	42,970,735 - 42,970,952	NCBI	Rnor6.0
Rnor_5.0	19	53,797,776 - 53,797,993	UniSTS	Rnor5.0
RGSC_v3.4	19	41,191,086 - 41,191,303	UniSTS	RGSC3.4
Celera	19	38,625,737 - 38,625,954	UniSTS
RH 3.4 Map	19	485.4	UniSTS
Cytogenetic Map	19	q12	UniSTS

BE117599

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	39,244,279 - 39,244,471 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	43,474,742 - 43,474,931	NCBI	Rnor6.0
Rnor_5.0	19	54,286,248 - 54,286,437	UniSTS	Rnor5.0
RGSC_v3.4	19	41,198,540 - 41,198,731	UniSTS	RGSC3.4
Celera	19	38,633,194 - 38,633,384	UniSTS
RH 3.4 Map	19	485.4	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	27	20	16	20			34	20	38
Low	1	17	30	21	3	21	8	11	40	15	3	11	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001402201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001402202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_341690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FQ230829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000078854

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	39,236,787 - 39,268,479 (-)	Ensembl
Rnor_6.0 Ensembl	19	42,964,586 - 42,972,101 (+)	Ensembl

RefSeq Acc Id:

XM_039098247 ⟹ XP_038954175

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	39,235,883 - 39,268,536 (-)	NCBI

RefSeq Acc Id:

XM_039098248 ⟹ XP_038954176

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	39,235,883 - 39,268,197 (-)	NCBI

RefSeq Acc Id:

XM_341690 ⟹ XP_341691

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	39,235,883 - 39,268,536 (-)	NCBI

Sequence:

