CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dichloroaniline
Accession: CHEBI:23696
browse the term
Synonyms: related_synonym: Dichloranilin; Formula=C6H5Cl2N; dichloroanilines
xref: CAS:27134-27-6; Wikipedia:Dichloroaniline
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Mpo
myeloperoxidase
multiple interactions
ISO
[[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline
CTD
PMID:20199096
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Acss2
acyl-CoA synthetase short-chain family member 2
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of ACSS2 mRNA
CTD
PMID:24172598
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Acvr1c
activin A receptor type 1C
increases expression
ISO
3,4-dichloroaniline results in increased expression of ACVR1C mRNA
CTD
PMID:24172598
NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327
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Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
increases expression
ISO
3,4-dichloroaniline results in increased expression of ADAMTS9 mRNA
CTD
PMID:24172598
NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
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Ajuba
ajuba LIM protein
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of AJUBA mRNA
CTD
PMID:24172598
NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
3,4-dichloroaniline results in increased expression of AKR1C1 mRNA
CTD
PMID:24172598
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
3,4-dichloroaniline results in increased expression of AKR1C2 mRNA
CTD
PMID:24172598
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression
ISO
3,4-dichloroaniline results in increased expression of AKR1C3 mRNA
CTD
PMID:24172598
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
EXP
3,4-dichloroaniline results in increased expression of ALDH1A3 mRNA
CTD
PMID:24172598
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Anln
anillin, actin binding protein
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of ANLN mRNA
CTD
PMID:24172598
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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Anp32e
acidic nuclear phosphoprotein 32 family member E
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of ANP32E mRNA
CTD
PMID:24172598
NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054
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Antxr2
ANTXR cell adhesion molecule 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of ANTXR2 mRNA
CTD
PMID:24172598
NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094
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Aox1
aldehyde oxidase 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of AOX1 mRNA
CTD
PMID:24172598
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Ass1
argininosuccinate synthase 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of ASS1 mRNA
CTD
PMID:24172598
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atf3
activating transcription factor 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of ATF3 mRNA
CTD
PMID:24172598
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atp6v0d2
ATPase H+ transporting V0 subunit D2
increases expression
ISO
3,4-dichloroaniline results in increased expression of ATP6V0D2 mRNA
CTD
PMID:24172598
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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Axl
Axl receptor tyrosine kinase
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of AXL mRNA
CTD
PMID:24172598
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
3,4-dichloroaniline results in increased expression of BMP6 mRNA
CTD
PMID:24172598
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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C3
complement C3
increases expression
ISO EXP
3,4-dichloroaniline results in increased expression of C3 mRNA
CTD
PMID:24172598
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C5h1orf210
similar to human chromosome 1 open reading frame 210
increases expression
ISO
3,4-dichloroaniline results in increased expression of C1ORF210 mRNA
CTD
PMID:24172598
NCBI chr 5:132,048,755...132,051,913
Ensembl chr 5:132,048,773...132,051,925
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Ccdc113
coiled-coil domain containing 113
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CFAP263 mRNA
CTD
PMID:24172598
NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923
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Ccn1
cellular communication network factor 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CCN1 mRNA
CTD
PMID:24172598
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Ccn2
cellular communication network factor 2
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CCN2 mRNA
CTD
PMID:24172598
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Cdcp1
CUB domain containing protein 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of CDCP1 mRNA
CTD
PMID:24172598
NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388
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Ceacam1
CEA cell adhesion molecule 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of CEACAM1 mRNA
CTD
PMID:24172598
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Cep126
centrosomal protein 126
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CEP126 mRNA
CTD
PMID:24172598
NCBI chr 8:5,200,576...5,267,740
Ensembl chr 8:5,218,509...5,267,467
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Cfap20dc
CFAP20 domain containing
increases expression
ISO
3,4-dichloroaniline results in increased expression of CFAP20DC mRNA
CTD
PMID:24172598
NCBI chr15:16,231,248...16,476,978
Ensembl chr15:16,231,299...16,476,977
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Cfap300
cilia and flagella associated protein 300
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CFAP300 mRNA
CTD
PMID:24172598
NCBI chr 8:5,180,180...5,198,840
Ensembl chr 8:5,180,675...5,198,807
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Cldn11
claudin 11
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CLDN11 mRNA
CTD
PMID:24172598
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
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Clgn
calmegin
increases expression
ISO
3,4-dichloroaniline results in increased expression of CLGN mRNA
CTD
PMID:24172598
NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
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Cndp1
carnosine dipeptidase 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of CNDP1 mRNA
CTD
PMID:24172598
NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765
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Col8a1
collagen type VIII alpha 1 chain
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of COL8A1 mRNA
CTD
PMID:24172598
NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
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Cstb
cystatin B
increases expression
ISO
3,4-dichloroaniline results in increased expression of CSTB mRNA
CTD
PMID:24172598
NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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Ctse
cathepsin E
increases expression
EXP
3,4-dichloroaniline results in increased expression of CTSE mRNA
CTD
PMID:24172598
NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502
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Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of CX3CL1 mRNA
CTD
PMID:24172598
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of CYP17A1 mRNA
CTD
PMID:31100596
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of CYP19A1 mRNA
CTD
PMID:31100596
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of CYP1A1 mRNA; 3,4-dichloroaniline results in increased expression of CYP1A1 protein
CTD
PMID:21784029 PMID:24172598
