Nat2 (N-acetyltransferase 2) - Rat Genome Database

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Gene: Nat2 (N-acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Nat2 (Ensembl: Nat1)
Name: N-acetyltransferase 2 (Ensembl:N-acetyltransferase 1)
RGD ID: 70492
Description: Enables arylamine N-acetyltransferase activity. Involved in several processes, including digestive tract development; response to hypoxia; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1); PARTICIPATES IN caffeine pharmacokinetics pathway; caffeine metabolic pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-aminobenzoic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arylamide acetylase 2; arylamine N-acetyltransferase 2; AT-2; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; N-Acetyltransferase-2 (arylamine N-acetyltransferase); NAT-2; Nat2a
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81626,974,874 - 27,005,191 (-)NCBIGRCr8
mRatBN7.21622,207,362 - 22,238,513 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1622,208,194 - 22,238,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1625,582,055 - 25,607,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,012,550 - 29,042,472 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01624,947,433 - 24,973,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01623,960,709 - 23,991,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,844,909 - 23,875,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,845,894 - 23,876,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11623,845,891 - 23,876,526 (-)NCBI
Celera1622,342,838 - 22,372,771 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-dimethylaniline  (ISO)
2-acetamidofluorene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-naphthylamine  (ISO)
2-phenylethylamine  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4-aminobenzoic acid  (EXP,ISO)
4-aminosalicylic acid  (ISO)
4-chloroaniline  (ISO)
4-Hexyloxyaniline  (ISO)
4-Nitrosobiphenyl  (ISO)
5-acetamido-6-formamido-3-methyluracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetyl-CoA  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-4-amine  (EXP,ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carotenoid  (ISO)
chlorzoxazone  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dapsone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
dimethocaine  (ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
folic acid  (ISO)
genistein  (ISO)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hexamethylene diisocyanate  (ISO)
hydralazine  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
isoniazide  (EXP,ISO)
MeIQ  (ISO)
MeIQx  (EXP,ISO)
mesalamine  (ISO)
metacetamol  (ISO)
N-hydroxy-2-acetamidofluorene  (ISO)
N-hydroxy-4-acetylaminobiphenyl  (ISO)
N-hydroxy-4-aminobiphenyl  (ISO)
N-Hydroxy-IQ  (ISO)
N-hydroxy-PhIP  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nitrofen  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
PhIP  (ISO)
procainamide  (ISO)
procymidone  (EXP)
quercetin  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfadiazine  (ISO)
sulfamethazine  (ISO)
sulfamethoxazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
xanthohumol  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Arif E, etal., Clin Chim Acta. 2007 Jul;382(1-2):37-42. Epub 2007 Mar 24.
2. The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancer. Ayaz L, etal., Cell Biochem Funct. 2008 Apr;26(3):329-33.
3. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Bandmann O, etal., Lancet. 1997 Oct 18;350(9085):1136-9.
4. Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat. Barker DF, etal., Drug Metab Dispos. 2008 Dec;36(12):2445-51. Epub 2008 Sep 17.
5. 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. Belogubova EV, etal., Cancer Lett. 2005 Apr 28;221(2):177-83.
6. N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects. Brocvielle H, etal., Skin Pharmacol Appl Skin Physiol. 2003 Nov-Dec;16(6):386-92.
7. GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. Chatzimichalis M, etal., J Laryngol Otol. 2010 Mar;124(3):318-23. Epub 2009 Nov 19.
8. Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers. Dai Y, etal., Ind Health. 2009 Oct;47(5):479-86.
9. Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure. Dani M, etal., Drug Metab Dispos. 2010 Mar;38(3):357-60. doi: 10.1124/dmd.109.029991. Epub 2009 Dec 9.
10. Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal gland. Ebisawa T, etal., Eur J Biochem 1995 Feb 15;228(1):129-37.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. [Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. Gra OA, etal., Genetika. 2010 Feb;46(2):262-71.
14. Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. Hein DW, etal., Environ Mol Mutagen. 2002;40(3):161-7.
15. NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis. Higuchi N, etal., World J Gastroenterol. 2007 Dec 7;13(45):6003-8.
16. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders. Hirvonen A, etal., J Natl Cancer Inst. 1996 Dec 18;88(24):1853-6.