show sequence

GACCAATAGGAGCTCGCTAAGCCGCGGCCGGAGGGTGGGAAGAGTTGCTCACTGTGCGCGGTAG
GTTTTGCGCGGTAGCGACGGCAGAAGTCCCGCTCGGGATGTCCGACTTGGTCCCCGCAGTGGTG
GCTCATGAAGCAATGGACTGCGGTCTTCAGGTACCATTAGACGGTACTCTAGAACAAGCCGCCC
CAACTGAAGTCATCAGCCATGGGGCACCACTTCTCCAGCCTCCGCCTTCTGACTTGGTCAGCAG
CCAAGGCGAAGCGCTTGTTCAGCCTGCCCCTGCTGACGTGGTCAGCAGCCAAGGCGGACTGCCC
ACTCTGCAGCCTGTGCCACCAGCATCCATTGATTTGACGGAGGAAGTACAGCCCGCAGAGGAGA
ATATGGAGATTGTCGATCCGGGAACTTCGGAGGAGCGCAGTGAGGGGTCAGGCACTAACGGTGC
CGTCGGAGCGGCTCCATCAGTTTCAATGAACTACTTCATCAGCGGGCTGCAGAGGCTTCATACC
ATGCTGGAGTTGCTGAGACCTTCATCGTCACAGTCAGACCACAGTGCGGGGGGGCCAATAAGAA
GGAGGAGAAGAACAGGATTCGTTTCGAGGGCAAGAACTGGAGGGTCTCAGAGGCTAAACAATGC
CAGGTTGAGAACCTTCTTTCAGGTGAGCAGGTCTCAGCCTTACCCAGTAGCCTCTGCTCATGGT
TCAGAGGCCAGGACCCCACCCTCGGGAACTGATTCCGACAGCGACAGCTCTGCAGAGAATGAAG
AGGCCGCTGCCCGGGCGGAAGAGCCTGAGGCTGCTGTCCCAGAACAAGGAGTTATCTCAACAGA
CCAAGAAGCTGCATCTGTCACAGGAGGTGACGCATCCCCTAAAAAGCAGTCTCCCCAGAAGCCC
ATCGTTCTACCCACTGTGGAAGATGAGGAAGGGGAAACTTGCACGATCTGTTTGGAACAGTGGA
CCAGTGCTGGGGACCACCGGCTCTCAGCTTTACGCTGCGGGCACCTCTTTGGATATAGATGCAT
TTTTAAATGGCTCAAAGGACAAACACGAAAATGTCCTCAGTGCAACAAGAAAGCCAAGCACAGT
GACATCGTTGTCCTTTATGCCCGGTCCCTGAGAGCTTTGGACACTACTGAACAGGAGCGCATGA
AGAGTGACCTACTGAGTGAGCAGGCTCTCCGGAAGCAGGCCGAGCTGGAATCCGCCCAGTGCCG
GCTCCAGCTTCAGGTCCTTATGGATAAATGCACGAAACTCAATAGCCGTGTCCAGGACTTGGAG
AAGCTTATGGTGCGGCATCAGGGCCCAGCAGGACAGCAGTGCAGCGGCTCCCAAGCACTTTGTG
GGAGCTGCCTGCCCTCCAGCCAGAGCCAGCGCAAATACAGCTCAGAGAAGACCTTCACAGTATC
TCAGACGGGAAACTGCCGAATCATGGCGTATTGCGATGGTCTGAGCTGCTTGGTGGCATCCCAG
CCCTCTCCTCAGGCTTCCTTCCTTCCAGGCTTTGGTGTTAAGATGCTGAGTACTGCGAACATGA
GAAGCAGTCAGTACATCCCTATGCATAGCAAGCAGATTCGTGGACTAGCTTTCAGCAATCAATC
CAAAGGCTTGCTCCTCTCCGCCTCCCTTGACAACACCATTAAACTGACCAGCCTAGAAACAAAT
ACTGTGGTGCAGACTTACAACACTGGACGCCCTGTCTGGAGCTGTTGCTGGTGTCTTGACGAAA
ACAATTACATCTACGCTGGACTGGCCAATGGTTCAATTCTGATCTATGACTTACGGAACACAAA
TACCTATGTCCAGGAATTAGTTCCTCAGAAAGCCAGATGTCCTCTGGTGTCCCTGTCATATTTA
CCCAGAGCTGCGGTGACTGCATTTCCTTACGGTGGGGTGCTGGCTGGAACCTTGGAGAATGCCT
CCTTCTGGGAGCTAAAAACAGACTTTTGTCATAAGCCTCATGTGCTATCCTTGGAGCCAGGGGG
CTTTGTAGACTTTCAGACAGAGAGCAGCACCCGACACTGTCTTGTGACATACAGGCCTGATAAA
AGCCATAACACCGTGCGAACTGTGCTGTTGGAGATGTCTTACAGACTGGATGACGCTGGCGAGC
CGGTCCGCTCCTGCCTTCCTGTGCAGACATTCCTCGGGGGACCCACTTGCAAACTGTTAACCAA
AAGTGCCATCTTCCAGAGCCCAGAGAACGATGGCAGTGTCCACGTGTGCACTGCAGATGAAGCG
TCACAGTCTGCCCTGGTGTGGAATGCTGGCAGTGGCTCATTGCTGCAGAACCTGAAGACTGATG
AGCCTGTCTTGGACATCTGCCCTTTTGAGACGAATCAGAACAGCTACTTGGCCACCTTGACCGA
GAAGATTGTCCACATTTATAAATGGGAGTGAGCGTGGCCGTGAGACCGCTAGGCACGCCGCTAG
TTAATGTGGCATAGTCTGGAGCACCTCATGACTCCAAACAAGATCGCTGTCTACATGCTGGAGC
TGGAACTTCTGGATCATGGTTCATTGGATTAGTGTGATTGTGTGCGGTTTACACCAAATGAGTA
CCTTTGTGAATCTTGCCTGGAAATTTTTTACTTAATTCTATAGGATCTTACAGTCCTCTCAACT
ACCATTTAGGATATGAGTGCACACCAAGCATTTGGGGGTTGTAATAGCCAACCTAAATTGTCGT
GTCAGTTAGGCTAATTGGCTTAAAAGCAGCACACTACAGGCCTGCCATGCTTCTTGGATGCAAA
AGATAGGCGGGCGAGTCTTCCATTAAGCACAAAGGGCACTGTTCATATCCTGTGTAGGATTTGA
CCTATTTCCAAGTCTGAATGCTTACAACCTTTTAGCGACTATTTCGCCCAGACCCCTGCACTGC
TTGCTGCCCCCAATGTCTGGTACTTCAGTGTGGTGTGCTTTGTGGCAACAAGTTCCATCCCCGG
CATCCAGGCCGACTCAAATGTTGGCAAGGCTGGTGGTGGAGGTGGCTGATGAGCCGCCATATGC
AAAACCATATCAAGCCCCGTTGCATTGTGGGAGGTAAGGAAAGGGACCGGGTGGTTGGGATTTT
TCTGGTTAGCTTGGGATGCTGGGGGGGTTTTACTCCCCCTAAAGTCAATGCCTAAGGATATATA
GTTCCCAAGTAAAGGTTCCCCCCACCCCCTTTTTTTCTGAAAAGGTTGTTAATGAAGTGGATAT
GCTCAGGAAGGTAACAGTGGCTAGAGATCTGTGGGAGGCAGGAAGGAAGACTCTTAGAAACTTC
CGTCATGGCGGTCCTGCACAGTCCAGCATCTAGAGGTTTGCTCGGGTTTGTCTACTTGGCCTTA
GGCTACCCCACTGAGCCACTGCCCTACAACACCTTGTCTCAAGGTGTGGCCAACCTGTCTGATT
TCTCTCAGATGTTCCTTGATGAAGCACTATCTTTTTTAATAAAAATTCTTTCATGCCTGTCAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001389130	(Get FASTA)	NCBI Sequence Viewer
	NP_001389131	(Get FASTA)	NCBI Sequence Viewer
	XP_038954175	(Get FASTA)	NCBI Sequence Viewer
	XP_038954176	(Get FASTA)	NCBI Sequence Viewer
	XP_341691	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_038954175 ⟸ XM_039098247
- Peptide Label:	isoform X2