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of CYP1A2 mRNA; 3,4-dichloroaniline results in increased expression of CYP1A2 protein
CTD
PMID:21784029
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of CYP1B1 mRNA
CTD
PMID:24172598
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
increases expression
ISO
3,4-dichloroaniline results in increased expression of CYP4F3 mRNA
CTD
PMID:24172598
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
increases expression
ISO
3,4-dichloroaniline results in increased expression of DNAJB9 mRNA
CTD
PMID:24172598
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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Dner
delta/notch-like EGF repeat containing
increases expression
ISO
3,4-dichloroaniline results in increased expression of DNER mRNA
CTD
PMID:24172598
NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637
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Dpp4
dipeptidylpeptidase 4
increases expression
ISO
3,4-dichloroaniline results in increased expression of DPP4 mRNA
CTD
PMID:24172598
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dst
dystonin
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of DST mRNA
CTD
PMID:24172598
NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
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Efemp1
EGF containing fibulin extracellular matrix protein 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of EFEMP1 mRNA
CTD
PMID:24172598
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
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Egr1
early growth response 1
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of EGR1 mRNA
CTD
PMID:24172598
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Elovl6
ELOVL fatty acid elongase 6
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of ELOVL6 mRNA
CTD
PMID:24172598
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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Eno2
enolase 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of ENO2 mRNA
CTD
PMID:24172598
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Entpd3
ectonucleoside triphosphate diphosphohydrolase 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of ENTPD3 mRNA
CTD
PMID:24172598
NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943
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Erp27
endoplasmic reticulum protein 27
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of ERP27 mRNA
CTD
PMID:24172598
NCBI chr 4:169,804,656...169,821,660
Ensembl chr 4:169,804,658...169,821,660
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Fgfbp1
fibroblast growth factor binding protein 1
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of FGFBP1 mRNA
CTD
PMID:24172598
NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496
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Fkbp1b
FKBP prolyl isomerase 1B
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of FKBP1B mRNA
CTD
PMID:24172598
NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
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Fstl1
follistatin-like 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of FSTL1 mRNA
CTD
PMID:24172598
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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Fyb1
FYN binding protein 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of FYB1 mRNA
CTD
PMID:24172598
NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
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Gask1b
golgi associated kinase 1B
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of GASK1B mRNA
CTD
PMID:24172598
NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477
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Gdf15
growth differentiation factor 15
increases expression
EXP
3,4-dichloroaniline results in increased expression of GDF15 mRNA
CTD
PMID:24172598
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gjb6
gap junction protein, beta 6
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of GJB6 mRNA
CTD
PMID:24172598
NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582
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Has2
hyaluronan synthase 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of HAS2 mRNA
CTD
PMID:24172598
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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Hist1h2al1
histone cluster 1 H2A family like 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of H2AC6 mRNA
CTD
PMID:24172598
NCBI chr17:42,707,954...42,708,420
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Hpgd
15-hydroxyprostaglandin dehydrogenase
increases expression
ISO
3,4-dichloroaniline results in increased expression of HPGD mRNA
CTD
PMID:24172598
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of HSD17B2 mRNA
CTD
PMID:24172598
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of HSD17B7 mRNA
CTD
PMID:24172598
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Hspa6l-ps1
heat shock protein family A (Hsp70) member 6 like, pseudogene 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of HSPA6 mRNA
CTD
PMID:24172598
NCBI chr13:83,273,176...83,274,317
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Id3
inhibitor of DNA binding 3
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of ID3 mRNA
CTD
PMID:24172598
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of IDI1 mRNA
CTD
PMID:24172598
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Ifitm3
interferon induced transmembrane protein 3
increases expression
EXP
3,4-dichloroaniline results in increased expression of IFITM3 mRNA
CTD
PMID:24172598
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
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Igfbp3
insulin-like growth factor binding protein 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of IGFBP3 mRNA
CTD
PMID:24172598
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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Igfbp6
insulin-like growth factor binding protein 6
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of IGFBP6 mRNA
CTD
PMID:24172598
NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
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Il1rl1
interleukin 1 receptor-like 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of IL1RL1 mRNA
CTD
PMID:24172598
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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Il1rn
interleukin 1 receptor antagonist
increases expression
ISO
3,4-dichloroaniline results in increased expression of IL1RN mRNA
CTD
PMID:24172598
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Itga1
integrin subunit alpha 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of ITGA1 mRNA
CTD
PMID:24172598
NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
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Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KCNJ2 mRNA
CTD
PMID:24172598
NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445
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Kif20a
kinesin family member 20A
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KIF20A mRNA
CTD
PMID:24172598
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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Klhl13
kelch-like family member 13
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KLHL13 mRNA
CTD
PMID:24172598
NCBI chr X:113,942,309...114,107,299
Ensembl chr X:113,942,309...114,107,321
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Klhl24
kelch-like family member 24
increases expression
EXP
3,4-dichloroaniline results in increased expression of KLHL24 mRNA
CTD
PMID:24172598
NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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Klrc3
killer cell lectin like receptor C3
