CALR (calreticulin) - Rat Genome Database
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Gene: CALR (calreticulin) Sus scrofa
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Symbol: CALR
Name: calreticulin
RGD ID: 14085339
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); hormone binding (ortholog); iron ion binding (ortholog); INVOLVED IN cardiac muscle cell differentiation (ortholog); cellular response to lithium ion (ortholog); cellular response to organic substance (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Colorectal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN acrosomal vesicle (ortholog); cell surface (ortholog); collagen-containing extracellular matrix (ortholog); INTERACTS WITH sulfamethoxazole hydroxylamine; tert-butyl hydroperoxide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Calregulin; CRP55; Endoplasmic reticulum resident protein 60; ERp60; HACBP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,098,225 - 66,102,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,283,767 - 66,287,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell differentiation  (ISO)
cellular response to lithium ion  (ISO)
cellular response to organic substance  (ISO)
cellular senescence  (IEA)
cortical actin cytoskeleton organization  (IEA)
endoplasmic reticulum unfolded protein response  (IBA)
negative regulation of cell cycle arrest  (IEA)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IEA)
negative regulation of neuron differentiation  (IEA)
negative regulation of retinoic acid receptor signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of translation  (IEA)
negative regulation of trophoblast cell migration  (IEA)
peptide antigen assembly with MHC class I protein complex  (IEA)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
protein export from nucleus  (IEA)
protein folding  (IBA,IEA)
protein localization to nucleus  (IEA)
protein stabilization  (ISS)
regulation of meiotic nuclear division  (IEA)
response to drug  (ISO)
response to estradiol  (ISO)
response to organic substance  (ISO)
response to testosterone  (ISO)
spermatogenesis  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2016321   PMID:8672129   PMID:20222029   PMID:24398873   PMID:28770174  


Genomics

Comparative Map Data
CALR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,098,225 - 66,102,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,283,767 - 66,287,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,938,578 - 12,944,489 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,938,609 - 12,944,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,049,414 - 13,055,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,910,423 - 12,916,303 (+)NCBINCBI36hg18NCBI36
Build 341912,910,422 - 12,916,303NCBI
Celera1912,939,147 - 12,945,035 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,621,315 - 12,627,203 (+)NCBIHuRef
CHM1_11913,049,914 - 13,055,824 (+)NCBICHM1_1
Calr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,568,717 - 85,573,560 (-)NCBIGRCm39mm39
GRCm38884,842,088 - 84,846,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,841,850 - 84,846,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,365,987 - 87,370,830 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,731,955 - 87,736,972 (-)NCBImm8
Celera889,141,243 - 89,146,089 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.21NCBI
Calr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,956,771 - 25,961,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,956,771 - 25,961,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,932,394 - 36,937,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,964,775 - 24,969,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,969,631 - 24,974,494 (+)NCBI
Celera1922,865,445 - 22,870,340 (+)NCBICelera
Cytogenetic Map19q11NCBI
Calr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,985,147 - 31,989,372 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,985,147 - 31,989,372 (+)NCBIChiLan1.0ChiLan1.0
CALR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,242,900 - 13,249,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,242,900 - 13,249,416 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,501,013 - 12,506,909 (+)NCBIMhudiblu_PPA_v0panPan3
CALR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,251,777 - 49,255,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,251,390 - 49,255,291 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Calr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,994,695 - 1,999,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,618,691 - 11,624,299 (+)NCBI
ChlSab1.1 Ensembl611,618,396 - 11,623,792 (+)Ensembl
Calr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901511,295 - 515,208 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015020   ⟹   ENSSSCP00000014615
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,098,225 - 66,102,083 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045310   ⟹   ENSSSCP00000049968
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,098,261 - 66,102,082 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000048882   ⟹   ENSSSCP00000042930
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,098,225 - 66,102,340 (-)Ensembl
RefSeq Acc Id: NM_001174133   ⟹   NP_001167604
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1266,098,263 - 66,102,074 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001167604 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADD52600 (Get FASTA)   NCBI Sequence Viewer  
  P28491 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001167604   ⟸   NM_001174133
- Peptide Label: precursor
- UniProtKB: P28491 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014615   ⟸   ENSSSCT00000015020
RefSeq Acc Id: ENSSSCP00000042930   ⟸   ENSSSCT00000048882
RefSeq Acc Id: ENSSSCP00000049968   ⟸   ENSSSCT00000045310