17. 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats. Jefferson FA, etal., Toxicol Sci. 2009 Jan;107(1):293-7. Epub 2008 Oct 8.
18. Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer. Jiao L, etal., Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2379-86.
19. Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acids. Jones RF, etal., Carcinogenesis. 1996 Aug;17(8):1729-33.
20. N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia. Kamel AM, etal., Tumour Biol. 2015 Aug;36(8):6341-8. doi: 10.1007/s13277-015-3320-7. Epub 2015 Mar 25.
21. Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Kim JM, etal., Pharmacogenomics. 2010 Jul;11(7):951-8.
22. N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy. Korpinen E, etal., Pharmacogenetics. 1999 Oct;9(5):627-33.
23. [Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population]. Kozhekbaeva ZhM, etal., Mol Biol (Mosk). 2009 Jan-Feb;43(1):62-76.
24. Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias. Lemos MC, etal., Carcinogenesis. 1999 Jul;20(7):1225-9.
25. Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats. Li X, etal., Pharmacology. 2014;93(1-2):76-83. doi: 10.1159/000358128. Epub 2014 Feb 15.
26. Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinking. Lu CM, etal., Urol Int. 2005;75(4):360-4.
27. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Majumder M, etal., Int J Cancer. 2007 May 15;120(10):2148-56.
28. Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis. Makarova SI, etal., Bull Exp Biol Med. 2005 Jun;139(6):662-4.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis. Nacak M, etal., Int J Dermatol. 2006 Mar;45(3):323-6.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Neri M, etal., Mutat Res. 2005 Dec 30;592(1-2):36-44. Epub 2005 Jul 1.
33. Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine. Ohtani T, etal., Br J Dermatol. 2003 May;148(5):1035-9.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Ozawa S, etal., Int J Cancer. 2002 Dec 1;102(4):418-21.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study. Potts LF, etal., BMC Med Genet. 2012 Mar 17;13:16. doi: 10.1186/1471-2350-13-16.
39. Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma. Prawan A, etal., Eur J Cancer Prev. 2005 Jun;14(3):245-50.
40. Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure. Pronko PS, etal., Pharmacol Toxicol. 2002 Mar;90(3):150-4.
41. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats. Purewal M, etal., Cancer Epidemiol Biomarkers Prev 2000 May;9(5):529-32.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Comprehensive gene review and curation RGD comprehensive gene curation
46. NAT2 acetylator genotypes confer no effect on the risk of developing adult acute leukemia: a case-control study. Rollinson S, etal., Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):567-8.
47. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Rothman N, etal., Nat Genet. 2010 Nov;42(11):978-84. doi: 10.1038/ng.687. Epub 2010 Oct 24.
48. NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus. Sabbagh N, etal., Pharmacogenetics. 1997 Apr;7(2):131-5.
49. CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome. Silveira VS, etal., Mol Cell Biochem. 2012 May;364(1-2):217-23. doi: 10.1007/s11010-011-1220-8. Epub 2012 Jan 4.
50. Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. Sobti RC, etal., DNA Cell Biol. 2009 Sep;28(9):443-9.
51. Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer. Suzuki H, etal., Carcinogenesis. 2008 Jun;29(6):1184-91. Epub 2008 May 21.
52. N-acetyltransferase 2 polymorphisms in patients with Behcet's disease. Tamer L, etal., Clin Exp Dermatol. 2005 Jan;30(1):56-60.
53. N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. Tamer L, etal., Curr Eye Res. 2005 Oct;30(10):835-9.
54. Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma. Tamer L, etal., Tuberk Toraks. 2006;54(2):137-43.
55. Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinoma. Unal M, etal., Head Neck. 2005 Dec;27(12):1056-60.
56. N-acetyltransferase 2 gene polymorphism and presbycusis. Unal M, etal., Laryngoscope. 2005 Dec;115(12):2238-41.
57. [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]. Viktorova TV, etal., Genetika. 2003 Jun;39(6):855-7.
58. Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. von Schmiedeberg S, etal., Adv Exp Med Biol. 1999;455:147-52.
59. Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. Wadelius M, etal., Pharmacogenetics. 2000 Feb;10(1):35-41.
60. Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene. Wakefield L, etal., Mamm Genome. 2007 Apr;18(4):270-6. Epub 2007 May 9.
