Animal Diseases - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Animal Diseases	go back to main search page
Accession:	DOID:9004985	browse the term
Definition:	Diseases that occur in VERTEBRATE animals.
Synonyms:	primary_id:	MESH:D000820
	xref:	EFO:0005932
	subset:	RGD_JBrowse_slim

show annotations for term's descendants Sort by:
Rat (1752) Mouse (1422) Human (1418) Chinchilla (1222) Bonobo (1292) Dog (1359) Squirrel (1239) Pig (1324) Green Monkey (1278) Naked Mole-rat (1218) All
Genes (1402) QTL (224) Strains (126)

Acute Experimental Autoimmune Encephalomyelitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myelin-associated glycoprotein

protein:decreased expression:optic nerve

RGD

NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656

G

zinc finger CCCH type containing 12A

disease_progression

RGD

NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351

Acute Experimental Pancreatitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

treatment

RGD

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

Bcl2-like 1

protein:increased expression:pancreas, mitochondrion (rat)

RGD

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

treatment

RGD

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

cyclin-dependent kinase inhibitor 1A

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

endothelin receptor type A

treatment

RGD

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

Fas cell surface death receptor

severity

protein:increased expression:Kupffer cell:

RGD

PMID:15797225 PMID:15797225

RGD:14700708, RGD:14700708

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

severity

protein:increased expression:Kupffer cell:

RGD

PMID:15797225 PMID:15797225

RGD:14700708, RGD:14700708

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

glutathione synthetase

RGD

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

high mobility group box 1

treatment

RGD

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heat shock protein family A (Hsp70) member 5

protein:increased expression:neutrophil:

RGD

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

treatment

RGD

PMID:23706497 PMID:10201790

RGD:10402063, RGD:11520782

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

treatment

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 4

treatment

RGD

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

Janus kinase 1

treatment

RGD

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

kynurenine 3-monooxygenase

disease_progression

RGD

PMID:26752518 PMID:28398044

RGD:11342439, RGD:13703053

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

KRAS proto-oncogene, GTPase

RGD

NCBI chr 4:178,185,418...178,218,484

G

lysosomal-associated membrane protein 2

protein:decreased expression:pancreas

RGD

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

microtubule-associated protein 1 light chain 3 alpha

treatment

RGD

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

MDM2 proto-oncogene

protein:increased expression:pancreas (rat)

RGD

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

microRNA 155

treatment

RGD

PMID:29937734 PMID:30497068

RGD:21403683, RGD:21408596

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

poly (ADP-ribose) polymerase 1

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

RGD

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

protein C receptor

treatment

protein:increased expression:blood

RGD

PMID:25688263 PMID:24749346

RGD:13515127, RGD:13515128

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

platelet-activating factor receptor

treatment

RGD

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

regenerating family member 1 alpha

severity

mRNA:increased expression:pancreas (rat)

RGD

PMID:1985964 PMID:19129610

RGD:729900, RGD:9850139

NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570

G

regenerating family member 3 beta

protein:increased expression:serum (rat)

RGD

NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015

G

serpin family C member 1

treatment

RGD

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serine peptidase inhibitor, Kazal type 1

treatment

RGD

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

tumor necrosis factor

associated with Anemia, Hemolytic

RGD

PMID:12845374 PMID:15164724

RGD:10449461, RGD:1580295

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

protein:increased expression:serum

RGD

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

protein:increased expression:serum

RGD

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

von Willebrand factor

protein:increased expression:plasma:

RGD

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

Animal Disease Models

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

CTD Direct Evidence: marker/mechanism

PMID:16472600 PMID:29808285

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 6

CTD Direct Evidence: marker/mechanism

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

acyl-CoA synthetase long-chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

adenosylhomocysteinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

CTD Direct Evidence: marker/mechanism

PMID:25658812 PMID:32045588

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

CTD Direct Evidence: marker/mechanism

PMID:16642209 PMID:17963606

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 5 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

alkaline phosphatase, biomineralization associated

CTD Direct Evidence: marker/mechanism

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

acidic nuclear phosphoprotein 32 family member A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

apurinic/apyrimidinic endodeoxyribonuclease 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor protein

CTD Direct Evidence: marker/mechanism

PMID:12746438 PMID:16651627 PMID:25881725 PMID:27567873 PMID:31939705

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 4

CTD Direct Evidence: marker/mechanism

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

arginase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

artemin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:131,458,596...131,470,193
Ensembl chr 5:131,464,756...131,468,025

G

ATPase copper transporting alpha

CTD Direct Evidence: marker/mechanism

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

CTD Direct Evidence: marker/mechanism

PMID:11803042 PMID:15911138 PMID:21146535 PMID:21364284

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

axin 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

bradykinin receptor B2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

BSCL2 lipid droplet biogenesis associated, seipin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421

G

basic leucine zipper and W2 domains 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628

G

calcium voltage-gated channel subunit alpha1 D

CTD Direct Evidence: marker/mechanism

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

calcitonin-related polypeptide alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calcyon neuron-specific vesicular protein

CTD Direct Evidence: marker/mechanism

NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551

G

carbonic anhydrase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

chaperonin containing TCP1 subunit 5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

cadherin 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

claudin 11

CTD Direct Evidence: marker/mechanism

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

CLN6, transmembrane ER protein

CTD Direct Evidence: marker/mechanism

NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360

G

CLN8, transmembrane ER and ERGIC protein

CTD Direct Evidence: marker/mechanism

NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774

G

cannabinoid receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

collagen type II alpha 1 chain

CTD Direct Evidence: marker/mechanism

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cysteine and glycine rich protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytosolic thiouridylase subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:94,115,431...94,121,224
Ensembl chr 1:94,115,420...94,121,221

G

cytosolic thiouridylase subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:50,539,184...50,544,629
Ensembl chr19:50,539,352...50,544,623

