RGD Reference Report - Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety.

Authors: Uzsoki, B  Toth, M  Hernadi, I 
Citation: Uzsoki B, etal., Neurosci Lett. 2011 Jul 25;499(3):219-23. Epub 2011 Jun 6.
RGD ID: 6480479
Pubmed: PMID:21669254   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2011.05.231   (Journal Full-text)

In this study we provide evidence that animals of the same population, although identical in age and sex, have individual reactions to the prefrontal modulation of adrenoceptors. We have examined the dose-dependent action of alpha(2)-adrenoceptor agents on the anxiety of rats with different response to novelty in the elevated plus maze (EPM) apparatus. Rats were divided into high (HR) and low responder (LR) groups based on their locomotor activity in a novel open field environment. HR rats also showed increased locomotion and low anxiety in the EPM. Prefrontal injection of alpha(2)-receptor antagonist yohimbine, BRL44408 or imiloxan caused anxiety only in HR rats. The alpha(2A/D)-receptor agonist guanfacine increased anxiety levels of both groups. However, the effective dose was lower in HR rats. The present results propose different prefrontal adrenoceptor sensitivity of rats showing distinct baseline activity levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADRA2AHumananxiety disorder  ISOAdra2a (Rattus norvegicus) RGD 
Adra2aRatanxiety disorder  IMP  RGD 
Adra2aMouseanxiety disorder  ISOAdra2a (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra2a  (adrenoceptor alpha 2A)

Genes (Mus musculus)
Adra2a  (adrenergic receptor, alpha 2a)

Genes (Homo sapiens)
ADRA2A  (adrenoceptor alpha 2A)


Additional Information