Ryr2 (ryanodine receptor 2, cardiac) - Rat Genome Database

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Gene: Ryr2 (ryanodine receptor 2, cardiac) Mus musculus
Analyze
Symbol: Ryr2
Name: ryanodine receptor 2, cardiac
RGD ID: 1557868
MGI Page MGI
Description: Enables several functions, including calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; cardiac muscle hypertrophy; and left ventricular cardiac muscle tissue morphogenesis. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of calcium channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330127I20Rik; calcium release channel; cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; ryanodine receptor 2; ryanodine receptor type 2; RYR-2; type 2 ryanodine receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391311,567,985 - 12,121,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl1311,567,988 - 12,121,831 (-)Ensembl
GRCm381311,553,099 - 12,106,945 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1311,553,102 - 12,106,945 (-)EnsemblGRCm38mm10GRCm38
MGSCv371311,645,370 - 12,199,212 (-)NCBIGRCm37mm9NCBIm37
MGSCv361311,608,677 - 12,160,499 (-)NCBImm8
Celera1311,467,020 - 12,025,871 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 2  (IEA,ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
autism spectrum disorder  (ISO)
Brugada syndrome  (ISO)
cardiac arrest  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (IEA,ISO)
catecholaminergic polymorphic ventricular tachycardia 2  (ISO)
Childhood Schizophrenia  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diastolic Dysfunction  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1AA  (ISO)
dilated cardiomyopathy 1B  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Familial Sudden Death  (ISO)
Familial Ventricular Tachycardia  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
heart disease  (IEA,ISO)
Hereditary Leiomyomatosis and Renal Cell Cancer  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
Infant Death  (ISO)
left ventricular noncompaction  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
malignant mesothelioma  (ISO)
Myocardial Ischemia  (ISO)
parathyroid carcinoma  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
Syncope  (ISO)
Tachycardia  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Fibrillation, Paroxysmal Familial, 1  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17beta-estradiol  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atenolol  (ISO)
baclofen  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bicuculline  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
carvedilol  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cocaine  (EXP,ISO)
Cuprizon  (ISO)
cyclic ADP-ribose  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
flutamide  (EXP)
folic acid  (EXP)
fonofos  (ISO)
gentamycin  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
linsidomine  (ISO)
maraviroc  (EXP)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mifepristone  (EXP)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nicotine  (EXP,ISO)
O-methyleugenol  (ISO)
ouabain  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
perindopril  (ISO)
phenytoin  (ISO)
picrotoxin  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
razoxane  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
ryanodine  (EXP,ISO)
SCH 23390  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (EXP,ISO)
terbufos  (ISO)
thalidomide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transmembrane transport  (IMP,ISO)
calcium ion transport  (IDA,IMP,IPI,ISO)
calcium ion transport into cytosol  (ISO)
calcium-mediated signaling  (IMP)
calcium-mediated signaling using intracellular calcium source  (ISO)
cardiac muscle contraction  (ISO)
cardiac muscle hypertrophy  (IMP)
cellular calcium ion homeostasis  (IMP)
cellular response to caffeine  (IDA,ISO)
cellular response to epinephrine stimulus  (IMP)
cytosolic calcium ion transport  (IMP)
detection of calcium ion  (ISO)
embryonic heart tube morphogenesis  (IMP)
establishment of protein localization to endoplasmic reticulum  (ISO)
ion transmembrane transport  (ISO)
ion transport  (IEA)
left ventricular cardiac muscle tissue morphogenesis  (IMP)
manganese ion transmembrane transport  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
positive regulation of heart rate  (IMP)
positive regulation of sequestering of calcium ion  (ISO)