G

DEK proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

G

7-dehydrocholesterol reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dystrophin

CTD Direct Evidence: marker/mechanism

PMID:22795790 PMID:26930420 PMID:30074247

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

destrin, actin depolymerizing factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

eukaryotic translation initiation factor 2B subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601

G

eukaryotic translation initiation factor 3 subunit E

CTD Direct Evidence: marker/mechanism

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

elongator acetyltransferase complex subunit 3

CTD Direct Evidence: marker/mechanism

NCBI chr15:39,754,635...39,816,482
Ensembl chr15:39,754,632...39,816,445

G

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

erb-b2 receptor tyrosine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor VII

CTD Direct Evidence: therapeutic

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

PMID:22536412 PMID:26590112

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillarin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

FKBP prolyl isomerase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

Fos proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GAR1 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

GATA binding protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

glial fibrillary acidic protein

CTD Direct Evidence: marker/mechanism

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GLI family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

glucosamine-phosphate N-acetyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739

G

golgi membrane protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

glucose-6-phosphate isomerase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutamate ionotropic receptor NMDA type subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate-rich WD repeat containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201

G

H1.10 linker histone

CTD Direct Evidence: marker/mechanism

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

heart and neural crest derivatives expressed 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891

G

hemoglobin subunit beta

CTD Direct Evidence: marker/mechanism

PMID:23975182 PMID:29255069

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heparin-binding EGF-like growth factor

CTD Direct Evidence: marker/mechanism

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

helicase, lymphoid specific

CTD Direct Evidence: marker/mechanism

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

heterogeneous nuclear ribonucleoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

isocitrate dehydrogenase (NADP(+)) 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interferon-induced protein with tetratricopeptide repeats 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

CTD Direct Evidence: therapeutic

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

CTD Direct Evidence: marker/mechanism

PMID:27580383 PMID:28411859

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

inosine monophosphate dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

importin 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285

G

importin 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

interleukin-1 receptor-associated kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

G

inositol 1,4,5-trisphosphate receptor, type 3

CTD Direct Evidence: marker/mechanism

PMID:37047547 PMID:38679149

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

Klotho

CTD Direct Evidence: marker/mechanism

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

kininogen 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

karyopherin subunit alpha 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:26390243 PMID:27588471 PMID:33380422

NCBI chr 4:178,185,418...178,218,484

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

leptin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lamin B1

CTD Direct Evidence: marker/mechanism

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

mitogen activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

CTD Direct Evidence: marker/mechanism

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

CTD Direct Evidence: marker/mechanism

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

CTD Direct Evidence: marker/mechanism

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

methyl CpG binding protein 2

CTD Direct Evidence: marker/mechanism

PMID:28592917 PMID:33010341

NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689

G

MET proto-oncogene, receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 219a-1

CTD Direct Evidence: therapeutic

NCBI chr20:4,829,687...4,829,796
Ensembl chr20:4,829,687...4,829,796

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MRE11 homolog, double strand break repair nuclease

CTD Direct Evidence: marker/mechanism

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mitochondrial ribosomal protein L12

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein S5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:114,821,046...114,837,291
Ensembl chr 3:114,821,046...114,837,291

G

MX dynamin like GTPase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

myosin binding protein C3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

nucleolin

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:27012417 PMID:29255069

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NOP56 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

NOP58 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

nephrocystin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:104,621,908...104,662,383
Ensembl chr 8:104,621,864...104,662,383

G

nucleophosmin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

nucleophosmin/nucleoplasmin, 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591

G

natriuretic peptide B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group H, member 4

CTD Direct Evidence: marker/mechanism

PMID:29142166 PMID:32062620

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nudix hydrolase 21

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682

G

NUS1 dehydrodolichyl diphosphate synthase subunit

CTD Direct Evidence: marker/mechanism

NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561

G

purinergic receptor P2X 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

poly(A) binding protein, cytoplasmic 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979

G

pterin-4 alpha-carbinolamine dehydratase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292

G

phosphodiesterase 6B

CTD Direct Evidence: marker/mechanism

NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450

G

phosphatidylinositol glycan anchor biosynthesis, class N

CTD Direct Evidence: marker/mechanism

NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790

G

Pim-1 proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

polycystin 1, transient receptor potential channel interacting

CTD Direct Evidence: marker/mechanism

NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128

G

RNA polymerase I and III subunit D

CTD Direct Evidence: marker/mechanism

NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624

G

peter pan homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938

G

protein kinase C, gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

parkin RBR E3 ubiquitin protein ligase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

phosphoserine aminotransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

presenilin 1

CTD Direct Evidence: marker/mechanism

PMID:16651627 PMID:27567873

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

parathyroid hormone

CTD Direct Evidence: therapeutic

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

RAN guanine nucleotide release factor

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

G

RNA terminal phosphate cyclase-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

replication factor C subunit 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

ras homolog family member A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ribosomal protein L10A

CTD Direct Evidence: marker/mechanism

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L13A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463

G

ribosomal protein L27A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein L36A

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892
Ensembl chr20:97,766,179...97,768,892

G

ribosomal protein SA

CTD Direct Evidence: marker/mechanism

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase catalytic subunit M1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

ribosome biogenesis regulator 1 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

radical S-adenosyl methionine domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

S100 calcium binding protein A10

CTD Direct Evidence: marker/mechanism

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium binding protein B

CTD Direct Evidence: marker/mechanism

PMID:12888777 PMID:34792689

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

SATB homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

serpin family E member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

SH3 and PX domains 2B

CTD Direct Evidence: marker/mechanism

NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170

G

serine hydroxymethyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820

G

solute carrier family 15 member 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 29 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 4 member 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 4 member 7

CTD Direct Evidence: marker/mechanism

NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

synuclein alpha

CTD Direct Evidence: marker/mechanism

PMID:21892157 PMID:26075822

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

small nucleolar RNA, C/D box 22

CTD Direct Evidence: marker/mechanism

NCBI chr11:9,097,799...9,097,923
Ensembl chr11:9,097,799...9,097,923

G

small nuclear ribonucleoprotein polypeptide G

CTD Direct Evidence: marker/mechanism

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
Ensembl chr X:118,812,252...118,819,826

G

superoxide dismutase 1

CTD Direct Evidence: marker/mechanism

PMID:12586733 PMID:12684256 PMID:19227972 PMID:20177826 PMID:21867702 More...

