Ctse (cathepsin E) - Rat Genome Database

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Gene: Ctse (cathepsin E) Rattus norvegicus
Analyze
Symbol: Ctse
Name: cathepsin E
RGD ID: 2446
Description: Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (cathepsin E); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CEA; CEB; Ctsea
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp327
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,644,168 - 45,666,722 (+)NCBIGRCr8
mRatBN7.21343,091,954 - 43,114,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,092,128 - 43,114,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,695,406 - 45,717,865 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,983,544 - 47,006,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,248,051 - 44,270,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,426,833 - 48,449,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,426,820 - 48,449,490 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,498,965 - 53,521,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,582,911 - 44,605,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,596,953 - 44,619,284 (+)NCBI
Celera1343,430,588 - 43,452,924 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butyric acid  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
furan  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nitrofen  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing. Finzi G, etal., Histochemistry. 1993 Mar;99(3):201-11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues. Nakanishi H, etal., Exp Neurol. 1994 Mar;126(1):119-28.
5. Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E. Okamoto K, etal., Arch Biochem Biophys 1995 Sep 10;322(1):103-11.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia. Sastradipura DF, etal., J Neurochem. 1998 May;70(5):2045-56.
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11. Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells. Tsukuba T, etal., FEBS J. 2006 Jan;273(1):219-29.
Additional References at PubMed
PMID:1601038   PMID:2105725   PMID:7789521   PMID:7983070   PMID:8339772   PMID:8765029   PMID:8809073   PMID:9180269   PMID:11719510   PMID:12204120   PMID:12631277   PMID:15100295  
PMID:15489334   PMID:16997486   PMID:22730688   PMID:23376485   PMID:27116544  


Genomics

Comparative Map Data
Ctse
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,644,168 - 45,666,722 (+)NCBIGRCr8
mRatBN7.21343,091,954 - 43,114,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,092,128 - 43,114,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,695,406 - 45,717,865 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,983,544 - 47,006,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,248,051 - 44,270,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,426,833 - 48,449,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,426,820 - 48,449,490 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,498,965 - 53,521,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,582,911 - 44,605,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,596,953 - 44,619,284 (+)NCBI
Celera1343,430,588 - 43,452,924 (+)NCBICelera
Cytogenetic Map13q13NCBI
CTSE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,009,264 - 206,023,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,008,535 - 206,023,909 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,317,473 - 206,332,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,484,082 - 204,498,727 (+)NCBINCBI36Build 36hg18NCBI36
Celera1179,116,519 - 179,131,198 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,247,760 - 177,262,405 (+)NCBIHuRef
T2T-CHM13v2.01205,273,263 - 205,287,895 (-)NCBIT2T-CHM13v2.0
Ctse
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,566,052 - 131,603,245 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,566,044 - 131,603,243 (+)EnsemblGRCm39 Ensembl
GRCm381131,638,314 - 131,675,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,638,306 - 131,675,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,534,891 - 133,572,084 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,465,860 - 133,503,049 (+)NCBIMGSCv36mm8
Celera1134,250,340 - 134,281,876 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.14NCBI
Ctse
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,641,311 - 41,653,296 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,641,412 - 41,653,261 (-)NCBIChiLan1.0ChiLan1.0
CTSE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2143,346,170 - 43,361,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1143,311,665 - 43,326,899 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,617,421 - 181,632,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,900,746 - 185,915,368 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,900,746 - 185,915,519 (-)Ensemblpanpan1.1panPan2
CTSE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,368,711 - 2,380,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,369,265 - 2,380,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,461,257 - 2,473,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,365,859 - 2,377,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,365,857 - 2,377,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,359,989 - 2,371,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,751,514 - 2,763,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,952,739 - 2,964,581 (-)NCBIUU_Cfam_GSD_1.0
Ctse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,245,473 - 69,258,551 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365576,485,755 - 6,498,833 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365576,485,783 - 6,498,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12523,318,421 - 23,333,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2523,319,248 - 23,332,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605524,017,015 - 24,031,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctse
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248075,291,736 - 5,305,104 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248075,291,993 - 5,306,507 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ctse
191 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:342
Count of miRNA genes:178
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000009241, ENSRNOT00000048391
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat

Markers in Region
RH133382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,114,058 - 43,114,246 (+)MAPPERmRatBN7.2
Rnor_6.01348,449,047 - 48,449,234NCBIRnor6.0
Rnor_5.01353,521,159 - 53,521,346UniSTSRnor5.0
RGSC_v3.41344,604,798 - 44,604,985UniSTSRGSC3.4
Celera1343,452,481 - 43,452,668UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 28 20 19 20 2 4 7
Low 35 29 21 21 7 8 50 33 34 4 7
Below cutoff 2 1 3 24 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009241   ⟹   ENSRNOP00000009242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,092,138 - 43,114,502 (+)Ensembl
Rnor_6.0 Ensembl1348,427,038 - 48,449,490 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048391   ⟹   ENSRNOP00000048353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,092,128 - 43,114,492 (+)Ensembl
Rnor_6.0 Ensembl1348,426,820 - 48,449,463 (+)Ensembl
RefSeq Acc Id: NM_001401267   ⟹   NP_001388196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,644,215 - 45,666,722 (+)NCBI
mRatBN7.21343,091,999 - 43,114,505 (+)NCBI
RefSeq Acc Id: NM_012938   ⟹   NP_037070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,644,215 - 45,666,722 (+)NCBI
mRatBN7.21343,091,999 - 43,114,505 (+)NCBI
Rnor_6.01348,427,038 - 48,449,490 (+)NCBI
Rnor_5.01353,498,965 - 53,521,605 (+)NCBI
RGSC_v3.41344,582,911 - 44,605,241 (+)RGD
Celera1343,430,588 - 43,452,924 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249749   ⟹   XP_006249811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,644,168 - 45,666,722 (+)NCBI
mRatBN7.21343,091,954 - 43,114,509 (+)NCBI
Rnor_6.01348,426,833 - 48,449,493 (+)NCBI
Rnor_5.01353,498,965 - 53,521,605 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037070   ⟸   NM_012938
- Peptide Label: isoform 1 precursor
- UniProtKB: A6IC26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249811   ⟸   XM_006249749
- Peptide Label: isoform X1
- UniProtKB: Q63701 (UniProtKB/Swiss-Prot),   P16228 (UniProtKB/Swiss-Prot),   A6IC25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048353   ⟸   ENSRNOT00000048391
RefSeq Acc Id: ENSRNOP00000009242   ⟸   ENSRNOT00000009241
RefSeq Acc Id: NP_001388196   ⟸   NM_001401267
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P16228 (UniProtKB/Swiss-Prot),   Q63701 (UniProtKB/Swiss-Prot),   A6IC25 (UniProtKB/TrEMBL)
Protein Domains
Aspartic peptidase N-terminal   Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16228-F1-model_v2 AlphaFold P16228 1-398 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698805
Promoter ID:EPDNEW_R9322
Type:initiation region
Name:Ctse_1
Description:cathepsin E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9323  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,426,899 - 48,426,959EPDNEW
RGD ID:13698798
Promoter ID:EPDNEW_R9323
Type:initiation region
Name:Ctse_2
Description:cathepsin E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9322  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,438,388 - 48,438,448EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2446 AgrOrtholog
BioCyc Gene G2FUF-18343 BioCyc
Ensembl Genes ENSRNOG00000006963 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065019437 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009241 ENTREZGENE
  ENSRNOT00000009241.4 UniProtKB/Swiss-Prot
  ENSRNOT00000048391 ENTREZGENE
  ENSRNOT00000048391.5 UniProtKB/Swiss-Prot
  ENSRNOT00065032756 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
  6.10.140.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acid Proteases UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599861 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25424 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72542 IMAGE-MGC_LOAD
NCBI Gene 25424 ENTREZGENE
PANTHER BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED UniProtKB/TrEMBL
  CATHEPSIN E UniProtKB/TrEMBL
  PTHR47966 UniProtKB/Swiss-Prot
  PTHR47966:SF26 UniProtKB/Swiss-Prot
Pfam A1_Propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctse PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006963 RatGTEx
  ENSRNOG00065019437 RatGTEx
Superfamily-SCOP Acid proteases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC206570
UniProt A6IC24_RAT UniProtKB/TrEMBL
  A6IC25 ENTREZGENE, UniProtKB/TrEMBL
  A6IC26 ENTREZGENE, UniProtKB/TrEMBL
  A6IC27_RAT UniProtKB/TrEMBL
  CATE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63701 ENTREZGENE
UniProt Secondary Q63701 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ctse  cathepsin E  Ctsea  Cathepsin E  Symbol and Name updated 625702 APPROVED
2002-06-10 Ctsea  Cathepsin E      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression present in spleen 728265
gene_protein contains two identical subunits with molecular mass of 42 kDa 728265