CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: melibiose
Accession: CHEBI:28053
browse the term
Definition: A glycosylglucose formed by an alpha-(1->6)-linkage between D-galactose and D-glucose.
Synonyms: exact_synonym: alpha-D-galactopyranosyl-(1->6)-D-glucopyranose
related_synonym: (Gal)1 (Glc)1; 6-O-alpha-D-galactopyranosyl-D-glucopyranose; D-Melibiose; D-mellibiose; Formula=C12H22O11; Gal-alpha(1,6)Glc; InChI=1S/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12+/m1/s1; InChIKey=DLRVVLDZNNYCBX-ABXHMFFYSA-N; SMILES=OC[C@H]1O[C@H](OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O; WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1a_1-5]/1-2/a6-b1; alpha-D-Gal-(1->6)-D-Glc; alpha-D-Galp-(1->6)-D-Glcp; alpha-D-galactosyl-(1->6)-D-glucose
alt_id: CHEBI:20943; CHEBI:25182; CHEBI:60170; CHEBI:6733
xref: CAS:585-99-9; GlyGen:G09165XB; GlyTouCan:G09165XB; Gmelin:887780; HMDB:HMDB0000048; KEGG:C05402; KEGG:G01275; KNApSAcK:C00001142
xref_mesh: MESH:D008553
xref: MetaCyc:MELIBIOSE; PMID:12797744; PMID:17006649; PMID:17724458; PMID:19846069; PMID:19913595; PMID:27577255; PMID:27794607; PMID:28453942; PMID:3290105; PMID:718021; PMID:7524207; Reaxys:1292781; Wikipedia:Melibiose
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Bag3
BAG cochaperone 3
increases expression
ISO
Melibiose results in increased expression of BAG3 mRNA
CTD
PMID:30335591
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
G
Hspb8
heat shock protein family B (small) member 8
increases expression
ISO
Melibiose results in increased expression of HSPB8 mRNA
CTD
PMID:30335591
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
Melibiose results in increased expression of MAP1LC3B mRNA
CTD
PMID:30335591
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
G
Sqstm1
sequestosome 1
increases expression
ISO
Melibiose results in increased expression of SQSTM1 mRNA
CTD
PMID:30335591
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Tfeb
transcription factor EB
affects localization multiple interactions
ISO
Melibiose affects the localization of TFEB protein Cyclosporine inhibits the reaction [Melibiose affects the localization of TFEB protein]
CTD
PMID:30335591
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
G
Zkscan3
zinc finger with KRAB and SCAN domains 3
increases expression
ISO
Melibiose results in increased expression of ZKSCAN3 mRNA
CTD
PMID:30335591
NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in decreased expression of BAX protein]
CTD
PMID:34227456
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO EXP
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] royal jelly inhibits the reaction [Fluorides results in increased expression of BCL2 protein]
CTD
PMID:30896085 PMID:34227456
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bdnf
brain-derived neurotrophic factor
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in decreased expression of BDNF protein]
CTD
PMID:34227456
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Casp3
caspase 3
multiple interactions
ISO EXP
royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP3 protein]
CTD
PMID:30896085 PMID:34227456
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp6
caspase 6
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP6 protein]
CTD
PMID:34227456
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
G
Casp9
caspase 9
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP9 protein]
CTD
PMID:34227456
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
EXP ISO
royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; royal jelly inhibits the reaction [Fluorides results in decreased activity of CAT protein] royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
CTD
PMID:20369241 PMID:30896085 PMID:34227456
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccnd1
cyclin D1
multiple interactions
ISO
royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA]
CTD
PMID:35099105
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
E2f1
E2F transcription factor 1
multiple interactions
EXP
royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA]
CTD
PMID:27496854
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
Esr1
estrogen receptor 1
multiple interactions affects binding increases activity
ISO
Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein] royal jelly results in increased activity of ESR1 protein
CTD
PMID:15946813 PMID:17287592
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions affects binding
ISO
Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein]
CTD
PMID:15946813 PMID:17287592
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in increased expression of GSK3B protein]
CTD
PMID:34227456
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Ins1
insulin 1
multiple interactions
EXP
royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein]
CTD
PMID:18981581
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions decreases expression
ISO EXP
royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA] royal jelly results in decreased expression of MYC mRNA royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA]
CTD
PMID:27496854 PMID:35099105
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in decreased expression of NFE2L2 protein]
CTD
PMID:34227456
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]
CTD
PMID:30896085
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
royal jelly inhibits the reaction [Fluorides results in increased expression of RELA protein]
CTD
PMID:34227456
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tff1
trefoil factor 1
increases expression
ISO
royal jelly results in increased expression of TFF1 mRNA
CTD
PMID:15946813
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
G
Tp53
tumor protein p53
multiple interactions
ISO
royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]
CTD
PMID:30896085
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Vegfa
vascular endothelial growth factor A
increases expression
ISO EXP
royal jelly results in increased expression of VEGFA mRNA
CTD
PMID:15946813 PMID:17287592
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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