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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:Reelin signaling pathway
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Accession:PW:0000388 term browser browse the term
Definition:The reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
Synonyms:related_synonym: reelin-mediated signaling pathway
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Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200062 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO PID PID:200062 NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:176,358,904...176,417,646 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200062 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:53,384,656...53,468,067 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO PID PID:200062 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO PID PID:200062 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,978,911...65,989,272 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200062 NCBI chr11:97,033,033...97,067,457
Ensembl chr11:97,024,782...97,067,457 		JBrowse link
G Dab1 DAB adaptor protein 1 TAS
ISO 		PID
RGD		 PMID:12670697 PID:200062, RGD:727518 NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID
RGD		 PMID:12778121 PID:200062, RGD:2324970 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 TAS RGD PMID:18237558 RGD:2325284 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A TAS
ISO 		PID
RGD		 PMID:18237558 PID:200062, RGD:2325284 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B TAS
ISO 		PID
RGD		 PMID:18237558 PID:200062, RGD:2325284 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200062 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901 		JBrowse link
G Itgb1 integrin subunit beta 1 ISO PID
RGD		 PMID:15583703 PID:200062, RGD:2325851 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Lrp8 LDL receptor related protein 8 ISO PID
RGD		 PMID:19846452 PID:200062, RGD:2324974 NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:127,792,299...127,864,207 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO PID PID:200062 NCBI chr14:79,876,002...79,888,011
Ensembl chr14:79,875,708...79,890,034 		JBrowse link
G Map1b microtubule-associated protein 1B ISO PID PID:200062 NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200062 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO PID PID:200062 NCBI chr 1:212,404,685...212,417,986
Ensembl chr 1:212,403,680...212,417,983 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200062 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapt microtubule-associated protein tau ISO PID PID:200062 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200062 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO PID
RGD		 PMID:17330141 PID:200062, RGD:4107040 NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196 		JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:55,156,778...55,208,800
Ensembl chr 8:55,156,779...55,176,836 		JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:90,009,085...90,011,611
Ensembl chr 1:90,009,085...90,011,611 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200062 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID
RGD		 PMID:17167084 PID:200062, RGD:4108507 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200062 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200062 NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119 		JBrowse link
G Reln reelin TAS
ISO 		PID
RGD		 PMID:12670697 PID:200062, RGD:727518 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Vldlr very low density lipoprotein receptor TAS
ISO 		PID
RGD		 PMID:12670697 PID:200062, RGD:727518 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab1 DAB adaptor protein 1 TAS RGD PMID:12670697 RGD:727518 NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:124,369,415...124,742,584 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901 		JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Lrp8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:127,792,299...127,864,207 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr10:60,031,441...60,090,259
Ensembl chr10:60,032,514...60,090,196 		JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:55,156,778...55,208,800
Ensembl chr 8:55,156,779...55,176,836 		JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:90,009,085...90,011,611
Ensembl chr 1:90,009,085...90,011,611 		JBrowse link
G Reln reelin TAS RGD PMID:12670697 RGD:727518 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Vldlr very low density lipoprotein receptor ISS RGD PMID:12764038 RGD:1358468 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway pertinent to the brain and nervous system 466
        Reelin signaling pathway 32
          altered Reelin signaling pathway 11
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      glycoconjugated protein signaling pathway 416
        glycoprotein signaling pathway 300
          Reelin signaling pathway 32
            altered Reelin signaling pathway 11
paths to the root