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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:anxiety disorder
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Accession:DOID:2030 term browser browse the term
Definition:A cognitive disorder that involves an excessive, irrational dread of everyday situations. (DO)
Synonyms:exact_synonym: ANXIETY;   Neurotic Anxiety State;   anxiety disorders;   anxiety neuroses;   anxiety state;   neurotic anxiety states
 narrow_synonym: HARM AVOIDANCE
 related_synonym: SEROTONIN TRANSPORTER ACTIVITY, INCREASED/DECREASED
 primary_id: MESH:D001008
 alt_id: OMIM:607834
 xref: EFO:0005230;   EFO:0006788;   ICD10CM:F41.9;   NCI:C2878
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

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anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26767952 NCBI chr  X:14,032,231...14,094,163
Ensembl chr  X:14,030,233...14,077,785 		JBrowse link
G ADAR adenosine deaminase RNA specific ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr20:9,194,611...9,241,102
Ensembl chr20:9,219,937...9,241,329 		JBrowse link
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 PMID:16118787 PMID:18305461 PMID:20532872 NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:21669254 RGD:6480479 NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932 		JBrowse link
G APOE apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:32057829 NCBI chr 6:38,377,154...38,381,219
Ensembl chr 6:38,376,887...38,381,438 		JBrowse link
G APP amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19664757 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G ARC activity regulated cytoskeleton associated protein ameliorates ISO associated with alcohol use disorder
associated with alcohol dependence		 RGD PMID:18322102 PMID:21182574 PMID:24103311 PMID:25814047 RGD:401938616 RGD:401938648 RGD:401938652 RGD:401938663 NCBI chr 8:136,857,402...136,860,933
Ensembl chr 8:136,859,438...136,860,628 		JBrowse link
G AVPR1B arginine vasopressin receptor 1B treatment ISO RGD PMID:21956463 PMID:24654684 RGD:14700666 RGD:14700676 NCBI chr25:23,234,651...23,244,403
Ensembl chr25:23,234,823...23,241,159 		JBrowse link
G BDNF brain derived neurotrophic factor treatment
ameliorates		 ISO associated with alcohol use disorder
associated with alcohol dependence		 RGD PMID:18322102 PMID:24103311 PMID:25283985 PMID:25814047 RGD:151356735 RGD:401938616 RGD:401938652 RGD:401938663 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CARTPT CART prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12600694 NCBI chr 4:66,058,755...66,060,635
Ensembl chr 4:66,058,769...66,061,112 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Sciatic Neuropathy; RGD PMID:24907405 RGD:8661781 NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728 		JBrowse link
G CHD8 chromodomain helicase DNA binding protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35365720 NCBI chr29:21,856,434...21,924,761
Ensembl chr29:21,856,263...21,924,787 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19220484 PMID:29944862 NCBI chr26:4,747,734...4,779,231
Ensembl chr26:4,749,766...4,776,822 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:23419392 NCBI chr20:9,245,803...9,255,430
Ensembl chr20:9,247,231...9,253,795 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15081793 PMID:18690112 NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment ISO associated with alcohol use disorder RGD PMID:18322102 PMID:32014377 RGD:401827932 RGD:401938616 NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832 		JBrowse link
G CRH corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:7816204 PMID:8736133 PMID:11440811 PMID:11875628 PMID:12424556 More... NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10742108 NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116 		JBrowse link
G CRP C-reactive protein ISO CTD Direct Evidence: marker/mechanism
associated with Coronary Disease;		 CTD
RGD		 PMID:18603621 PMID:20194079 RGD:9491832 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
G CTNND2 catenin delta 2 susceptibility ISO DNA:polymorphism:multiple (human) RGD PMID:24256404 RGD:40902831 NCBI chr 4:10,499,822...11,426,432
Ensembl chr 4:10,500,761...10,762,677 		JBrowse link
G DISC1 DISC1 scaffold protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:29643356 NCBI chr25:68,886,451...69,274,774
Ensembl chr25:68,946,430...69,263,198 		JBrowse link
G DIXDC1 DIX domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27752079 NCBI chr 1:103,276,780...103,377,110
Ensembl chr 1:103,286,346...103,378,387 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23791455 NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:decreased expression:hypothalamus: RGD PMID:23529784 RGD:9588317 NCBI chr 2:37,128,635...37,176,033
Ensembl chr 2:37,146,538...37,174,570 		JBrowse link
