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ONTOLOGY REPORT - ANNOTATIONS

Term:response to caffeine
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Accession:GO:0031000 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.


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response to caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor involved_in ISO RGD
MGI		 PMID:16481441 GO_REF:0000096 MGI:4417868 RGD:1625231 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO RGD PMID:17236787 RGD:1599474 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:6149265 RGD:2303533 NCBI chr 5:31,211,964...31,235,823
Ensembl chr 5:31,212,124...31,235,823 		JBrowse link
G Dhodh dihydroorotate dehydrogenase ISO RGD PMID:6149265 RGD:2303533 NCBI chr 8:110,319,876...110,335,330
Ensembl chr 8:110,317,975...110,335,305 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:24717552 RGD:9590296 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Dnmt3b DNA methyltransferase 3B ISO RGD PMID:24717552 RGD:9590296 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO RGD PMID:12834266 RGD:9685460 NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046 		JBrowse link
G Fkbp1a FK506 binding protein 1a acts_upstream_of_or_within IMP (PMID:15289441) MGI PMID:15289441 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type acts_upstream_of_or_within IMP (PMID:11404425) MGI PMID:11404425 NCBI chr18:67,221,369...67,359,863
Ensembl chr18:67,221,287...67,359,863 		JBrowse link
G Hdac1 histone deacetylase 1 ISO RGD PMID:24717552 RGD:9590296 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac2 histone deacetylase 2 ISO RGD PMID:24717552 RGD:9590296 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:22995397 RGD:8661261 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il6 interleukin 6 ISO Cell shortening response decreased RGD PMID:15845578 RGD:2306941 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO RGD
MGI		 PMID:21940847 PMID:22995397 GO_REF:0000096 MGI:4417868 RGD:6483017 RGD:8661261 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:18486259 RGD:2301880 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit involved_in ISO RGD
MGI		 PMID:19608206 GO_REF:0000096 MGI:4417868 RGD:2316809 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit involved_in ISO RGD
MGI		 PMID:19608206 GO_REF:0000096 MGI:4417868 RGD:2316809 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prss2 serine protease 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:41,498,710...41,502,013
Ensembl chr 6:41,498,721...41,502,013 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac involved_in
acts_upstream_of_or_within		 IDA
ISO		 (MGI:1345009|PMID:10473538)
(PMID:14593104)		 UniProt
MGI		 PMID:10473538 PMID:14593104 GO_REF:0000119 MGI:1345009 MGI:4834177 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Sdc2 syndecan 2 ISO RGD PMID:16458123 RGD:2311709 NCBI chr15:32,920,869...33,034,867
Ensembl chr15:32,920,869...33,035,081 		JBrowse link
G Trp53 transformation related protein 53 ISO RGD PMID:16544096 RGD:2290579 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Try10 trypsin 10 ISO RGD PMID:2726780 RGD:1599974 NCBI chr 6:41,331,039...41,334,878
Ensembl chr 6:41,331,039...41,334,848 		JBrowse link
cellular response to caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casq2 calsequestrin 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:101,993,731...102,053,830
Ensembl chr 3:101,993,731...102,053,830 		JBrowse link
G Chek1 checkpoint kinase 1 ISO RGD PMID:11278490 RGD:2316109 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 involved_in ISO (PMID:22406107) BHF-UCL PMID:22406107 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:107,833,650...107,839,193
Ensembl chr 3:107,833,650...107,839,133 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha ISO RGD PMID:17516843 RGD:10059651 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle involved_in IMP
ISO		 (MGI:74313|PMID:7621815) UniProt
MGI		 PMID:7621815 GO_REF:0000119 MGI:4834177 MGI:74313 NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac involved_in
acts_upstream_of_or_within		 IDA
ISO		 (MGI:1267127|PMID:9628868), (MGI:5431202|PMID:22406107)
(PMID:12089338)		 UniProt
MGI		 PMID:9628868 PMID:12089338 PMID:22406107 GO_REF:0000119 MGI:1267127 MGI:4834177 MGI:5431202 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within IMP (PMID:23325319) MGI PMID:23325319 NCBI chr 4:134,265,203...134,279,477
Ensembl chr 4:134,265,203...134,279,477 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 involved_in IMP (MGI:1927695|PMID:10967099) BHF-UCL PMID:10967099 MGI:1927695 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Tmem38a transmembrane protein 38A acts_upstream_of_or_within IGI (PMID:17611541) MGI PMID:17611541 NCBI chr 8:73,325,033...73,341,128
Ensembl chr 8:73,325,899...73,341,126 		JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within IGI (PMID:17611541) MGI PMID:17611541 NCBI chr 4:53,825,988...53,862,019
Ensembl chr 4:53,826,045...53,862,019 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO RGD PMID:22319196 RGD:10043374 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28576
    response to stimulus 10773
      response to chemical 5403
        response to organic substance 3912
          response to organonitrogen compound 1456
            response to purine-containing compound 244
              response to caffeine 33
                cellular response to caffeine + 12
paths to the root