RefSeq Acc Id:

XP_341691 ⟸ XM_341690

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSDLVPAVVAHEAMDCGLQVPLDGTLEQAAPTEVISHGAPLLQPPPSDLVSSQGEALVQPAPAD
VVSSQGGLPTLQPVPPASIDLTEEVQPAEENMEIVDPGTSEERSEGSGTNGAVGAAPSVSMNYF
ISGLQRLHTMLELLRPSSSQSDHSAGGPIRRRRRTGFVSRARTGGSQRLNNARLRTFFQVSRSQ
PYPVASAHGSEARTPPSGTDSDSDSSAENEEAAARAEEPEAAVPEQGVISTDQEAASVTGGDAS
PKKQSPQKPIVLPTVEDEEGETCTICLEQWTSAGDHRLSALRCGHLFGYRCIFKWLKGQTRKCP
QCNKKAKHSDIVVLYARSLRALDTTEQERMKSDLLSEQALRKQAELESAQCRLQLQVLMDKCTK
LNSRVQDLEKLMVRHQGPAGQQCSGSQALCGSCLPSSQSQRKYSSEKTFTVSQTGNCRIMAYCD
GLSCLVASQPSPQASFLPGFGVKMLSTANMRSSQYIPMHSKQIRGLAFSNQSKGLLLSASLDNT
IKLTSLETNTVVQTYNTGRPVWSCCWCLDENNYIYAGLANGSILIYDLRNTNTYVQELVPQKAR
CPLVSLSYLPRAAVTAFPYGGVLAGTLENASFWELKTDFCHKPHVLSLEPGGFVDFQTESSTRH
CLVTYRPDKSHNTVRTVLLEMSYRLDDAGEPVRSCLPVQTFLGGPTCKLLTKSAIFQSPENDGS
VHVCTADEASQSALVWNAGSGSLLQNLKTDEPVLDICPFETNQNSYLATLTEKIVHIYKWE

hide sequence

RefSeq Acc Id:	XP_038954176 ⟸ XM_039098248
- Peptide Label:	isoform X3

Protein Domains

RING-type

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305243	AgrOrtholog
Ensembl Genes	ENSRNOG00000051461	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000084997	ENTREZGENE
	ENSRNOP00000084997.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078854	ENTREZGENE
	ENSRNOT00000078854.2	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	RFWD3	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
NCBI Gene	Rfwd3	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RFWD3	UniProtKB/TrEMBL
	PTHR16047	UniProtKB/TrEMBL
Pfam	zf-RING_2	UniProtKB/TrEMBL
PhenoGen	Rfwd3	PhenoGen
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8I6A1A6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Rfwd3	ring finger and WD repeat domain 3	NEWGENE_1305243	ring finger and WD repeat domain 3	Data Merged	737654	PROVISIONAL
2014-08-25	NEWGENE_1305243	ring finger and WD repeat domain 3			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-06	Rfwd3	ring finger and WD repeat domain 3	RGD1305243_predicted	similar to hypothetical protein FLJ34389 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305243_predicted	similar to hypothetical protein FLJ34389 (predicted)	LOC361409_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC361409_predicted	similar to hypothetical protein FLJ34389 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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