G DRD2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.H313H (human)		 CTD
RGD		 PMID:9513185 PMID:18305461 PMID:20532872 RGD:1358603 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G EOMES eomesodermin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26415720 NCBI chr15:72,257,626...72,264,563 JBrowse link
G ESR2 estrogen receptor 2 treatment ISO RGD PMID:24015243 PMID:24631553 RGD:10045678 RGD:7364908 NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28616095 NCBI chr  X:122,635,383...122,674,298
Ensembl chr  X:122,635,439...122,674,355 		JBrowse link
G FNTB farnesyltransferase, CAAX box, subunit beta ISO DNA:SNP:CDS:multiple (human) RGD PMID:35642741 RGD:401854249 NCBI chr24:42,197,998...42,275,863
Ensembl chr24:42,198,704...42,276,898 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr24:52,497,465...52,501,161
Ensembl chr24:52,497,521...52,501,514 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18313124 NCBI chr27:3,858,741...4,013,385
Ensembl chr27:3,858,910...4,006,582 		JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility ISO DNA:snp(s)
protein:decreased expression:hippocampus		 RGD PMID:22328461 PMID:28986280 RGD:405850254 RGD:6480264 NCBI chr10:56,351,495...56,396,476
Ensembl chr10:56,353,253...56,396,524 		JBrowse link
G GDNF glial cell derived neurotrophic factor no_association ISO DNA:SNPs, haplotypes:rs3812047, rs3096140 (human)
DNA:SNPs:multiple		 RGD PMID:24324616 RGD:405849392 NCBI chr 4:36,662,033...36,691,761
Ensembl chr 4:36,665,009...36,684,257 		JBrowse link
G GLO1 glyoxalase I ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr17:33,446,134...33,472,240
Ensembl chr17:33,446,145...33,473,699 		JBrowse link
G GNB1 G protein subunit beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22113448 NCBI chr20:129,654,890...129,765,765
Ensembl chr20:129,707,085...129,766,667 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17434465 NCBI chr21:95,264,905...96,060,822
Ensembl chr21:95,264,765...96,050,554 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:22884333 RGD:9686419 NCBI chr 4:44,029,173...44,443,669 JBrowse link
G HDAC2 histone deacetylase 2 ISO associated with alcohol use disorder ;mRNA,protein:increased expression:amygdala (rat) RGD PMID:23485013 PMID:25814047 RGD:401938652 RGD:9590265 NCBI chr13:59,873,248...59,904,542
Ensembl chr13:59,873,767...59,905,742 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:25741868 NCBI chr 1:110,457,799...110,466,361
Ensembl chr 1:110,457,537...110,466,095 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO OMIM:607834 RGD
MouseDO		 PMID:21512427 RGD:5683629 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:12040062 RGD:625756 NCBI chr13:2,143,646...2,145,943
Ensembl chr13:2,144,313...2,145,485 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:17074317 RGD:1625000 NCBI chr  X:102,190,355...102,499,928
Ensembl chr  X:102,325,731...102,497,278 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16828124 PMID:21859099 RGD:6482189 NCBI chr 9:84,081,713...84,191,112
Ensembl chr 9:84,083,396...84,190,876 		JBrowse link
G IFNA2 interferon alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12297606 NCBI chr12:58,468,018...58,469,825 JBrowse link
G KDM3B lysine demethylase 3B ISO RGD PMID:24397026 RGD:9590119 NCBI chr23:41,027,490...41,111,560
Ensembl chr23:41,062,020...41,112,469 		JBrowse link
G KLF7 KLF transcription factor 7 ISO ClinVar Annotator: match by term: Anxiety ClinVar PMID:17434132 PMID:18094723 PMID:25741868 PMID:28492532 PMID:29251763 NCBI chr10:92,854,234...92,943,908
Ensembl chr10:92,859,000...92,944,062 		JBrowse link
G L1CAM L1 cell adhesion molecule ISO protein:increased expression: brain, multiple (rat) RGD PMID:19746433 RGD:6483075 NCBI chr  X:128,285,128...128,309,173
Ensembl chr  X:128,285,130...128,299,570 		JBrowse link
G LOC103231899 ETS transcription factor ELK1 ameliorates ISO associated with alcohol use disorder RGD PMID:18322102 RGD:401938616 NCBI chr  X:44,812,681...44,827,657 JBrowse link
G LOC103243260 corticotropin-releasing factor receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9299637 PMID:22231481 NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712 		JBrowse link
G LOC103246766 cytochrome P450 3A8 ISO protein:altered activity::treatment RGD PMID:17376576 RGD:5685599 NCBI chr28:13,297,566...13,330,023 JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25653350 NCBI chr21:69,460,345...70,916,684 JBrowse link
G MANEA mannosidase endo-alpha susceptibility ISO DNA:SNP:3'utr: (rs1133503) (Human) RGD PMID:24473444 RGD:401851911 NCBI chr13:20,496,677...20,529,201
Ensembl chr13:20,496,686...20,530,819 		JBrowse link
G MAPT microtubule associated protein tau ISO CTD Direct Evidence: marker/mechanism CTD PMID:29860433 NCBI chr16:59,894,400...60,020,723
Ensembl chr16:59,890,221...59,955,612 		JBrowse link