positive regulation of the force of heart contraction  (ISO)
Purkinje myocyte to ventricular cardiac muscle cell signaling  (IMP)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of AV node cell action potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IGI)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of heart rate  (IMP,ISO)
regulation of SA node cell action potential  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO)
release of sequestered calcium ion into cytosol  (IBA,ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IDA,IMP,ISO)
response to caffeine  (IDA,ISO)
response to calcium ion  (ISO)
response to hypoxia  (IDA)
response to magnesium ion  (ISO)
response to muscle activity  (ISO)
response to muscle stretch  (ISO)
response to nutrient  (ISO)
response to redox state  (ISO)
response to xenobiotic stimulus  (ISO)
sarcoplasmic reticulum calcium ion transport  (ISO)
transmembrane transport  (IEA)
type B pancreatic cell apoptotic process  (IMP,ISO)
ventricular cardiac muscle cell action potential  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal afterhyperpolarization  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal epicardium morphology  (IAGP)
abnormal fetal cardiomyocyte morphology  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal mycardial fiber calcium currents  (IAGP)
abnormal mycoardial fiber sodium currents  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal sarcoplasmic reticulum morphology  (IAGP)
abnormal sinus arrhythmia  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal T wave  (IAGP)
absent heartbeat  (IAGP)
atrial fibrillation  (IAGP)
atrioventricular block  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiomyopathy  (IAGP)
congestive heart failure  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating glucose level  (IEA)
decreased heart rate  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased survivor rate  (IAGP)
decreased ventricle muscle contractility  (IAGP)
disorganized myocardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
fetal growth retardation  (IAGP)
heart left ventricle hypertrophy  (IAGP)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased response of heart to induced stress  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
increased thymus weight  (IAGP)
increased tumor incidence  (IAGP)
irregular heartbeat  (IAGP)
large lymphoid organs  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethargy  (IAGP)
myositis  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
sinus bradycardia  (IAGP)
thick interventricular septum  (IAGP)
thick ventricular wall  (IAGP)
thin interventricular septum  (IAGP)
thymus cortex hyperplasia  (IAGP)
tonic-clonic seizures  (IAGP)
ventricular fibrillation  (IAGP)
ventricular premature beat  (IAGP)
ventricular tachycardia  (IAGP)
References

Additional References at PubMed
PMID:4600883   PMID:7621815   PMID:7635066   PMID:7876312   PMID:7959768   PMID:8898078   PMID:9027500   PMID:9070932   PMID:9124414   PMID:9204703   PMID:9242641   PMID:9384575  
PMID:9628868   PMID:9986730   PMID:10349636   PMID:10473538   PMID:10788707   PMID:11042159   PMID:11076861   PMID:11429443   PMID:11472062   PMID:11784029   PMID:11812828   PMID:11860456  
PMID:12089338   PMID:12169647   PMID:12324472   PMID:12477932   PMID:12676814   PMID:12777394   PMID:12837242   PMID:12919952   PMID:14550562   PMID:14557272   PMID:14592808   PMID:14593104  
PMID:14610273   PMID:14633990   PMID:14715536   PMID:14963485   PMID:14985349   PMID:15024040   PMID:15033925   PMID:15044459   PMID:15073377   PMID:15102471   PMID:15280431   PMID:15777620  
PMID:15890976   PMID:16141072   PMID:16141073   PMID:16157601   PMID:16164837   PMID:16204356   PMID:16213210   PMID:16239587   PMID:16249315   PMID:16352659   PMID:16407108   PMID:16481613  
PMID:16602821   PMID:16672364   PMID:16678258   PMID:16785989   PMID:16825580   PMID:16844763   PMID:16873551   PMID:16985003   PMID:17322175   PMID:17360443   PMID:17363382   PMID:17404231  
PMID:17431507   PMID:17452324   PMID:17652368   PMID:17707398   PMID:17717301   PMID:17872467   PMID:17921453   PMID:18077344   PMID:18206662   PMID:18287559   PMID:18316483   PMID:18326664  
PMID:18388322   PMID:18403125   PMID:18419777   PMID:18434328   PMID:18434746   PMID:18468998   PMID:18483626   PMID:18643873   PMID:18799693   PMID:19011160   PMID:19033399   PMID:19096022  
