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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dioxane
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Accession:CHEBI:47032 term browser browse the term
Definition:A dioxane with oxygen atoms at positions 1 and 4.
Synonyms:related_synonym: 1,4-DIETHYLENE DIOXIDE;   1,4-Dioxan;   1,4-dioxacyclohexane;   Formula=C4H8O2;   InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2;   InChIKey=RYHBNJHYFVUHQT-UHFFFAOYSA-N;   SMILES=C1COCCO1;   di(ethylene oxide);   glycol ethylene ether;   p-Dioxane;   tetrahydro-1,4-dioxin;   tetrahydro-p-dioxin;   tetrahydro-para-dioxin
 alt_id: CHEBI:34064;   CHEBI:41951;   CHEBI:46925
 xref: CAS:123-91-1;   DrugBank:DB03316;   KEGG:C14440;   LINCS:LSM-37087
 xref_mesh: MESH:C025223
 xref: PDBeChem:DIO;   PMID:14550759;   PMID:18044507;   PMID:20598439;   PPDB:1638;   Reaxys:102551;   Wikipedia:1\,4-Dioxane


show annotations for term's descendants           Sort by:
1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas achalasia, adrenocortical insufficiency, alacrimia increases expression EXP 1,4-dioxane results in increased expression of AAAS mRNA CTD PMID:33693819 NCBI chr15:102,246,682...102,259,194
Ensembl chr15:102,246,687...102,259,206 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression EXP 1,4-dioxane results in increased expression of AOX1 mRNA CTD PMID:33693819 NCBI chr 1:58,068,963...58,145,569
Ensembl chr 1:58,069,090...58,145,572 		JBrowse link
G Aox3 aldehyde oxidase 3 increases expression EXP 1,4-dioxane results in increased expression of AOX3 mRNA CTD PMID:33693819 NCBI chr 1:58,152,294...58,241,380
Ensembl chr 1:58,152,289...58,239,857 		JBrowse link
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 decreases expression EXP 1,4-dioxane results in decreased expression of ATP6V0D2 mRNA CTD PMID:33693819 NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605 		JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 increases expression EXP 1,4-dioxane results in increased expression of ATP8B5 mRNA CTD PMID:33693819 NCBI chr 4:43,266,716...43,373,831
Ensembl chr 4:43,267,159...43,373,833 		JBrowse link
G AY036118 cDNA sequence AY036118 decreases expression EXP 1,4-dioxane results in decreased expression of AY036118 mRNA CTD PMID:33693819 NCBI chr17:40,158,556...40,209,276 JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP 1,4-dioxane results in increased expression of BTG2 mRNA CTD PMID:33693819 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 1,4-dioxane results in increased expression of CCNG1 mRNA CTD PMID:33693819 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 1,4-dioxane results in decreased expression of CPQ mRNA CTD PMID:33693819 NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698 		JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions ISO 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO 1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
1,4-dioxane results in increased activity of CYP2E1 protein
1,4-dioxane results in increased expression of CYP2E1 mRNA		 CTD PMID:15490126 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression EXP 1,4-dioxane results in decreased expression of CYP2G1 mRNA CTD PMID:33693819 NCBI chr 7:26,508,352...26,520,622
Ensembl chr 7:26,508,317...26,520,630 		JBrowse link
G Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 decreases expression EXP 1,4-dioxane results in decreased expression of CYP3A16 mRNA CTD PMID:33693819 NCBI chr 5:145,373,119...145,406,550
Ensembl chr 5:145,373,119...145,406,533 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression EXP 1,4-dioxane results in increased expression of DDIAS mRNA CTD PMID:33693819 NCBI chr 7:92,506,734...92,523,455
Ensembl chr 7:92,506,733...92,523,455 		JBrowse link
G Dglucy D-glutamate cyclase increases expression EXP 1,4-dioxane results in increased expression of DGLUCY mRNA CTD PMID:33693819 NCBI chr12:100,745,316...100,838,869
Ensembl chr12:100,745,316...100,863,240 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression EXP 1,4-dioxane results in increased expression of EDA2R mRNA CTD PMID:33693819 NCBI chr  X:96,375,936...96,420,786
Ensembl chr  X:96,377,446...96,420,822 		JBrowse link
G Egr1 early growth response 1 increases expression EXP 1,4-dioxane results in increased expression of EGR1 mRNA CTD PMID:33693819 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP 1,4-dioxane results in increased expression of EPHX1 mRNA CTD PMID:33693819 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression EXP 1,4-dioxane results in decreased expression of ERBB4 mRNA CTD PMID:33693819 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression EXP 1,4-dioxane results in increased expression of FITM1 mRNA CTD PMID:33693819 NCBI chr14:55,813,131...55,814,409
Ensembl chr14:55,813,074...55,814,411 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 decreases expression EXP 1,4-dioxane results in decreased expression of FRAS1 mRNA CTD PMID:33693819 NCBI chr 5:96,518,622...96,932,592