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

spermidine synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine racemase

CTD Direct Evidence: marker/mechanism

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

serine threonine kinase 39

CTD Direct Evidence: marker/mechanism

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

spermatid perinuclear RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

succinate-CoA ligase GDP-forming subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

T-box transcription factor 20

CTD Direct Evidence: marker/mechanism

NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175

G

transcription factor 7 like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

G

transcription factor A, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

thyroglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210

G

transforming growth factor, beta receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

translocase of inner mitochondrial membrane 10

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 8A1

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960

G

TIMP metallopeptidase inhibitor 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

thymidine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

translocase of outer mitochondrial membrane 40

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

alpha tocopherol transfer protein

CTD Direct Evidence: marker/mechanism

PMID:11095717 PMID:11752462

NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

uridine-cytidine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

valosin-containing protein

CTD Direct Evidence: marker/mechanism

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

vimentin

CTD Direct Evidence: marker/mechanism

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 11

CTD Direct Evidence: marker/mechanism

NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294

G

XIAP associated factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770

G

X-ray repair cross complementing 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

X-ray repair cross complementing 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762

Animal Helminthiasis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

protein:increased expression:plasmacytoid dendritic cell

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Animal Hepatitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

treatment

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine receptor 1

RGD

NCBI chr 8:123,556,286...123,561,841

G

ceruloplasmin

protein:increased expression:lymph, plasma

RGD

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carbamoyl-phosphate synthase 1

protein:increased expression:plasma

RGD

NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033

G

C-X-C motif chemokine ligand 1

mRNA:increased expression:liver

RGD

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

mRNA:increased expression:liver

RGD

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

H19 imprinted maternally expressed transcript

CTD Direct Evidence: marker/mechanism

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

intercellular adhesion molecule 1

treatment

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

lipocalin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

MET proto-oncogene, receptor tyrosine kinase

mRNA:increased expression:liver (rat)

RGD

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

ornithine transcarbamylase

protein:increased expression:plasma

RGD

NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918

G

solute carrier organic anion transporter family member 1B2

RGD

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

trefoil factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

ubiquitin D

CTD Direct Evidence: marker/mechanism

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

vasoactive intestinal peptide

RGD

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

Animal Lameness

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

synuclein alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

Animal Mammary Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA synthetase long-chain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin, beta

CTD Direct Evidence: marker/mechanism

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actinin alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

adenylate cyclase 5

CTD Direct Evidence: marker/mechanism

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

activated leukocyte cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

annexin A1

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942 PMID:22248470

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A4

CTD Direct Evidence: marker/mechanism

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

APC regulator of WNT signaling pathway

CTD Direct Evidence: marker/mechanism

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

aquaporin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

amphiregulin

mRNA:increased expression:mammary gland

RGD

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ATP synthase inhibitory factor subunit 1

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

brain abundant, membrane attached signal protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

BRCA1, DNA repair associated

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

capping actin protein of muscle Z-line subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

calcium/calmodulin dependent serine protein kinase

CTD Direct Evidence: marker/mechanism

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

cyclin D1

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:14522882 PMID:16316942 PMID:17173897

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin H

CTD Direct Evidence: marker/mechanism

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

C-C motif chemokine receptor 3

RGD

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

CD40 molecule

treatment

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

cell division cycle 42

CTD Direct Evidence: marker/mechanism

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 4

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:14522882

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

onset

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CDP-diacylglycerol synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681

G

calponin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

collagen type V alpha 1 chain

CTD Direct Evidence: marker/mechanism

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

catechol-O-methyltransferase

protein:increased expression:mammary gland, cytoplasm
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18424824 PMID:6337293

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

coronin 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534

G

casein beta

CTD Direct Evidence: marker/mechanism

PMID:9879772 PMID:16316942

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

casein kappa

CTD Direct Evidence: marker/mechanism

NCBI chr14:20,154,032...20,160,585
Ensembl chr14:20,154,032...20,160,587

G

diazepam binding inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

desmin

CTD Direct Evidence: marker/mechanism

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dual specificity phosphatase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

eukaryotic translation elongation factor 1 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

EGF containing fibulin extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

epidermal growth factor receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 5A

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

epithelial cell adhesion molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

epoxide hydrolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 2

CTD Direct Evidence: marker/mechanism

PMID:8603490 PMID:38892447

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

PMID:15637090 PMID:17173897 PMID:34606849

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ezrin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

F11 receptor

RGD

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

fatty acid binding protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fibroblast growth factor 2

RGD

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibronectin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

furin (paired basic amino acid cleaving enzyme)

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

G0/G1switch 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glycine amidinotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

guanine deaminase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

gamma-glutamyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

G protein subunit alpha i2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

glutathione synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

H3.3 histone B

CTD Direct Evidence: marker/mechanism

NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709
Ensembl chr13:101,256,480...101,258,709

G

hemoglobin alpha, adult chain 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

heterogeneous nuclear ribonucleoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

inhibitor of DNA binding 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

insulin-like growth factor 2

mRNA:increased expression:mammary gland

RGD

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 6 cytokine family signal transducer