G MDK midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:19217924 NCBI chr 1:18,945,355...18,948,394
Ensembl chr 1:18,946,378...18,947,134 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22231481 NCBI chr  X:128,445,028...128,519,892
Ensembl chr  X:128,453,577...128,455,785 		JBrowse link
G MIF macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20177408 NCBI chr19:7,000,837...7,001,700
Ensembl chr19:7,000,793...7,001,757 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:20051490 RGD:5688287 NCBI chr16:15,442,315...15,629,411
Ensembl chr16:15,462,640...15,628,512 		JBrowse link
G NPS neuropeptide S ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:19339610 PMID:21466221 NCBI chr 9:120,168,749...120,176,288 JBrowse link
G NPY neuropeptide Y susceptibility ISO DNA:SNPs, haplotypes
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:11440811 PMID:22328461 RGD:6480264 NCBI chr21:34,068,533...34,076,205
Ensembl chr21:34,068,530...34,075,127 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 treatment ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:11440811 PMID:21803058 RGD:10448284 NCBI chr 7:109,774,700...109,794,543
Ensembl chr 7:109,774,918...109,776,905 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ameliorates ISO associated with alcohol use disorder RGD PMID:18322102 RGD:401938616 NCBI chr12:95,477,612...95,836,734
Ensembl chr12:95,479,447...95,620,364 		JBrowse link
G OPRM1 opioid receptor mu 1 treatment ISO RGD PMID:32014377 RGD:401827932 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:19228979 NCBI chr 2:33,749,520...33,750,981
Ensembl chr 2:33,750,108...33,750,968 		JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815072 NCBI chr23:6,316,428...6,482,959
Ensembl chr23:6,316,428...6,486,751 		JBrowse link
G RAI1 retinoic acid induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18285828 NCBI chr16:16,717,767...16,847,014
Ensembl chr16:16,760,189...16,849,346 		JBrowse link
G SERPINA1 serpin family A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659342 NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500 		JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18272690 NCBI chr 6:43,718,904...43,776,814
Ensembl chr 6:43,716,714...43,773,945 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19120712 NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased OMIM
ClinVar		 PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G TAFA2 TAFA chemokine like family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29339520 NCBI chr11:57,598,179...58,095,527
Ensembl chr11:57,597,697...57,763,149 		JBrowse link
G TG thyroglobulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:30373627 NCBI chr 8:127,293,797...127,567,218
Ensembl chr 8:127,293,834...127,567,771 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20194079
G UCN urocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16488545 NCBI chr14:80,303,210...80,304,910
Ensembl chr14:80,304,416...80,304,790 		JBrowse link
acute stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) ISO RGD PMID:20645790 RGD:5509849 NCBI chr28:12,328,304...12,335,302
Ensembl chr28:12,331,039...12,335,076 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28696432 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:19628221 RGD:9585647 NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377 		JBrowse link
Acute Stress Disorders, Traumatic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2A 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:15507224 RGD:401900762 NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432 		JBrowse link
dopamine beta-hydroxylase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase ISO ClinVar Annotator: match by term: Orthostatic hypotension 1 OMIM
ClinVar		 PMID:7715704 PMID:9536098 PMID:11170900 PMID:11857564 PMID:14598346 More... NCBI chr12:4,474,041...4,498,942
Ensembl chr12:4,474,958...4,498,910 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:21209083 RGD:5685690 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
generalized anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 severity ISO protein:increased expression:serum (human) RGD PMID:27512921 RGD:39938860 NCBI chr28:20,491,874...20,497,966
Ensembl chr28:20,492,188...20,493,315 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B sexual_dimorphism ISO associated with attention deficit hyperactivity disorder;DNA:SNPs: :rs11568817, rs6296(human) RGD PMID:28923721 RGD:405650695 NCBI chr13:2,143,646...2,145,943
Ensembl chr13:2,144,313...2,145,485 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 treatment ISO DNA:repeats, haplotype:promoter: RGD PMID:22907732 RGD:36947386 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G ZNF462 zinc finger protein 462 ISO MouseDO NCBI chr12:32,532,853...32,687,262
Ensembl chr12:32,520,334...32,685,464 		JBrowse link
