Hells (helicase, lymphoid specific) - Rat Genome Database

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Gene: Hells (helicase, lymphoid specific) Mus musculus
Analyze
Symbol: Hells
Name: helicase, lymphoid specific
RGD ID: 1616865
MGI Page MGI
Description: Enables chromatin binding activity. Involved in kidney development; lymphocyte proliferation; and negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; chromosomal DNA methylation maintenance following DNA replication; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including gut; hippocampus; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI323785; E130115I21Rik; L; LSH; Ly; lymphocyte-specific helicase; Lysh; P; PASG; proliferation-associated SNF2-like protein; YFK8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,913,282 - 38,958,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,919,359 - 38,959,495 (+)EnsemblGRCm39 Ensembl
GRCm381938,930,262 - 38,970,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,930,915 - 38,971,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,005,480 - 39,042,767 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,996,134 - 39,033,421 (+)NCBIMGSCv36mm8
Celera1939,732,380 - 39,769,659 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
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Evidence
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Reference
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Original Reference(s)
HellsMousehigh grade glioma severityISOHELLS (Homo sapiens)13702468 RGD 
HellsMousePremature Aging  IMP 10402190 RGD 
Object Symbol
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Original Reference(s)
HellsMousegenetic disease  ISOHELLS (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
HellsMouseimmunodeficiency-centromeric instability-facial anomalies syndrome 4  ISOHELLS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21596365 more ...
Object Symbol
Species
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Evidence
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Reference
Notes
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Original Reference(s)
HellsMouseAnimal Disease Models  ISOHELLS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
HellsMouseExperimental Liver Cirrhosis  ISOHELLS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
HellsMouselung adenocarcinoma  ISOHELLS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
HellsMousepolycystic ovary syndrome  ISOHELLS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21411543
Object Symbol
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Original Reference(s)
HellsMouseimmunodeficiency-centromeric instability-facial anomalies syndrome 4  ISOHELLS (Homo sapiens)7240710 OMIM 

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Object Symbol
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Reference
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Original Reference(s)
HellsMouse(-)-demecolcine decreases expressionISOHELLS (Homo sapiens)6480464Demecolcine results in decreased expression of HELLS mRNACTDPMID:23649840
HellsMouse(S)-nicotine multiple interactionsEXP 6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
HellsMouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of HELLS mRNACTDPMID:28960355
HellsMouse1,4-dioxane increases expressionEXP 64804641 and 4-dioxane results in increased expression of HELLS proteinCTDPMID:20025956
HellsMouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsEXP 6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
HellsMouse1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionEXP 64804641-Methyl-4-phenyl-1 more ...CTDPMID:20230807
HellsMouse1-naphthyl isothiocyanate decreases expressionISOHells (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of HELLS mRNACTDPMID:25380136
HellsMouse14-Deoxy-11,12-didehydroandrographolide decreases expressionISOHELLS (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in decreased expression of HELLS mRNACTDPMID:22101062
HellsMouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of HELLS mRNACTDPMID:17942748
HellsMouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HELLS mRNACTDPMID:17942748
HellsMouse17beta-estradiol multiple interactionsEXP 6480464ESR1 protein promotes the reaction [Estradiol results in increased expression of HELLS mRNA]CTDPMID:25210133
HellsMouse17beta-estradiol increases expressionISOHELLS (Homo sapiens)6480464Estradiol results in increased expression of HELLS mRNACTDPMID:19167446
HellsMouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HELLS mRNACTDPMID:25210133
HellsMouse2,2',5,5'-tetrachlorobiphenyl increases expressionISOHells (Rattus norvegicus)64804642 more ...CTDPMID:23829299
HellsMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHells (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of HELLS mRNACTDPMID:21215274 and PMID:33387578
HellsMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of HELLS mRNACTDPMID:26377647
HellsMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HELLS mRNACTDPMID:17942748
HellsMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHELLS (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of HELLS mRNACTDPMID:20106945
HellsMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HELLS mRNACTDPMID:17942748
HellsMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751

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Biological Process
1 to 19 of 19 rows