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KLRC3 mRNA
CTD
PMID:24172598
NCBI chr 4:163,105,081...163,112,737
Ensembl chr 4:163,106,024...163,112,336
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Klrg2
killer cell lectin like receptor G2
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KLRG2 mRNA
CTD
PMID:24172598
NCBI chr 4:67,360,216...67,374,867
Ensembl chr 4:67,363,919...67,374,147
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Knl1
kinetochore scaffold 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of KNL1 mRNA
CTD
PMID:24172598
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
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Krt34
keratin 34
increases expression
ISO
3,4-dichloroaniline results in increased expression of KRT34 mRNA
CTD
PMID:24172598
NCBI chr10:84,969,988...84,974,098
Ensembl chr10:84,970,017...84,974,040
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Lamb3
laminin subunit beta 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of LAMB3 mRNA
CTD
PMID:24172598
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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Lcn2
lipocalin 2
increases expression
ISO EXP
3,4-dichloroaniline results in increased expression of LCN2 mRNA
CTD
PMID:24172598
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Maf
MAF bZIP transcription factor
increases expression
ISO
3,4-dichloroaniline results in increased expression of MAF mRNA
CTD
PMID:24172598
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
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Matn3
matrilin 3
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of MATN3 mRNA
CTD
PMID:24172598
NCBI chr 6:31,748,517...31,768,564
Ensembl chr 6:31,748,474...31,768,101
G
Mctp1
multiple C2 and transmembrane domain containing 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of MCTP1 mRNA
CTD
PMID:24172598
NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
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Mex3b
mex-3 RNA binding family member B
increases expression
EXP
3,4-dichloroaniline results in increased expression of MEX3B mRNA
CTD
PMID:24172598
NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354
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Mical2
microtubule associated monooxygenase, calponin and LIM domain containing 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of MICAL2 mRNA
CTD
PMID:24172598
NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719 Ensembl chr 1:166,345,859...166,471,719
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of MMP1 mRNA
CTD
PMID:24172598
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp10
matrix metallopeptidase 10
increases expression
ISO
3,4-dichloroaniline results in increased expression of MMP10 mRNA
CTD
PMID:24172598
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp13
matrix metallopeptidase 13
increases expression
EXP
3,4-dichloroaniline results in increased expression of MMP13 mRNA
CTD
PMID:24172598
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mmp3
matrix metallopeptidase 3
increases expression
EXP
3,4-dichloroaniline results in increased expression of MMP3 mRNA
CTD
PMID:24172598
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mpo
myeloperoxidase
multiple interactions
ISO
[[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline
CTD
PMID:20199096
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Msrb3
methionine sulfoxide reductase B3
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of MSRB3 mRNA
CTD
PMID:24172598
NCBI chr 7:56,260,985...56,426,004
Ensembl chr 7:56,303,308...56,425,496
G
Muc1
mucin 1, cell surface associated
increases expression
ISO
3,4-dichloroaniline results in increased expression of MUC1 mRNA
CTD
PMID:24172598
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Muc16
mucin 16, cell surface associated
increases expression
ISO
3,4-dichloroaniline results in increased expression of MUC16 mRNA
CTD
PMID:24172598
NCBI chr 8:16,164,531...16,323,126
G
Myo10
myosin X
increases expression
ISO
3,4-dichloroaniline results in increased expression of MYO10 mRNA
CTD
PMID:24172598
NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030
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Nat2
N-acetyltransferase 2
increases acetylation
ISO
NAT2 protein results in increased acetylation of 3,4-dichloroaniline
CTD
PMID:15627487
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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Ndrg1
N-myc downstream regulated 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of NDRG1 mRNA
CTD
PMID:24172598
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Nedd9
neural precursor cell expressed, developmentally down-regulated 9
decreases expression increases expression
ISO EXP
3,4-dichloroaniline results in decreased expression of NEDD9 mRNA 3,4-dichloroaniline results in increased expression of NEDD9 mRNA
CTD
PMID:24172598
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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Nt5e
5' nucleotidase, ecto
increases expression
ISO
3,4-dichloroaniline results in increased expression of NT5E mRNA
CTD
PMID:24172598
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Nusap1
nucleolar and spindle associated protein 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of NUSAP1 mRNA
CTD
PMID:24172598
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Ostm1
osteoclastogenesis associated transmembrane protein 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of OSTM1 mRNA
CTD
PMID:24172598
NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
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Pappa
pappalysin
increases expression
ISO
3,4-dichloroaniline results in increased expression of PAPPA mRNA
CTD
PMID:24172598
NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
3,4-dichloroaniline results in increased expression of PDK4 mRNA
CTD
PMID:24172598
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pgbd5
piggyBac transposable element derived 5
increases expression
ISO
3,4-dichloroaniline results in increased expression of PGBD5 mRNA
CTD
PMID:24172598
NCBI chr19:52,336,751...52,401,906
Ensembl chr19:52,336,751...52,402,397
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Plaur
plasminogen activator, urokinase receptor
increases expression
ISO
3,4-dichloroaniline results in increased expression of PLAUR mRNA
CTD
PMID:24172598
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Pld5
phospholipase D family, member 5
increases expression
ISO
3,4-dichloroaniline results in increased expression of PLD5 mRNA
CTD
PMID:24172598
NCBI chr13:87,895,694...88,232,868
Ensembl chr13:87,896,369...88,232,868
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Plk2
polo-like kinase 2
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of PLK2 mRNA
CTD
PMID:24172598
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Prdm1
PR/SET domain 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of PRDM1 mRNA
CTD
PMID:24172598
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Prnp
prion protein
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of PRNP mRNA
CTD
PMID:24172598
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
G
Prss23
serine protease 23
increases expression
EXP
3,4-dichloroaniline results in increased expression of PRSS23 mRNA
CTD
PMID:24172598
NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091
G
Ptger4
prostaglandin E receptor 4
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of PTGER4 mRNA
CTD
PMID:24172598
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
3,4-dichloroaniline results in increased expression of PTGS2 mRNA
CTD
PMID:24172598
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptprz1
protein tyrosine phosphatase, receptor type Z1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of PTPRZ1 mRNA
