Ryr1 (ryanodine receptor 1, skeletal muscle) - Rat Genome Database
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Gene: Ryr1 (ryanodine receptor 1, skeletal muscle) Mus musculus
Analyze
Symbol: Ryr1
Name: ryanodine receptor 1, skeletal muscle
RGD ID: 1316414
MGI Page MGI
Description: Exhibits protease binding activity; ryanodine-sensitive calcium-release channel activity; and voltage-gated calcium channel activity. Involved in several processes, including animal organ development; cellular response to caffeine; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Localizes to T-tubule; endoplasmic reticulum; and junctional membrane complex. Is expressed in several structures, including brain; embryo mesenchyme; heart; sciatic nerve; and skeletal musculature. Used to study central core myopathy and malignant hyperthermia. Human ortholog(s) of this gene implicated in central core myopathy and malignant hyperthermia. Orthologous to human RYR1 (ryanodine receptor 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; long term depression; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',3,3',6,6'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI528790; calcium release channel; R; ryanodine receptor 1; Ryr; RYR-1; s; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; skrr; type 1 ryanodine receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,702,765 - 28,824,599 (-)NCBIGRCm39mm39
GRCm38729,003,340 - 29,125,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,003,344 - 29,125,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,788,359 - 29,910,170 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,712,104 - 28,833,911 (-)NCBImm8
Celera723,565,768 - 23,695,212 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormal Reflexes  (ISO)
alopecia  (ISO)
ankyloglossia  (ISO)
Arthrogryposis  (ISO)
arthrogryposis due to muscular dystrophy  (ISO)
atrial heart septal defect  (ISO)
Autoimmune Hypothyroidism  (ISO)
autoimmune thyroiditis  (ISO)
Axial Myopathy, Late-Onset  (ISO)
caudal regression syndrome  (ISO)
central core myopathy  (IEA,ISO)
centronuclear myopathy  (ISO)
clubfoot  (ISO)
Colonic Atresia  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
congenital fiber-type disproportion  (ISO,ISS)
Congenital Hip Dislocation  (ISO)
congenital muscular dystrophy  (ISO)
congenital myasthenic syndrome  (ISO)
congenital myopathy  (ISO)
Congenital Neuromuscular Disease, with Uniform Type 1 Fiber  (ISO)
congenital ptosis  (ISO)
congenital structural myopathy  (ISO)
Contracture  (ISO)
craniosynostosis  (ISO)
dilated cardiomyopathy  (ISO)
distal arthrogryposis  (ISO)
Dwarfism  (ISO)
Eczema  (ISO)
epilepsy  (ISO)
esotropia  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hashimoto Disease  (ISO)
hydronephrosis  (ISO)
Hydrops Fetalis  (ISO)
hypertrophic cardiomyopathy  (ISO)
ichthyosis  (ISO)
intellectual disability  (ISO)
Intracranial Hemorrhages  (ISO)
isolated elevated serum creatine phosphokinase levels  (ISO)
King Denborough Syndrome  (ISO)
Language Development Disorders  (ISO)
learning disability  (ISO)
Malignant Fever  (ISO)
malignant hyperthermia  (IEA,ISO)
Malignant Hypothermia  (ISO)
Minicore Myopathy with External Ophthalmoplegia  (ISO)
Mitochondrial Progressive Myopathy with Congenital Cataract, Hearing Loss, and Developmental Delay  (ISO)
Muscle Cramp  (ISO)
Muscle Hypotonia  (ISO)
Muscle Rigidity  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
Myalgia  (ISO)
myopathy  (ISO)
Myotonia  (ISO)
neuromuscular disease  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
Odontogenic Tumors  (ISO)
osteoporosis  (ISO)
polyhydramnios  (ISO)
psoriasis  (ISO)
ptosis  (ISO)
pulmonary valve stenosis  (ISO)
purpura  (ISO)
renal cell carcinoma  (ISO)
Rhabdomyolysis  (ISO)
rigid spine muscular dystrophy 1  (ISO)
scoliosis  (ISO)
sensory peripheral neuropathy  (ISO)
thrombocytopenia  (ISO)
Ventricular Tachycardia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4-chloro-m-cresol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
baclofen  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysene  (EXP)
dantrolene  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
flubendiamide  (EXP)
folic acid  (EXP)
graphite  (EXP)
halothane  (ISO)
L-methionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
pioglitazone  (EXP)
raloxifene  (ISO)
ryanodine  (EXP,ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
spermine  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tetracaine  (EXP)
titanium dioxide  (EXP)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cell physiology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal mitochondrial shape  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle electrophysiology  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal posture  (IAGP)
abnormal potassium ion homeostasis  (IAGP)
abnormal respiratory quotient  (IEA)
