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Gene: SCN11A (sodium voltage-gated channel alpha subunit 11) Homo sapiens
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Symbol: SCN11A
Name: sodium voltage-gated channel alpha subunit 11
RGD ID: 1342640
Description: Predicted to have voltage-gated sodium channel activity. Predicted to be involved in several processes, including membrane depolarization during action potential; neuronal action potential; and regulation of sensory perception of pain. Localizes to extracellular exosome. Implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FEPS3; hNaN; HSAN7; NaN; NAV1.9; peripheral nerve sodium channel 5; PN5; SCN12A; sensory neuron sodium channel 2; SNS-2; sodium channel protein type 11 subunit alpha; sodium channel protein type XI subunit alpha; sodium channel, voltage gated, type XI alpha subunit; sodium channel, voltage-gated, type xi, alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha; sodium channel, voltage-gated, type XII, alpha polypeptide; voltage-gated sodium channel Nav1.9; voltage-gated sodium channel subunit alpha Nav1.9
Orthologs:
Mus musculus (house mouse) : Scn11a (sodium channel, voltage-gated, type XI, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Scn11a (sodium voltage-gated channel alpha subunit 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn11a (sodium voltage-gated channel alpha subunit 11)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN11A (sodium voltage-gated channel alpha subunit 11)
Canis lupus familiaris (dog) : SCN11A (sodium voltage-gated channel alpha subunit 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn11a (sodium voltage-gated channel alpha subunit 11)
Sus scrofa (pig) : SCN11A (sodium voltage-gated channel alpha subunit 11)
Chlorocebus sabaeus (African green monkey) : SCN11A (sodium voltage-gated channel alpha subunit 11)
Heterocephalus glaber (naked mole-rat) : Scn11a (sodium voltage-gated channel alpha subunit 11)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,845,764 - 39,052,157 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl338,845,767 - 39,051,941 (-)EnsemblGRCh38hg38GRCh38
GRCh38338,845,764 - 39,051,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,887,260 - 38,995,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,862,264 - 38,967,056 (-)NCBINCBI36hg18NCBI36
Build 34338,862,263 - 38,967,056NCBI
Celera338,826,267 - 38,932,035 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,929,417 - 39,033,960 (-)NCBIHuRef
CHM1_1338,838,871 - 38,946,272 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SCN11A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1342640
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.