F5 (coagulation factor V) - Rat Genome Database

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Gene: F5 (coagulation factor V) Homo sapiens
Symbol: F5
Name: coagulation factor V
RGD ID: 1344593
Description: Predicted to have copper ion binding activity. Predicted to be involved in blood circulation and blood coagulation. Localizes to extracellular vesicle and membrane. Implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Biomarker of colorectal adenoma; hepatitis; liver cirrhosis; and portal hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activated protein c cofactor; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; factor V Leiden; FVL; PCCF; proaccelerin, labile factor; RPRGL1; THPH2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1169,511,951 - 169,586,588 (-)EnsemblGRCh38hg38GRCh38
GRCh381169,511,951 - 169,586,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,481,189 - 169,555,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,747,816 - 167,822,393 (-)NCBINCBI36hg18NCBI36
Build 341166,215,066 - 166,287,379NCBI
Celera1142,590,970 - 142,665,548 (-)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1140,703,881 - 140,778,453 (-)NCBIHuRef
CHM1_11170,903,222 - 170,977,927 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (IAGP)
Acute Liver Failure  (IEP)
Behcet's disease  (IAGP)
blood coagulation disease  (EXP)
brain ischemia  (EXP)
breast cancer  (IAGP)
Budd-Chiari syndrome  (IAGP)
cerebral infarction  (IAGP)
Colonic Neoplasms  (EXP,ISO)
colorectal adenoma  (IEP)
Dysarthria  (IAGP)
Dyspnea  (IAGP)
end stage renal disease  (IAGP)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor V deficiency  (IAGP)
familial adenomatous polyposis  (EXP)
Femur Head Necrosis  (IAGP)
Fetal Death  (IAGP)
gastrointestinal stromal tumor  (IAGP)
Habitual Abortions  (IAGP)
hemorrhagic disease  (IAGP)
hepatitis  (IEP)
Hereditary Thrombophilia  (EXP)
Hirschsprung's disease  (IAGP)
hypereosinophilic syndrome  (IAGP)
liver cirrhosis  (EXP,IAGP,IEP)
membranoproliferative glomerulonephritis  (ISO)
Mesenteric Ischemia  (EXP)
myocardial infarction  (EXP,IAGP)
Myocardial Ischemia  (IAGP)
non-arteritic anterior ischemic optic neuropathy  (IAGP)
parathyroid carcinoma  (IAGP)
Peritoneal Fibrosis  (ISO)
portal hypertension  (IEP)
pre-eclampsia  (IAGP)
prostate cancer  (IAGP)
pulmonary embolism  (IAGP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IAGP)
retinal artery occlusion  (IAGP)
retinal vein occlusion  (EXP,IAGP)
sagittal sinus thrombosis  (EXP)
sensorineural hearing loss  (IAGP)
Sepsis  (IAGP,ISO)
Septic Peritonitis  (ISO)
Spontaneous Abortions  (EXP,IAGP)
Stroke  (EXP,IAGP)
thrombocytopenia  (IAGP)
Thromboembolism  (EXP,IAGP)
thrombophilia due to activated protein C resistance  (IAGP)
thrombophilia due to thrombin defect  (IAGP)
thrombosis  (EXP,IAGP,ISO)
Venous Thromboembolism  (EXP,IAGP)
Venous Thrombosis  (EXP,IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acenocoumarol  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
antimony(0)  (EXP)
antirheumatic drug  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
aspalathin  (EXP)
atorvastatin calcium  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
calcitriol  (EXP)
calcium dichloride  (EXP)
chloroprene  (ISO)
chromium atom  (EXP)
chrysene  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clomiphene  (EXP)
cobalt dichloride  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
dorsomorphin  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
Ethyl icosapentate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
glycidol  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levonorgestrel  (EXP)
lithium chloride  (EXP)
mercury atom  (EXP)
mercury dibromide  (EXP)
mercury(0)  (EXP)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (EXP)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenprocoumon  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
propanal  (EXP)
propiconazole  (ISO)
quinapril hydrochloride  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
warfarin  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)