abnormal rib morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal sarcoplasmic reticulum morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal spleen weight  (IEA)
abnormal thoracic cage shape  (IAGP)
abnormal Z line morphology  (IAGP)
acidemia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cleft secondary palate  (IAGP)
cyanosis  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased grip strength  (IAGP)
decreased skeletal muscle fiber diameter  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased total body fat amount  (IAGP)
delayed bone ossification  (IAGP)
delayed heart development  (IAGP)
domed cranium  (IAGP)
edema  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
fetal growth retardation  (IAGP)
hindlimb paralysis  (IAGP)
hypercapnia  (IAGP)
impaired muscle contractility  (IAGP)
impaired muscle relaxation  (IAGP)
impaired skeletal muscle contractility  (IAGP)
increased body weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating potassium level  (IAGP)
increased core body temperature  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased spleen weight  (IEA)
increased susceptibility to malignant hyperthermia  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
muscle tetany  (IAGP)
muscle twitch  (IAGP)
muscle weakness  (IAGP)
myopathy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no spontaneous movement  (IAGP)
omphalocele  (IAGP)
ostium primum atrial septal defect  (IAGP)
ostium secundum atrial septal defect  (IAGP)
paralysis  (IAGP)
pectus excavatum  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
skeletal muscle degeneration  (IAGP)
skin edema  (IAGP)
thin ribs  (IAGP)
tight skin  (IAGP)
translucent skin  (IAGP)
underdeveloped hair follicles  (IAGP)
unresponsive to tactile stimuli  (IAGP)
References

Additional References at PubMed
PMID:1315127   PMID:1774073   PMID:1967823   PMID:1970795   PMID:2300206   PMID:2421615   PMID:3161450   PMID:4600883   PMID:7515481   PMID:7621815   PMID:7635066   PMID:7724570  
PMID:7832748   PMID:7876312   PMID:7931345   PMID:7959768   PMID:8288260   PMID:8598910   PMID:8618963   PMID:8626432   PMID:8812484   PMID:8910220   PMID:8943043   PMID:9054435  
PMID:9124414   PMID:9192302   PMID:9204703   PMID:9242641   PMID:9384575   PMID:9461216   PMID:9472036   PMID:9480761   PMID:9489997   PMID:9799464   PMID:9817784   PMID:9986730  
PMID:10213392   PMID:10349636   PMID:10444070   PMID:10473538   PMID:10736313   PMID:10788707   PMID:11042159   PMID:11076861   PMID:11159936   PMID:11217851   PMID:11500519   PMID:11784029  
PMID:11818962   PMID:11852053   PMID:11860456   PMID:12023238   PMID:12364321   PMID:12376096   PMID:12414688   PMID:12466851   PMID:12477932   PMID:12486242   PMID:12640042   PMID:12642598  
PMID:12654335   PMID:12704193   PMID:12732639   PMID:12954602   PMID:14592808   PMID:14592949   PMID:14610273   PMID:14660561   PMID:14672973   PMID:15033925   PMID:15102471   PMID:15280431  
PMID:15289441   PMID:15313613   PMID:15381065   PMID:15469935   PMID:15536090   PMID:15619962   PMID:15894801   PMID:15972723   PMID:16141072   PMID:16141073   PMID:16246297   PMID:16284304  
PMID:16357209   PMID:16484216   PMID:16602821   PMID:16737973   PMID:16762927   PMID:16844763   PMID:16920191   PMID:17033962   PMID:17074386   PMID:17118445   PMID:17122579   PMID:17158949  
PMID:17520475   PMID:17925380   PMID:17942409   PMID:18003898   PMID:18089560   PMID:18206662   PMID:18215135   PMID:18268335   PMID:18313230   PMID:18322139   PMID:18394989   PMID:18403125  
PMID:18434328   PMID:18434746   PMID:18488020   PMID:18556650   PMID:18643873   PMID:18650434   PMID:18663468   PMID:18676612   PMID:18772199   PMID:18927079   PMID:19011160   PMID:19033399  
PMID:19131108   PMID:19198614   PMID:19246389   PMID:19398467   PMID:19549818   PMID:19802526   PMID:19959667   PMID:19966218   PMID:20207743   PMID:20479108   PMID:20479110   PMID:20519450  
PMID:20576841   PMID:20926377   PMID:20955474   PMID:20961389   PMID:20978128   PMID:21150295   PMID:21156754   PMID:21262876   PMID:21267068   PMID:21289290   PMID:21441923   PMID:21575570  
PMID:21646399   PMID:21784520   PMID:21803290   PMID:21803293   PMID:21825032   PMID:21858002   PMID:21873635   PMID:21896730   PMID:21933672   PMID:21969454   PMID:22036948   PMID:22131268  
PMID:22139840   PMID:22203976   PMID:22231556   PMID:22355118   PMID:22411552   PMID:22504960   PMID:22505613   PMID:22853897   PMID:22939628   PMID:22962299   PMID:23070698   PMID:23071115  
PMID:23152933   PMID:23159934   PMID:23223241   PMID:23247505   PMID:23278119   PMID:23308296   PMID:23413940   PMID:23454728   PMID:23463619   PMID:23482488   PMID:23509717   PMID:23695157  
PMID:23785297   PMID:23798496   PMID:23818578   PMID:23918386   PMID:23992453   PMID:24123915   PMID:24143248   PMID:24325401   PMID:24509862   PMID:24703692   PMID:24962901   PMID:25239916  