Ensembl chr 5:96,521,814...96,932,587 		JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression EXP 1,4-dioxane results in increased expression of GSTA1 mRNA CTD PMID:33693819 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression EXP 1,4-dioxane results in increased expression of GSTM1 mRNA CTD PMID:33693819 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression EXP 1,4-dioxane results in increased expression of GSTM2 mRNA CTD PMID:33693819 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gstm2-ps1 glutathione S-transferase mu 2 (muscle), pseudogene 1 increases expression EXP 1,4-dioxane results in increased expression of GSTM2-PS1 mRNA CTD PMID:33693819 NCBI chr 5:116,770,540...116,771,664
Ensembl chr 5:116,770,967...116,771,623 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP 1,4-dioxane results in increased expression of GSTM3 mRNA CTD PMID:33693819 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gstp-ps glutathione S-transferase, pi, pseudogene increases expression EXP 1,4-dioxane results in increased expression of GSTP-PS mRNA CTD PMID:33693819 NCBI chr 1:191,758,036...191,762,461
Ensembl chr 1:191,758,120...191,758,750 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression EXP 1,4-dioxane results in increased expression of GSTP1 mRNA CTD PMID:33693819 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 decreases expression EXP 1,4-dioxane results in decreased expression of H2-AB1 mRNA CTD PMID:33693819 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2ax H2A.X variant histone increases expression EXP
ISO		 1,4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 PMID:37258237 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hectd2os Hectd2, opposite strand increases expression EXP 1,4-dioxane results in increased expression of HECTD2OS mRNA CTD PMID:33693819 NCBI chr19:36,596,818...36,666,879
Ensembl chr19:36,475,152...36,683,878 		JBrowse link
G Hells helicase, lymphoid specific increases expression EXP 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr19:38,913,282...38,958,914
Ensembl chr19:38,919,359...38,959,495 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP 1,4-dioxane results in increased expression of HES1 mRNA CTD PMID:33693819 NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614 		JBrowse link
G Hexb hexosaminidase B decreases expression EXP 1,4-dioxane results in decreased expression of HEXB mRNA CTD PMID:33693819 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression EXP 1,4-dioxane results in increased expression of ID1 mRNA CTD PMID:33693819 NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression EXP 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536 		JBrowse link
G Meg3 maternally expressed 3 decreases expression EXP 1,4-dioxane results in decreased expression of MEG3 mRNA CTD PMID:33693819 NCBI chr12:109,506,879...109,538,163
Ensembl chr12:109,506,877...109,538,165 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mup20 major urinary protein 20 increases expression EXP 1,4-dioxane results in increased expression of MUP20 mRNA CTD PMID:33693819 NCBI chr 4:61,929,604...61,972,380
Ensembl chr 4:61,968,471...61,972,395 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression EXP 1,4-dioxane results in decreased expression of NAALADL2 mRNA CTD PMID:33693819 NCBI chr 3:23,852,267...25,198,425
Ensembl chr 3:23,852,266...25,198,425 		JBrowse link
G Ncmap noncompact myelin associated protein decreases expression EXP 1,4-dioxane results in decreased expression of NCMAP mRNA CTD PMID:33693819 NCBI chr 4:135,096,887...135,125,551
Ensembl chr 4:135,096,887...135,125,538 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression EXP 1,4-dioxane results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression EXP 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:155,945,071...156,198,282
Ensembl chr  X:155,945,071...156,198,308 		JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 increases expression EXP 1,4-dioxane results in increased expression of PHLDA3 mRNA CTD PMID:33693819 NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874 		JBrowse link
G Pim1 proviral integration site 1 increases expression EXP 1,4-dioxane results in increased expression of PIM1 mRNA CTD PMID:33693819 NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression EXP 1,4-dioxane results in decreased expression of PPP1R10 mRNA CTD PMID:33693819 NCBI chr17:36,227,404...36,243,175
Ensembl chr17:36,227,326...36,243,175 		JBrowse link
G Prl2c3 prolactin family 2, subfamily c, member 3 increases expression EXP 1,4-dioxane results in increased expression of PRL2C3 protein CTD PMID:20025956 NCBI chr13:12,805,705...12,814,982
Ensembl chr13:12,805,705...12,814,968 		JBrowse link
G Pygo1 pygopus 1 decreases expression EXP 1,4-dioxane results in decreased expression of PYGO1 mRNA CTD PMID:33693819 NCBI chr 9:72,832,927...72,859,868
Ensembl chr 9:72,832,927...72,859,463 		JBrowse link