CTD
PMID:24172598
NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
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Ralbp1
ralA binding protein 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of RALBP1 mRNA
CTD
PMID:24172598
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
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Rarres1
retinoic acid receptor responder 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of RARRES1 mRNA
CTD
PMID:24172598
NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
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Rbck1
RANBP2-type and C3HC4-type zinc finger containing 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of RBCK1 mRNA
CTD
PMID:24172598
NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
G
Rnf128
ring finger protein 128
increases expression
EXP
3,4-dichloroaniline results in increased expression of RNF128 mRNA
CTD
PMID:24172598
NCBI chr X:103,183,643...103,298,431
Ensembl chr X:103,183,831...103,298,423
G
Rora
RAR-related orphan receptor A
increases expression
ISO
3,4-dichloroaniline results in increased expression of RORA mRNA
CTD
PMID:24172598
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
G
Scd
stearoyl-CoA desaturase
increases expression
ISO
3,4-dichloroaniline results in increased expression of SCD mRNA
CTD
PMID:24172598
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Scg5
secretogranin V
increases expression
ISO
3,4-dichloroaniline results in increased expression of SCG5 mRNA
CTD
PMID:24172598
NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
G
Scrn1
secernin 1
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of SCRN1 mRNA
CTD
PMID:24172598
NCBI chr 4:83,632,125...83,694,225
Ensembl chr 4:83,632,131...83,693,852
G
Serpinb2
serpin family B member 2
increases expression decreases expression
ISO EXP
3,4-dichloroaniline results in increased expression of SERPINB2 mRNA 3,4-dichloroaniline results in decreased expression of SERPINB2 mRNA
CTD
PMID:24172598
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
G
Slc16a6
solute carrier family 16, member 6
increases expression
ISO
3,4-dichloroaniline results in increased expression of SLC16A6 mRNA
CTD
PMID:24172598
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
G
Slc1a6
solute carrier family 1 member 6
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of SLC1A6 mRNA
CTD
PMID:24172598
NCBI chr 7:10,841,836...10,870,424
Ensembl chr 7:10,841,837...10,870,449
G
Slco4a1
solute carrier organic anion transporter family, member 4a1
increases expression
ISO
3,4-dichloroaniline results in increased expression of SLCO4A1 mRNA
CTD
PMID:24172598
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
G
Smpd3
sphingomyelin phosphodiesterase 3
increases expression
EXP
3,4-dichloroaniline results in increased expression of SMPD3 mRNA
CTD
PMID:24172598
NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
G
Sohlh2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of SOHLH2 mRNA
CTD
PMID:24172598
NCBI chr 2:139,362,246...139,384,700
Ensembl chr 2:139,362,246...139,384,699
G
Sowaha
sosondowah ankyrin repeat domain family member A
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of SOWAHA mRNA
CTD
PMID:24172598
NCBI chr10:37,641,823...37,645,390
Ensembl chr10:37,643,444...37,645,102
G
Spc24
SPC24 component of NDC80 kinetochore complex
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of SPC24 mRNA
CTD
PMID:24172598
NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310
G
St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of ST6GAL1 mRNA
CTD
PMID:24172598
NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of STAR mRNA
CTD
PMID:31100596
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Sult1b1
sulfotransferase family 1B member 1
increases expression
EXP
3,4-dichloroaniline results in increased expression of SULT1B1 mRNA
CTD
PMID:24172598
NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
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Sun3
Sad1 and UNC84 domain containing 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of SUN3 mRNA
CTD
PMID:24172598
NCBI chr14:83,710,136...83,748,982
Ensembl chr14:83,710,140...83,735,830
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Taf9b
TATA-box binding protein associated factor 9b
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TAF9B mRNA
CTD
PMID:24172598
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
G
Tent5b
terminal nucleotidyltransferase 5B
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TENT5B mRNA
CTD
PMID:24172598
NCBI chr 5:145,695,358...145,702,668
Ensembl chr 5:145,695,362...145,706,073
G
Tgfbi
transforming growth factor, beta induced
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of TGFBI mRNA
CTD
PMID:24172598
NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of TIMP1 mRNA
CTD
PMID:24172598
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tmcc3
transmembrane and coiled-coil domain family 3
increases expression
ISO
3,4-dichloroaniline results in increased expression of TMCC3 mRNA
CTD
PMID:24172598
NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
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Tmem117
transmembrane protein 117
increases expression
ISO
3,4-dichloroaniline results in increased expression of TMEM117 mRNA
CTD
PMID:24172598
NCBI chr 7:125,757,591...126,219,692
Ensembl chr 7:125,757,591...126,219,690
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Tmem154
transmembrane protein 154
increases expression
ISO
3,4-dichloroaniline results in increased expression of TMEM154 mRNA
CTD
PMID:24172598
NCBI chr 2:170,015,247...170,054,903
Ensembl chr 2:170,015,184...170,052,481
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Tmem40
transmembrane protein 40
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TMEM40 mRNA
CTD
PMID:24172598
NCBI chr 4:148,791,509...148,819,287
Ensembl chr 4:148,791,505...148,823,665
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Tnfaip8l1
TNF alpha induced protein 8 like 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TNFAIP8L1 mRNA
CTD
PMID:24172598
NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254
G
Tnfsf13b
TNF superfamily member 13b
increases expression
ISO
3,4-dichloroaniline results in increased expression of TNFSF13B mRNA
CTD
PMID:24172598
NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
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Tp63
tumor protein p63
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of TP63 mRNA
CTD
PMID:24172598
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
G
Tprg1
tumor protein p63 regulated 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TPRG1 mRNA
CTD
PMID:24172598
NCBI chr11:75,322,470...75,449,907
Ensembl chr11:75,322,470...75,449,907
G
Trib3
tribbles pseudokinase 3
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of TRIB3 mRNA
CTD
PMID:24172598
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim59
tripartite motif-containing 59
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TRIM59 mRNA
CTD
PMID:24172598
NCBI chr 2:153,269,210...153,281,185
Ensembl chr 2:153,268,584...153,281,031
G
Trim6
tripartite motif containing 6
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of TRIM6 mRNA
CTD
PMID:24172598
NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914
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Ubd
ubiquitin D
increases expression
EXP
3,4-dichloroaniline results in increased expression of UBD mRNA
CTD
PMID:24172598
NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
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Vgll1
vestigial-like family member 1
decreases expression
ISO
3,4-dichloroaniline results in decreased expression of VGLL1 mRNA
CTD
PMID:24172598
NCBI chr X:134,979,657...134,996,007
G
Zbtb1
zinc finger and BTB domain containing 1
increases expression
ISO