  
Object Symbol
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Original Reference(s)
HellsMouseapoptotic process acts_upstream_ofIMPMGI:21785862290270 PMID:11325543MGIPMID:11325543
HellsMousecell division involved_inIEAUniProtKB-KW:KW-01322290270 UniProtGO_REF:0000043
HellsMousecellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEP 2290270 PMID:20439489MGIPMID:20439489
HellsMousechromatin remodeling acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:11711429MGIPMID:11711429
HellsMousechromosomal DNA methylation maintenance following DNA replication acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:11711429MGIPMID:11711429
HellsMouseDNA methylation-dependent constitutive heterochromatin formation involved_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMouseDNA methylation-dependent constitutive heterochromatin formation involved_inIMP 2290270 PMID:15647320UniProtPMID:15647320
HellsMouseheterochromatin formation acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:15448183MGIPMID:15448183
HellsMousekidney development involved_inIMP 2290270 PMID:11325543UniProtPMID:11325543
HellsMouselymphocyte differentiation acts_upstream_of_or_withinTAS 2290270 PMID:11325543MGIPMID:11325543
HellsMouselymphocyte proliferation involved_inIEP 2290270 PMID:10781083UniProtPMID:10781083
HellsMouselymphocyte proliferation involved_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMousenegative regulation of apoptotic process acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:11325543MGIPMID:11325543
HellsMousenegative regulation of gene expression via chromosomal CpG island methylation involved_inIMP 2290270 PMID:15105378UniProtPMID:15105378
HellsMousenegative regulation of gene expression via chromosomal CpG island methylation involved_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMousenegative regulation of intrinsic apoptotic signaling pathway acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:11325543MGIPMID:11325543
HellsMousepericentric heterochromatin formation involved_inIMP 2290270 PMID:14612388UniProtPMID:14612388
HellsMousepericentric heterochromatin formation involved_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMouseurogenital system development acts_upstream_of_or_withinIMPMGI:21785862290270 PMID:11325543MGIPMID:11325543
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Cellular Component

  
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Original Reference(s)
HellsMousechromosome, centromeric region located_inIDA 2290270 PMID:14612388UniProtPMID:14612388
HellsMousenucleus located_inIDA 2290270 PMID:11555636MGIPMID:11555636
HellsMousenucleus is_active_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMousepericentric heterochromatin is_active_inIBAPANTHER:PTN002245661 and MGI:1062092290270 GO_CentralGO_REF:0000033
HellsMousepericentric heterochromatin located_inIDA 2290270 PMID:14612388UniProtPMID:14612388

Molecular Function

  

1 to 20 of 68 rows
Object Symbol
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Original Reference(s)
HellsMouseabnormal axial skeleton morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal chromosome morphology  IAGP 5509061 MGIPMID:11711429
HellsMouseabnormal chromosome number  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal coat/hair pigmentation  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal DNA methylation  IAGP 5509061 MGIPMID:32001511
HellsMouseabnormal DNA methylation during gametogenesis  IAGP 5509061 MGIPMID:32001511
HellsMouseabnormal gait  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal kidney morphology  IAGP 5509061 MGIPMID:11325543
HellsMouseabnormal kidney morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal long bone epiphysis morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal long bone morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal meiosis  IAGP 5509061 MGIPMID:32001511
HellsMouseabnormal proximal convoluted tubule morphology  IAGP 5509061 MGIPMID:11325543
HellsMouseabnormal renal tubule morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal thoracic vertebrae morphology  IAGP 5509061 MGIPMID:15105378
HellsMouseabnormal tibia morphology  IAGP 5509061 MGIPMID:15105378
HellsMousealopecia  IAGP 5509061 MGIPMID:15105378
HellsMousearrest of male meiosis  IAGP 5509061 MGIPMID:32001511
HellsMouseatelectasis  IAGP 5509061 MGIPMID:15105378
HellsMousecachexia  IAGP 5509061 MGIPMID:15105378
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#
Reference Title
Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Sun LQ, etal., Genes Dev. 2004 May 1;18(9):1035-46. Epub 2004 Apr 22.
5. Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3ß-E2F1 Axis Linking Reversely with Survival in Gliomas. Xiao D, etal., Theranostics. 2017 Jan 1;7(1):132-143. doi: 10.7150/thno.17032. eCollection 2017.
PMID:8647447   PMID:9878251   PMID:10349636   PMID:10781083   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11325543   PMID:11357197   PMID:11555636   PMID:11711429  
PMID:12466851   PMID:12471446   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14517253   PMID:14610273   PMID:14612388   PMID:15226823   PMID:15448183   PMID:15489334   PMID:15647320  
PMID:16141072   PMID:16141073   PMID:16395332   PMID:17115026   PMID:17726103   PMID:18487951   PMID:18799693   PMID:20161795   PMID:20362541   PMID:20362542   PMID:20439489   PMID:20439742  
PMID:21149390   PMID:21349825   PMID:21427231   PMID:21589869   PMID:21677750   PMID:21873635   PMID:22083510   PMID:22516201   PMID:22770845   PMID:22946062   PMID:24194600   PMID:24457600  
PMID:24711395   PMID:25170028   PMID:27179028   PMID:27626380   PMID:28378742   PMID:28442710   PMID:28621576   PMID:30220967   PMID:30516846   PMID:31493975   PMID:31970665   PMID:32001511  
PMID:32071286   PMID:32325033   PMID:32554809   PMID:32727902   PMID:32900989   PMID:33047671   PMID:33159050   PMID:36114006   PMID:36194437   PMID:37709749   PMID:37839992   PMID:38335290  
PMID:38355793  



