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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketoprofen
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Accession:CHEBI:6128 term browser browse the term
Definition:An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Synonyms:exact_synonym: 2-(3-benzoylphenyl)propanoic acid
 related_synonym: 2-(3-Benzoylphenyl)propionic acid;   3-Benzoyl-alpha-methylbenzeneacetic acid;   3-Benzoylhydratropic acid;   Formula=C16H14O3;   InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19);   InChIKey=DKYWVDODHFEZIM-UHFFFAOYSA-N;   L'Acide (benzoyl-3-phenyl)-2-propionique;   Orudis (TN);   SMILES=CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1;   m-Benzoylhydratropic acid
 xref: CAS:22071-15-4;   DrugBank:DB01009;   Drug_Central:1528;   HMDB:HMDB0015144;   KEGG:C01716;   KEGG:D00132;   LINCS:LSM-1955
 xref_mesh: MESH:D007660
 xref: PMID:11452775;   PMID:12772856;   PMID:18969772;   Reaxys:2216071;   Wikipedia:Ketoprofen


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ketoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Ketoprofen binds to ALB protein CTD PMID:9353694 PMID:19596536 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Ketoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ketoprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Ketoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
EXP Ketoprofen results in increased expression of MPO protein
pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]
CTD PMID:16080005 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Ketoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] CTD PMID:11095985 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ren renin multiple interactions ISO Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] CTD PMID:1924052 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Ketoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ketoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G Sell selectin L decreases expression ISO Ketoprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Ketoprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
increases uptake
ISO Ketoprofen results in decreased activity of SLC22A9 protein
SLC22A9 protein results in increased uptake of Ketoprofen
CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases uptake
ISO Ketoprofen results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased uptake of Ketoprofen
CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Ketoprofen results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:10903797 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
increases glucuronidation
ISO Ketoprofen results in decreased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Ketoprofen
CTD PMID:15593333 PMID:15843492 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975 PMID:15843492 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Ketoprofen CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases glucuronidation
EXP
ISO
UGT1A6 protein affects the metabolism of Ketoprofen
UGT1A6 protein results in increased glucuronidation of Ketoprofen
CTD PMID:15336321 PMID:15843492 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975 PMID:15843492 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Ketoprofen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Ketoprofen; UGT2B7 protein results in increased glucuronidation of Ketoprofen
CTD PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19821
    role 19769
      biological role 19769
        xenobiotic 18452
          ketoprofen 27
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fatty acid 16008
                                            saturated fatty acid 15984
                                              propionic acid 3687
                                                ketoprofen 27
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