Slc35f6 (solute carrier family 35, member F6)

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Gene: Slc35f6 (solute carrier family 35, member F6) Rattus norvegicus

Analyze

Symbol:

Slc35f6

Name:

solute carrier family 35, member F6

RGD ID:

1309228

Description:

Predicted to enable transmembrane transporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Predicted to be located in several cellular components, including lysosomal membrane; mitochondrion; and nucleoplasm. Predicted to be active in intracellular membrane-bounded organelle and membrane. Orthologous to human SLC35F6 (solute carrier family 35 member F6); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ANT2-binding protein; ANT2BP; LOC298851; RGD1309228; similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415); solute carrier family 35 member F6; transmembrane protein C2orf18 homolog; transport and Golgi organization 9 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC35F6 (solute carrier family 35 member F6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc35f6 (solute carrier family 35, member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc35f6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC35F6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC35F6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc35f6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC35F6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC35F6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc35f6 (solute carrier family 35 member F6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC35F6 (solute carrier family 35 member F6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc35f6 (solute carrier family 35, member F6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc35f6 (solute carrier family 35 member F6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C29H12.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tango9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	25,725,822 - 25,737,720 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,725,819 - 25,737,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	26,018,501 - 26,030,325 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,334,378 - 26,346,202 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,814,017 - 25,825,856 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	27,095,144 - 27,106,982 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	27,095,141 - 27,107,030 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,910,710 - 36,922,612 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,708,502 - 25,720,340 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,711,455 - 25,723,293 (-)	NCBI
Celera	6	25,209,088 - 25,220,923 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Tatton-Brown-Rahman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

atrazine (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

fipronil (EXP)

folic acid (ISO)

gentamycin (EXP)

methimazole (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (EXP)

phenylmercury acetate (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ISO,ISS)

positive regulation of cell population proliferation (ISO,ISS)

transmembrane transport (IEA)

Cellular Component

cytosol (IEA,ISO)

intracellular membrane-bounded organelle (IBA,ISO)

lysosomal membrane (ISO,ISS)

lysosome (ISO)

membrane (IBA,IEA)

mitochondrion (ISO,ISS)

nucleoplasm (IEA,ISO)

Molecular Function

protein binding (ISO)

transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16367739	PMID:17897319	PMID:19056867	PMID:19154410	PMID:20957757	PMID:23376485

Genomics

Comparative Map Data

Slc35f6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	25,725,822 - 25,737,720 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,725,819 - 25,737,730 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	26,018,501 - 26,030,325 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	26,334,378 - 26,346,202 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,814,017 - 25,825,856 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	27,095,144 - 27,106,982 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	27,095,141 - 27,107,030 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,910,710 - 36,922,612 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	25,708,502 - 25,720,340 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	25,711,455 - 25,723,293 (-)	NCBI
Celera	6	25,209,088 - 25,220,923 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

SLC35F6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	26,764,284 - 26,781,231 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	26,764,284 - 26,781,231 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	26,987,152 - 27,004,099 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	26,840,646 - 26,857,603 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	26,898,798 - 26,914,715	NCBI
Celera	2	26,833,199 - 26,850,160 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	26,728,866 - 26,745,828 (+)	NCBI		HuRef
CHM1_1	2	26,916,870 - 26,933,831 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	26,805,872 - 26,822,820 (+)	NCBI		T2T-CHM13v2.0

Slc35f6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	30,805,272 - 30,817,073 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	30,805,277 - 30,817,073 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,647,939 - 30,659,729 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,647,933 - 30,659,729 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	30,950,312 - 30,962,102 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	30,924,544 - 30,936,310 (+)	NCBI		MGSCv36	mm8
Celera	5	28,126,432 - 28,138,222 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	16.74	NCBI

Slc35f6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	8,773,989 - 8,787,549 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	8,774,225 - 8,787,549 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC35F6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2A	99,737,570 - 99,755,558 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	26,762,690 - 26,780,492 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	26,854,078 - 26,871,820 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	26,854,078 - 26,871,820 (+)	Ensembl	panpan1.1		panPan2

