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ONTOLOGY REPORT - ANNOTATIONS

Term:apoptotic mitochondrial changes
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Accession:GO:0008637 term browser browse the term
Definition:The morphological and physiological alterations undergone by mitochondria during apoptosis.
Comment:This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.

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apoptotic mitochondrial changes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm2 AIF family member 2 acts_upstream_of_or_within ISO (PMID:11980907) MGI PMID:11980907 NCBI chrNW_004955437:21,111,298...21,126,487
Ensembl chrNW_004955437:21,110,798...21,126,482 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 acts_upstream_of_or_within ISO (PMID:12869584) MGI PMID:12869584 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:30131474 RGD:15036798 NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO (PMID:19061639) BHF-UCL PMID:19061639 NCBI chrNW_004955493:6,559,995...6,578,461
Ensembl chrNW_004955493:6,559,995...6,578,461 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 ISO (PMID:9843949)
(PMID:12925707)		 HGNC-UCL
MGI		 PMID:9843949 PMID:12925707 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bcl2 BCL2 apoptosis regulator acts_upstream_of_or_within ISO (PMID:14707049) MGI PMID:14707049 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Bik BCL2 interacting killer acts_upstream_of_or_within ISO (PMID:9525867) MGI PMID:9525867 NCBI chrNW_004955413:28,277,727...28,294,032 JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO (PMID:14707049) MGI PMID:14707049 NCBI chrNW_004955411:32,270,881...32,275,236
Ensembl chrNW_004955411:32,270,881...32,275,236 		JBrowse link
G Dap3 death associated protein 3 acts_upstream_of_or_within ISO (PMID:11017876) MGI PMID:11017876 NCBI chrNW_004955545:1,951,008...1,981,174
Ensembl chrNW_004955545:1,951,150...1,980,861 		JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 homolog acts_upstream_of_or_within ISO (PMID:38693257) MGI PMID:38693257 NCBI chrNW_004955494:3,722,359...3,730,217
Ensembl chrNW_004955494:3,722,519...3,728,622 		JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384 		JBrowse link
G Hk2 hexokinase 2 acts_upstream_of_or_within ISO (PMID:18350175) MGI PMID:18350175 NCBI chrNW_004955424:10,897,528...10,966,025
Ensembl chrNW_004955424:10,897,485...10,966,025 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:21854881 RGD:10402841 NCBI chrNW_004955403:3,062,724...3,073,419
Ensembl chrNW_004955403:3,063,133...3,073,419 		JBrowse link
G Jtb jumping translocation breakpoint acts_upstream_of_or_within ISO (PMID:17369841) MGI PMID:17369841 NCBI chrNW_004955545:569,473...571,725
Ensembl chrNW_004955545:569,473...571,725 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 acts_upstream_of_or_within ISO (PMID:15882989) MGI PMID:15882989 NCBI chrNW_004955446:11,022,091...11,090,136
Ensembl chrNW_004955446:11,021,971...11,090,136 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:12869584) MGI PMID:12869584 NCBI chrNW_004955543:444,314...449,201
Ensembl chrNW_004955543:444,314...449,201 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO (PMID:18350175) MGI PMID:18350175 NCBI chrNW_004955437:13,295,766...13,301,918
Ensembl chrNW_004955437:13,295,663...13,302,175 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of_or_within ISO (PMID:16717086) MGI PMID:16717086 NCBI chrNW_004955463:7,229,717...7,249,490
Ensembl chrNW_004955463:7,226,912...7,249,490 		JBrowse link
G Rnf7 ring finger protein 7 acts_upstream_of_or_within ISO (PMID:10082581) MGI PMID:10082581 NCBI chrNW_004955508:4,001,441...4,003,518 JBrowse link
G Slc25a4 solute carrier family 25 member 4 acts_upstream_of_or_within ISO (PMID:18350175) MGI PMID:18350175 NCBI chrNW_004955403:23,878,329...23,882,322
Ensembl chrNW_004955403:23,878,329...23,882,322 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO (PMID:11226230) MGI PMID:11226230 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
