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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:139347 term browser browse the term
Definition:A retinoid that is all-trans-retinal carrying an oxo substituent at position 4 on the cyclohexenyl ring.
Synonyms:exact_synonym: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal
 related_synonym: 4-Oxoretinaldehyde;   4-ketoretinal;   4-oxoretinal;   Formula=C20H26O2;   InChI=1S/C20H26O2/c1-15(7-6-8-16(2)12-14-21)9-10-18-17(3)19(22)11-13-20(18,4)5/h6-10,12,14H,11,13H2,1-5H3/b8-6+,10-9+,15-7+,16-12+;   InChIKey=PLILDISEFZJECC-RMWYGNQTSA-N;   SMILES=C1(C)(C)C(\\C=C\\C(=C\\C=C\\C(=C\\C(=O)[H])\\C)\\C)=C(C)C(CC1)=O;   all-trans-4-ketoretinal;   all-trans-4-oxo-retinal
 xref: CAS:33532-44-4
 xref_mesh: MESH:C099660
 xref: PMID:10415093;   PMID:12528465;   PMID:15369820;   PMID:1775535;   PMID:17943179;   PMID:8643496;   Reaxys:2508352

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all-trans-4-oxoretinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        inhibitor 18241
          gap junctional intercellular communication inhibitor 33
            all-trans-retinal 33
              all-trans-4-oxoretinal 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            formyl group 7850
                                              aldehyde 7850
                                                alpha,beta-unsaturated aldehyde 1301
                                                  enal 1301
                                                    retinal 39
                                                      all-trans-retinal 33
                                                        all-trans-4-oxoretinal 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.