G Rad51 RAD51 recombinase increases expression ISO 1,4-dioxane results in increased expression of RAD51 mRNA CTD PMID:37258237 NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression EXP 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550 		JBrowse link
G Rcan2 regulator of calcineurin 2 decreases expression EXP 1,4-dioxane results in decreased expression of RCAN2 mRNA CTD PMID:33693819 NCBI chr17:44,112,243...44,350,407
Ensembl chr17:44,112,242...44,350,407 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression EXP 1,4-dioxane results in decreased expression of RGS1 mRNA CTD PMID:33693819 NCBI chr 1:144,120,407...144,124,862
Ensembl chr 1:144,118,034...144,124,980 		JBrowse link
G Rps8-ps4 ribosomal protein S8, pseudogene 4 decreases expression EXP 1,4-dioxane results in decreased expression of RPS8-PS4 mRNA CTD PMID:33693819 NCBI chr 7:13,066,532...13,067,210
Ensembl chr 7:13,066,571...13,067,182 		JBrowse link
G Rsrp1 arginine/serine rich protein 1 decreases expression EXP 1,4-dioxane results in decreased expression of RSRP1 mRNA CTD PMID:33693819 NCBI chr 4:134,650,936...134,654,681
Ensembl chr 4:134,650,903...134,654,982 		JBrowse link
G Serpina1e serine (or cysteine) peptidase inhibitor, clade A, member 1E decreases expression EXP 1,4-dioxane results in decreased expression of SERPINA1E mRNA CTD PMID:33693819 NCBI chr12:103,913,190...103,923,156
Ensembl chr12:103,913,190...103,925,234 		JBrowse link
G Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 increases expression EXP 1,4-dioxane results in increased expression of SERPINA7 mRNA CTD PMID:33693819 NCBI chr  X:137,979,998...137,985,985
Ensembl chr  X:137,980,006...137,985,985 		JBrowse link
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 increases expression EXP 1,4-dioxane results in increased expression of SLC17A8 mRNA CTD PMID:33693819 NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115 		JBrowse link
G Sugct succinyl-CoA glutarate-CoA transferase decreases expression EXP 1,4-dioxane results in decreased expression of SUGCT mRNA CTD PMID:33693819 NCBI chr13:17,032,057...17,869,380
Ensembl chr13:17,032,057...17,870,138 		JBrowse link
G Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 decreases expression EXP 1,4-dioxane results in decreased expression of SULT1C2 mRNA CTD PMID:33693819 NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367 		JBrowse link
G Sult3a1 sulfotransferase family 3A, member 1 decreases expression EXP 1,4-dioxane results in decreased expression of SULT3A1 mRNA CTD PMID:33693819 NCBI chr10:33,727,016...33,755,471
Ensembl chr10:33,733,717...33,755,528 		JBrowse link
G Sult3a2 sulfotransferase family 3A, member 2 decreases expression EXP 1,4-dioxane results in decreased expression of SULT3A2 mRNA CTD PMID:33693819 NCBI chr10:33,642,420...33,662,700
Ensembl chr10:33,642,420...33,662,700 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP 1,4-dioxane results in increased expression of TGIF1 mRNA CTD PMID:33693819 NCBI chr17:71,151,200...71,160,527
Ensembl chr17:71,151,200...71,160,541 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression EXP 1,4-dioxane results in decreased expression of TSC22D3 mRNA CTD PMID:33693819 NCBI chr  X:139,440,277...139,501,257
Ensembl chr  X:139,440,277...139,501,408 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 decreases expression EXP 1,4-dioxane results in decreased expression of UGT1A1 mRNA CTD PMID:33693819 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases expression EXP 1,4-dioxane results in increased expression of UGT2B35 mRNA CTD PMID:33693819 NCBI chr 5:87,148,719...87,161,133
Ensembl chr 5:87,148,719...87,161,134 		JBrowse link
G Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 increases expression EXP 1,4-dioxane results in increased expression of UGT2B5 mRNA CTD PMID:33693819 NCBI chr 5:87,272,805...87,288,199
Ensembl chr 5:87,272,819...87,288,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22306
    role 22291
      biological role 22290
        biochemical role 21503
          metabolite 21452
            1,4-dioxane 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 22306
    subatomic particle 22301
      composite particle 22301
        hadron 22301
          baryon 22301
            nucleon 22301
              atomic nucleus 22301
                atom 22301
                  main group element atom 22181
                    p-block element atom 22181
                      carbon group element atom 21983
                        carbon atom 21923
                          organic molecular entity 21923
                            organic molecule 21749
                              organic cyclic compound 21365
                                organic heterocyclic compound 20379
                                  organic heteromonocyclic compound 18766
                                    saturated organic heteromonocyclic parent 12160
                                      dioxane 69
                                        1,4-dioxane 69
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