PMID:25384984   PMID:25548159   PMID:25564733   PMID:25619131   PMID:25640239   PMID:25874477   PMID:26025922   PMID:26114725   PMID:26134413   PMID:26462735   PMID:26494785   PMID:26575622  
PMID:26831464   PMID:26910427   PMID:27150455   PMID:27382027   PMID:27621462   PMID:27655403   PMID:27802169   PMID:27841305   PMID:28465322   PMID:28724790   PMID:29130937   PMID:29543863  
PMID:29593014   PMID:29701772   PMID:29949772   PMID:30071129   PMID:30236258   PMID:30420428   PMID:30563862   PMID:30689883   PMID:30770808   PMID:30786075   PMID:30870432   PMID:31044239  
PMID:31107960   PMID:31199454   PMID:32325033   PMID:33037202  


Genomics

Comparative Map Data
Ryr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,702,765 - 28,824,599 (-)NCBIGRCm39mm39
GRCm38729,003,340 - 29,125,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,003,344 - 29,125,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,788,359 - 29,910,170 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,712,104 - 28,833,911 (-)NCBImm8
Celera723,565,768 - 23,695,212 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
RYR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1938,433,691 - 38,587,564 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1938,433,699 - 38,587,564 (+)EnsemblGRCh38hg38GRCh38
GRCh381938,433,691 - 38,587,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371938,924,340 - 39,078,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,616,180 - 43,770,044 (+)NCBINCBI36hg18NCBI36
Build 341943,616,179 - 43,770,012NCBI
Celera1935,726,452 - 35,880,238 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1935,371,495 - 35,526,332 (+)NCBIHuRef
CHM1_11938,924,701 - 39,079,134 (+)NCBICHM1_1
Ryr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0187,959,596 - 88,066,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,959,712 - 88,066,101 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,135,622 - 89,241,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,116,098 - 84,254,503 (-)NCBIRGSC3.4rn4RGSC3.4
Celera178,682,691 - 78,812,242 (-)NCBICelera
Cytogenetic Map1q21NCBI
Ryr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468879,951 - 1,000,036 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468879,807 - 1,000,118 (-)NCBIChiLan1.0ChiLan1.0
RYR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,099,196 - 44,256,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,106,036 - 44,256,327 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,527,466 - 35,685,446 (+)NCBIMhudiblu_PPA_v0panPan3
RYR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1114,461,348 - 114,579,493 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11114,461,350 - 114,579,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ryr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049368011,185,615 - 1,298,416 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1647,339,759 - 47,458,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,840,240 - 42,960,110 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2NCBI
RYR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl633,080,758 - 33,213,788 (+)Ensembl
ChlSab1.1633,080,443 - 33,234,478 (+)NCBI
Ryr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479411,888,211 - 12,004,457 (+)NCBI

Position Markers
AI528790  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,003,373 - 29,003,512UniSTSGRCm38
MGSCv37729,788,392 - 29,788,531UniSTSGRCm37
Celera723,565,801 - 23,565,940UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map7A2-B3UniSTS
Whitehead/MRC_RH7401.22UniSTS
AW534727  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38729,069,088 - 29,069,629UniSTSGRCm38
MGSCv37729,854,107 - 29,854,648UniSTSGRCm37
Celera723,639,537 - 23,640,078UniSTS
Cytogenetic Map7A2-B3UniSTS
Ryr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A2-B3UniSTS
Ryr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A2-B3UniSTS
cM Map710.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7269777136697919Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined71028944244289559Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71060637344606511Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71899486940024609Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72719819161202351Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72760637337142942Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72789112561891125Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:190
Interacting mature miRNAs:194
Transcripts:ENSMUST00000032813, ENSMUST00000179893
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC165142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ308737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ310365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ310366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY268935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032813   ⟹   ENSMUSP00000032813