neurocirculatory asthenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 ISO ClinVar Annotator: match by term: Neurocirculatory asthenia ClinVar PMID:10684912 PMID:11875370 NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643 		JBrowse link
obsessive-compulsive disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO associated with morphine withdrawal disorder;mRNA:decreased expression:nucleus accumbens RGD PMID:12836135 PMID:31693870 RGD:401959588 RGD:734644 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CCKBR cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:8878350 NCBI chr 1:58,555,463...58,569,949
Ensembl chr 1:58,555,321...58,568,031 		JBrowse link
G COMT catechol-O-methyltransferase ISO RGD PMID:11840516 RGD:1300383 NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO associated with morphine withdrawal disorder;protein:increased phosphorylation:nucleus accumbens RGD PMID:31693870 RGD:401959588 NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832 		JBrowse link
G HOXB8 homeobox B8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11779477 NCBI chr16:69,025,089...69,027,937
Ensembl chr16:69,025,040...69,028,392 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 1:343,613...345,782
Ensembl chr 1:343,506...346,637 		JBrowse link
G HTR1D 5-hydroxytryptamine receptor 1D ISO CTD Direct Evidence: marker/mechanism CTD PMID:10621951 NCBI chr20:109,482,357...109,485,176
Ensembl chr20:109,482,863...109,483,996 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to ClinVar
OMIM		 PMID:9635956 PMID:12476319 PMID:15364038 NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:17267119 RGD:6482188 NCBI chr 9:84,081,713...84,191,112
Ensembl chr 9:84,083,396...84,190,876 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO ClinVar Annotator: match by term: Obsessive-compulsive disorder | ClinVar Annotator: match by term: Obsessive-compulsive disorder, susceptibility to | ClinVar Annotator: match by term: Serotonin transporter activity, increased/decreased OMIM
ClinVar		 PMID:7865169 PMID:8632190 PMID:8788073 PMID:11335745 PMID:11559314 More... NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
G SLITRK5 SLIT and NTRK like family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20418887 NCBI chr 3:66,566,718...66,574,096
Ensembl chr 3:66,569,866...66,572,742 		JBrowse link
Orthostatic Hypotension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082591 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G COL1A2 collagen type I alpha 2 chain ISO ClinVar Annotator: match by term: Orthostatic hypotension ClinVar NCBI chr21:54,602,780...54,639,832
Ensembl chr21:54,602,398...54,632,780 		JBrowse link
G GNB3 G protein subunit beta 3 susceptibility ISO DNA:SNP: : 825C>T (human) RGD PMID:11910300 RGD:1580406 NCBI chr11:6,873,043...6,880,676
Ensembl chr11:6,874,351...6,880,179 		JBrowse link
G LOC103243509 neuroendocrine secretory protein 55 susceptibility ISO DNA:SNP: : 393T>C(human) RGD PMID:11910300 RGD:1580406 NCBI chr 2:5,233,893...5,303,433
Ensembl chr 2:5,233,874...5,249,192 		JBrowse link
G OPRD1 opioid receptor delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr20:103,950,505...104,002,459 JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2981652 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
Orthostatic Hypotension 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB561 cytochrome b561 ISO ClinVar Annotator: match by term: Orthostatic hypotension 2 OMIM
ClinVar		 NCBI chr16:57,831,350...57,850,225
Ensembl chr16:57,839,614...57,844,989 		JBrowse link
Orthostatic Intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC6A2 solute carrier family 6 member 2 ISO ClinVar Annotator: match by term: SLC6A2-related disorder OMIM
ClinVar		 PMID:25741868 PMID:28492532 NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643 		JBrowse link
panic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12825092 NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:14656453 NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932 		JBrowse link
G CCKBR cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8878350 PMID:15354400 RGD:1358454 NCBI chr 1:58,555,463...58,569,949
Ensembl chr 1:58,555,321...58,568,031 		JBrowse link
G COMT catechol-O-methyltransferase ISO ClinVar Annotator: match by term: CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM ClinVar PMID:7304673 PMID:7585135 PMID:8807664 PMID:8886163 PMID:8941353 More... NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422 		JBrowse link
G CRH corticotropin releasing hormone ISO RGD PMID:14675801 RGD:1358525 NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO RGD PMID:20817074 PMID:21421022 RGD:5683630 RGD:5683631 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212 		JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12073167 NCBI chr 1:1,965,128...1,969,090 JBrowse link