PMID:19120137   PMID:19298530   PMID:19383796   PMID:19386262   PMID:19549818   PMID:19578067   PMID:19603549   PMID:19703963   PMID:20009080   PMID:20080623   PMID:20080988   PMID:20157052  
PMID:20224043   PMID:20226167   PMID:20372981   PMID:20427316   PMID:20431056   PMID:20479242   PMID:20518593   PMID:20519450   PMID:20595652   PMID:20615971   PMID:20621925   PMID:20944434  
PMID:20966392   PMID:21098440   PMID:21099115   PMID:21099118   PMID:21113126   PMID:21267068   PMID:21270101   PMID:21421818   PMID:21645850   PMID:21673970   PMID:21677750   PMID:21680895  
PMID:21743453   PMID:21768539   PMID:21788490   PMID:21873635   PMID:21888910   PMID:21986507   PMID:22158709   PMID:22298808   PMID:22302785   PMID:22328512   PMID:22374134   PMID:22406107  
PMID:22504960   PMID:22511749   PMID:22711277   PMID:22722659   PMID:22798524   PMID:22828895   PMID:22846424   PMID:22867515   PMID:22869620   PMID:22930804   PMID:22939628   PMID:23131176  
PMID:23152493   PMID:23278119   PMID:23295832   PMID:23363625   PMID:23413940   PMID:23454728   PMID:23463619   PMID:23482488   PMID:23516528   PMID:23540699   PMID:23595884   PMID:23666671  
PMID:23678000   PMID:23715556   PMID:23723061   PMID:23733959   PMID:23746327   PMID:23836685   PMID:23856523   PMID:23871484   PMID:23918386   PMID:23992453   PMID:24030498   PMID:24104877  
PMID:24123915   PMID:24139989   PMID:24186966   PMID:24194600   PMID:24315909   PMID:24398018   PMID:24441828   PMID:24445321   PMID:24576293   PMID:24743769   PMID:24747296   PMID:24755079  
PMID:24758151   PMID:24805197   PMID:24812280   PMID:24949568   PMID:24952909   PMID:25087098   PMID:25093823   PMID:25193470   PMID:25193700   PMID:25193703   PMID:25239916   PMID:25245290  
PMID:25332179   PMID:25367193   PMID:25389315   PMID:25524238   PMID:25605235   PMID:25619687   PMID:25694159   PMID:25775566   PMID:25850710   PMID:26025922   PMID:26039991   PMID:26080362  
PMID:26109063   PMID:26121139   PMID:26217001   PMID:26261328   PMID:26289036   PMID:26316108   PMID:26321200   PMID:26348911   PMID:26378152   PMID:26405799   PMID:26410369   PMID:26545784  
PMID:26555638   PMID:26674963   PMID:26695843   PMID:26857906   PMID:26888649   PMID:26897459   PMID:27161030   PMID:27169737   PMID:27217161   PMID:27422983   PMID:27482086   PMID:27582498  
PMID:27621312   PMID:27623776   PMID:27626380   PMID:27643434   PMID:27703263   PMID:27725084   PMID:27766308   PMID:27789712   PMID:27909078   PMID:28065668   PMID:28077437   PMID:28082361  
PMID:28096415   PMID:28158491   PMID:28302382   PMID:28316073   PMID:28389603   PMID:28620067   PMID:28631094   PMID:28724790   PMID:28961276   PMID:29037982   PMID:29150444   PMID:29170159  
PMID:29248564   PMID:29401432   PMID:29402414   PMID:29427818   PMID:29477366   PMID:29730765   PMID:29986885   PMID:30169578   PMID:30181262   PMID:30209242   PMID:30355031   PMID:30541771  
PMID:30586718   PMID:30779710   PMID:30786075   PMID:30835254   PMID:31028179   PMID:31030596   PMID:31078384   PMID:31138677   PMID:31155924   PMID:31182474   PMID:31235574   PMID:31456413  
PMID:31591206   PMID:31712577   PMID:31805819   PMID:32007269   PMID:32007997   PMID:32173907   PMID:32325033   PMID:32580946   PMID:32641776   PMID:32669538   PMID:32672536   PMID:32683896  
PMID:32713021   PMID:32966798   PMID:33397958   PMID:33536282   PMID:34022226  


Genomics

Comparative Map Data
Ryr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391311,567,985 - 12,121,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl1311,567,988 - 12,121,831 (-)Ensembl
GRCm381311,553,099 - 12,106,945 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1311,553,102 - 12,106,945 (-)EnsemblGRCm38mm10GRCm38
MGSCv371311,645,370 - 12,199,212 (-)NCBIGRCm37mm9NCBIm37
MGSCv361311,608,677 - 12,160,499 (-)NCBImm8
Celera1311,467,020 - 12,025,871 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.38NCBI
RYR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1237,042,184 - 237,833,988 (+)EnsemblGRCh38hg38GRCh38
GRCh381237,042,184 - 237,833,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371237,205,484 - 237,997,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361235,272,325 - 236,063,911 (+)NCBINCBI36hg18NCBI36
Build 341233,531,742 - 234,322,694NCBI
Celera1210,455,038 - 211,246,790 (+)NCBI
Cytogenetic Map1q43NCBI
HuRef1207,662,133 - 208,453,675 (+)NCBIHuRef
CHM1_11238,478,098 - 239,269,604 (+)NCBICHM1_1
