RGD Reference Report - Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. - Rat Genome Database

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Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.

Authors: Jin, JS  Hsieh, DS  Loh, SH  Chen, A  Yao, CW  Yen, CY 
Citation: Jin JS, etal., Mod Pathol. 2006 Mar;19(3):447-52.
RGD ID: 2315091
Pubmed: PMID:16439987   (View Abstract at PubMed)
DOI: DOI:10.1038/modpathol.3800495   (Journal Full-text)

Matriptase is a type II transmembrane serine protease expressed by cells of surface epithelial origin, including epithelial ovarian tumor cells. Matriptase cleaves and activates proteins implicated in the progression of cancer and represents a potential prognostic and therapeutic target. The aim of this study was to examine the expression of matriptase in ovarian tumors and to assign clinicopathological correlations. Immunohistochemical analysis of matriptase was performed in tissue microarrays of 164 ovarian neoplasms including 84 serous adenocarcinomas, 23 mucinous adenocarcinomas, 10 endometrioid adenocarcinomas, six yolk sac tumors, 12 clear cell carcinomas, six dysgerminomas, eight granulosa cell tumors, four transitional cell carcinomas, five fibromas, and six Brenner tumors. All ovarian tumors except the fibromas and Brenner tumors showed significant expression of matriptase. The matriptase scores were significantly higher in the tumors than in their nontumor counterparts (304+/-26 for serous adenocarcinoma; 361+/-28 for mucinous adenocarcinoma; 254+/-17 for endometrioid adenocarcinoma; 205+/-19 for yolk sac tumor; 162+/-16 for clear cell carcinoma; 109+/-11 for dysgerminoma; 105+/-9 for granulosa cell tumor; and 226+/-18 for transitional cell carcinoma). Matriptase scores in serous adenocarcinoma were correlated with TNM stage and FIGO stage. Our findings demonstrate for the first time that matriptase is overexpressed in many malignant ovarian tumors. It may be a novel biomarker for diagnosis and treatment of malignant ovarian tumors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dysgerminoma  IEP 2315091protein:increased expression:ovaryRGD 
dysgerminoma  ISOST14 (Homo sapiens)2315091; 2315091protein:increased expression:ovaryRGD 
Endometrioid Carcinomas  IEP 2315091associated with Ovarian Neoplasms and protein:increased expression:ovaryRGD 
Endometrioid Carcinomas  ISOST14 (Homo sapiens)2315091; 2315091associated with Ovarian Neoplasms and protein:increased expression:ovaryRGD 
granulosa cell tumor  IEP 2315091protein:increased expression:ovaryRGD 
granulosa cell tumor  ISOST14 (Homo sapiens)2315091; 2315091protein:increased expression:ovaryRGD 
Ovarian Neoplasms  IEP 2315091protein:increased expression:ovaryRGD 
Ovarian Neoplasms  ISOST14 (Homo sapiens)2315091; 2315091protein:increased expression:ovaryRGD 

Objects Annotated

Genes (Rattus norvegicus)
St14  (ST14 transmembrane serine protease matriptase)

Genes (Mus musculus)
St14  (suppression of tumorigenicity 14 (colon carcinoma))

Genes (Homo sapiens)
ST14  (ST14 transmembrane serine protease matriptase)


Additional Information