61. N-acetyltransferase 2 polymorphism in patients with diabetes mellitus. Yalin S, etal., Cell Biochem Funct. 2007 Jul-Aug;25(4):407-11.
62. N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Zanrosso CW, etal., Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3037-43. doi: 10.1158/1055-9965.EPI-10-0508. Epub 2010 Sep 30.
63. Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in Brazil. Zanrosso CW, etal., Leuk Lymphoma. 2012 Feb;53(2):323-7. doi: 10.3109/10428194.2011.619605. Epub 2011 Nov 25.
64. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. Zhang X, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):289-94. Epub 2005 Sep 28.
Additional References at PubMed
PMID:7545952   PMID:7773298   PMID:8528272   PMID:10862519   PMID:12815365   PMID:15081601   PMID:15872051   PMID:17567587   PMID:18799801   PMID:28359264  


Genomics

Comparative Map Data
Nat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81626,974,874 - 27,005,191 (-)NCBIGRCr8
mRatBN7.21622,207,362 - 22,238,513 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1622,208,194 - 22,238,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1625,582,055 - 25,607,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,012,550 - 29,042,472 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01624,947,433 - 24,973,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01623,960,709 - 23,991,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,844,909 - 23,875,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,845,894 - 23,876,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11623,845,891 - 23,876,526 (-)NCBI
Celera1622,342,838 - 22,372,771 (-)NCBICelera
Cytogenetic Map16p14NCBI
NAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38818,386,301 - 18,401,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl818,391,282 - 18,401,218 (+)EnsemblGRCh38hg38GRCh38
GRCh37818,248,792 - 18,258,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36818,293,035 - 18,303,003 (+)NCBINCBI36Build 36hg18NCBI36
Build 34818,293,034 - 18,302,962NCBI
Celera817,214,719 - 17,224,685 (+)NCBICelera
Cytogenetic Map8p22NCBI
HuRef816,793,030 - 16,802,996 (+)NCBIHuRef
CHM1_1818,450,223 - 18,460,188 (+)NCBICHM1_1
T2T-CHM13v2.0818,654,127 - 18,668,742 (+)NCBIT2T-CHM13v2.0
Nat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,947,527 - 67,955,296 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,947,510 - 67,955,236 (+)EnsemblGRCm39 Ensembl
GRCm38867,494,875 - 67,502,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,494,858 - 67,502,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,018,774 - 70,026,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36870,423,937 - 70,431,559 (+)NCBIMGSCv36mm8
Celera870,048,329 - 70,056,034 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.38NCBI
NAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2736,864,493 - 36,879,973 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1812,589,733 - 12,605,213 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0817,606,445 - 17,623,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1814,561,281 - 14,576,669 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl814,575,455 - 14,576,327 (+)Ensemblpanpan1.1panPan2
NAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1816,451,144 - 16,494,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl816,493,749 - 16,494,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605225,767,584 - 25,768,860 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nat2
184 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:115
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000044198
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1
Low 1 41 57 41 19 41 7 9 42 35 37 11 7
Below cutoff 2 1 2 32 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU573978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB919766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB961380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC977175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD018790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U23418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018854   ⟹   ENSRNOP00000018854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,218,220 - 22,238,516 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000044198   ⟹   ENSRNOP00000051430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,555 - 22,238,513 (-)Ensembl