Hells
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,913,282 - 38,958,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,919,359 - 38,959,495 (+)EnsemblGRCm39 Ensembl
GRCm381938,930,262 - 38,970,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,930,915 - 38,971,051 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,005,480 - 39,042,767 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,996,134 - 39,033,421 (+)NCBIMGSCv36mm8
Celera1939,732,380 - 39,769,659 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.57NCBI
HELLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381094,545,788 - 94,613,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1094,545,329 - 94,613,905 (+)EnsemblGRCh38hg38GRCh38
GRCh371096,305,545 - 96,361,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,295,564 - 96,351,846 (+)NCBINCBI36Build 36hg18NCBI36
Build 341096,295,563 - 96,351,845NCBI
Celera1090,045,660 - 90,101,938 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1089,932,081 - 89,988,296 (+)NCBIHuRef
CHM1_11096,587,374 - 96,643,612 (+)NCBICHM1_1
T2T-CHM13v2.01095,424,900 - 95,493,015 (+)NCBIT2T-CHM13v2.0
Hells
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,113,580 - 246,159,230 (+)NCBIGRCr8
mRatBN7.21236,701,704 - 236,748,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,701,758 - 236,746,844 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,125,577 - 245,167,789 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,018,896 - 252,061,072 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,857,143 - 244,899,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,901,856 - 257,953,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,614,731 - 257,791,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,766,691 - 257,949,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01265,357,043 - 265,402,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,246,843 - 243,262,459 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,793,113 - 233,835,276 (+)NCBICelera
Cytogenetic Map1q53NCBI
Hells
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507990,429 - 1,034,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955507995,389 - 1,034,852 (+)NCBIChiLan1.0ChiLan1.0
HELLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28106,573,712 - 106,642,121 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110106,579,467 - 106,647,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01091,282,330 - 91,344,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11094,790,137 - 94,847,209 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1094,790,292 - 94,847,209 (+)Ensemblpanpan1.1panPan2
HELLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1288,660,866 - 8,705,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl288,661,008 - 8,705,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha288,837,652 - 8,882,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,924,517 - 8,969,255 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,924,655 - 8,969,265 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1288,640,526 - 8,685,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0288,671,482 - 8,716,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,842,995 - 8,887,709 (+)NCBIUU_Cfam_GSD_1.0
Hells
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721338,989,077 - 39,029,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936601626,823 - 662,465 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936601626,354 - 662,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HELLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,924,536 - 105,955,430 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,923,727 - 105,967,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214115,770,403 - 115,812,864 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HELLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1987,780,897 - 87,835,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl987,796,502 - 87,834,619 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604848,579,766 - 48,645,153 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hells
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247375,892,705 - 5,954,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hells
1305 total Variants

Predicted Target Of
Summary Value
Count of predictions:1082
Count of miRNA genes:615
Interacting mature miRNAs:749
Transcripts:ENSMUST00000025965, ENSMUST00000127968, ENSMUST00000128949, ENSMUST00000138292, ENSMUST00000145051, ENSMUST00000155465
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse

1 to 10 of 30 rows
AI323785  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381073,142,414 - 73,142,704UniSTSGRCm38
GRCm381938,967,873 - 38,968,157UniSTSGRCm38
MGSCv371939,042,363 - 39,042,647UniSTSGRCm37
MGSCv371072,605,162 - 72,605,452UniSTSGRCm37
Celera1939,769,255 - 39,769,539UniSTS
Celera1074,209,177 - 74,209,467UniSTS
Cytogenetic Map19C3-D1UniSTS
Whitehead/MRC_RH19370.21UniSTS
UniSTS:237938  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381938,965,568 - 38,965,865UniSTSGRCm38
MGSCv371939,040,058 - 39,040,355UniSTSGRCm37
Celera1939,766,937 - 39,767,234UniSTS
Cytogenetic Map19C3-D1UniSTS
Hells  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3-D1UniSTS
cM Map19 UniSTS