mitochondrial fragmentation involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg3 autophagy related 3 involved_in ISO (PMID:20723759) UniProt PMID:20723759 NCBI chrNW_004955427:12,881,454...12,906,399 JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:12499352) HGNC-UCL PMID:12499352 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) BHF-UCL PMID:20436456 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099 		JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:15824730) UniProt PMID:15824730 NCBI chrNW_004955403:46,027,997...46,042,154
Ensembl chrNW_004955403:46,027,998...46,042,154 		JBrowse link
G Dnm1l dynamin 1 like involved_in ISO (PMID:12499352) RGD
HGNC-UCL		 PMID:12499352 PMID:17443673 RGD:12738363 NCBI chrNW_004955505:3,025,742...3,081,491
Ensembl chrNW_004955505:3,023,018...3,081,680 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in ISO (PMID:16778220) UniProt PMID:16778220 NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO RGD PMID:18940801 RGD:2314538 NCBI chrNW_004955456:16,057,158...16,060,623
Ensembl chrNW_004955456:16,038,221...16,060,623 		JBrowse link
G Nptx1 neuronal pentraxin 1 ISO RGD PMID:22279230 RGD:6903322 NCBI chrNW_004955506:2,447,429...2,456,612
Ensembl chrNW_004955506:2,447,109...2,456,965 		JBrowse link
G Ppp2r2b protein phosphatase 2 regulatory subunit Bbeta ISO RGD PMID:18940801 RGD:2314538 NCBI chrNW_004955415:7,054,296...7,510,179
Ensembl chrNW_004955415:7,090,671...7,511,995 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:28761318 RGD:13432138 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26618722) ParkinsonsUK-UCL PMID:26618722 NCBI chrNW_004955448:207,582...240,264
Ensembl chrNW_004955448:204,991...240,160 		JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO (PMID:20436477) MGI PMID:20436477 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in ISO (PMID:18188704) UniProt PMID:18188704 NCBI chrNW_004955507:6,138,511...6,144,823
Ensembl chrNW_004955507:6,138,071...6,144,823 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (PMID:11700312) MGI PMID:11700312 NCBI chrNW_004955445:10,368,869...10,520,246
Ensembl chrNW_004955445:10,369,514...10,603,953 		JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004955481:7,149,836...7,199,296
Ensembl chrNW_004955481:7,149,241...7,199,296 		JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004955442:16,528,886...16,534,856 JBrowse link
G Vdac2 voltage dependent anion channel 2 involved_in ISO (PMID:31015432) UniProt PMID:31015432 NCBI chrNW_004955437:16,857,715...16,871,717
Ensembl chrNW_004955437:16,853,433...16,872,345 		JBrowse link
negative regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO (PMID:18371312) BHF-UCL PMID:18371312 NCBI chrNW_004955402:34,857,317...34,885,169
Ensembl chrNW_004955402:34,857,317...34,885,169 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:17980495 RGD:11561965 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099 		JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO (PMID:24312627) UniProt PMID:24312627 NCBI chrNW_004955484:9,443,090...9,447,142
Ensembl chrNW_004955484:9,443,090...9,447,095 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 ISO RGD PMID:22564366 RGD:9681467 NCBI chrNW_004955403:23,878,329...23,882,322
Ensembl chrNW_004955403:23,878,329...23,882,322 		JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chrNW_004955402:34,857,317...34,885,169
Ensembl chrNW_004955402:34,857,317...34,885,169 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:15901672) ComplexPortal PMID:15901672 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (PMID:27098698) UniProt PMID:27098698 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004955583:730,353...731,301
Ensembl chrNW_004955583:730,289...731,260 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:269,382...313,056
Ensembl chrNW_004955442:238,597...283,328 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chrNW_004955534:497,518...500,309
Ensembl chrNW_004955534:496,933...510,934 		JBrowse link
G Slc35f6 solute carrier family 35 member F6 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chrNW_004955469:8,774,225...8,787,549
Ensembl chrNW_004955469:8,773,989...8,787,549 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) UniProt PMID:21723035 NCBI chrNW_004955411:5,372,713...5,380,033