3,4-dichloroaniline results in increased expression of ZBTB1 mRNA
CTD
PMID:24172598
NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
G
Zc3h13
zinc finger CCCH type containing 13
decreases expression
EXP
3,4-dichloroaniline results in decreased expression of ZC3H13 mRNA
CTD
PMID:24172598
NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
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Zfp866
zinc finger protein 866
increases expression
EXP
3,4-dichloroaniline results in increased expression of CXCL5 mRNA
CTD
PMID:24172598
NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932
G
Adora1
adenosine A1 receptor
multiple interactions
EXP
[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Adra2a
adrenoceptor alpha 2A
multiple interactions
ISO EXP
Clonidine binds to and results in increased activity of ADRA2A protein [5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD
PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Adra2b
adrenoceptor alpha 2B
multiple interactions
ISO
Clonidine binds to and results in increased activity of ADRA2B protein
CTD
PMID:10217548
NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
G
Adra2c
adrenoceptor alpha 2C
multiple interactions increases response to substance
ISO EXP
Clonidine binds to and results in increased activity of ADRA2C protein ADRA2C results in increased susceptibility to Clonidine
CTD
PMID:8987795 PMID:10217548
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
Clonidine results in increased expression of AIFM1 protein
CTD
PMID:28115640
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
G
Apoa1
apolipoprotein A1
decreases expression
ISO
Clonidine results in decreased expression of APOA1 protein
CTD
PMID:2193493
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
G
Apoa2
apolipoprotein A2
decreases expression
ISO
Clonidine results in decreased expression of APOA2 protein
CTD
PMID:2193493
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Avp
arginine vasopressin
increases expression
EXP
Clonidine results in increased expression of AVP protein
CTD
PMID:7400963
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
G
Bad
BCL2-associated agonist of cell death
increases expression
ISO
Clonidine results in increased expression of BAD protein
CTD
PMID:28115640
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Clonidine results in decreased expression of BCL2 protein
CTD
PMID:28115640
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
increases expression
EXP
Clonidine results in increased expression of BCL2L1 mRNA
CTD
PMID:12423672
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Casp2
caspase 2
increases activity
ISO
Clonidine results in increased activity of CASP2 protein
CTD
PMID:28115640
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases expression increases activity
EXP ISO
Clonidine results in increased expression of CASP3 mRNA Clonidine results in increased activity of CASP3 protein
CTD
PMID:15351510 PMID:28115640
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity
ISO
Clonidine results in increased activity of CASP8 protein
CTD
PMID:28115640
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
Clonidine results in increased activity of CASP9 protein
CTD
PMID:28115640
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
CTD
PMID:12107048
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides]
CTD
PMID:12598592
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Comt
catechol-O-methyltransferase
increases expression
EXP
Clonidine results in increased expression of COMT mRNA
CTD
PMID:12423672
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions increases metabolic processing
ISO
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD
PMID:31585114
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
CTD
PMID:12560108
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Gal
galanin and GMAP prepropeptide
increases activity
EXP
Clonidine results in increased activity of GAL protein
CTD
PMID:10818254
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gh1
growth hormone 1
increases secretion multiple interactions increases expression
ISO EXP
Clonidine results in increased secretion of GH1 protein Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
CTD
PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 More...
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
G
Gnai1
G protein subunit alpha i1
affects response to substance
ISO
GNAI1 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai3
G protein subunit alpha i3
affects response to substance
ISO
GNAI3 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
EXP
Clonidine results in increased expression of HSP90AA1 mRNA
CTD
PMID:10684495
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Clonidine results in increased expression of HSPD1 mRNA
CTD
PMID:10684495
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Ifng
interferon gamma
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]
CTD
PMID:16192389
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases secretion
ISO
Clonidine results in increased secretion of IL10 protein
CTD
PMID:16612254
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1a
interleukin 1 alpha
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]
CTD
PMID:16192389
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions
ISO EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD
PMID:12065299 PMID:16192389
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]
CTD
PMID:16192389
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Ins2
insulin 2
decreases secretion
ISO
Clonidine results in decreased secretion of INS protein
CTD
PMID:707001
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Itgam
integrin subunit alpha M
multiple interactions
ISO
[Clonidine cotreated with Forearm Reperfusion Injury] increases expression of ITGAM protein in local neutrophils
RGD
PMID:22987052
RGD:329853767
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nppa
natriuretic peptide A
increases expression
EXP
Clonidine results in increased expression of NPPA protein
CTD
PMID:18378355
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Npy
neuropeptide Y
increases expression multiple interactions decreases expression
EXP
Clonidine results in increased expression of NPY mRNA Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD
PMID:1878751
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Oprm1
opioid receptor, mu 1
multiple interactions increases response to substance
EXP
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine OPRM1 results in increased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
G
Pdcd4
programmed cell death 4
decreases expression
ISO
Clonidine results in decreased expression of PDCD4 mRNA
CTD
PMID:21873647
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
G
Pomc
proopiomelanocortin
increases expression multiple interactions increases secretion decreases expression
ISO EXP
Clonidine results in increased expression of POMC protein [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form] Clonidine results in decreased expression of POMC protein [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD
PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Prl
prolactin
increases expression multiple interactions
ISO EXP
Clonidine results in increased expression of PRL protein Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD
PMID:1678730 PMID:16401171
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Ren
renin
increases activity decreases activity decreases expression multiple interactions
ISO
Clonidine results in increased activity of REN protein Clonidine results in decreased activity of REN protein Clonidine results in decreased expression of REN protein [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD
PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 More...
