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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gap junctional intercellular communication inhibitor
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Accession:CHEBI:67195 term browser browse the term
Definition:An inhibitor that interferes with the process of gap junctional intercellular communication.
Synonyms:related_synonym: gap junctional intercellular communication inhibitors
 xref: Wikipedia:Gap_junction


show annotations for term's descendants           Sort by:
all-trans-4-oxoretinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
all-trans-retinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca4 ATP binding cassette subfamily A member 4 affects transport ISO ABCA4 protein affects the transport of Retinaldehyde CTD PMID:16968212 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide increases metabolic processing EXP ADH4 protein results in increased metabolism of Retinaldehyde CTD PMID:17279314 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Retinaldehyde CTD PMID:19014918 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
increases metabolic processing		 ISO AKR1B10 protein results in increased reduction of Retinaldehyde
AKR1B10 protein results in increased metabolism of Retinaldehyde		 CTD PMID:19014918 PMID:21329680 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases metabolic processing ISO AKR1B7 protein results in increased metabolism of Retinaldehyde CTD PMID:21329680 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction ISO AKR1C3 protein results in increased reduction of Retinaldehyde CTD PMID:23261716 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin affects binding ISO Retinaldehyde binds to ALB protein CTD PMID:17217919 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
affects oxidation		 ISO
EXP		 [ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde; ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]; ALDH1A1 protein binds to and results in increased oxidation of Retinaldehyde
Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]		 CTD PMID:10559215 PMID:17167544 PMID:23220587 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions EXP ALDH1A2 protein binds to and results in increased oxidation of Retinaldehyde CTD PMID:23220587 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases oxidation ISO ALDH1A3 protein results in increased oxidation of Retinaldehyde CTD PMID:17526768 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases metabolic processing		 ISO [ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde
ALDH2 protein results in increased metabolism of Retinaldehyde		 CTD PMID:10559215 PMID:11744614 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases activity EXP Retinaldehyde results in increased activity of ALDH3A1 protein CTD PMID:17126819 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Areg amphiregulin increases expression ISO Retinaldehyde results in increased expression of AREG mRNA CTD PMID:16470170 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Retinaldehyde results in increased expression of ATF4 mRNA CTD PMID:25331497 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Btc betacellulin decreases expression ISO Retinaldehyde results in decreased expression of BTC mRNA CTD PMID:16470170 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Casp3 caspase 3 increases activity ISO Retinaldehyde results in increased activity of CASP3 protein CTD PMID:25331497 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [Retinaldehyde co-treated with Dihydrotestosterone] results in increased expression of CYP26A1 mRNA
Retinaldehyde results in increased expression of CYP26A1 mRNA		 CTD PMID:17526768 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Retinaldehyde results in increased expression of DDIT3 mRNA CTD PMID:25331497 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dhrs4 dehydrogenase/reductase 4 increases reduction ISO DHRS4 protein results in increased reduction of Retinaldehyde CTD PMID:12680773 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Retinaldehyde results in increased expression of GCLC mRNA CTD PMID:25331497 PMID:27751755 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Retinaldehyde results in increased expression of HBEGF mRNA CTD PMID:16470170 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Retinaldehyde results in increased expression of HMOX1 mRNA CTD PMID:25331497 PMID:27751755 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Retinaldehyde results in increased expression of HSPA5 protein CTD PMID:25331497 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Retinaldehyde results in increased expression of NFE2L2 mRNA CTD PMID:25331497 PMID:27751755 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Retinaldehyde results in increased cleavage of PARP1 protein CTD PMID:25331497 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Retinaldehyde results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Retinaldehyde results in increased expression of PPP1R15A mRNA CTD PMID:25331497 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Rbp1 retinol binding protein 1 multiple interactions ISO ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde] CTD PMID:10559215 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Rdh10 retinol dehydrogenase 10 increases chemical synthesis ISO RDH10 protein results in increased chemical synthesis of Retinaldehyde CTD PMID:17473173 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh12 retinol dehydrogenase 12 increases metabolic processing ISO RDH12 protein results in increased metabolism of Retinaldehyde CTD PMID:16269441 NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388 		JBrowse link
G Rdh5 retinol dehydrogenase 5 increases chemical synthesis ISO RDH5 protein results in increased chemical synthesis of Retinaldehyde CTD PMID:16968212 NCBI chr 7:1,340,545...1,347,361
Ensembl chr 7:1,340,934...1,351,558 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 increases chemical synthesis
multiple interactions
increases metabolic processing		 ISO
EXP		 RPE65 protein results in increased chemical synthesis of Retinaldehyde
[13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]
RPE65 protein results in increased metabolism of Retinaldehyde		 CTD PMID:16026160 PMID:16411761 PMID:16828753 PMID:17251447 PMID:19060264 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases reduction
increases chemical synthesis		 ISO SDR16C5 protein results in increased reduction of Retinaldehyde
SDR16C5 protein results in increased chemical synthesis of Retinaldehyde		 CTD PMID:18926804 PMID:27793605 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        inhibitor 18756
          gap junctional intercellular communication inhibitor 33
            all-trans-retinal + 33
paths to the root