Ensembl chrNW_004955411:5,373,251...5,379,767 		JBrowse link
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:18977203) UniProt PMID:18977203 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:15901672) ComplexPortal PMID:15901672 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174 		JBrowse link
G Fxn frataxin involved_in ISO (PMID:16608849) UniProt PMID:16608849 NCBI chrNW_004955434:3,983,225...4,008,324
Ensembl chrNW_004955434:3,980,653...4,008,761 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein involved_in ISO (PMID:18417609) FlyBase PMID:18417609 NCBI chrNW_004955510:3,674,303...3,688,747
Ensembl chrNW_004955510:3,674,303...3,689,449 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in ISO (PMID:12221075) BHF-UCL PMID:12221075 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G Hgf hepatocyte growth factor involved_in ISO (PMID:20655899) BHF-UCL PMID:20655899 NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family member 1A acts_upstream_of_or_within ISO (PMID:21856340) MGI PMID:21856340 NCBI chrNW_004955420:28,040,320...28,050,723
Ensembl chrNW_004955420:28,045,410...28,049,758 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in ISO (PMID:18977203) UniProt PMID:18977203 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Lmna lamin A/C acts_upstream_of_or_within ISO (PMID:21151901) MGI PMID:21151901 NCBI chrNW_004955545:2,290,076...2,310,982
Ensembl chrNW_004955545:2,290,037...2,313,033 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:18006463 RGD:12738362 NCBI chrNW_004955486:1,937,873...1,962,577
Ensembl chrNW_004955486:1,937,802...1,962,772 		JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO PMID:10590251
(PMID:15004034)		 UniProt PMID:10590251 PMID:15004034 RGD:10047155 NCBI chrNW_004955484:9,443,090...9,447,142
Ensembl chrNW_004955484:9,443,090...9,447,095 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:21149567)
(PMID:16839884)		 UniProt PMID:16839884 PMID:21149567 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chrNW_004955442:13,087,082...13,097,048
Ensembl chrNW_004955442:13,087,092...13,097,048 		JBrowse link
G Parl presenilin associated rhomboid like involved_in ISO (PMID:16839884) UniProt PMID:16839884 NCBI chrNW_004955420:23,549,125...23,581,782
Ensembl chrNW_004955420:23,548,672...23,582,137 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISO (PMID:19228691) UniProt PMID:19228691 NCBI chrNW_004955437:13,295,766...13,301,918
Ensembl chrNW_004955437:13,295,663...13,302,175 		JBrowse link
G Prelid1 PRELI domain containing 1 involved_in ISO (PMID:23931759) UniProt PMID:23931759 NCBI chrNW_004955408:29,551,253...29,554,778
Ensembl chrNW_004955408:29,551,424...29,554,436 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:19880420), (PMID:23453807) BHF-UCL PMID:19880420 PMID:23453807 NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 involved_in ISO (PMID:19729910) UniProt PMID:19729910 NCBI chrNW_004955490:7,825,202...7,832,347
Ensembl chrNW_004955490:7,825,251...7,833,772 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO (PMID:23931759) UniProt PMID:23931759 NCBI chrNW_004955455:11,195,399...11,198,402
Ensembl chrNW_004955455:11,195,399...11,198,402 		JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO (PMID:22304920) UniProt PMID:22304920 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (PMID:15967824) MGI PMID:15967824 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bcl2l11 BCL2 like 11 acts_upstream_of_or_within ISO (PMID:15967824) MGI PMID:15967824 NCBI chrNW_004955470:2,740,682...2,780,225 JBrowse link
G Bid BH3 interacting domain death agonist ISO RGD PMID:17893612 RGD:408346749 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Stpg1 sperm tail PG-rich repeat containing 1 involved_in ISO (PMID:23028632) UniProt PMID:23028632 NCBI chrNW_004955452:4,163,343...4,210,698
Ensembl chrNW_004955452:4,163,293...4,209,514 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004955452:7,372,917...7,375,072
Ensembl chrNW_004955452:7,373,001...7,375,856 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (PMID:26949185) UniProt PMID:26949185 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) UniProt PMID:26666268 PMID:30092269 NCBI chrNW_004955455:8,472,833...8,474,745