G MANEA mannosidase endo-alpha susceptibility ISO associated with substance dependence; DNA:SNP:3'utr: (rs1133503) (Human) RGD PMID:24473444 RGD:401851911 NCBI chr13:20,496,677...20,529,201
Ensembl chr13:20,496,686...20,530,819 		JBrowse link
G MAOA monoamine oxidase A ISO RGD PMID:15670397 RGD:1600723 NCBI chr  X:40,834,158...40,920,404
Ensembl chr  X:40,834,159...40,920,444 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism: : RGD PMID:24856568 RGD:12910826 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G TPH2 tryptophan hydroxylase 2 susceptibility ISO DNA:SNP:intron: (rs1386494) (human) RGD PMID:17123728 RGD:5686356 NCBI chr11:67,568,744...67,664,911 JBrowse link
phobic disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309392 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO DNA:tandem repeat polymorphism:3' end: RGD PMID:8832771 RGD:12738360 NCBI chr 1:343,613...345,782
Ensembl chr 1:343,506...346,637 		JBrowse link
G MED12 mediator complex subunit 12 ISO DNA:mutation:multiple RGD PMID:12216017 RGD:1358728 NCBI chr  X:60,915,796...60,939,220
Ensembl chr  X:60,915,703...60,937,677 		JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2554359 NCBI chr17:49,922,750...49,938,084
Ensembl chr17:49,928,321...49,938,631 		JBrowse link
post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr 6:42,186,028...42,193,105 JBrowse link
G BCL2 BCL2 apoptosis regulator ISO RGD PMID:23381833 RGD:10054113 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BDNF brain derived neurotrophic factor susceptibility
treatment		 ISO DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 PMID:28791385 RGD:10059367 RGD:401940159 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:32332995 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CASP9 caspase 9 ISO RGD PMID:25331812 RGD:13782181 NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688 		JBrowse link
G CNR2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr20:108,777,793...108,815,738
Ensembl chr20:108,813,579...108,814,661 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:18349090 NCBI chr17:36,432,595...36,551,233
Ensembl chr17:36,481,024...36,552,456 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:27421892 RGD:405255654 NCBI chr24:52,497,465...52,501,161
Ensembl chr24:52,497,521...52,501,514 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A treatment ISO RGD PMID:28791385 RGD:401940159 NCBI chr 5:9,233,028...9,707,322
Ensembl chr 5:9,286,775...9,462,828 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:25331812 RGD:13782181 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:21714072 RGD:5147887 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G MDM2 MDM2 proto-oncogene ISO RGD PMID:23174211 RGD:10412309 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr12:95,477,612...95,836,734
Ensembl chr12:95,479,447...95,620,364 		JBrowse link
G OPRM1 opioid receptor mu 1 severity ISO DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) RGD PMID:22143634 RGD:401827931 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 ISO RGD PMID:25331812 RGD:13782181 NCBI chr26:39,273,982...39,300,170
Ensembl chr26:39,272,997...39,349,966 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:17968352 RGD:8694407 NCBI chr27:42,404,028...42,437,988
Ensembl chr27:42,404,084...42,438,005 		JBrowse link
separation anxiety disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD4 dopamine receptor D4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20731709 NCBI chr 1:454,018...459,582 JBrowse link
G NGF nerve growth factor ISO protein:decreased expression:hippocampus RGD PMID:24407463 RGD:401976437 NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833 		JBrowse link
social phobia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNTNAP2 contactin associated protein 2 susceptibility ISO DNA:SNP: :rs2710102(human) RGD PMID:21193173 RGD:13450911 NCBI chr21:114,741,918...116,988,691 JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPB natriuretic peptide B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr20:119,930,931...119,933,391
Ensembl chr20:119,932,021...119,933,197 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15274
    disease of anatomical entity 14909
      nervous system disease 13001
        central nervous system disease 11635
          brain disease 10924
            disease of mental health 7859
              cognitive disorder 2073
                anxiety disorder 115
                  Neuroticism 0
                  acute stress disorder + 21
                  generalized anxiety disorder 4
                  neurocirculatory asthenia + 11
                  neurotic disorder 0
                  obsessive-compulsive disorder + 11
                  panic disorder + 11
                  phobic disorder + 5
                  post-traumatic stress disorder 18
                  separation anxiety disorder 2
paths to the root