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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14031420
Species: Sus scrofa
RGD Object: Gene
Symbol: ABCB4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:6076
Term: itraconazole
Definition: An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
Chemical ID: MESH:D017964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB4multiple interactionsEXP 6480464CTDItraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

PMID:21056966
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