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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketoprofen
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Accession:CHEBI:6128 term browser browse the term
Definition:An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Synonyms:exact_synonym: 2-(3-benzoylphenyl)propanoic acid
 related_synonym: 2-(3-Benzoylphenyl)propionic acid;   3-Benzoyl-alpha-methylbenzeneacetic acid;   3-Benzoylhydratropic acid;   Formula=C16H14O3;   InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19);   InChIKey=DKYWVDODHFEZIM-UHFFFAOYSA-N;   L'Acide (benzoyl-3-phenyl)-2-propionique;   Orudis (TN);   SMILES=CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1;   m-Benzoylhydratropic acid
 xref: CAS:22071-15-4;   DrugBank:DB01009;   Drug_Central:1528;   HMDB:HMDB0015144;   KEGG:C01716;   KEGG:D00132;   LINCS:LSM-1955
 xref_mesh: MESH:D007660
 xref: PMID:11452775;   PMID:12772856;   PMID:18969772;   Reaxys:2216071;   Wikipedia:Ketoprofen


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ketoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Ketoprofen binds to ALB protein CTD PMID:9353694, PMID:19596536 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Ketoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ketoprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Ketoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
EXP Ketoprofen results in increased expression of MPO protein
pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]
CTD PMID:16080005 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Ketoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] CTD PMID:11095985 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ren renin multiple interactions ISO Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] CTD PMID:1924052 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Ketoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ketoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
G Sell selectin L decreases expression ISO Ketoprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Ketoprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
increases uptake
ISO Ketoprofen results in decreased activity of SLC22A9 protein
SLC22A9 protein results in increased uptake of Ketoprofen
CTD PMID:12388633 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases uptake
ISO Ketoprofen results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased uptake of Ketoprofen
CTD PMID:12388633 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Ketoprofen results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:10903797 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
increases glucuronidation
ISO Ketoprofen results in decreased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Ketoprofen
CTD PMID:15593333, PMID:15843492 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975, PMID:15843492 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Ketoprofen CTD PMID:15843492 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases glucuronidation
EXP
ISO
UGT1A6 protein affects the metabolism of Ketoprofen
UGT1A6 protein results in increased glucuronidation of Ketoprofen
CTD PMID:15336321, PMID:15843492 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975, PMID:15843492 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Ketoprofen CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Ketoprofen; UGT2B7 protein results in increased glucuronidation of Ketoprofen
CTD PMID:8423545, PMID:8517101, PMID:15535975, PMID:15843492, PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          ketoprofen 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              propionic acid 3666
                                                ketoprofen 27
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