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:16263091 PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:9830022 PMID:10966924 PMID:16263091
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
G
Taar1
trace-amine-associated receptor 1
increases activity multiple interactions
ISO
Clonidine results in increased activity of TAAR1 protein [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:19725810
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
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Th
tyrosine hydroxylase
multiple interactions
EXP
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein
CTD
PMID:19067675
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Tnf
tumor necrosis factor
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]
CTD
PMID:16192389
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Clonidine results in increased expression of TNFAIP3 mRNA
CTD
PMID:21873647
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tpd52
tumor protein D52
increases expression
ISO
Clonidine results in increased expression of TPD52 mRNA
CTD
PMID:21873647
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
G
Adora1
adenosine A1 receptor
multiple interactions
EXP
[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
G
Adra2a
adrenoceptor alpha 2A
multiple interactions
ISO EXP
Clonidine binds to and results in increased activity of ADRA2A protein [5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD
PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Adra2b
adrenoceptor alpha 2B
multiple interactions
ISO
Clonidine binds to and results in increased activity of ADRA2B protein
CTD
PMID:10217548
NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
G
Adra2c
adrenoceptor alpha 2C
multiple interactions increases response to substance
ISO EXP
Clonidine binds to and results in increased activity of ADRA2C protein ADRA2C results in increased susceptibility to Clonidine
CTD
PMID:8987795 PMID:10217548
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
Clonidine results in increased expression of AIFM1 protein
CTD
PMID:28115640
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
G
Apoa1
apolipoprotein A1
decreases expression
ISO
Clonidine results in decreased expression of APOA1 protein
CTD
PMID:2193493
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa2
apolipoprotein A2
decreases expression
ISO
Clonidine results in decreased expression of APOA2 protein
CTD
PMID:2193493
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Avp
arginine vasopressin
increases expression
EXP
Clonidine results in increased expression of AVP protein
CTD
PMID:7400963
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
G
Bad
BCL2-associated agonist of cell death
increases expression
ISO
Clonidine results in increased expression of BAD protein
CTD
PMID:28115640
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Clonidine results in decreased expression of BCL2 protein
CTD
PMID:28115640
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
increases expression
EXP
Clonidine results in increased expression of BCL2L1 mRNA
CTD
PMID:12423672
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Casp2
caspase 2
increases activity
ISO
Clonidine results in increased activity of CASP2 protein
CTD
PMID:28115640
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
G
Casp3
caspase 3
increases expression increases activity
EXP ISO
Clonidine results in increased expression of CASP3 mRNA Clonidine results in increased activity of CASP3 protein
CTD
PMID:15351510 PMID:28115640
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
Clonidine results in increased activity of CASP8 protein
CTD
PMID:28115640
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
Clonidine results in increased activity of CASP9 protein
CTD
PMID:28115640
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
CTD
PMID:12107048
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides]
CTD
PMID:12598592
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Comt
catechol-O-methyltransferase
increases expression
EXP
Clonidine results in increased expression of COMT mRNA
CTD
PMID:12423672
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases metabolic processing multiple interactions
ISO
CYP2D6 protein results in increased metabolism of Clonidine [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD
PMID:31585114
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
CTD
PMID:12560108
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Gal
galanin and GMAP prepropeptide
increases activity
EXP
Clonidine results in increased activity of GAL protein
CTD
PMID:10818254
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gh1
growth hormone 1
increases secretion increases expression multiple interactions
ISO EXP
Clonidine results in increased secretion of GH1 protein Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
CTD
PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 More...
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
G
Gnai1
G protein subunit alpha i1
affects response to substance
ISO
GNAI1 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai3
G protein subunit alpha i3
affects response to substance
ISO
GNAI3 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
EXP
Clonidine results in increased expression of HSP90AA1 mRNA
CTD
PMID:10684495
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Clonidine results in increased expression of HSPD1 mRNA
CTD
PMID:10684495
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Ifng
interferon gamma
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]
CTD
PMID:16192389
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases secretion
ISO
Clonidine results in increased secretion of IL10 protein
CTD
PMID:16612254
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1a
interleukin 1 alpha
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]
CTD
PMID:16192389
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions
ISO EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD
PMID:12065299 PMID:16192389
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]
CTD
PMID:16192389
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Ins2
insulin 2
decreases secretion
ISO
Clonidine results in decreased secretion of INS protein
CTD
PMID:707001
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nppa
natriuretic peptide A
increases expression
EXP
Clonidine results in increased expression of NPPA protein
CTD
PMID:18378355
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Npy
neuropeptide Y
increases expression decreases expression multiple interactions
EXP
Clonidine results in increased expression of NPY mRNA Clonidine results in decreased expression of NPY mRNA Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD
PMID:1878751
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Oprm1
opioid receptor, mu 1
multiple interactions increases response to substance
EXP
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine OPRM1 results in increased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
G
Pdcd4
programmed cell death 4
decreases expression
ISO
Clonidine results in decreased expression of PDCD4 mRNA
CTD
PMID:21873647
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
G
Pomc
proopiomelanocortin
increases expression multiple interactions decreases expression increases secretion
ISO EXP
Clonidine results in increased expression of POMC protein [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone Clonidine results in decreased expression of POMC protein Clonidine results in increased secretion of POMC protein alternative form [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
CTD
PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Prl
prolactin
increases expression multiple interactions
ISO EXP
Clonidine results in increased expression of PRL protein Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD
PMID:1678730 PMID:16401171
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Ren
renin
increases activity multiple interactions decreases expression decreases activity
ISO
Clonidine results in increased activity of REN protein [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein Clonidine results in decreased expression of REN protein Clonidine results in decreased activity of REN protein
CTD
PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 More...