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013746 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005031194 UniProtKB/Swiss-Prot
  ENSSSCG00015041073 UniProtKB/Swiss-Prot
  ENSSSCG00025060946 UniProtKB/Swiss-Prot
  ENSSSCG00030008732 UniProtKB/Swiss-Prot
  ENSSSCG00035043864 UniProtKB/Swiss-Prot
  ENSSSCG00040013848 UniProtKB/Swiss-Prot
  ENSSSCG00045024306 UniProtKB/Swiss-Prot
  ENSSSCG00050059786 UniProtKB/Swiss-Prot
  ENSSSCG00055022230 UniProtKB/Swiss-Prot
  ENSSSCG00060013787 UniProtKB/Swiss-Prot
  ENSSSCG00065019328 UniProtKB/Swiss-Prot
  ENSSSCG00070008005 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014615 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000042930 UniProtKB/TrEMBL
  ENSSSCP00000049968 UniProtKB/TrEMBL
  ENSSSCP00005030953 UniProtKB/Swiss-Prot
  ENSSSCP00015022723 UniProtKB/Swiss-Prot
  ENSSSCP00025036365 UniProtKB/Swiss-Prot
  ENSSSCP00030005345 UniProtKB/Swiss-Prot
  ENSSSCP00035023460 UniProtKB/Swiss-Prot
  ENSSSCP00040007553 UniProtKB/Swiss-Prot
  ENSSSCP00045028773 UniProtKB/Swiss-Prot
  ENSSSCP00050034963 UniProtKB/Swiss-Prot
  ENSSSCP00055035089 UniProtKB/Swiss-Prot
  ENSSSCP00060007287 UniProtKB/Swiss-Prot
  ENSSSCP00065010535 UniProtKB/Swiss-Prot
  ENSSSCP00070012772 UniProtKB/TrEMBL
  ENSSSCP00070012779 UniProtKB/Swiss-Prot
  ENSSSCP00070012792 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015020 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000045310 UniProtKB/TrEMBL
  ENSSSCT00000048882 UniProtKB/TrEMBL
  ENSSSCT00005050130 UniProtKB/Swiss-Prot
  ENSSSCT00015056716 UniProtKB/Swiss-Prot
  ENSSSCT00025083589 UniProtKB/Swiss-Prot
  ENSSSCT00030011909 UniProtKB/Swiss-Prot
  ENSSSCT00035058366 UniProtKB/Swiss-Prot
  ENSSSCT00040018461 UniProtKB/Swiss-Prot
  ENSSSCT00045041455 UniProtKB/Swiss-Prot
  ENSSSCT00050081446 UniProtKB/Swiss-Prot
  ENSSSCT00055044054 UniProtKB/Swiss-Prot
  ENSSSCT00060018212 UniProtKB/Swiss-Prot
  ENSSSCT00065025731 UniProtKB/Swiss-Prot
  ENSSSCT00070015447 UniProtKB/TrEMBL
  ENSSSCT00070015454 UniProtKB/Swiss-Prot
  ENSSSCT00070015466 UniProtKB/TrEMBL
Gene3D-CATH 2.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calret/calnex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calret/calnex_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calreticulin/calnexin_P_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100381266 UniProtKB/Swiss-Prot
NCBI Gene CALR ENTREZGENE
PANTHER PTHR11073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Calreticulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CALRETICULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALRETICULIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALRETICULIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALRETICULIN_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ER_TARGET UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.48945 ENTREZGENE
UniProt A0A287AG29_PIG UniProtKB/TrEMBL
  A0A287B0P6_PIG UniProtKB/TrEMBL
  A0A4X1T9R5_PIG UniProtKB/TrEMBL
  A0A4X1TBI0_PIG UniProtKB/TrEMBL
  CALR_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D4N5N1 UniProtKB/Swiss-Prot
VGNC ID VGNC:86149 ENTREZGENE