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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:peritonitis
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Accession:DOID:8283 term browser browse the term
Definition:A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output. (DO)
Synonyms:exact_synonym: Primary Peritonitis;   Retractile mesenteritis;   Secondary Peritonitis;   acute generalized peritonitis;   primary bacterial peritonitis;   sclerosing mesenteritis
 primary_id: MESH:D010538
 xref: EFO:0008588;   ICD9CM:567.8
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
peritonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:16538883 RGD:1598512 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G ADA adenosine deaminase ISO protein:increased expression:peritoneal fluid
protein:decreased activity:serum		 RGD PMID:15969953 PMID:15373900 RGD:1624309, RGD:152995406 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G ALDOB aldolase, fructose-bisphosphate B ISO mRNA:increased expression:liver (rat) RGD PMID:8403244 RGD:2313429 NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO RGD PMID:18941242 RGD:5509607 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression: RGD PMID:22001349 RGD:6483066 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G C5 complement C5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19284563 PMID:19346296 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G CD40 CD40 molecule ISO RGD PMID:15780086 RGD:7248438 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:15780086 RGD:7248438 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G ESR1 estrogen receptor 1 treatment ISO RGD PMID:23063870 RGD:8553243 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 treatment ISO RGD PMID:23063870 RGD:8553243 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FOXP1 forkhead box P1 IMP human gene in a mouse model RGD PMID:18799727 RGD:11561898 NCBI chr 3:70,954,708...71,583,978
Ensembl chr 3:70,954,693...71,583,978 		JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha exacerbates ISO RGD PMID:20716766 RGD:42722627 NCBI chr17:4,932,277...4,935,023
Ensembl chr17:4,932,277...4,935,023 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:16713974 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 IMP RGD PMID:18962899 RGD:4140945 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GUSB glucuronidase beta ISO protein:altered expression:peritoneal cells (rat) RGD PMID:185091 RGD:42722008 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G IFNG interferon gamma treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19804847 PMID:28593696 RGD:14974254 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL6 interleukin 6 IEP RGD PMID:26601826 RGD:14975296 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGAM integrin subunit alpha M ameliorates ISO DNA:missense mutation:CDS:p.I332G (mouse) RGD PMID:32938725 RGD:329853755 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGB2 integrin subunit beta 2 ameliorates ISO RGD PMID:18239087 RGD:127345091 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G MIR155 microRNA 155 ISO associated with Hypothermia RGD PMID:25231976 PMID:24708712 RGD:21079419, RGD:21079469 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR21 microRNA 21 ISO RGD PMID:26382295 RGD:11342022 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G NPPA natriuretic peptide A IDA RGD PMID:23422200 RGD:7247713 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 treatment ISO RGD PMID:8113674 RGD:11541096 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PLAT plasminogen activator, tissue type IDA RGD PMID:18571586 RGD:6484139 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PLAU plasminogen activator, urokinase IDA RGD PMID:18571586 RGD:6484139 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:20693875 RGD:6484122 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547 		JBrowse link
G PTGIS prostaglandin I2 synthase ameliorates ISO RGD PMID:26611322 RGD:11536046 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137 		JBrowse link
G TMEM67 transmembrane protein 67 IAGP ClinVar Annotator: match by term: Peritonitis ClinVar PMID:19466712 PMID:19508969 PMID:19540516 PMID:19574260 PMID:20607301 More... NCBI chr 8:93,754,844...93,832,653
Ensembl chr 8:93,754,844...93,819,234 		JBrowse link
G TNF tumor necrosis factor ISO
IEP		 protein:increased expression:plasma RGD PMID:20819637 PMID:26601826 RGD:4143378, RGD:14975296 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G XDH xanthine dehydrogenase ISO RGD PMID:1443884 PMID:8367813 RGD:13210513, RGD:13210579 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
Septic Peritonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL4L2 C-C motif chemokine ligand 4 like 2 IEP associated with liver cirrhosis;Protein:increased expression:ascitic fluid��(human) RGD PMID:24797975 RGD:42722005 NCBI chr17:36,211,063...36,212,873
Ensembl chr17:36,210,924...36,212,878 		JBrowse link
G CLEC4M C-type lectin domain family 4 member M susceptibility ISO RGD PMID:15583012 RGD:39939009 NCBI chr19:7,763,243...7,769,605
Ensembl chr19:7,763,210...7,769,605 		JBrowse link
G CSF3 colony stimulating factor 3 treatment IDA RGD PMID:8656607 RGD:11039538 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO RGD PMID:18927430 RGD:40818433 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G F5 coagulation factor V disease_progression ISO RGD PMID:25690763 RGD:11564333 NCBI chr 1:169,511,951...169,586,481
Ensembl chr 1:169,511,951...169,586,588 		JBrowse link
G IL27 interleukin 27 exacerbates ISO RGD PMID:16880260 RGD:126790504 NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:plasma (rat) RGD PMID:19897171 RGD:11062137 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KL klotho disease_progression ISO RGD PMID:23364432 RGD:10403048 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
G MIR155 microRNA 155 IEP associatd with liver cirrhosis RGD PMID:28074870 RGD:21079477 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 treatment ISO RGD PMID:11850627 RGD:737789 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G PTEN phosphatase and tensin homolog ameliorates ISO associated with Escherichia Coli Infections RGD PMID:21521784 RGD:127285602 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G SERPINF1 serpin family F member 1 IEP protein:increased expression:peritoneal fluid (human) RGD PMID:8869327 RGD:30296661 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease by infectious agent 2737
      Intraabdominal Infections 46
        peritonitis 40
          Fitz-Hugh-Curtis Syndrome 0
          Septic Peritonitis 12
          Subphrenic Abscess 0
          acute female pelvic peritonitis 0
          diphtheritic peritonitis 0
          tuberculous peritonitis 0
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32346
      gastrointestinal system disease 8168
        Peritoneal Diseases 83
          peritonitis 40
            Fitz-Hugh-Curtis Syndrome 0
            Septic Peritonitis 12
            Subphrenic Abscess 0
            acute female pelvic peritonitis 0
            diphtheritic peritonitis 0
            tuberculous peritonitis 0
paths to the root