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ONTOLOGY REPORT - ANNOTATIONS

Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   mitochondrion outer membrane permeabilization involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death


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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F involved_in ISO
ISS		 (PMID:26387735)
GO_REF:0000024		 RGD
UniProt		 PMID:26387735 GO_REF:0000024 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin involved_in IMP
IEA		 PMID:26387735
GO_REF:0000107		 Ensembl PMID:26387735 GO_REF:0000107, RGD:13441202 NCBI chr19:51,117,088...51,151,228
Ensembl chr19:51,117,057...51,150,484 		JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1929260 (PMID:20436477)		 Ensembl
RGD		 PMID:20436477 GO_REF:0000107 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
IEA
ISS		 (PMID:18188704)
GO_REF:0000107		 RGD
Ensembl		 PMID:18188704 PMID:18188704 GO_REF:0000107, RGD:8553738 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IBA		 (PMID:18371312)
GO_REF:0000033		 RGD
GO_Central		 PMID:18371312 GO_REF:0000033 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (PMID:11700312) RGD PMID:11700312 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793 		JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) RGD PMID:12482879 NCBI chr10:65,198,700...65,262,807
Ensembl chr10:65,170,560...65,262,804 		JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12482879)		 UniProt
RGD		 PMID:12482879 GO_REF:0000024 NCBI chr10:14,858,954...14,864,751
Ensembl chr10:14,858,956...14,864,751 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO
ISS		 (PMID:31015432)
GO_REF:0000024		 RGD
UniProt		 PMID:31015432 GO_REF:0000024 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:18371312)		 Ensembl
UniProt
RGD		 PMID:18371312 GO_REF:0000024 GO_REF:0000107 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:15901672) RGD PMID:15901672 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15901672), (PMID:9393856)
GO_REF:0000114		 RGD
ComplexPortal		 PMID:9393856 PMID:15901672 GO_REF:0000114 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (PMID:15288121) RGD PMID:15288121 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:19096392) RGD PMID:19096392 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649 		JBrowse link
G Slc25a31 solute carrier family 25 member 31 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:19154410)		 UniProt
GO_Central
RGD		 PMID:19154410 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc35f6 solute carrier family 35, member F6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19154410)		 UniProt
RGD		 PMID:19154410 GO_REF:0000024 NCBI chr 6:25,725,822...25,737,720
Ensembl chr 6:25,725,819...25,737,730 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) RGD PMID:21723035 NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463 		JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS
IEA		 (PMID:22304920)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22304920 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1197519 (PMID:15967824) RGD PMID:15967824 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:99702 (PMID:15967824) RGD PMID:15967824 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Stpg1 sperm-tail PG-rich repeat containing 1 involved_in ISO
IBA		 (PMID:23028632)
GO_REF:0000033		 RGD
GO_Central		 PMID:23028632 GO_REF:0000033 NCBI chr 5:147,717,084...147,769,792
Ensembl chr 5:147,726,646...147,769,788 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) RGD PMID:19096392 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5796067|PMID:26949185)		 UniProt
RGD		 PMID:26949185 GO_REF:0000024 MGI:5796067 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) RGD PMID:26666268 PMID:30092269 NCBI chr20:12,725,839...12,727,638
Ensembl chr20:12,725,842...12,732,763 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5514334|PMID:16543145)		 UniProt
Ensembl
RGD		 PMID:16543145 GO_REF:0000024 GO_REF:0000107 MGI:5514334 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:5514334|PMID:16543145)		 UniProt
RGD		 PMID:16543145 GO_REF:0000024 MGI:5514334 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO UniProtKB:Q9HD36 (PMID:19255499) RGD PMID:19255499 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18591963) RGD PMID:18591963 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) RGD PMID:17828305 NCBI chr10:54,523,901...54,525,997
Ensembl chr10:54,523,585...54,525,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      cell death 2157
        programmed cell death 2157
          mitochondrial outer membrane permeabilization involved in programmed cell death 40
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 38
Path 2
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      cellular component organization or biogenesis 6956
        cellular component organization 6692
          organelle organization 3681
            mitochondrion organization 544
              mitochondrial membrane organization 116
                regulation of mitochondrial membrane permeability 59
                  positive regulation of mitochondrial membrane permeability 43
                    mitochondrial outer membrane permeabilization involved in programmed cell death 40
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 38
paths to the root