CTD Direct Evidence: marker/mechanism

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

insulin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

kinase insert domain receptor

RGD

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

kininogen 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

keratin 5

CTD Direct Evidence: marker/mechanism

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

keratin 71

CTD Direct Evidence: marker/mechanism

NCBI chr 7:132,873,532...132,898,975
Ensembl chr 7:132,873,540...132,882,325

G

galectin 7

CTD Direct Evidence: marker/mechanism

NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015

G

lin-7 homolog A, crumbs cell polarity complex component

CTD Direct Evidence: marker/mechanism

NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550

G

lipoprotein lipase

CTD Direct Evidence: marker/mechanism

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lipolysis stimulated lipoprotein receptor

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 1:86,185,769...86,201,952
Ensembl chr 1:86,186,431...86,201,952

G

mitogen-activated protein kinase kinase 6

RGD

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

malate dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

matrix Gla protein

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

macrophage migration inhibitory factor

CTD Direct Evidence: marker/mechanism

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

microRNA 100

CTD Direct Evidence: marker/mechanism

NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304

G

microRNA 10a

CTD Direct Evidence: marker/mechanism

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 10b

CTD Direct Evidence: marker/mechanism

NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546

G

microRNA 145

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

microRNA 199a-2

CTD Direct Evidence: marker/mechanism

NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063

G

microRNA 205

CTD Direct Evidence: marker/mechanism

NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985

G

matrix metallopeptidase 9

treatment

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myelin protein zero-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

mannose receptor, C type 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:90,261,986...90,323,187
Ensembl chr10:90,261,394...90,322,856

G

mitochondrially encoded cytochrome c oxidase I

CTD Direct Evidence: marker/mechanism

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

necdin, MAGE family member

CTD Direct Evidence: marker/mechanism

NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767

G

notch receptor 4

DNA, mRNA:mutation, alternative form

RGD

NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465

G

NMDA receptor synaptonuclear signaling and neuronal migration factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614

G

neurotrophic receptor tyrosine kinase 3

ameliorates

RGD

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

peptidyl arginine deiminase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

platelet derived growth factor subunit A

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

phosphatidylethanolamine binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

phosphoglycerate mutase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

progesterone receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prohibitin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

phosphoinositide-3-kinase regulatory subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase M1/2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

polo-like kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

peroxisome proliferator activated receptor alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxiredoxin 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

prolactin

CTD Direct Evidence: marker/mechanism

PMID:6280079 PMID:16316942

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prolactin receptor

CTD Direct Evidence: marker/mechanism

PMID:16316942 PMID:17173897

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

proteasome 20S subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890

G

proteasome activator subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

polypyrimidine tract binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397

G

prostaglandin E receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559

G

pleiotrophin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

RAN, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

RAS p21 protein activator 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RAS protein-specific guanine nucleotide-releasing factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:23,113,613...23,361,537
Ensembl chr 2:23,117,004...23,361,240

G

Ras association domain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14522882 PMID:21364977

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

retinol binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

retinol binding protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

reticulocalbin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295

G

REL proto-oncogene, NF-kB subunit

RGD

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELB proto-oncogene, NF-kB subunit

RGD

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

ribosomal protein L3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L6

CTD Direct Evidence: marker/mechanism

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein S14

CTD Direct Evidence: marker/mechanism

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

S100 calcium binding protein A6

CTD Direct Evidence: marker/mechanism

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein A8

CTD Direct Evidence: marker/mechanism

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

sphingosine-1-phosphate receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

scavenger receptor class B, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

stearoyl-CoA desaturase

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

selenoprotein P

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

serum/glucocorticoid regulated kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

solute carrier family 12 member 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 25 member 10

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

synuclein, gamma

CTD Direct Evidence: marker/mechanism

NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368

G

small nuclear ribonucleoprotein D3 polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978

G

superoxide dismutase 1

protein:decreased expression:mammary gland (rat)

RGD

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 9

CTD Direct Evidence: marker/mechanism

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

serine peptidase inhibitor, Kunitz type, 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:84,558,159...84,580,616
Ensembl chr 1:84,558,166...84,580,616

G

serine and arginine rich splicing factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:15609129 PMID:16316942 PMID:17173897 PMID:20235097

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

stathmin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

transferrin

CTD Direct Evidence: marker/mechanism

PMID:9879772 PMID:16316942

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

thyroid hormone responsive

CTD Direct Evidence: marker/mechanism

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

transketolase

CTD Direct Evidence: marker/mechanism

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

TLE family member 4, transcriptional corepressor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862

G

transmembrane protein 37

CTD Direct Evidence: marker/mechanism

NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077

G

tumor protein p53 inducible protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:27,818,327...27,825,753

G

tropomyosin 3

CTD Direct Evidence: marker/mechanism

PMID:12376462 PMID:16316942

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

transcriptional repressor GATA binding 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905

G

TSC22 domain family, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958

G

tubulin, beta 2B class IIb

CTD Direct Evidence: marker/mechanism

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

G

ubiquitin-conjugating enzyme E2I

CTD Direct Evidence: marker/mechanism

NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

uncoupling protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vesicle-associated membrane protein 8

CTD Direct Evidence: marker/mechanism

NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897

G

Wnt family member 1

RGD

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

G

Wnt family member 3

RGD

NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099

G

Wnt family member 6

RGD

NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523

G

xanthine dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

CTD Direct Evidence: marker/mechanism

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

Animal Toxoplasmosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 5

mRNA, protein:increased expression:blood vessel endothelial cell

RGD

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine receptor 2

RGD

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD209d molecule

treatment

RGD

NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171

G

forkhead box P3

mRNA:decreased expression:placenta:

RGD

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

heat shock protein family D (Hsp60) member 1

RGD

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

indoleamine 2,3-dioxygenase 1

RGD

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interleukin 17A

mRNA,protein:increased expression:placenta:

RGD

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 21

RGD

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 23 subunit alpha

RGD

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 2 receptor subunit beta

ameliorates

RGD

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 6

mRNA:increased expression:placenta:

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

low density lipoprotein receptor

RGD

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

microRNA 146a

ameliorates

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

nuclear receptor subfamily 4, group A, member 2

RGD

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

RAR-related orphan receptor C

mRNA:increased expression:placenta:

RGD

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

G

stimulator of interferon response cGAMP interactor 1

severity

RGD

NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335

Animal Viral Hepatitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

severity

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

ribonuclease L

disease_progression

associated with Coronaviridae Infections
associated with Middle East respiratory syndrome

RGD

PMID:28003490 PMID:27025250

RGD:40902624, RGD:40902807

NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704

avian influenza

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

severity
treatment

human protein in a mouse model

RGD

PMID:24800825 PMID:24800825

RGD:32716391, RGD:32716391

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

MX dynamin like GTPase 1

susceptibility

CTD Direct Evidence: therapeutic
human gene in a mouse model

CTD
RGD

PMID:178595 PMID:28396461

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

prostaglandin-endoperoxide synthase 2

RGD

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

receptor-interacting serine-threonine kinase 3

ameliorates

RGD

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

Avian Sarcoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ras homolog family member B

RGD

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

babesiosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

platelet and endothelial cell adhesion molecule 1

protein:decreased expression:serum (human)

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

borna disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldolase, fructose-bisphosphate C

mRNA, protein:decreased expression:cerebellum, Purkinje cell

RGD

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

activating transcription factor 4

protein:increased expression:cerebellum

RGD

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

protein:increased expression:cerebellum, hippocampus

RGD

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

brain-derived neurotrophic factor

mRNA:decreased expression:hippocampus

RGD

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

CD44 molecule

RGD

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

C-X3-C motif chemokine ligand 1

RGD

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

mRNA:increased expression:brain

RGD

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

DNA-damage inducible transcript 3

mRNA,protein:increased expression:cerebellum, hippocampus

RGD

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2A

protein:increased expression:cerebellum,hippocampus

RGD

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

gap junction protein, alpha 1

RGD

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 6

RGD

NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582

G

insulin-like growth factor 1

mRNA:increased expression:hippocampus

RGD

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 16

protein:increased expression:brain

RGD

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

macrophage migration inhibitory factor

protein:increased expression:astrocyte

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

metallothionein 3

RGD

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

nerve growth factor

mRNA:decreased expression:hippocampus

RGD

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

neurotrophin 3

mRNA:decreased expression:hippocampus

RGD

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 2

mRNA:decreased expression:cerebellum,hippocampus

RGD

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

neurotrophic receptor tyrosine kinase 3

mRNA:decreased expression:cerebellum,hippocampus

RGD

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

poly (ADP-ribose) glycohydrolase

mRNA:decreased expression:hippocampus

RGD

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

G

poly (ADP-ribose) polymerase 1

mRNA,protein:increased expression,increased activity:neuron, glial cell:

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

S100 calcium binding protein B

protein:decreased expression:cerebellum, cerebral cortex

RGD

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

solute carrier family 6 member 4

protein:increased expression:brain (rat)

RGD

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

X-box binding protein 1

mRNA,protein:altered expression:cerebellum,hippocampus

RGD

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Bovine Tuberculosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 23 subunit alpha

RGD

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 4

CTD Direct Evidence: therapeutic

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

Carcinoma, Lewis Lung

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

complement C3

treatment

RGD

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

coenzyme Q7, hydroxylase

susceptibility

RGD

NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158

G

colony stimulating factor 1 receptor

ameliorates

mouse cell line in a mouse model

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

interleukin 18

treatment

RGD

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 2

treatment

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin-1 receptor-associated kinase 3

RGD

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

junctional adhesion molecule 3

RGD

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

leukocyte cell-derived chemotaxin 2

CTD Direct Evidence: therapeutic

NCBI chr17:8,044,759...8,050,983
Ensembl chr17:8,044,759...8,050,983

G

mitogen activated protein kinase 14

ameliorates

mouse cell line in a mouse model

RGD

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

MYD88, innate immune signal transduction adaptor

treatment

mouse cell line in a mouse model

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

thioredoxin reductase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

Choroidal Neovascularization, Experimental

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

delta like canonical Notch ligand 4

treatment

RGD

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

serpin family E member 1

treatment
severity

mRNA:increased expression:retina (mouse)
human gene in mouse model

RGD

PMID:12766088 PMID:26610445 PMID:11292663 PMID:12766088

RGD:8547735, RGD:11073722, RGD:8547737, RGD:8547735

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

smoothened, frizzled class receptor

treatment

RGD

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

Chronic Experimental Pancreatitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cystathionine beta synthase

protein:increased expression:arcuate nucleus (rat)

RGD

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

GLI family zinc finger 1

RGD

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

interleukin 1 beta

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

NAD(P)H quinone dehydrogenase 1

treatment

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

patched 1

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

smoothened, frizzled class receptor

RGD

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

serine peptidase inhibitor, Kazal type 1

treatment

protein:increased secretion:pancreatic juice:

RGD

PMID:19904222 PMID:12123090 PMID:22173919

RGD:10043091, RGD:10044261, RGD:10044253

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

transforming growth factor, beta 1

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

Chronic Relapsing Experimental Autoimmune Encephalomyelitis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

mRNA:increased expression:spinal cord (rat)

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

neurofilament heavy chain

protein:decreased expression:spinal cord:

RGD

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

proteolipid protein 1

human sequence peptide in a mouse model; associated with Herpesviridae infections

RGD

NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032

G

serpin family E member 1

RGD

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

cryptosporidiosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mannose binding lectin 2

susceptibility

DNA:polymorphisms, haplotype:promoter,exon:

RGD

NCBI chr 1:228,016,439...228,024,736

G

microRNA 21

RNA:increased expression:ileum

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

Dog Diseases

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

copper metabolism domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501

G

dynamin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

Ehrlich tumor carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD40 molecule

treatment

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

treatment

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CEA cell adhesion molecule 20

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,622,077...79,643,782
Ensembl chr 1:79,622,077...79,643,782

Experimental Allergic Asthma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA synthetase long-chain family member 3

RGD

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

BCL2, apoptosis regulator

treatment

RGD

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

CD86 molecule

treatment

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

Fas cell surface death receptor

treatment

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

treatment

RGD

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

interleukin 23 subunit alpha

RGD

PMID:19935773 PMID:26344076

RGD:5037240, RGD:11251537

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

Experimental Arthritis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

protein:increased expression:serum

RGD

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

mRNA:altered expression:liver
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:intestinal mucosa (rat)

CTD
RGD

PMID:17827786 PMID:19152228 PMID:17827786

RGD:2315573, RGD:11040994

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 6

mRNA:decreased expression:kidney

RGD

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily G member 2

mRNA:decreased expression:small intestine

RGD

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

aggrecan

treatment

RGD

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

angiotensin I converting enzyme

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA synthetase long-chain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

ADAM metallopeptidase domain 10

RGD

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

ADAM metallopeptidase domain 17

RGD

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adiponectin, C1Q and collagen domain containing

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23326410 PMID:21681567 PMID:19026984

RGD:5685385, RGD:5686814

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine kinase

RGD

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adenosylhomocysteinase

RGD

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

exacerbates

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25194622 PMID:27032495 PMID:26221077

RGD:407420267, RGD:405878089

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

treatment

RGD

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 15-lipoxygenase

RGD

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

annexin A1

RGD

PMID:10403283 PMID:23267026

RGD:2306928, RGD:7421573

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

ameliorates

RGD

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

amine oxidase, copper containing 3

RGD

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein A4

protein:decreased expression:blood serum (rat)

RGD

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

arrestin, beta 1

protein:increased expression:knee, synoviocyte (rat)

RGD

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin, beta 2

protein:increased expression:knee, synoviocyte (rat)

RGD

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

RGD

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

BCL2 associated X, apoptosis regulator

treatment

RGD

PMID:21199477 PMID:22978269

RGD:10054249, RGD:10054498

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

treatment

RGD

PMID:21199477 PMID:22978269

RGD:10054249, RGD:10054498

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bone gamma-carboxyglutamate protein

protein:decreased expression:serum

RGD

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

Bruton tyrosine kinase

treatment

RGD

PMID:22228807 PMID:32083858

RGD:11040701, RGD:151665122

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

complement C3

treatment

RGD

PMID:20051658 PMID:7347767

RGD:7411688, RGD:11041098

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

RGD

PMID:20975959 PMID:12355496

RGD:5130175, RGD:1600637

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

calcineurin binding protein 1

RGD

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcitonin-related polypeptide alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene

treatment

RGD

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

Cbl proto-oncogene B

RGD

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

C-C motif chemokine ligand 2

treatment

mRNA, protein:increased expression:synovium

RGD

PMID:18292571 PMID:24583103 PMID:17052673 PMID:18726678

RGD:2307052, RGD:11526142, RGD:2307143, RGD:2307008

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

mRNA, protein:increased expression:synovium, monocytes

RGD

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

mRNA, protein:increased expression:synovium, monocytes

RGD

PMID:9637726 PMID:17052673

RGD:4889940, RGD:2307143

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

onset

RGD

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 1

ameliorates

RGD

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

C-C motif chemokine receptor 1

RGD

PMID:18608173 PMID:14674010

RGD:5688144, RGD:1582346

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

RGD

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 5

treatment

mRNA:increased expression:ankle (rat)

RGD

PMID:14674010 PMID:22289897

RGD:1582346, RGD:5687744

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

Cd28 molecule

RGD

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

Cd4 molecule

treatment

RGD

PMID:15479897 PMID:12010568

RGD:10058957, RGD:10058960

NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191

G

CD40 molecule

RGD

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

treatment

protein:increased expression:plasma (rat)

RGD

PMID:27218142 PMID:7689748 PMID:22611405

RGD:11344958, RGD:11352696, RGD:11352298

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD44 molecule

protein:increased expression:joint, macrophage, lymphocyte

RGD

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD46 molecule

RGD

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

CD59b molecule

RGD

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

Cd69 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

Cd80 molecule

RGD

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

cell division cycle 42

protein:increased activation:bone marrow, macrophage

RGD

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cyclin-dependent kinase inhibitor 2A

treatment

RGD

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

complement factor H

RGD

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

collagen type II alpha 1 chain

CTD Direct Evidence: marker/mechanism

PMID:16200597 PMID:21188452 PMID:23326410 PMID:24709313 PMID:25194622 More...

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19330884 PMID:19205849

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

coproporphyrinogen oxidase

protein:decreased activity:liver (rat)

RGD

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

G

corticotropin releasing hormone receptor 1

RGD

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

C-reactive protein

CTD Direct Evidence: marker/mechanism

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 1

protein:increased expression:dorsal root ganglion

RGD

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

treatment

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 3

treatment

RGD

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

C-terminal Src kinase

RGD

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

cytotoxic T-lymphocyte-associated protein 4

treatment

RGD

PMID:22354915 PMID:7543497

RGD:7204500, RGD:7204519

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

cathepsin B

mRNA:increased expression:knee joint, synovium (rat)

RGD

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin K

mRNA:increased expression:synovium, bone marrow

RGD

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin S

RGD

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X3-C motif chemokine ligand 1

RGD

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

protein:increased expression:spinal cord

RGD

PMID:17123734 PMID:11465708

RGD:4891969, RGD:4892002

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 1

RGD

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 6

severity

RGD

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

discoidin domain receptor tyrosine kinase 2

ameliorates

RGD

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

dihydroorotate dehydrogenase

RGD

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

deoxyribonuclease 2, lysosomal

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

DNA methyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dopamine receptor D1

treatment

mRNA:increased expression:corpus striatum (rat)