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,003,344 - 29,125,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000179893   ⟹   ENSMUSP00000137123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,003,344 - 29,125,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,068,999 - 29,072,077 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,114,183 - 29,125,179 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208010
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,045,196 - 29,047,514 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,022,099 - 29,046,683 (-)Ensembl
RefSeq Acc Id: ENSMUST00000208922
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,122,628 - 29,125,152 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214374   ⟹   ENSMUSP00000149042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl729,003,344 - 29,125,015 (-)Ensembl
RefSeq Acc Id: NM_009109   ⟹   NP_033135
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,576 (-)NCBI
GRCm38729,003,340 - 29,125,151 (-)NCBI
MGSCv37729,788,359 - 29,910,170 (-)RGD
Celera723,565,768 - 23,695,212 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006539689   ⟹   XP_006539752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
GRCm38729,003,340 - 29,125,179 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152814   ⟹   XP_036008707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
RefSeq Acc Id: XM_036152815   ⟹   XP_036008708
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
RefSeq Acc Id: XM_036152816   ⟹   XP_036008709
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
RefSeq Acc Id: XM_036152817   ⟹   XP_036008710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
RefSeq Acc Id: XM_036152818   ⟹   XP_036008711
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
RefSeq Acc Id: XM_036152819   ⟹   XP_036008712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,702,765 - 28,824,599 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033135   ⟸   NM_009109
- UniProtKB: E9PZQ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006539752   ⟸   XM_006539689
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSMUSP00000032813   ⟸   ENSMUST00000032813
RefSeq Acc Id: ENSMUSP00000137123   ⟸   ENSMUST00000179893
RefSeq Acc Id: ENSMUSP00000149042   ⟸   ENSMUST00000214374
RefSeq Acc Id: XP_036008712   ⟸   XM_036152819
- Peptide Label: isoform X7
RefSeq Acc Id: XP_036008710   ⟸   XM_036152817
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036008708   ⟸   XM_036152815
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036008711   ⟸   XM_036152818
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036008709   ⟸   XM_036152816
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036008707   ⟸   XM_036152814
- Peptide Label: isoform X1
Protein Domains
B30.2/SPRY   EF-hand   MIR   RYDR_ITPR

Promoters
RGD ID:6892512
Promoter ID:EPDNEW_M9707
Type:multiple initiation site
Name:Ryr1_1
Description:Mus musculus ryanodine receptor 1, skeletal muscle , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38729,125,152 - 29,125,212EPDNEW
RGD ID:6841968
Promoter ID:MM_KWN:49695
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_009109,   UC009GAR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,909,806 - 29,910,306 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99659 AgrOrtholog
Ensembl Genes ENSMUSG00000030592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032813 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000137123 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149042 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032813 UniProtKB/TrEMBL
  ENSMUST00000179893 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000214374 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryan_recept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanrecept_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY1_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY2_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY3_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20190 UniProtKB/Swiss-Prot
MGD MGI:99659 ENTREZGENE
NCBI Gene 20190 ENTREZGENE
PANTHER PTHR13715:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RR_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RYR1 RGD
PhenoGen Ryr1 PhenoGen
PRINTS RYANODINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.439745 ENTREZGENE
UniProt A0A1L1SQG7_MOUSE UniProtKB/TrEMBL
  E9PZQ0 ENTREZGENE
  K3W4M2_MOUSE UniProtKB/TrEMBL
  P70272_MOUSE UniProtKB/TrEMBL
  Q8C4R0_MOUSE UniProtKB/TrEMBL
  Q99JE8_MOUSE UniProtKB/TrEMBL
  RYR1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q60834 UniProtKB/Swiss-Prot
  Q61779 UniProtKB/Swiss-Prot
  Q61780 UniProtKB/Swiss-Prot
  Q62173 UniProtKB/Swiss-Prot
  Q62196 UniProtKB/Swiss-Prot
  Q62235 UniProtKB/Swiss-Prot
  Q78EJ6 UniProtKB/Swiss-Prot
  Q7TNG1 UniProtKB/Swiss-Prot
  Q80UQ5 UniProtKB/Swiss-Prot
  Q80X16 UniProtKB/Swiss-Prot
  Q99JF9 UniProtKB/Swiss-Prot