1 to 18 of 18 rows
RefSeq Transcripts NM_008234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC101775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02162533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF155210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC090671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U25691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSMUST00000025965   ⟹   ENSMUSP00000025965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,919,359 - 38,959,495 (+)Ensembl
GRCm38.p6 Ensembl1938,930,915 - 38,971,051 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,932,133 - 38,938,919 (+)Ensembl
GRCm38.p6 Ensembl1938,943,689 - 38,950,475 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,922,952 - 38,929,045 (+)Ensembl
GRCm38.p6 Ensembl1938,934,508 - 38,940,601 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,919,474 - 38,928,944 (+)Ensembl
GRCm38.p6 Ensembl1938,931,030 - 38,940,500 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145051   ⟹   ENSMUSP00000116710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,919,618 - 38,932,358 (+)Ensembl
GRCm38.p6 Ensembl1938,931,174 - 38,943,914 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,919,834 - 38,942,053 (+)Ensembl
GRCm38.p6 Ensembl1938,931,390 - 38,953,609 (+)Ensembl
RefSeq Acc Id: NM_008234   ⟹   NP_032260
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,919,434 - 38,956,721 (+)NCBI
GRCm381938,930,990 - 38,968,277 (+)NCBI
MGSCv371939,005,480 - 39,042,767 (+)RGD
Celera1939,732,380 - 39,769,659 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526699   ⟹   XP_006526762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,913,282 - 38,958,914 (+)NCBI
GRCm381938,930,262 - 38,970,470 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006526700   ⟹   XP_006526763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,936,000 - 38,958,914 (+)NCBI
GRCm381938,947,555 - 38,970,470 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032260   ⟸   NM_008234
- UniProtKB: Q8VDZ1 (UniProtKB/Swiss-Prot),   Q497T3 (UniProtKB/Swiss-Prot),   Q9CYV7 (UniProtKB/Swiss-Prot),   Q60848 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526762   ⟸   XM_006526699
- Peptide Label: isoform X1
- UniProtKB: Q8VDZ1 (UniProtKB/Swiss-Prot),   Q497T3 (UniProtKB/Swiss-Prot),   Q9CYV7 (UniProtKB/Swiss-Prot),   Q60848 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526763   ⟸   XM_006526700
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000116710   ⟸   ENSMUST00000145051
Ensembl Acc Id: ENSMUSP00000025965   ⟸   ENSMUST00000025965
Name Modeler Protein Id AA Range Protein Structure
AF-Q60848-F1-model_v2 AlphaFold Q60848 1-821 view protein structure

RGD ID:13679416
Promoter ID:EPDNEW_M23857
Type:initiation region
Name:Hells_1
Description:Mus musculus helicase, lymphoid specific , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381938,930,957 - 38,931,017EPDNEW
RGD ID:6830118
Promoter ID:MM_KWN:26991
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000050285,   OTTMUST00000050287,   OTTMUST00000050288,   OTTMUST00000050290
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361939,005,164 - 39,005,664 (+)MPROMDB


1 to 34 of 34 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000025001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025965 ENTREZGENE
  ENSMUST00000025965.12 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.10810 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  HELLS_N UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  SNF2-like_sf UniProtKB/Swiss-Prot
  SNF2/RAD54-like_C UniProtKB/Swiss-Prot
  SNF2_N UniProtKB/Swiss-Prot
KEGG Report mmu:15201 UniProtKB/Swiss-Prot
MGD MGI:106209 ENTREZGENE
NCBI Gene 15201 ENTREZGENE
PANTHER LYMPHOID-SPECIFIC HELICASE UniProtKB/Swiss-Prot
  LYMPHOID-SPECIFIC HELICASE UniProtKB/Swiss-Prot
Pfam Helicase_C UniProtKB/Swiss-Prot
  SNF2_N UniProtKB/Swiss-Prot
PhenoGen Hells PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
SMART DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt D3Z414_MOUSE UniProtKB/TrEMBL
  HELLS_MOUSE UniProtKB/Swiss-Prot
  Q497T3 ENTREZGENE
  Q60848 ENTREZGENE
  Q8VDZ1 ENTREZGENE
  Q9CYV7 ENTREZGENE
UniProt Secondary Q497T3 UniProtKB/Swiss-Prot
  Q8VDZ1 UniProtKB/Swiss-Prot
  Q9CYV7 UniProtKB/Swiss-Prot
1 to 34 of 34 rows