Rnor_6.0 Ensembl1623,961,067 - 23,991,570 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090726   ⟹   ENSRNOP00000070053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,217,885 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097045   ⟹   ENSRNOP00000078955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,327 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098891   ⟹   ENSRNOP00000086542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,217,800 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101421   ⟹   ENSRNOP00000087047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,282 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103383   ⟹   ENSRNOP00000086204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,282 - 22,222,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107612   ⟹   ENSRNOP00000086645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,218,082 - 22,238,520 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112079   ⟹   ENSRNOP00000086070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,208,194 - 22,216,331 (-)Ensembl
RefSeq Acc Id: NM_053854   ⟹   NP_446306
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,975,235 - 27,005,191 (-)NCBI
mRatBN7.21622,208,555 - 22,238,513 (-)NCBI
Rnor_6.01623,961,067 - 23,991,570 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
RGSC_v3.41623,845,894 - 23,876,528 (-)RGD
Celera1622,342,838 - 22,372,771 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253007   ⟹   XP_006253069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,974,874 - 26,984,008 (-)NCBI
mRatBN7.21622,207,362 - 22,217,850 (-)NCBI
Rnor_6.01623,960,709 - 23,970,375 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253008   ⟹   XP_006253070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,974,874 - 27,005,161 (-)NCBI
mRatBN7.21622,207,362 - 22,238,483 (-)NCBI
Rnor_6.01623,960,709 - 23,991,517 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253009   ⟹   XP_006253071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,974,874 - 26,984,008 (-)NCBI
mRatBN7.21622,207,362 - 22,217,850 (-)NCBI
Rnor_6.01623,960,709 - 23,966,609 (-)NCBI
Rnor_5.01623,844,909 - 23,875,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063275038   ⟹   XP_063131108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,974,874 - 27,004,829 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446306 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253069 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253070 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253071 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131108 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA56772 (Get FASTA)   NCBI Sequence Viewer  
  AAA70161 (Get FASTA)   NCBI Sequence Viewer  
  AAB53956 (Get FASTA)   NCBI Sequence Viewer  
  AAB60501 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53276 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53277 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53278 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53279 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53280 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53281 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53282 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53283 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53284 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53285 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53286 (Get FASTA)   NCBI Sequence Viewer  
  AAZ53287 (Get FASTA)   NCBI Sequence Viewer  
  ADD64385 (Get FASTA)   NCBI Sequence Viewer  
  ADD64386 (Get FASTA)   NCBI Sequence Viewer  
  ADD64387 (Get FASTA)   NCBI Sequence Viewer  
  ADD64388 (Get FASTA)   NCBI Sequence Viewer  
  ADD64389 (Get FASTA)   NCBI Sequence Viewer  
  ADD64390 (Get FASTA)   NCBI Sequence Viewer  
  ADD64391 (Get FASTA)   NCBI Sequence Viewer  
  ADD64392 (Get FASTA)   NCBI Sequence Viewer  
  ADD64393 (Get FASTA)   NCBI Sequence Viewer  
  ADD64394 (Get FASTA)   NCBI Sequence Viewer  
  ADD64395 (Get FASTA)   NCBI Sequence Viewer  
  ADD64396 (Get FASTA)   NCBI Sequence Viewer  
  ADD64397 (Get FASTA)   NCBI Sequence Viewer  
  ADD64398 (Get FASTA)   NCBI Sequence Viewer  
  CBF94888 (Get FASTA)   NCBI Sequence Viewer  
  CBG15315 (Get FASTA)   NCBI Sequence Viewer  
  CBV08408 (Get FASTA)   NCBI Sequence Viewer  
  CBV28761 (Get FASTA)   NCBI Sequence Viewer  
  EDL75947 (Get FASTA)   NCBI Sequence Viewer  
  EDL75948 (Get FASTA)   NCBI Sequence Viewer  
  EDL75949 (Get FASTA)   NCBI Sequence Viewer  
  EDL75950 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051430
  ENSRNOP00000051430.1
  ENSRNOP00000078955.1
  ENSRNOP00000086070
  ENSRNOP00000086070.1
  ENSRNOP00000086204
  ENSRNOP00000086204.1
  ENSRNOP00000087047.1
  ENSRNOP00055004934
  ENSRNOP00055004940
  ENSRNOP00055004943
  ENSRNOP00055004944
  ENSRNOP00055004948
  ENSRNOP00060021873
  ENSRNOP00060021881
  ENSRNOP00060021886
