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ONTOLOGY REPORT - ANNOTATIONS

Term:chronic inflammatory response
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Accession:GO:0002544 term browser browse the term
Definition:Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.


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chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO RGD PMID:20223282 RGD:4891140 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CAMP cathelicidin antimicrobial peptide involved_in IMP (PMID:9182550) UniProt PMID:9182550 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 involved_in ISO
IEA		 RGD
Ensembl		 PMID:10861753 GO_REF:0000107 RGD:4145481 NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:15104336 RGD:11526143 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:17164972 RGD:2307142 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CXCL13 C-X-C motif chemokine ligand 13 involved_in NAS (PMID:15284119) BHF-UCL PMID:15284119 NCBI chr 4:77,511,753...77,611,834
Ensembl chr 4:77,511,753...77,611,834 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:23165424 RGD:7207259 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022 		JBrowse link
G PTGES prostaglandin E synthase ISO RGD PMID:12707354 RGD:2300108 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042 		JBrowse link
G S100A8 S100 calcium binding protein A8 involved_in ISO
IEA		 RGD
Ensembl		 PMID:8343166 GO_REF:0000107 RGD:633930 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073 		JBrowse link
G S100A9 S100 calcium binding protein A9 involved_in ISO
IBA
IEA		 RGD
GO_Central
TreeGrafter		 PMID:8343166 GO_REF:0000033 GO_REF:0000118 RGD:633930 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,845,764...39,051,944
Ensembl chr 3:38,845,764...39,052,157 		JBrowse link
G SPN sialophorin ISO RGD PMID:10486239 RGD:2303982 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEP (PMID:18674744) BHF-UCL PMID:18674744 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:10706728 GO_REF:0000107 RGD:2313132 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VNN1 vanin 1 involved_in IEA
ISS		 (PMID:14966568) Ensembl
BHF-UCL		 PMID:14966568 GO_REF:0000107 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055 		JBrowse link
chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO RGD PMID:11123369 RGD:1598898 NCBI chr20:34,231,981...34,311,836
Ensembl chr20:34,280,268...34,311,802 		JBrowse link
G IL10 interleukin 10 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:12452830) Ensembl
MGI		 PMID:12452830 GO_REF:0000107 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:15050649 RGD:1626679 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:15050649 RGD:1626679 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G ORM1 orosomucoid 1 ISO RGD PMID:16166348 RGD:2316639 NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479 		JBrowse link
G TNF tumor necrosis factor involved_in IMP (PMID:14512626) BHF-UCL PMID:14512626 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
granuloma formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPB CCAAT enhancer binding protein beta involved_in ISS UniProt GO_REF:0000024 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G UNC13D unc-13 homolog D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17420270) Ensembl
MGI		 PMID:17420270 GO_REF:0000107 NCBI chr17:75,827,225...75,844,404
Ensembl chr17:75,827,225...75,844,785 		JBrowse link
negative regulation of chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25447050) Ensembl
MGI		 PMID:25447050 GO_REF:0000107 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384)
(PMID:16769892)		 Ensembl
MGI		 PMID:16275384 PMID:16769892 GO_REF:0000107 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G IL4 interleukin 4 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:16869003 GO_REF:0000118 RGD:2317300 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
negative regulation of chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12452830) Ensembl
MGI		 PMID:12452830 GO_REF:0000107 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
negative regulation of chronic inflammatory response to non-antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:24447880 RGD:9491776 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
positive regulation of chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18436652) Ensembl
MGI		 PMID:18436652 GO_REF:0000107 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790 		JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:19129291 RGD:2314463 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
positive regulation of chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTA lymphotoxin alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9834074) Ensembl
MGI		 PMID:9834074 GO_REF:0000107 NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9834074) Ensembl
MGI		 PMID:9834074 GO_REF:0000107 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
positive regulation of chronic inflammatory response to non-antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16841096) Ensembl
MGI		 PMID:16841096 GO_REF:0000107 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
regulation of chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 involved_in TAS (PMID:10488085) BHF-UCL PMID:10488085 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19670
    response to stimulus 10180
      response to stress 4600
        defense response 2115
          inflammatory response 1040
            chronic inflammatory response 33
              chronic inflammatory response to antigenic stimulus + 7
              chronic inflammatory response to non-antigenic stimulus + 2
              granuloma formation + 2
              negative regulation of chronic inflammatory response + 6
              positive regulation of chronic inflammatory response + 5
              regulation of chronic inflammatory response + 12
paths to the root