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Gene: Rfwd3 (ring finger and WD repeat domain 3) Rattus norvegicus
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Symbol: Rfwd3
Name: ring finger and WD repeat domain 3
Description: Predicted to have MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; mitotic G1 DNA damage checkpoint; and regulation of DNA damage checkpoint. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3); INTERACTS WITH bisphenol A; cobalt dichloride; ochratoxin A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: E3 ubiquitin-protein ligase RFWD3-like; LOC361409; RGD1305243; similar to hypothetical protein FLJ34389
Orthologs:
Homo sapiens (human) : RFWD3 (ring finger and WD repeat domain 3)  HGNC  Alliance
Mus musculus (house mouse) : Rfwd3 (ring finger and WD repeat domain 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfwd3 (ring finger and WD repeat domain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RFWD3 (ring finger and WD repeat domain 3)
Canis lupus familiaris (dog) : RFWD3 (ring finger and WD repeat domain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfwd3 (ring finger and WD repeat domain 3)
Sus scrofa (pig) : RFWD3 (ring finger and WD repeat domain 3)
Chlorocebus sabaeus (African green monkey) : RFWD3 (ring finger and WD repeat domain 3)
Heterocephalus glaber (naked mole-rat) : Rfwd3 (ring finger and WD repeat domain 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01942,960,597 - 42,971,894 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,964,586 - 42,972,101 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01953,787,638 - 53,798,031 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01954,289,116 - 54,310,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,190,144 - 41,222,888 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11941,195,928 - 41,258,147 (-)NCBI
Celera1938,624,801 - 38,656,469 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Rfwd3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305243
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.