SLC35F6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	20,793,821 - 20,807,987 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	20,793,964 - 20,806,775 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	20,687,739 - 20,714,321 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,115,081 - 21,141,661 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,115,127 - 21,131,879 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	20,801,940 - 20,828,509 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	20,813,289 - 20,839,902 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	20,859,303 - 20,885,884 (+)	NCBI		UU_Cfam_GSD_1.0

Slc35f6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,092,294 - 65,108,035 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,731,058 - 5,760,987 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936493	5,731,106 - 5,747,270 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC35F6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	112,280,661 - 112,296,865 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	112,280,654 - 112,296,874 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	119,279,988 - 119,296,212 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC35F6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,853,736 - 80,869,946 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,850,555 - 80,869,894 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	31,275,651 - 31,291,136 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc35f6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	8,875,438 - 8,888,571 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	8,875,717 - 8,890,439 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc35f6
24 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	793
Count of miRNA genes:	288
Interacting mature miRNAs:	372
Transcripts:	ENSRNOT00000012558
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat

Markers in Region

RH134259

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	25,725,852 - 25,726,035 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	27,095,172 - 27,095,354	NCBI	Rnor6.0
Rnor_5.0	6	36,910,741 - 36,910,923	UniSTS	Rnor5.0
RGSC_v3.4	6	25,708,530 - 25,708,712	UniSTS	RGSC3.4
Celera	6	25,209,116 - 25,209,298	UniSTS
RH 3.4 Map	6	95.6	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	29	29	7	29			73	25	41	9
Low		17	28	12	12	12	8	11	1	10		2	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012558 ⟹ ENSRNOP00000012558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,725,819 - 25,737,730 (-)	Ensembl
Rnor_6.0 Ensembl	6	27,095,141 - 27,107,030 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095130 ⟹ ENSRNOP00000082156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,726,874 - 25,737,692 (-)	Ensembl

RefSeq Acc Id:

NM_001017451 ⟹ NP_001017451

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	25,725,825 - 25,737,664 (-)	NCBI
Rnor_6.0	6	27,095,144 - 27,106,982 (-)	NCBI
Rnor_5.0	6	36,910,710 - 36,922,612 (-)	NCBI
RGSC_v3.4	6	25,708,502 - 25,720,340 (-)	RGD
Celera	6	25,209,088 - 25,220,923 (-)	RGD

Sequence:

show sequence

CTGGTTTAGGTGGTCTCCGGTGTCCACCACTATGGCCTGGACAAAGTACCAGTTGTTCCTGGCC
GGGCTCATGCTGGTCACCGGCTCCATCAACACGCTTTCAGCAAAGTGGGCGGACAACTTCGAAG
CTGAGGGCTGTGGAGGAAGCCAGGAGCACAGCTTCAAGCATCCCTTCGTCCAGGCAGTGGGCAT
GTTCCTGGGAGAGTTCTCGTGCCTTGCTGCCTTCTACCTGCTCAAATGCCGAGCCAGAAGACAA
TCAGACTCCAGTGTAGAGCCCCGGCAGCCCTTCAACGCCCTACTTTTCCTGCCCCCAGCCCTAT
GTGACATGACTGGGACTAGCATCATGTATGTGGCCCTGAACATGACCAGTGCCTCAAGCTTCCA
GATGCTGCGGGGTGCAGTGATCATCTTCACAGGCCTGTTCTCAGTGGCCTTCCTGGACCGGAGG
CTGGTACCAAGCCAGTGGCTGGGCATCCTGATCACTATTGCGGGACTGGTGGTCGTTGGCCTGG
CTGACCTCCTGAGCAAGCATGACAGTCAACACAAGCTCAGTGAAGTAATCACAGGTGACTTGTT
GATCATCATGGCCCAGATCATCATTGCCATCCAGATGGTGCTAGAGGAGAAGTTTGTCTACAAA
CACAACATCCACCCACTCCAGGCAGTGGGCATCGAGGGCTTCTTCGGCTTTGTGATCCTCTCCC
TACTGCTGGTGCCCATGTACTACATCCCCACTGCCTCCTTTAGTGGCAACCCTCGTGGGGTGCT
GGAAGACGCTCTGGATGCCTTCTGCCAGGTGGGCCGGCAGCCCCTGATCGCCCTGGCTCTGCTG
GGTAACATCAGCAGCATTGCCTTCTTCAACTTTTCGGGGATCAGTGTCACCAAGGAACTGAGTG
CCACCACCCGCATGGTACTAGACACCCTGCGCACCGTGGTCATCTGGGCCTTCACCCTCGCACT
GGGCTGGGAGGTCTTCCATCCACTGCAGATCCTTGGTTTCCTCATCCTCCTTATGGGCACCGCC
CTGTACAACGGGCTGCACCGACCACTGCTAGCCTGCCTGTCCAGACGCTGGCGACACCCTACCC
AGGAGGGAGAGCAAGAGAGACTGCTGGGTGACAGCCGGACTCCCATCAATGAGACCAGCTGAGC
TGCAGTGGGATCTCTATTGCCACCAGATGGCTGAGGCCATGCAGACCGGTGGGCTGTGAGTGCC
CTGTCCCAAGGCCTCACCCCACCCATCCCTACTGACCCCACTGCACAGTTGCTGCTGGAGAGGA
TGGGAGGACACCAGGTCCTGCTTTATTCCTGAGGCCTGAAATATTGGGACCCAGCCCCCACAGG
CTCAGCTATGGCAACCACTCTCAGCCTCCCAGTTCTGCTGCACTAGAACAAAATTGCGAACTTG
AATGGCAAGAAATTACAACCCTAGTATTTCTGTTACACACTAACTTGTGGTAGAATATCTAGCT
TCTGAACTGTAAGCTACAGAGAAGTCAGCTAACAGGTTCAAACCAGAACTAAGAGACTATTCTG
CAAAGCCTGTCTAAAAACCTGGTTTCTGGCTCAGCTGCAGGCTCTGTGCGTGCCCAGGTCTGTG
CTTTGCAGCACAGGTGTATATAATGTGTCCTTGGTGCCTTGCAGCCCCAGCATCCTGTGGGCCT
CTGATTGTCACTGGTATGAGAAAAGAGTTGCACACCAGTATTCCTCCTCCCCATGGTGGGCTCT
TTGATATTTTTATTTTGGTTTGGCTTGGGGTTTTTGCCATTACATGGCCCTGGCTATCCTGAAA
CTCATGATGTAGACCAGGCTAACCTCAAACTCACAGAGATTCACCTACTACTTCCTCAGTGCGG
ATTAAAAGTGTACATCTTCATGCCCAACACCTCCTTGATGTTTTGATGTTCTGTTCTTCAGACC
CCAAGGCCTCTCTGCCTGGGGCATTCCTGGCAGCCCTTGGAAATCACTTCACAAACTTGTTTTG
TTTTCTTTTGTTTTGTTTGAAACGAAAGTCTTATTGTGTAGCACCAGCATTCAACTTCCTATTC
AACTTCCTCACACTCAGCCTTCCTGCCTCACCCTCCCAAGTGCTGAGAGACTGGAATGCGAAGC
ACTGCCCAGAAAAGCTTCCATTTTAAACTAAGGAGACCAAAGCCTGTTGGCAAGAGGGATCTGT
GCTTACTGCCGGCTTGGGCCAAAGACCTGAGAGGCCTCTATATCCGAAGCTCCATGACTGTTAG
AGAGACCTAGAGCCAGTGTGGCCCCACTCCCAGTAATCCAGACCCATAATGTCCACAGGATGAC
ATACTTACCAGGGGTCTTCCTTAGTGGGTAAGCTGGCATCCCCAGCACTGGGTTAAATGCTTCA
TCCTCACTCCCTCTCATGATATCTGCAAAGGGAAAAGCCAAGGCACTCCCAGGAGGCAAAGTGA
GGCACGCACAGAACCAGTGTCCCAACCAGCCACGTGTGGCCCACTGCTATACAGGTCTCTGTGG
GCCTTTGGGGTGGCTTTCTATGACTGGGCTAAAAAAACTAATATTGTTACCCTGCAGATGCTCT
CACTCTCGGTAGAAGAAAGGCAGCAGGAAGGAGCCCTGGGGCCCTGGCCGCCCTTAATTACATA
CAGCCTTGCCTGTGGGGATGTTTTAAGTGGGGATGTCCTAAGTGGCAGTTCAATAGTAAACACT
AACAGCTTTCTTTGTGAGGGGAAGGGGCCTTGATTAGCAAAGCCCTTGCATTTGACTCCAACAG
ATTCTAATGGTGTGTCAAGGAAGGAAACTTCCTTTCTGTTAGCTCGGAGTCCCAGAGCCCCAAG
CTTCTCTGGACTACAGTCTGTCACAGGGAGAAGTAAATGGGAATTCTGTGCCTATTTACTCAAG
GTGACAGAAAGTGGCAGCTGTCTTGTACAAAAATAAAAACCAGGGCCCTAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111916 ⟹ XP_038967844