Ensembl chrNW_004955455:8,472,833...8,479,129 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:16543145) UniProt PMID:16543145 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (PMID:16543145) UniProt PMID:16543145 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:19255499) ParkinsonsUK-UCL PMID:19255499 NCBI chrNW_004955482:5,885,807...5,896,386
Ensembl chrNW_004955482:5,884,839...5,896,389 		JBrowse link
G Siva1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chrNW_004955538:3,197,983...3,202,782 JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:14,242,239...14,249,276
Ensembl chrNW_004955442:14,242,423...14,249,309 		JBrowse link
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death involved_in ISO (PMID:17289999) UniProt PMID:17289999 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:12485416 RGD:2317097 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:21262771)
(PMID:14963330)		 UniProt PMID:14963330 PMID:21262771 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004955574:1,167,790...1,174,966
Ensembl chrNW_004955574:1,167,242...1,174,966 		JBrowse link
G Bcl2l11 BCL2 like 11 involved_in ISO (PMID:17289999)
(PMID:21041309)		 UniProt
BHF-UCL		 PMID:17289999 PMID:21041309 NCBI chrNW_004955470:2,740,682...2,780,225 JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO (PMID:21041309)
(PMID:10950869)
(PMID:32029622)
(PMID:17289999), (PMID:21262771)		 BHF-UCL
RGD
UniProt		 PMID:10950869 PMID:17289999 PMID:21041309 PMID:21262771 PMID:25623406 More... RGD:408345233 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Bik BCL2 interacting killer involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004955413:28,277,727...28,294,032 JBrowse link
G Bmf Bcl2 modifying factor involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004955416:7,048,654...7,068,917
Ensembl chrNW_004955416:7,052,290...7,068,910 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) BHF-UCL PMID:20436456 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099 		JBrowse link
G Fam162a family with sequence similarity 162 member A involved_in ISO (PMID:15082785) UniProt PMID:15082785 NCBI chrNW_004955427:21,668,180...21,695,004
Ensembl chrNW_004955427:21,667,922...21,694,844 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902 		JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in ISO (PMID:18852119) UniProt PMID:18852119 NCBI chrNW_004955588:427,102...438,578 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19880420) BHF-UCL PMID:19880420 NCBI chrNW_004955452:1,171,115...1,186,338
Ensembl chrNW_004955452:1,171,205...1,185,125 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18936091 RGD:6482750 NCBI chrNW_004955413:24,431,592...24,482,229
Ensembl chrNW_004955413:24,429,589...24,482,537 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586), (PMID:17289999)
(PMID:14500711), (PMID:14699081), (PMID:15705586)		 BHF-UCL
UniProt		 PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999 NCBI chrNW_004955402:44,005,517...44,010,722 JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in ISO (PMID:22266862) UniProt PMID:22266862 NCBI chrNW_004955420:2,550,392...2,566,448
Ensembl chrNW_004955420:2,549,142...2,566,564 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:14963330) UniProt PMID:14963330 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
G Wdr35 WD repeat domain 35 ISO RGD PMID:23289926 RGD:11553920 NCBI chrNW_004955469:2,484,972...2,546,562
Ensembl chrNW_004955469:2,482,353...2,546,578 		JBrowse link
regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (PMID:14963330)
(PMID:23744079)		 MGI PMID:14963330 PMID:23744079 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO (PMID:23744079)
(PMID:14963330)		 MGI PMID:14963330 PMID:23744079 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha acts_upstream_of_or_within ISO (PMID:23051746) MGI PMID:23051746 NCBI chrNW_004955415:4,247,307...4,307,402
Ensembl chrNW_004955415:4,247,014...4,307,458 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO (PMID:20436477)
(PMID:23744079)		 MGI PMID:20436477 PMID:23744079 NCBI chrNW_004955422:672,301...690,989
Ensembl chrNW_004955422:672,301...690,989 		JBrowse link
