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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monocyclic heteroarene
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Accession:CHEBI:38179 term browser browse the term
Synonyms:related_synonym: monocyclic heteroarenes


show annotations for term's descendants           Sort by:
5-methyl-pyrazole-3-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP 5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein CTD PMID:20952482 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633 		JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity		 EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein		 CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284 		JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]		 CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882 		JBrowse link
histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HRH2 histamine receptor H2 multiple interactions EXP [Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides CTD PMID:12665126 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,673...81,932,275 		JBrowse link
isoxaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to isoxaben CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944 		JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Losartan affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
methimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Methimazole CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076 		JBrowse link
G TPO thyroid peroxidase decreases activity EXP Methimazole results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression		 EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein
Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein		 CTD PMID:15681703 PMID:16123675 PMID:22037733 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
SB 203580 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of AKT1 protein] CTD PMID:31744678
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA] CTD PMID:38438008 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA] CTD PMID:38438008 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] CTD PMID:38438008 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA] CTD PMID:19265715 PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CLDN1 claudin 1 multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA] CTD PMID:37271275 PMID:38438008 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA] CTD PMID:38438008 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein] CTD PMID:38438008 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein] CTD PMID:37271275 PMID:38438008
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein] CTD PMID:31744678 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA] CTD PMID:37271275 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein] CTD PMID:31744678 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [SB 203580 co-treated with etoxazole] results in increased phosphorylation of MAPK8 protein CTD PMID:31744678 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA] CTD PMID:37271275 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228 		JBrowse link
G OCLN occludin multiple interactions EXP [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA] CTD PMID:37271275 PMID:38438008 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6 protein] CTD PMID:31744678 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein] CTD PMID:31744678 NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein] CTD PMID:21783819 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein] CTD PMID:21783819 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein] CTD PMID:38438008 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF protein] CTD PMID:38438008 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
sunitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 decreases expression EXP Sunitinib results in decreased expression of GJA1 protein CTD PMID:32877659 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G TNNT2 troponin T2, cardiac type decreases expression EXP Sunitinib results in decreased expression of TNNT2 protein CTD PMID:32877659 NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396 		JBrowse link
valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Valsartan results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5164
    chemical entity 5164
      molecular entity 5163
        polyatomic entity 5143
          molecule 4990
            cyclic compound 4931
              organic cyclic compound 4931
                organic heterocyclic compound 4720
                  heteroarene 141
                    monocyclic heteroarene 40
                      1,3-oxazole 0
                      arsole + 0
                      azole + 40
                      diazine + 0
                      furan + 0
                      imidazole + 0
                      isothiazole 0
                      isoxazole 0
                      oxazirene 0
                      oxirene 0
                      pyrazole + 1
                      pyrazolium 0
                      pyridine + 0
                      pyridine-d5 0
                      pyrrole + 0
                      selenophene 0
                      tellurophene 0
                      thiazole + 0
                      thiirene 0
                      thiophene + 0
                      triazine + 0
                      triazole + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5164
    subatomic particle 5155
      composite particle 5155
        hadron 5155
          baryon 5155
            nucleon 5155
              atomic nucleus 5155
                atom 5155
                  main group element atom 5127
                    p-block element atom 5124
                      carbon group element atom 5042
                        carbon atom 5041
                          organic molecular entity 5041
                            organic molecule 4990
                              organic cyclic compound 4931
                                organic heterocyclic compound 4720
                                  heteroarene 141
                                    monocyclic heteroarene 40
                                      1,3-oxazole 0
                                      arsole + 0
                                      azole + 40
                                      diazine + 0
                                      furan + 0
                                      imidazole + 0
                                      isothiazole 0
                                      isoxazole 0
                                      oxazirene 0
                                      oxirene 0
                                      pyrazole + 1
                                      pyrazolium 0
                                      pyridine + 0
                                      pyridine-d5 0
                                      pyrrole + 0
                                      selenophene 0
                                      tellurophene 0
                                      thiazole + 0
                                      thiirene 0
                                      thiophene + 0
                                      triazine + 0
                                      triazole + 0
paths to the root