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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Intraabdominal Infections
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Accession:DOID:9002654 term browser browse the term
Definition:Infection within the PERITONEAL CAVITY. A frequent cause is an ANASTOMOTIC LEAK following surgery.
Synonyms:exact_synonym: Intra Abdominal Infections;   Intra-Abdominal Infection;   Intraabdominal Infection
 primary_id: MESH:D059413


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appendicitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin ISO RGD PMID:21663567 RGD:5147751 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16367942 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased expression:appendix RGD PMID:19153874 RGD:6483822 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ret ret proto-oncogene ISO ClinVar Annotator: match by term: Appendicitis ClinVar PMID:11230481 PMID:15320968 PMID:16384843 PMID:16849421 PMID:18058472 More... NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
diverticulitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nalf1 NALCN channel auxiliary factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28585551 NCBI chr16:79,713,577...80,236,295
Ensembl chr16:79,713,724...80,235,120 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO mRNA:decreased expression:colonic mucosa (human) RGD PMID:18491196 RGD:38549586 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
diverticulitis of colon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd163 CD163 molecule exacerbates ISO protein:increased expression:sigmoid colon (human) RGD PMID:21553154 RGD:40925945 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd68 Cd68 molecule severity ISO associated with steroid use;protein:increased expression:sigmoid colon (human) RGD PMID:21553154 RGD:40925945 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
peritonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP RGD PMID:16538883 RGD:1598512 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Ada adenosine deaminase IDA
IEP		 protein:increased expression:peritoneal fluid
protein:decreased activity:serum		 RGD PMID:15969953 PMID:15373900 RGD:1624309, RGD:152995406 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B IEP mRNA:increased expression:liver (rat) RGD PMID:8403244 RGD:2313429 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:18941242 RGD:5509607 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression: RGD PMID:22001349 RGD:6483066 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C5 complement C5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19284563 PMID:19346296 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:15780086 RGD:7248438 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:15780086 RGD:7248438 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Esr1 estrogen receptor 1 treatment IDA RGD PMID:23063870 RGD:8553243 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 treatment IDA RGD PMID:23063870 RGD:8553243 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Foxp1 forkhead box P1 ISO human gene in a mouse model RGD PMID:18799727 RGD:11561898 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha exacerbates ISO RGD PMID:20716766 RGD:42722627 NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16713974 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO RGD PMID:18962899 RGD:4140945 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gusb glucuronidase, beta IEP protein:altered expression:peritoneal cells (rat) RGD PMID:185091 RGD:42722008 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19804847 PMID:28593696 RGD:14974254 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:26601826 RGD:14975296 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M ameliorates ISO DNA:missense mutation:CDS:p.I332G (mouse) RGD PMID:32938725 RGD:329853755 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 ameliorates ISO RGD PMID:18239087 RGD:127345091 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Mir155 microRNA 155 ISO associated with Hypothermia RGD PMID:25231976 PMID:24708712 RGD:21079419, RGD:21079469 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir21 microRNA 21 ISO RGD PMID:26382295 RGD:11342022 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:23422200 RGD:7247713 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 treatment ISO RGD PMID:8113674 RGD:11541096 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:18571586 RGD:6484139 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:18571586 RGD:6484139 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO RGD PMID:20693875 RGD:6484122 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Ptgis prostaglandin I2 synthase ameliorates ISO RGD PMID:26611322 RGD:11536046 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Tmem67 transmembrane protein 67 ISO ClinVar Annotator: match by term: Peritonitis ClinVar PMID:19466712 PMID:19508969 PMID:19540516 PMID:19574260 PMID:20607301 More... NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
G Tnf tumor necrosis factor IEP
ISO		 protein:increased expression:plasma RGD PMID:20819637 PMID:26601826 RGD:4143378, RGD:14975296 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xdh xanthine dehydrogenase IEP RGD PMID:1443884 PMID:8367813 RGD:13210513, RGD:13210579 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Septic Peritonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4m C-type lectin domain family 4 member M susceptibility ISO RGD PMID:15583012 RGD:39939009 NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:8656607 RGD:11039538 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO RGD PMID:18927430 RGD:40818433 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V disease_progression ISO RGD PMID:25690763 RGD:11564333 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G Il27 interleukin 27 exacerbates ISO RGD PMID:16880260 RGD:126790504 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:plasma (rat) RGD PMID:19897171 RGD:11062137 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kl Klotho disease_progression ISO RGD PMID:23364432 RGD:10403048 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Mir155 microRNA 155 ISO associatd with liver cirrhosis RGD PMID:28074870 RGD:21079477 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 treatment ISO RGD PMID:11850627 RGD:737789 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO associated with Escherichia Coli Infections RGD PMID:21521784 RGD:127285602 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Serpinf1 serpin family F member 1 ISO protein:increased expression:peritoneal fluid (human) RGD PMID:8869327 RGD:30296661 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19055
    disease by infectious agent 2250
      Intraabdominal Infections 45
        Typhlitis 0
        appendicitis 5
        diverticulitis + 4
        peritonitis + 39
paths to the root