Ryr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21758,389,925 - 58,975,641 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1758,389,925 - 58,975,142 (+)Ensembl
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Ryr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554922,648,956 - 3,076,509 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554922,647,597 - 3,275,512 (-)NCBIChiLan1.0ChiLan1.0
RYR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11217,598,069 - 218,384,849 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1217,815,676 - 218,383,509 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01212,600,198 - 213,387,312 (+)NCBIMhudiblu_PPA_v0panPan3
RYR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.142,371,868 - 2,908,132 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl42,373,114 - 2,907,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha42,419,733 - 3,146,551 (-)NCBI
ROS_Cfam_1.042,390,864 - 3,118,926 (-)NCBI
UMICH_Zoey_3.142,386,589 - 3,119,270 (-)NCBI
UNSW_CanFamBas_1.042,522,518 - 3,249,453 (-)NCBI
UU_Cfam_GSD_1.042,743,722 - 3,470,663 (-)NCBI
Ryr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934439,237,258 - 39,734,210 (-)NCBI
SpeTri2.0NW_00493648415,402,488 - 15,825,410 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1453,652,245 - 54,406,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11453,652,140 - 54,406,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21457,571,491 - 58,014,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q22-q23NCBI
RYR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12574,169,024 - 74,951,371 (+)NCBI
ChlSab1.1 Ensembl2574,389,122 - 74,953,451 (+)Ensembl
Vero_WHO_p1.0NW_02366605576,267,928 - 77,050,853 (+)NCBI
Ryr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477512,954,653 - 13,650,449 (-)NCBI

Position Markers
24.MHAa93f12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,951,738 - 11,951,934UniSTSGRCm38
MGSCv371312,044,005 - 12,044,201UniSTSGRCm37
Celera1311,871,054 - 11,871,250UniSTS
Cytogenetic Map13A1-A2UniSTS
Whitehead_YAC13 UniSTS
Ryr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371311,645,753 - 11,645,835UniSTSGRCm37
MGSCv371311,645,701 - 11,645,863UniSTSGRCm37
Celera1311,467,351 - 11,467,513UniSTS
Celera1311,467,403 - 11,467,485UniSTS
Cytogenetic Map13A1-A2UniSTS
cM Map137.0UniSTS
cM Map137.0UniSTS
D13Mit134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,904,727 - 11,904,847UniSTSGRCm38
MGSCv371311,996,994 - 11,997,114UniSTSGRCm37
Celera1311,823,828 - 11,823,948UniSTS
Cytogenetic Map13A1-A2UniSTS
cM Map136.0UniSTS
Whitehead/MRC_RH1314.97UniSTS
Whitehead_YAC13 UniSTS
PMC21940P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,553,381 - 11,553,630UniSTSGRCm38
MGSCv371311,645,648 - 11,645,897UniSTSGRCm37
Celera1311,467,298 - 11,467,547UniSTS
Cytogenetic Map13A1-A2UniSTS
D13Sfk12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,832,892 - 11,833,078UniSTSGRCm38
MGSCv371311,925,159 - 11,925,345UniSTSGRCm37
Celera1311,747,924 - 11,748,110UniSTS
Cytogenetic Map13A1-A2UniSTS
cM Map137.0UniSTS
D13Sfk11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,881,396 - 11,881,552UniSTSGRCm38
MGSCv371311,973,663 - 11,973,819UniSTSGRCm37
Celera1311,800,501 - 11,800,657UniSTS
Cytogenetic Map13A1-A2UniSTS
cM Map137.0UniSTS
Ryr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1-A2UniSTS
Ryr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1-A2UniSTS
cM Map137.0UniSTS
Ryr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,553,434 - 11,553,596UniSTSGRCm38
MGSCv371311,645,701 - 11,645,863UniSTSGRCm37
Celera1311,467,351 - 11,467,513UniSTS
Cytogenetic Map13A1-A2UniSTS
cM Map137.0UniSTS
Ryr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381311,553,486 - 11,553,568UniSTSGRCm38
MGSCv371311,645,753 - 11,645,835UniSTSGRCm37
Celera1311,467,403 - 11,467,485UniSTS
Cytogenetic Map13A1-A2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123404636Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123404636Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123404636Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined13133994099Mouse
