Tmem38a (transmembrane protein 38A) - Rat Genome Database
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Gene: Tmem38a (transmembrane protein 38A) Mus musculus
Analyze
Symbol: Tmem38a
Name: transmembrane protein 38A
RGD ID: 1550335
MGI Page MGI
Description: Exhibits identical protein binding activity and potassium channel activity. Involved in several processes, including cellular response to caffeine; potassium ion transmembrane transport; and regulation of sequestering of calcium ion. Localizes to nuclear membrane and sarcoplasmic reticulum. Is expressed in head mesenchyme; tongue; and vertebral axis musculature. Orthologous to human TMEM38A (transmembrane protein 38A); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110001E17Rik; 27 kDa sarcoplasmic reticulum protein; AI413399; mg33a; mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; TRI; TRIC-A; TRICA; trimeric intracellular cation channel type A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,325,033 - 73,341,128 (+)NCBIGRCm39mm39
GRCm38872,571,189 - 72,587,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,572,055 - 72,587,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37875,096,002 - 75,111,183 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,501,092 - 75,516,273 (+)NCBImm8
Celera876,918,441 - 76,933,607 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17611541   PMID:18035970  
PMID:19095005   PMID:20858894   PMID:21267068   PMID:21803293   PMID:23592776   PMID:24526676   PMID:27264872   PMID:30907436   PMID:31805819  


Genomics

Comparative Map Data
Tmem38a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,325,033 - 73,341,128 (+)NCBIGRCm39mm39
GRCm38872,571,189 - 72,587,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,572,055 - 72,587,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv37875,096,002 - 75,111,183 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,501,092 - 75,516,273 (+)NCBImm8
Celera876,918,441 - 76,933,607 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
TMEM38A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,661,139 - 16,690,023 (+)EnsemblGRCh38hg38GRCh38
GRCh381916,661,139 - 16,690,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,771,938 - 16,799,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,632,938 - 16,660,830 (+)NCBINCBI36hg18NCBI36
Build 341916,632,937 - 16,660,814NCBI
Celera1916,673,777 - 16,701,673 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,340,650 - 16,368,543 (+)NCBIHuRef
CHM1_11916,771,437 - 16,799,383 (+)NCBICHM1_1
Tmem38a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01618,960,197 - 18,974,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,959,315 - 18,974,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,822,741 - 18,837,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,669,835 - 17,684,440 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,668,985 - 17,684,446 (-)NCBI
Celera1617,478,830 - 17,493,434 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tmem38a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,132,111 - 1,144,380 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,132,111 - 1,144,335 (-)NCBIChiLan1.0ChiLan1.0
TMEM38A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,129,060 - 17,159,002 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,129,842 - 17,159,002 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,150,715 - 16,179,256 (+)NCBIMhudiblu_PPA_v0panPan3
TMEM38A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,877,524 - 45,894,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,876,642 - 45,895,054 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem38a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,965,220 - 3,984,120 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM38A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,929,049 - 60,960,467 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,929,043 - 60,960,527 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,517,874 - 60,526,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103234112
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,169,143 - 15,200,372 (+)NCBI
ChlSab1.1 Ensembl615,170,033 - 15,200,481 (+)Ensembl
Tmem38a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908837,753 - 849,972 (-)NCBI

Position Markers
AI413399  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,586,987 - 72,587,150UniSTSGRCm38
MGSCv37875,110,886 - 75,111,049UniSTSGRCm37
Celera876,933,310 - 76,933,473UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8772.05UniSTS
UniSTS:235927  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,572,579 - 72,572,787UniSTSGRCm38
MGSCv37875,096,478 - 75,096,686UniSTSGRCm37
Celera876,918,917 - 76,919,125UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:385
Count of miRNA genes:302
Interacting mature miRNAs:329
Transcripts:ENSMUST00000034244
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_151663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB261158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC172623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC182435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU707844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF988666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034244   ⟹   ENSMUSP00000034244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,572,073 - 72,587,282 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211914   ⟹   ENSMUSP00000148844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,572,091 - 72,586,181 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212763   ⟹   ENSMUSP00000148388
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,572,055 - 72,586,175 (+)Ensembl
RefSeq Acc Id: NM_001357278   ⟹   NP_001344207
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357279   ⟹   NP_001344208
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357280   ⟹   NP_001344209
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357284   ⟹   NP_001344213
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144534   ⟹   NP_653117
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
MGSCv37875,096,002 - 75,111,183 (+)RGD
Celera876,918,441 - 76,933,607 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_151663
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,667 - 73,341,128 (+)NCBI
GRCm38872,571,823 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312988   ⟹   XP_017168477
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,033 - 73,341,128 (+)NCBI
GRCm38872,571,189 - 72,587,284 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154325   ⟹   XP_036010218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,325,866 - 73,341,128 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_653117   ⟸   NM_144534
- Peptide Label: isoform 1
- UniProtKB: Q3TMP8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168477   ⟸   XM_017312988
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001344208   ⟸   NM_001357279
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001344209   ⟸   NM_001357280
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001344213   ⟸   NM_001357284
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001344207   ⟸   NM_001357278
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000148844   ⟸   ENSMUST00000211914
RefSeq Acc Id: ENSMUSP00000034244   ⟸   ENSMUST00000034244
RefSeq Acc Id: ENSMUSP00000148388   ⟸   ENSMUST00000212763
RefSeq Acc Id: XP_036010218   ⟸   XM_036154325
- Peptide Label: isoform X1

Promoters
RGD ID:8667495
Promoter ID:EPDNEW_M11774
Type:initiation region
Name:Tmem38a_1
Description:Mus musculus transmembrane protein 38A , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,572,044 - 72,572,104EPDNEW
RGD ID:6843854
Promoter ID:MM_KWN:54877
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Liver,   Spleen
Transcripts:UC009MGI.1,   UC009MGJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36875,095,026 - 75,096,132 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921416 AgrOrtholog
Ensembl Genes ENSMUSG00000031791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034244 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148388 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000148844 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034244 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211914 UniProtKB/TrEMBL
  ENSMUST00000212763 ENTREZGENE, UniProtKB/TrEMBL
InterPro TRIC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74166 UniProtKB/Swiss-Prot
MGD MGI:1921416 ENTREZGENE
NCBI Gene 74166 ENTREZGENE
PANTHER PTHR12454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TRIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem38a PhenoGen
UniGene Mm.212927 ENTREZGENE
UniProt A0A1D5RLJ0_MOUSE UniProtKB/TrEMBL
  A0A1D5RMM9_MOUSE UniProtKB/TrEMBL
  Q3TMP8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A5A6S4 UniProtKB/Swiss-Prot
  A7LBB7 UniProtKB/Swiss-Prot
  Q3TZB9 UniProtKB/Swiss-Prot
  Q91WL2 UniProtKB/Swiss-Prot