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	25,725,822 - 25,737,720 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017451	(Get FASTA)	NCBI Sequence Viewer
	XP_038967844	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85904	(Get FASTA)	NCBI Sequence Viewer
	EDM02984	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012558
	ENSRNOP00000082156.1
GenBank Protein	Q5RKH7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001017451 ⟸ NM_001017451
- Peptide Label:	precursor
- UniProtKB:	Q5RKH7 (UniProtKB/Swiss-Prot), A6HAC9 (UniProtKB/TrEMBL), A0A8I5ZTZ0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAWTKYQLFLAGLMLVTGSINTLSAKWADNFEAEGCGGSQEHSFKHPFVQAVGMFLGEFSCLAA FYLLKCRARRQSDSSVEPRQPFNALLFLPPALCDMTGTSIMYVALNMTSASSFQMLRGAVIIFT GLFSVAFLDRRLVPSQWLGILITIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIIAI QMVLEEKFVYKHNIHPLQAVGIEGFFGFVILSLLLVPMYYIPTASFSGNPRGVLEDALDAFCQV GRQPLIALALLGNISSIAFFNFSGISVTKELSATTRMVLDTLRTVVIWAFTLALGWEVFHPLQI LGFLILLMGTALYNGLHRPLLACLSRRWRHPTQEGEQERLLGDSRTPINETS hide sequence

RefSeq Acc Id:

ENSRNOP00000012558 ⟸ ENSRNOT00000012558

RefSeq Acc Id:	XP_038967844 ⟸ XM_039111916
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000082156 ⟸ ENSRNOT00000095130

Protein Domains

EamA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RKH7-F1-model_v2	AlphaFold	Q5RKH7	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694463

Promoter ID:

EPDNEW_R4986

Type:

initiation region

Name:

Slc35f6_1

Description:

solute carrier family 35, member F6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	27,107,024 - 27,107,084	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309228	AgrOrtholog
BioCyc Gene	G2FUF-38313	BioCyc
Ensembl Genes	ENSRNOG00000009459	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012558	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000095130.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.3730.20	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7193745	IMAGE-MGC_LOAD
InterPro	SLC35_F1/F2/F6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UCP036436	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:298851	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94739	IMAGE-MGC_LOAD
NCBI Gene	298851	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 35 MEMBER F6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SLC35F	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc35f6	PhenoGen
PIRSF	UCP036436	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009459	RatGTEx
Superfamily-SCOP	Multidrug resistance efflux transporter EmrE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZTZ0	ENTREZGENE, UniProtKB/TrEMBL
	A6HAC9	ENTREZGENE, UniProtKB/TrEMBL
	Q5RKH7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-18	Slc35f6	solute carrier family 35, member F6	RGD1309228	similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1309228	similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415)	RGD1309228_predicted	similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309228_predicted	similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415) (predicted)	LOC298851_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC298851_predicted	similar to putative protein, with at least 9 transmembrane domains, of eukaryotic origin (43.9 kD) (2G415) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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