RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: granulosa cell tumor
Accession: DOID:2999
browse the term
Definition: A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma. (DO)
Synonyms: exact_synonym: Cancer of Granulosa Cells; Granulosa Cell Cancer; Granulosa Cell Cancers; Granulosa Cell Tumors; Granulosa Cells Cancer; Granulosa Cells Cancers; Granulosa cell tumor, somatic; granulosa cell neoplasm; granulosa cell tumor, adult type; granulosa cell tumour, sarcomatoid; malignant granulosa cell neoplasm
primary_id: MESH:D006106
xref: EFO:1000032 ; NCI:C24000 ; NCI:C3070 ; NCI:C4205
For additional species annotation, visit the
Alliance of Genome Resources .
G
Amh
anti-Mullerian hormone
disease_progression
ISO
RGD
PMID:19359032
RGD:2315639
NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Bmp4
bone morphogenetic protein 4
ISO
mRNA:increased expression:ovary
RGD
PMID:16488995
RGD:1643593
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Ccnd2
cyclin D2
ISO
mRNA:increased expression:ovary
RGD
PMID:11994539
RGD:2289157
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
ISO
RGD
PMID:12203782
RGD:2296066
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
G
Cdkn2b
cyclin-dependent kinase inhibitor 2B
ISO
RGD
PMID:12203782
RGD:2296066
NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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Cmklr1
chemerin chemokine-like receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29653259
NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
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Ctnnb1
catenin beta 1
ISO ISS
MouseDO RGD
PMID:16488995
RGD:1643593
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Fancf
FA complementation group F
disease_progression susceptibility
ISO
DNA:hypermethylation:promoter
RGD
PMID:15574200 PMID:21915857
RGD:2298508 , RGD:11049141
NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923
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Fhit
fragile histidine triad diadenosine triphosphatase
ISO
DNA:hypermethylation:promoter, ovary
RGD
PMID:15574200
RGD:2298508
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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Fshr
follicle stimulating hormone receptor
ISO
RGD
PMID:11994539
RGD:2289157
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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Gnai2
G protein subunit alpha i2
ISO
ClinVar Annotator: match by term: Granulosa cell tumor, somatic
ClinVar
PMID:2116665
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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Kit
KIT proto-oncogene receptor tyrosine kinase
ISO
mRNA:decreased expression:ovary
RGD
PMID:18028988
RGD:2302173
NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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Lepr
leptin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28861689
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
ISO
RGD
PMID:15967102 PMID:11994539
RGD:2302176 , RGD:2289157
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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Mgmt
O-6-methylguanine-DNA methyltransferase
ISO
DNA:hypermethylation:promoter (human)
RGD
PMID:14970867
RGD:2317693
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
ISO
RGD
PMID:11994539
RGD:2289157
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:11994539
RGD:2289157
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rarres2
retinoic acid receptor responder 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29653259
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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Sgk1
serum/glucocorticoid regulated kinase 1
ISO
RGD
PMID:11994539
RGD:2289157
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Smad1
SMAD family member 1
ISO
RGD
PMID:17967875
RGD:2299978
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smad5
SMAD family member 5
ISO
RGD
PMID:17967875
RGD:2299978
NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
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St14
ST14 transmembrane serine protease matriptase
ISO
protein:increased expression:ovary
RGD
PMID:16439987
RGD:2315091
NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517
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Vegfa
vascular endothelial growth factor A
ISO
RGD
PMID:19524286
RGD:2315463
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Wif1
Wnt inhibitory factor 1
ISO
mRNA:increased expression:ovary
RGD
PMID:16488995
RGD:1643593
NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
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Gnai2
G protein subunit alpha i2
ISO
ClinVar Annotator: match by term: Granulosa cell tumor of the ovary
ClinVar
PMID:2116665
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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