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:16263091 PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:9830022 PMID:10966924 PMID:16263091
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
G
Taar1
trace-amine-associated receptor 1
increases activity multiple interactions
ISO
Clonidine results in increased activity of TAAR1 protein [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:19725810
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
G
Th
tyrosine hydroxylase
multiple interactions
EXP
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein
CTD
PMID:19067675
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Tnf
tumor necrosis factor
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]
CTD
PMID:16192389
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Clonidine results in increased expression of TNFAIP3 mRNA
CTD
PMID:21873647
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tpd52
tumor protein D52
increases expression
ISO
Clonidine results in increased expression of TPD52 mRNA
CTD
PMID:21873647
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
G
Adora1
adenosine A1 receptor
multiple interactions
EXP
[1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
G
Adra2a
adrenoceptor alpha 2A
multiple interactions
ISO EXP
Clonidine binds to and results in increased activity of ADRA2A protein [5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine
CTD
PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Adra2b
adrenoceptor alpha 2B
multiple interactions
ISO
Clonidine binds to and results in increased activity of ADRA2B protein
CTD
PMID:10217548
NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
G
Adra2c
adrenoceptor alpha 2C
multiple interactions increases response to substance
ISO EXP
Clonidine binds to and results in increased activity of ADRA2C protein ADRA2C results in increased susceptibility to Clonidine
CTD
PMID:8987795 PMID:10217548
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
G
Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
Clonidine results in increased expression of AIFM1 protein
CTD
PMID:28115640
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
G
Apoa1
apolipoprotein A1
decreases expression
ISO
Clonidine results in decreased expression of APOA1 protein
CTD
PMID:2193493
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
G
Apoa2
apolipoprotein A2
decreases expression
ISO
Clonidine results in decreased expression of APOA2 protein
CTD
PMID:2193493
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
G
Avp
arginine vasopressin
increases expression
EXP
Clonidine results in increased expression of AVP protein
CTD
PMID:7400963
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
G
Bad
BCL2-associated agonist of cell death
increases expression
ISO
Clonidine results in increased expression of BAD protein
CTD
PMID:28115640
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Clonidine results in decreased expression of BCL2 protein
CTD
PMID:28115640
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
increases expression
EXP
Clonidine results in increased expression of BCL2L1 mRNA
CTD
PMID:12423672
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
G
Casp2
caspase 2
increases activity
ISO
Clonidine results in increased activity of CASP2 protein
CTD
PMID:28115640
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
G
Casp3
caspase 3
increases expression increases activity
EXP ISO
Clonidine results in increased expression of CASP3 mRNA Clonidine results in increased activity of CASP3 protein
CTD
PMID:15351510 PMID:28115640
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
Clonidine results in increased activity of CASP8 protein
CTD
PMID:28115640
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
Clonidine results in increased activity of CASP9 protein
CTD
PMID:28115640
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
CTD
PMID:12107048
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cftr
CF transmembrane conductance regulator
multiple interactions
ISO
Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides]
CTD
PMID:12598592
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
G
Comt
catechol-O-methyltransferase
increases expression
EXP
Clonidine results in increased expression of COMT mRNA
CTD
PMID:12423672
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases metabolic processing multiple interactions
ISO
CYP2D6 protein results in increased metabolism of Clonidine [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine
CTD
PMID:31585114
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
CTD
PMID:12560108
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Gal
galanin and GMAP prepropeptide
increases activity
EXP
Clonidine results in increased activity of GAL protein
CTD
PMID:10818254
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gh1
growth hormone 1
increases secretion multiple interactions increases expression
ISO EXP
Clonidine results in increased secretion of GH1 protein Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein
CTD
PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 PMID:17889730 More...
