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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Myocarditis
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Accession:DOID:9002311 term browser browse the term
Definition:Experimental autoimmune myocarditis is a model of inflammatory heart disease and subsequent dilated cardiomyopathy (DCM). Inoculation with purified cardiac myosin combined with FREUND'S ADJUVANT triggers the disease in rats and mice.
Synonyms:exact_synonym: EAM


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Experimental Autoimmune Myocarditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO RGD PMID:23674516 RGD:8695925 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP protein:increased expression:heart RGD PMID:24599045 RGD:8696002 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Camp cathelicidin antimicrobial peptide disease_progression ISO RGD PMID:23867818 RGD:408427364 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Casp3 caspase 3 treatment IEP
ISO		 RGD PMID:28903333 PMID:23833961 RGD:13702869, RGD:13702874 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:23833961 RGD:13702874 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:23833961 RGD:13702874 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 IEP RGD PMID:17060028 RGD:1625364 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cav2 caveolin 2 IEP RGD PMID:17060028 RGD:1625364 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 disease_progression IEP mRNA, protein:increased expression:heart, serum (rat) RGD PMID:11472393 RGD:8549580 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd28 Cd28 molecule treatment
severity		 IDA
ISO		 RGD PMID:19907173 PMID:8759765 RGD:13702882, RGD:13702883 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule treatment IMP RGD PMID:25297507 RGD:13702884 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Fgl2 fibrinogen-like 2 severity IEP RGD PMID:28892130 RGD:38549573 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Foxp3 forkhead box P3 severity
treatment		 IEP RGD PMID:28892130 PMID:19907173 RGD:38549573, RGD:13702882 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP RGD PMID:30024944 RGD:13792695 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Hamp hepcidin antimicrobial peptide IEP mRNA:increased expression:heart RGD PMID:19615879 RGD:11041636 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:increased expression:heart, serum RGD PMID:24599045 RGD:8696002 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 treatment IEP RGD PMID:21927577 RGD:5685668 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IEP RGD PMID:11701617 RGD:13702911 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 treatment IEP RGD PMID:19907173 RGD:13702882 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 treatment IMP RGD PMID:15902684 RGD:8549607 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO mouse gene in a rat model RGD PMID:15795329 RGD:8551728 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:26339812 RGD:11062109 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 IEP RGD PMID:15306225 RGD:7242784 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Myh6 myosin heavy chain 6 ISO RGD PMID:10199887 RGD:12792956 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP protein:increased expression:myocardium (rat) RGD PMID:15167281 RGD:8553039 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:heart, cardiomyocyte (rat) RGD PMID:18774541 RGD:9831381 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rorc RAR-related orphan receptor C severity IEP RGD PMID:28892130 RGD:38549573 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rps6 ribosomal protein S6 IDA RGD PMID:22014063 RGD:11041642 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Sirt1 sirtuin 1 treatment IEP RGD PMID:17322642 RGD:9586020 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    Animal Diseases 1752
      Animal Disease Models 1699
        Experimental Autoimmune Myocarditis 29
Path 2
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      respiratory system disease 5241
        thoracic disease 4049
          heart disease 3473
            cardiomyopathy 1427
              extrinsic cardiomyopathy 127
                myocarditis 118
                  autoimmune myocarditis 31
                    Experimental Autoimmune Myocarditis 29
paths to the root