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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketoprofen
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Accession:CHEBI:6128 term browser browse the term
Definition:An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
Synonyms:exact_synonym: 2-(3-benzoylphenyl)propanoic acid
 related_synonym: 2-(3-Benzoylphenyl)propionic acid;   3-Benzoyl-alpha-methylbenzeneacetic acid;   3-Benzoylhydratropic acid;   Formula=C16H14O3;   InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19);   InChIKey=DKYWVDODHFEZIM-UHFFFAOYSA-N;   L'Acide (benzoyl-3-phenyl)-2-propionique;   Orudis (TN);   SMILES=CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1;   m-Benzoylhydratropic acid
 xref: CAS:22071-15-4;   DrugBank:DB01009;   Drug_Central:1528;   HMDB:HMDB0015144;   KEGG:C01716;   KEGG:D00132;   LINCS:LSM-1955
 xref_mesh: MESH:D007660
 xref: PMID:11452775;   PMID:12772856;   PMID:18969772;   Reaxys:2216071;   Wikipedia:Ketoprofen


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ketoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Ketoprofen binds to ALB protein CTD PMID:9353694 PMID:19596536 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Ketoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Ketoprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ketoprofen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Ketoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:10903797 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10903797 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions		 EXP Ketoprofen results in increased expression of MPO protein
pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]		 CTD PMID:16080005 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Ketoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] CTD PMID:11095985 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ren renin multiple interactions ISO Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] CTD PMID:1924052 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Ketoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ketoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Sell selectin L decreases expression ISO Ketoprofen results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Ketoprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
increases uptake		 ISO Ketoprofen results in decreased activity of SLC22A9 protein
SLC22A9 protein results in increased uptake of Ketoprofen		 CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases uptake		 ISO Ketoprofen results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased uptake of Ketoprofen		 CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Ketoprofen results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:10903797 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
increases glucuronidation		 ISO Ketoprofen results in decreased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Ketoprofen		 CTD PMID:15593333 PMID:15843492 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975 PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Ketoprofen CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases glucuronidation		 EXP
ISO		 UGT1A6 protein affects the metabolism of Ketoprofen
UGT1A6 protein results in increased glucuronidation of Ketoprofen		 CTD PMID:15336321 PMID:15843492 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ketoprofen CTD PMID:15535975 PMID:15843492 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Ketoprofen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation		 ISO Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Ketoprofen; UGT2B7 protein results in increased glucuronidation of Ketoprofen		 CTD PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
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  CHEBI ontology 19811
    role 19818
      biological role 19785
        xenobiotic 18731
          ketoprofen 27
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  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        fatty acid 16689
                                          saturated fatty acid 16375
                                            propionic acid 3806
                                              ketoprofen 27
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