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
G
Gnai1
G protein subunit alpha i1
affects response to substance
ISO
GNAI1 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai3
G protein subunit alpha i3
affects response to substance
ISO
GNAI3 affects the susceptibility to Clonidine
CTD
PMID:15207363
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
EXP
Clonidine results in increased expression of HSP90AA1 mRNA
CTD
PMID:10684495
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Clonidine results in increased expression of HSPD1 mRNA
CTD
PMID:10684495
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Ifng
interferon gamma
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]
CTD
PMID:16192389
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases secretion
ISO
Clonidine results in increased secretion of IL10 protein
CTD
PMID:16612254
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1a
interleukin 1 alpha
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]
CTD
PMID:16192389
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions
ISO EXP
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]
CTD
PMID:12065299 PMID:16192389
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il2
interleukin 2
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]
CTD
PMID:16192389
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Ins2
insulin 2
decreases secretion
ISO
Clonidine results in decreased secretion of INS protein
CTD
PMID:707001
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nppa
natriuretic peptide A
increases expression
EXP
Clonidine results in increased expression of NPPA protein
CTD
PMID:18378355
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Npy
neuropeptide Y
increases expression multiple interactions decreases expression
EXP
Clonidine results in increased expression of NPY mRNA Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]
CTD
PMID:1878751
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Oprm1
opioid receptor, mu 1
multiple interactions increases response to substance
EXP
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine OPRM1 results in increased susceptibility to Clonidine
CTD
PMID:8987795
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
G
Pdcd4
programmed cell death 4
decreases expression
ISO
Clonidine results in decreased expression of PDCD4 mRNA
CTD
PMID:21873647
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
G
Pomc
proopiomelanocortin
increases expression multiple interactions increases secretion decreases expression
ISO EXP
Clonidine results in increased expression of POMC protein [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form] Clonidine results in decreased expression of POMC protein [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone
CTD
PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Prl
prolactin
increases expression multiple interactions
ISO EXP
Clonidine results in increased expression of PRL protein Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]
CTD
PMID:1678730 PMID:16401171
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Ren
renin
increases activity decreases activity decreases expression multiple interactions
ISO
Clonidine results in increased activity of REN protein Clonidine results in decreased activity of REN protein Clonidine results in decreased expression of REN protein [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
CTD
PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 PMID:7837211 PMID:12014310 PMID:20833658 More...
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16263091
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:16263091 PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO EXP
Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:9830022 PMID:10966924 PMID:16263091
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
G
Taar1
trace-amine-associated receptor 1
increases activity multiple interactions
ISO
Clonidine results in increased activity of TAAR1 protein [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD
PMID:19725810
NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
G
Th
tyrosine hydroxylase
multiple interactions
EXP
[Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein
CTD
PMID:19067675
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Tnf
tumor necrosis factor
multiple interactions
EXP
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]
CTD
PMID:16192389
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Clonidine results in increased expression of TNFAIP3 mRNA
CTD
PMID:21873647
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
G
Tpd52
tumor protein D52
increases expression
ISO
Clonidine results in increased expression of TPD52 mRNA
CTD
PMID:21873647
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
Propanil binds to and results in increased activity of AHR protein
CTD
PMID:18835618
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Ar
androgen receptor
affects binding multiple interactions
EXP ISO
Propanil binds to AR protein Dihydrotestosterone inhibits the reaction [Propanil results in increased activity of AR protein]; Propanil inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:14565775 PMID:15064155 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
ISO
Propanil results in increased expression of DNAJB1 mRNA
CTD
PMID:24356939
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Propanil binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
Propanil results in decreased expression of HMGCS1 mRNA
CTD
PMID:24356939
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
Propanil results in increased expression of HSPA1B mRNA
CTD
PMID:24356939
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
Propanil results in decreased expression of IDI1 mRNA
CTD
PMID:24356939
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
G
Ifng
interferon gamma
multiple interactions
ISO
Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG mRNA]; Lipopolysaccharides promotes the reaction [Propanil results in increased expression of IFNG protein]
CTD
PMID:7679225
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il2
interleukin 2
multiple interactions decreases stability
ISO
Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Propanil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] Propanil results in decreased stability of IL2 mRNA
CTD
PMID:9925799
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il6
interleukin 6
multiple interactions decreases secretion
ISO
Propanil promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] Propanil results in decreased secretion of IL6 protein
CTD
PMID:9201266 PMID:9221836 PMID:17585980
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]
CTD
PMID:11312646
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:17355946
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Propanil binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
Propanil binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD
PMID:11312646
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Sqle
squalene epoxidase
decreases expression
ISO
Propanil results in decreased expression of SQLE mRNA
CTD
PMID:24356939
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Propanil binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Propanil binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tnf
tumor necrosis factor
decreases expression increases expression decreases secretion multiple interactions
ISO
Propanil results in decreased expression of TNF protein Propanil results in increased expression of TNF protein Propanil results in decreased secretion of TNF protein Lipopolysaccharides promotes the reaction [Propanil results in increased expression of TNF protein]; Propanil inhibits the reaction [[NFKB1 protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [[RELA protein binds to NFKB1 protein] which binds to TNF promoter]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Propanil inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:7679225 PMID:9201266 PMID:9221836 PMID:11312646 PMID:17355946
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Zfp628
zinc finger protein 628
decreases expression
ISO
Propanil results in decreased expression of ZNF628 mRNA
CTD
PMID:24356939
NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19841
chemical entity
19839
molecular entity
19839
polyatomic entity
19797
heteroatomic molecular entity
19754
halide
18661
organohalogen compound
18535
organochlorine compound
18307
chlorobenzenes
14839
chloroaniline
234
dichloroaniline
219
2,3-dichloroaniline
0
2,4-dichloroaniline
1
2,5-dichloroaniline
0
2,6-dichloroaniline +
52
3,4-dichloroaniline +
172
3,5-dichloroaniline
0
Path 2
CHEBI ontology
19841
subatomic particle
19839
composite particle
19839
hadron
19839
baryon
19839
nucleon
19839
atomic nucleus
19839
atom
19839
main group element atom
19789
main group molecular entity
19789
s-block molecular entity
19626
hydrogen molecular entity
19613
hydrides
19120
inorganic hydride
18118
pnictogen hydride
18107
nitrogen hydride
18014
azane
17824
ammonia
17823
organic amino compound
17823
aromatic amine
15424
anilines
14421
substituted aniline
14063
chloroaniline
234
dichloroaniline
219
2,3-dichloroaniline
0
2,4-dichloroaniline
1
2,5-dichloroaniline
0
2,6-dichloroaniline +
52
3,4-dichloroaniline +
172
3,5-dichloroaniline
0