gap junctional intercellular communication inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gap junctional intercellular communication inhibitor	go back to main search page
Accession:	CHEBI:67195	browse the term
Definition:	An inhibitor that interferes with the process of gap junctional intercellular communication.
Synonyms:	related_synonym:	gap junctional intercellular communication inhibitors
	xref:	Wikipedia:Gap_junction

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Rat (35) Mouse (35) Human (36) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (35)

all-trans-4-oxoretinal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

increases reduction

AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction

AKR1B10 protein results in increased reduction of 4-oxoretinaldehyde

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

all-trans-retinal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 4

affects transport

ABCA4 protein affects the transport of Retinaldehyde

NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases metabolic processing

ADH4 protein results in increased metabolism of Retinaldehyde

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

aldo-keto reductase family 1 member B1

increases reduction

AKR1B1 protein results in increased reduction of Retinaldehyde

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction
increases metabolic processing

AKR1B10 protein results in increased reduction of Retinaldehyde
AKR1B10 protein results in increased metabolism of Retinaldehyde

PMID:19014918 PMID:21329680

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member B7

increases metabolic processing

AKR1B7 protein results in increased metabolism of Retinaldehyde

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldo-keto reductase family 1, member C3

increases reduction

AKR1C3 protein results in increased reduction of Retinaldehyde

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

albumin

affects binding

Retinaldehyde binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions
affects oxidation

[ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde; ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]; ALDH1A1 protein binds to and results in increased oxidation of Retinaldehyde
Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]

PMID:10559215 PMID:17167544 PMID:23220587

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

multiple interactions

ALDH1A2 protein binds to and results in increased oxidation of Retinaldehyde

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 1 family, member A3

increases oxidation

ALDH1A3 protein results in increased oxidation of Retinaldehyde

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

aldehyde dehydrogenase 2 family member

multiple interactions
increases metabolic processing

[ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde
ALDH2 protein results in increased metabolism of Retinaldehyde

PMID:10559215 PMID:11744614

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

increases activity

Retinaldehyde results in increased activity of ALDH3A1 protein

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

amphiregulin

increases expression

Retinaldehyde results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

activating transcription factor 4

increases expression

Retinaldehyde results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

betacellulin

decreases expression

Retinaldehyde results in decreased expression of BTC mRNA

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

caspase 3

increases activity

Retinaldehyde results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 26, subfamily a, polypeptide 1

multiple interactions
increases expression

[Retinaldehyde co-treated with Dihydrotestosterone] results in increased expression of CYP26A1 mRNA
Retinaldehyde results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

DNA-damage inducible transcript 3

increases expression

Retinaldehyde results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dehydrogenase/reductase 4

increases reduction

DHRS4 protein results in increased reduction of Retinaldehyde

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Retinaldehyde results in increased expression of GCLC mRNA

PMID:25331497 PMID:27751755

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

heparin-binding EGF-like growth factor

increases expression

Retinaldehyde results in increased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

heme oxygenase 1

increases expression

Retinaldehyde results in increased expression of HMOX1 mRNA

PMID:25331497 PMID:27751755

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

increases expression

Retinaldehyde results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

NFE2 like bZIP transcription factor 2

increases expression

Retinaldehyde results in increased expression of NFE2L2 mRNA

PMID:25331497 PMID:27751755

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

increases cleavage

Retinaldehyde results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PPARG coactivator 1 alpha

increases expression

Retinaldehyde results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Retinaldehyde results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

retinol binding protein 1

multiple interactions

ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

retinol dehydrogenase 10

increases chemical synthesis

RDH10 protein results in increased chemical synthesis of Retinaldehyde

NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572

G

retinol dehydrogenase 12

increases metabolic processing

RDH12 protein results in increased metabolism of Retinaldehyde

NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388

G

retinol dehydrogenase 5

increases chemical synthesis

RDH5 protein results in increased chemical synthesis of Retinaldehyde

NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558

G

retinoid isomerohydrolase RPE65

increases chemical synthesis
increases metabolic processing
multiple interactions

RPE65 protein results in increased chemical synthesis of Retinaldehyde
RPE65 protein results in increased metabolism of Retinaldehyde
[13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde
[13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]

PMID:16026160 PMID:16411761 PMID:16828753 PMID:17251447 PMID:19060264

NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403

G

short chain dehydrogenase/reductase family 16C, member 5

increases reduction
increases chemical synthesis

SDR16C5 protein results in increased reduction of Retinaldehyde
SDR16C5 protein results in increased chemical synthesis of Retinaldehyde

PMID:18926804 PMID:27793605

NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970

heptan-1-ol

term browser

Symbol

Object Name

Qualifiers

Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

increases activity

Heptanol results in increased activity of CFTR protein

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

gap junction protein, alpha 1

decreases phosphorylation

Heptanol results in decreased phosphorylation of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19915
role	19885
biological role	19883
inhibitor	18931
gap junctional intercellular communication inhibitor	35
all-trans-retinal +	33
heptan-1-ol	2

paths to the root