  ENSRNOP00060021892
  ENSRNOP00060021894
  ENSRNOP00065005043
  ENSRNOP00065005044
GenBank Protein P50298 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_446306   ⟸   NM_053854
- UniProtKB: P50298 (UniProtKB/Swiss-Prot),   Q45G59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253070   ⟸   XM_006253008
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL),   A6KFK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253069   ⟸   XM_006253007
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL),   A6KFK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253071   ⟸   XM_006253009
- Peptide Label: isoform X1
- UniProtKB: G3V9K9 (UniProtKB/TrEMBL),   A6KFK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051430   ⟸   ENSRNOT00000044198
RefSeq Acc Id: ENSRNOP00000070053   ⟸   ENSRNOT00000090726
RefSeq Acc Id: ENSRNOP00000086645   ⟸   ENSRNOT00000107612
RefSeq Acc Id: ENSRNOP00000086204   ⟸   ENSRNOT00000103383
RefSeq Acc Id: ENSRNOP00000078955   ⟸   ENSRNOT00000097045
RefSeq Acc Id: ENSRNOP00000086070   ⟸   ENSRNOT00000112079
RefSeq Acc Id: ENSRNOP00000086542   ⟸   ENSRNOT00000098891
RefSeq Acc Id: ENSRNOP00000087047   ⟸   ENSRNOT00000101421
RefSeq Acc Id: ENSRNOP00000018854   ⟸   ENSRNOT00000018854
RefSeq Acc Id: XP_063131108   ⟸   XM_063275038
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50298-F1-model_v2 AlphaFold P50298 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700061
Promoter ID:EPDNEW_R10585
Type:multiple initiation site
Name:Nat2_1
Description:N-acetyltransferase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01623,991,528 - 23,991,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70492 AgrOrtholog
BioCyc Gene G2FUF-11677 BioCyc
Ensembl Genes ENSRNOG00000049498 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055004040 UniProtKB/Swiss-Prot
  ENSRNOG00060015924 UniProtKB/Swiss-Prot
  ENSRNOG00065004978 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044198 ENTREZGENE
  ENSRNOT00000044198.2 UniProtKB/TrEMBL
  ENSRNOT00000097045.1 UniProtKB/TrEMBL
  ENSRNOT00000101421.1 UniProtKB/TrEMBL
  ENSRNOT00000103383.1 UniProtKB/TrEMBL
  ENSRNOT00000112079.1 UniProtKB/TrEMBL
  ENSRNOT00055006442 UniProtKB/Swiss-Prot
  ENSRNOT00055006448 UniProtKB/Swiss-Prot
  ENSRNOT00055006452 UniProtKB/Swiss-Prot
  ENSRNOT00055006453 UniProtKB/Swiss-Prot
  ENSRNOT00055006457 UniProtKB/Swiss-Prot
  ENSRNOT00060027262 UniProtKB/Swiss-Prot
  ENSRNOT00060027272 UniProtKB/Swiss-Prot
  ENSRNOT00060027279 UniProtKB/Swiss-Prot
  ENSRNOT00060027288 UniProtKB/Swiss-Prot
  ENSRNOT00060027292 UniProtKB/Swiss-Prot
  ENSRNOT00065007267 UniProtKB/Swiss-Prot
  ENSRNOT00065007268 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116632 ENTREZGENE
PANTHER ARYLAMINE N-ACETYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAT1 RGD
PhenoGen Nat2 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049498 RatGTEx
  ENSRNOG00055004040 RatGTEx
  ENSRNOG00060015924 RatGTEx
  ENSRNOG00065004978 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLT4_RAT UniProtKB/TrEMBL
  A6KFK5 ENTREZGENE, UniProtKB/TrEMBL
  ARY2_RAT UniProtKB/Swiss-Prot
  G3V9K9 ENTREZGENE, UniProtKB/TrEMBL
  P50298 ENTREZGENE
  Q45G59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Nat2  N-acetyltransferase 2  Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-04-23 Nat2  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nat1h  N-acetyltransferase 1h (arylamine N-acetyltransferase)  Name and Symbol changed 629549 APPROVED
2014-04-23 Nat1h  N-acetyltransferase 1h (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Name and Symbol changed 629549 APPROVED
2013-02-27 Nat1h  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat2  N-acetyltransferase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-27 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat1h  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Nat2a  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Nat2  N-acetyltransferase 2  Nat2a  N-acetyltransferase 2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Nat1  N-acetyltransferase 1 (arylamine N-acetyltransferase)  Nat2  N-Acetyltransferase-2 (arylamine N-acetyltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nat2  N-Acetyltransferase-2 (arylamine N-acetyltransferase)    N-Acetyltransferase-2  Name updated 1299863 APPROVED
2002-06-10 Nat2  N-Acetyltransferase-2      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease rapid NAT2 genotype associated with increased colorectal cancer risk 70274
gene_function catalyses conversion of Phip and other heterocyclic amines to DNA reactive form 70274
gene_function catalyses conversion of Phip and other heterocyclic amines to DNA reactive form 70294