RGD

PMID:23762129 PMID:23762129

RGD:7248592, RGD:7248592

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

treatment

mRNA:increased expression:corpus striatum (rat)

RGD

PMID:23762129 PMID:23762129

RGD:7248592, RGD:7248592

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

endothelin 1

mRNA:increased expression:inguinal lymph node (mouse)

RGD

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor

CTD Direct Evidence: therapeutic

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

treatment

associated with Osteoporosis

RGD

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor II, thrombin

RGD

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

severity

RGD

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

F2R like trypsin receptor 1

RGD

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

Fas ligand

treatment

RGD

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fc gamma receptor 1A

protein:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12875993 PMID:16670289 PMID:32510872

RGD:9685708, RGD:127338469

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 2A

onset

RGD

PMID:18354234 PMID:16623928

RGD:5508446, RGD:5508457

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

Fc gamma receptor 2B

RGD

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

fibroblast growth factor 8

RGD

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

Fibroblast growth factor receptor 1

RGD

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

Fms related receptor tyrosine kinase 1

RGD

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 3

RGD

NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474

G

Fos proto-oncogene, AP-1 transcription factor subunit

treatment

RGD

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box P3

treatment

mRNA,protein:decreased expression:lung

RGD

PMID:29264841 PMID:23643080

RGD:38549364, RGD:38599003

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

gap junction protein, alpha 1

RGD

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

GLI family zinc finger 1

treatment

RGD

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

glucose-6-phosphate isomerase

RGD

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

G protein-coupled receptor kinase 2

disease_progression
treatment

protein:increased expression:aorta (rat)
protein:altered expression:T cell (rat)

RGD

PMID:28653218 PMID:28349925 PMID:28631356

RGD:13513975, RGD:13513979, RGD:13513976

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

granulin precursor

RGD

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

CTD Direct Evidence: marker/mechanism

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glucuronidase, beta

treatment

RGD

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hepatitis A virus cellular receptor 2

mRNA,protein:altered expression:bone:

RGD

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

histone deacetylase 6

treatment

RGD

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

hypoxia inducible factor 1 subunit alpha

treatment

RGD

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

protein:altered localization:cytoplasm, extracellular matrix

RGD

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA reductase

RGD

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

haptoglobin

mRNA, protein:increased expression:tendon, ankle
protein:increased expression:serum

RGD

PMID:12801280 PMID:15899029

RGD:1626375, RGD:1626370

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

heat shock protein family D (Hsp60) member 1

RGD

PMID:15529360 PMID:10882416

RGD:1624244, RGD:12910542

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

interferon gamma

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19203382 PMID:22450443 PMID:12412757 PMID:7774621

RGD:2311498, RGD:10755750

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

protein:decreased expression:plasma

RGD

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

mRNA, protein:increased expression:kidney, serum

RGD

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

inhibitor of nuclear factor kappa B kinase subunit beta

treatment

RGD

PMID:21087862 PMID:19652024

RGD:7495772, RGD:7495778

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

treatment

RGD

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

treatment

CTD Direct Evidence: marker/mechanism|therapeutic
protein:decreased expression:serum:

CTD
RGD

PMID:20974942 PMID:22450443 PMID:19193354 PMID:19169271 PMID:23140046 More...

RGD:2311059, RGD:8662976, RGD:7193038, RGD:7364838, RGD:1626677

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:10444273 PMID:17665443 PMID:11860705

RGD:4889497, RGD:8549606

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

RGD

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 17A

treatment

IMP
ISO
IEP
IDA

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

CTD
RGD

PMID:20974942 PMID:20925596 PMID:23377547 PMID:21194185 PMID:20925596

RGD:4781444, RGD:9130803, RGD:9068936, RGD:4781444

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

disease_progression

RGD

PMID:19096963 PMID:15147345

RGD:4889415, RGD:4889503

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

protein:increased expression:serum:

RGD

PMID:20379758 PMID:19169271

RGD:6907373, RGD:8662976

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

CTD
RGD

PMID:19330884 PMID:20131233 PMID:20974942 PMID:22450443 PMID:21557995 More...

RGD:7175317, RGD:13792834, RGD:10755447, RGD:7193038

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

treatment

rat model treated with human protein
human gene in a rat model
mRNA:increased expression:popliteal lymph node (rat)
mouse model treated with human protein

RGD

PMID:15270736 PMID:12727108 PMID:10921508 PMID:22267332 PMID:23006786

RGD:1626677, RGD:8551745, RGD:8551741, RGD:8549801, RGD:6907376

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

treatment

protein:increased expression:serum:

RGD

PMID:19169271 PMID:2492102

RGD:8662976, RGD:10047055

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 20

RGD

NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625

G

interleukin 2 receptor subunit alpha

RGD

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 33

CTD Direct Evidence: marker/mechanism

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:10444273 PMID:16869003 PMID:23972727 PMID:23140046

RGD:2317300, RGD:10402790, RGD:7193038

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

treatment

IEP
ISO
IDA
IMP

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20131233 PMID:20974942 PMID:22450443 PMID:24028507 PMID:8607900 More...