10449140Eosn2_meosinophil differential 2 (mouse)134672634046726Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)134672634046726Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13329344237293650Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13329344237293650Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13329344237293650Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13343134237431502Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13349603037496173Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13390000075900000Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13436402652947604Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:734
Count of miRNA genes:283
Interacting mature miRNAs:306
Transcripts:ENSMUST00000021750, ENSMUST00000170156
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02114845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF295105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB387101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU921357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT572985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021750   ⟹   ENSMUSP00000021750
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,567,988 - 12,121,831 (-)Ensembl
GRCm38.p6 Ensembl1311,553,102 - 12,106,945 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170156   ⟹   ENSMUSP00000127991
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,567,989 - 12,121,831 (-)Ensembl
GRCm38.p6 Ensembl1311,553,103 - 12,106,945 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220597   ⟹   ENSMUSP00000152051
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,785,926 - 12,121,831 (-)Ensembl
GRCm38.p6 Ensembl1311,771,040 - 12,106,945 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220712   ⟹   ENSMUSP00000152669
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,650,407 - 11,675,121 (-)Ensembl
GRCm38.p6 Ensembl1311,635,521 - 11,660,235 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221018
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,824,711 - 11,844,540 (-)Ensembl
GRCm38.p6 Ensembl1311,809,825 - 11,829,654 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,932,148 - 12,121,345 (-)Ensembl
GRCm38.p6 Ensembl1311,917,262 - 12,106,459 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221527   ⟹   ENSMUSP00000152510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,602,100 - 11,661,494 (-)Ensembl
GRCm38.p6 Ensembl1311,587,214 - 11,646,608 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221609
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,762,170 - 11,765,720 (-)Ensembl
GRCm38.p6 Ensembl1311,747,284 - 11,750,834 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,744,260 - 11,746,614 (-)Ensembl
GRCm38.p6 Ensembl1311,729,374 - 11,731,728 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221916
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,649,452 - 11,661,428 (-)Ensembl
GRCm38.p6 Ensembl1311,634,566 - 11,646,542 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221941
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,654,490 - 11,702,801 (-)Ensembl
GRCm38.p6 Ensembl1311,639,604 - 11,687,915 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222113
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,586,866 - 11,599,480 (-)Ensembl
GRCm38.p6 Ensembl1311,571,980 - 11,584,594 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222386
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,784,092 - 11,787,402 (-)Ensembl
GRCm38.p6 Ensembl1311,769,206 - 11,772,516 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1311,589,825 - 11,599,840 (-)Ensembl
GRCm38.p6 Ensembl1311,574,939 - 11,584,954 (-)Ensembl
RefSeq Acc Id: NM_023868   ⟹   NP_076357
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391311,567,989 - 12,121,831 (-)NCBI
GRCm381311,553,103 - 12,106,945 (-)NCBI
MGSCv371311,645,370 - 12,199,212 (-)RGD
Celera1311,467,020 - 12,025,871 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516610   ⟹   XP_006516673
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391311,567,985 - 12,121,831 (-)NCBI
GRCm381311,553,099 - 12,106,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244296   ⟹   XP_011242598
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391311,568,126 - 12,121,831 (-)NCBI
GRCm381311,553,099 - 12,106,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315455   ⟹   XP_017170944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391311,568,126 - 12,121,831 (-)NCBI
GRCm381311,553,099 - 12,106,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315460   ⟹   XP_017170949
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391311,568,126 - 12,121,831 (-)NCBI
GRCm381311,553,099 - 12,106,945 (-)NCBI
Sequence: