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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridine
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Accession:CHEBI:16227 term browser browse the term
Definition:An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.
Synonyms:related_synonym: Azabenzene;   Formula=C5H5N;   InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H;   InChIKey=JUJWROOIHBZHMG-UHFFFAOYSA-N;   SMILES=c1ccncc1;   py
 alt_id: CHEBI:14974;   CHEBI:26415;   CHEBI:8662
 xref: CAS:110-86-1;   Gmelin:1996;   HMDB:HMDB0000926;   KEGG:C00747
 xref_mesh: MESH:C023666
 xref: PDBeChem:0PY;   PMID:24364496;   PMID:24425539;   PMID:8070089;   Reaxys:103233;   Wikipedia:Pyridine


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pyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 increases activity EXP pyridine results in increased activity of ALAS1 protein CTD PMID:10413312 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Cd86 CD86 molecule increases expression ISO pyridine results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity		 ISO
EXP		 CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]
pyridine results in increased expression of CYP1A1 mRNA; pyridine results in increased expression of CYP1A1 protein
pyridine results in increased activity of CYP1A1 protein		 CTD PMID:1857340 PMID:2241968 PMID:7493548 PMID:7511897 PMID:10413312 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
increases activity		 EXP pyridine results in increased expression of CYP1A2 mRNA; pyridine results in increased expression of CYP1A2 protein
pyridine results in increased activity of CYP1A2 protein		 CTD PMID:1857340 PMID:7493548 PMID:10413312 PMID:10463385 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases activity
affects activity		 EXP INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; INS protein affects the reaction [pyridine results in increased expression of CYP2B1 protein]; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B1 protein]
pyridine results in increased expression of CYP2B1 mRNA; pyridine results in increased expression of CYP2B1 protein
pyridine results in increased activity of CYP2B1 protein
pyridine affects the activity of CYP2B1 protein		 CTD PMID:1610360 PMID:7587954 PMID:8246169 PMID:10215695 PMID:11181506 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
increases expression
increases activity
affects activity		 EXP pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B2 protein]
pyridine results in increased expression of CYP2B2 mRNA; pyridine results in increased expression of CYP2B2 protein
pyridine results in increased activity of CYP2B2 protein
pyridine affects the activity of CYP2B2 protein		 CTD PMID:1610360 PMID:7587954 PMID:8246169 PMID:11181506 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity		 ISO
EXP		 CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]
pyridine results in increased activity of CYP2E1 protein
pyridine results in increased expression of CYP2E1 mRNA; pyridine results in increased expression of CYP2E1 protein
[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]
pyridine results in decreased activity of CYP2E1 protein		 CTD PMID:1379807 PMID:1610360 PMID:1968335 PMID:2241968 PMID:7587954 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases activity		 EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]
pyridine results in increased expression of CYP3A2 mRNA; pyridine results in increased expression of CYP3A2 protein
pyridine results in increased activity of CYP3A2 protein		 CTD PMID:11181506 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
increases activity		 EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA]
pyridine results in increased expression of CYP3A23-3A1 mRNA; pyridine results in increased expression of CYP3A23-3A1 protein
pyridine results in increased activity of CYP3A23-3A1 protein		 CTD PMID:11181506 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA] CTD PMID:8825185 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP pyridine analog binds to and results in decreased activity of GRIN2B protein CTD PMID:17768047 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression		 EXP pyridine results in increased activity of HMOX1 protein
pyridine results in increased expression of HMOX1 mRNA; pyridine results in increased expression of HMOX1 protein		 CTD PMID:10413312 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO pyridine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; INS protein affects the reaction [pyridine results in increased expression of CYP2B1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein] CTD PMID:10215695 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA] CTD PMID:8825185 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO pyridine analog binds to KCNH2 protein CTD PMID:17768047 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
2-pyridylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP		 2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] CTD PMID:9657254 PMID:16143415 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO 2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA
HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]		 CTD PMID:9657254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
dipicolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glud1 glutamate dehydrogenase 1 multiple interactions
decreases activity		 ISO dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]
dipicolinic acid results in decreased activity of GLUD1 protein		 CTD PMID:26639393 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO dipicolinic acid promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:31678113 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
quinolinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase affects abundance EXP ACMSD protein affects the abundance of Quinolinic Acid CTD PMID:17896587 NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Quinolinic Acid results in increased activity of AHR protein CTD PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Quinolinic Acid results in increased expression of BAX mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]		 CTD PMID:30130594 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Quinolinic Acid results in decreased expression of BCL2 mRNA
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]		 CTD PMID:30130594 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Quinolinic Acid results in increased expression of BDNF mRNA CTD PMID:15698628 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions		 EXP Quinolinic Acid results in increased expression of CASP3 mRNA
Quinolinic Acid results in increased activity of CASP3 protein
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]		 CTD PMID:29981346 PMID:30130594 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression		 EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 PMID:20450929 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions
decreases activity		 EXP Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] CTD PMID:2976130 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP [Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein CTD PMID:12899943 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Drd1 dopamine receptor D1 decreases expression EXP Quinolinic Acid results in decreased expression of DRD1 protein CTD PMID:12207953 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Quinolinic Acid results in increased expression of DRD2 protein CTD PMID:12207953 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein CTD PMID:24211709 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 EXP Quinolinic Acid results in increased phosphorylation of EIF2S1 protein
[Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:24211709 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Quinolinic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinolinic Acid results in increased expression of FOS mRNA CTD PMID:15698628 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Quinolinic Acid results in increased activity of G6PD protein CTD PMID:30876764 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]		 CTD PMID:24211709 PMID:29981346 PMID:30130594 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]
Quinolinic Acid results in increased expression of IL6 mRNA; Quinolinic Acid results in increased expression of IL6 protein		 CTD PMID:29981346 PMID:30130594 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein CTD PMID:30876764 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:31678113 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein CTD PMID:30876764 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 EXP [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] CTD PMID:30130594 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Quinolinic Acid CTD PMID:21378209 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein CTD PMID:12207953 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
increases expression		 EXP Quinolinic Acid results in decreased expression of SLC6A3 protein
Quinolinic Acid results in increased expression of SLC6A3 protein		 CTD PMID:12207953 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
multiple interactions		 EXP Quinolinic Acid results in decreased activity of SOD1 protein
Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein]		 CTD PMID:12899943 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30876764 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]
Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein		 CTD PMID:20450929 PMID:30130594 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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  CHEBI ontology 19874
    role 19844
      chemical role 19473
        environmental contaminant 18852
          pyridine 51
            2,6-dimethylpyridine 0
            2-pyridylethylamine 8
            3-pyridinecarbonitrile 0
            6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide 0
            pyridinedicarboxylic acid + 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteromonocyclic compound 17791
                                    pyridines 11517
                                      pyridine 51
                                        2,6-dimethylpyridine 0
                                        2-pyridylethylamine 8
                                        3-pyridinecarbonitrile 0
                                        6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide 0
                                        pyridinedicarboxylic acid + 30
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