RGD:10755447, RGD:11060267, RGD:11049553, RGD:11049551

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

RGD

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

integrin subunit alpha 4

treatment

RGD

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit beta 2

RGD

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

protein:increased expression:endothelial cell

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

jagged canonical Notch ligand 1

RGD

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 1

treatment

RGD

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

treatment

RGD

PMID:22339472 PMID:23711144 PMID:22800927

RGD:10403066, RGD:10403081, RGD:10403074

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Janus kinase 3

treatment

RGD

PMID:25762693 PMID:18234077 PMID:21434883

RGD:11533938, RGD:11533944, RGD:11533942

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

potassium calcium-activated channel subfamily N member 4

ameliorates

RGD

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

kallikrein B1

RGD

PMID:22739815 PMID:9783057

RGD:7297047, RGD:7327138

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 2

peptidoglycan-polysaccharide-induced arthritis in Lewis rats

RGD

PMID:9214434 PMID:1996642

RGD:1600547, RGD:11059895

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

kynurenine aminotransferase 1

RGD

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

leptin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

RGD

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

mitogen-activated protein kinase kinase kinase 5

RGD

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

macrophage migration inhibitory factor

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

microRNA 146a

mRNA:increased expression:joints (mouse)

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 152

CTD Direct Evidence: marker/mechanism
miRNA:decreased exression:synovial membrane of synovial joint

CTD
RGD

PMID:25194984 PMID:25194984

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 23b

treatment

mRNA:decreased expression:joint (mouse)

PMID:22660635 PMID:22660635

RGD:155663483, RGD:155663483

NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763

G

microRNA 26a

CTD Direct Evidence: therapeutic

NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378

G

matrix metallopeptidase 1

RGD

PMID:21288455 PMID:24011916 PMID:21108488

RGD:7207362, RGD:8549748, RGD:7207365

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

treatment

RGD

PMID:24244039 PMID:11435459

RGD:8694124, RGD:1582329

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 3

treatment

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:ankle joint

CTD
RGD

PMID:20974942 PMID:20703013 PMID:24244039 PMID:24244039 PMID:24011916 More...

RGD:7241231, RGD:8694124, RGD:8694124, RGD:8549748, RGD:8693318

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

protein:increased expression:cartilage, serum, synovial fluid

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

CTD Direct Evidence: marker/mechanism

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded ATP synthase membrane subunit 8

susceptibility

DNA:transversion: :m.7778G>T (mouse)

RGD

NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961

G

mechanistic target of rapamycin kinase

treatment

RGD

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

RGD

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myogenic differentiation 1

treatment

RGD

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

myogenin

treatment

RGD

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

neutrophil cytosolic factor 1

severity

DNA:missense mutations:cds:p.M106V, p.M153T (rat)

RGD

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nucleotide-binding oligomerization domain containing 2

RGD

PMID:21424514 PMID:20131263

RGD:5508728, RGD:8552884

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nitric oxide synthase 2

protein:increased expression:ankle joint (mouse)

RGD

PMID:12826065 PMID:21880869

RGD:1358527, RGD:5509060

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

treatment

RGD

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

neuropeptide S receptor 1

treatment

RGD

NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558

G

NAD(P)H quinone dehydrogenase 1

severity

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 2

RGD

NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377

G

nuclear receptor subfamily 1, group H, member 3

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 3, group C, member 1

treatment

RGD

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

NRAS proto-oncogene, GTPase

RGD

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

neurotensin

RGD

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

orosomucoid 1

protein:increased expression:liver

RGD

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

purinergic receptor P2Y12

RGD

NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361

G

peptidylglycine alpha-amidating monooxygenase

RGD

NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965

G

poly (ADP-ribose) polymerase 1

severity

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prodynorphin

treatment

RGD

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:knee joint, blood vessels (mouse)

RGD

PMID:22548760 PMID:14613294 PMID:21982514

RGD:6484738, RGD:6771222, RGD:6771177

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

placental growth factor

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

RGD

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

RGD

PMID:20374644 PMID:18412166

RGD:6482684, RGD:6482696

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

plasminogen activator, urokinase

RGD

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

proopiomelanocortin

treatment

RGD

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

PR/SET domain 1

CTD Direct Evidence: therapeutic

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

patched 1

treatment

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin E receptor 4

treatment
disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:tarsal joint, synovium (rat)

CTD
RGD

PMID:18287210 PMID:20423341 PMID:11207665 PMID:18287210

RGD:10003041, RGD:10043377, RGD:10003052

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

mRNA, protein:increased expression:paw

RGD

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 3

mRNA:increased expression:paw (rat)

RGD

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin-endoperoxide synthase 1

mRNA, protein:increased expression:synovium

RGD

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

mRNA, protein:increased expression:synovium
protein:increased expression:autopod joint

RGD

PMID:18758904 PMID:22289897 PMID:21765105

RGD:2300221, RGD:5687744, RGD:5508310

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 22

protein:increased expression:metatarsophalangeal joint, mononuclear cell (rat)

RGD

NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779

G

recombination activating 2

CTD Direct Evidence: therapeutic

NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066

G

RT1 class II, locus Db1

RGD

PMID:21665435 PMID:19950279

RGD:5147558, RGD:5147586

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

S100 calcium binding protein A8

RGD

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

RGD

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

serpin family C member 1

protein:decreased expression:plasma

RGD

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

secreted frizzled-related protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

sonic hedgehog signaling molecule

treatment

RGD

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

solute carrier family 11 member 1

severity

RGD

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

secretory leukocyte peptidase inhibitor

treatment

protein:decreased expression:articular cartilage of joint

RGD

PMID:10449524 PMID:9744360

RGD:634208, RGD:9999431

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

smoothened, frizzled class receptor

treatment

RGD

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

suppressor of cytokine signaling 3

mRNA:increased expression:mononuclear cell

RGD

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

sialophorin

associated with Staphylococcal Infections

RGD

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

signal transducer and activator of transcription 1

protein:increased tyrosine phosphorylation:macrophage, synovial cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15188379 PMID:14674010

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15188379 PMID:21937456 PMID:23711144

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tachykinin, precursor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transforming growth factor, beta 1

RGD

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

protein:increased expression:synovium

RGD

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

thrombomodulin

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 4

RGD

NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558

G

tight junction protein 1

RGD

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 2

RGD

PMID:21725847 PMID:20131263

RGD:7241099, RGD:8552884

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630