G Naif1 nuclear apoptosis inducing factor 1 involved_in ISO (PMID:16378748) UniProt PMID:16378748 NCBI chrNW_004955419:656,311...661,928
Ensembl chrNW_004955419:656,275...661,928 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent 1K involved_in ISO (PMID:17374715) UniProt PMID:17374715 NCBI chrNW_004955474:12,229,658...12,250,783
Ensembl chrNW_004955474:12,229,090...12,253,542 		JBrowse link
G Them4 thioesterase superfamily member 4 involved_in ISO (PMID:19168129) UniProt PMID:19168129 NCBI chrNW_004955589:517,489...545,779
Ensembl chrNW_004955589:517,600...547,649 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:14963330) MGI PMID:14963330 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18591963) UniProt PMID:18591963 NCBI chrNW_004955452:1,059,168...1,066,096
Ensembl chrNW_004955452:1,058,930...1,066,096 		JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) UniProt PMID:17828305 NCBI chrNW_004955467:9,489,867...9,493,275
Ensembl chrNW_004955467:9,489,867...9,493,275 		JBrowse link
regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr3 phospholipid scramblase 3 involved_in ISO (PMID:14573790), (PMID:18358005) UniProt PMID:14573790 PMID:18358005 NCBI chrNW_004955467:9,534,462...9,539,738
Ensembl chrNW_004955467:9,535,261...9,539,738 		JBrowse link
release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:11311799) MGI PMID:11311799 NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393 		JBrowse link
G Bad BCL2 associated agonist of cell death acts_upstream_of_or_within ISO (PMID:12431371) MGI PMID:12431371 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO positive regulation
(PMID:10950869)
(PMID:21041309)
(PMID:16199525), (PMID:9843949)		 RGD
BHF-UCL		 PMID:9843949 PMID:10950869 PMID:16199525 PMID:18252800 PMID:21041309 RGD:2313987 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO (PMID:17052454)
(PMID:14963330)
(PMID:12925707), (PMID:14614769), (PMID:14623868), (PMID:9560217)
(PMID:16199525), (PMID:17052454), (PMID:25609812), (PMID:9843949)		 RGD
MGI
UniProt		 PMID:9560217 PMID:9843949 PMID:10724126 PMID:12925707 PMID:14614769 More... RGD:14394498 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO (PMID:11463392) UniProt PMID:11463392 NCBI chrNW_004955574:1,167,790...1,174,966
Ensembl chrNW_004955574:1,167,242...1,174,966 		JBrowse link
G Bcl2 BCL2 apoptosis regulator involved_in ISO (PMID:9843949) HGNC-UCL PMID:9843949 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:9843949)
(PMID:17052454)		 HGNC-UCL
MGI		 PMID:9843949 PMID:17052454 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within		 ISO (PMID:18084238)
(PMID:11369777)
(PMID:17052454)		 RGD
CACAO
MGI
HGNC-UCL		 PMID:11369777 PMID:17052454 PMID:18084238 PMID:18252800 RGD:2313987 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (PMID:27505430) UniProt PMID:27505430 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:11964411 RGD:625521 NCBI chrNW_004955420:28,438,806...28,443,458
Ensembl chrNW_004955420:28,438,806...28,443,458 		JBrowse link
G Ggct gamma-glutamylcyclotransferase involved_in ISO (PMID:16765912) UniProt PMID:16765912 NCBI chrNW_004955410:31,732,272...31,739,020
Ensembl chrNW_004955410:31,731,312...31,739,020 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO induces release following removal of NGF from sympathetic neurons RGD PMID:11301023 RGD:2290592 NCBI chrNW_004955464:1,107,598...1,110,326 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:15504737 RGD:2298783 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:12952892)
(PMID:14699081)		 MGI
UniProt		 PMID:12952892 PMID:14699081 NCBI chrNW_004955402:44,005,517...44,010,722 JBrowse link
G Sfn stratifin involved_in ISO (PMID:11574543) HGNC-UCL PMID:11574543 NCBI chrNW_004955452:6,217,519...6,218,481
Ensembl chrNW_004955452:6,217,698...6,218,444 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:11839804 RGD:2301029 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO (PMID:15642323)
(PMID:10212301)		 MGI PMID:10212301 PMID:15642323 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 acts_upstream_of_or_within ISO (PMID:15044455) MGI PMID:15044455 NCBI chrNW_004955468:85,681...94,300
Ensembl chrNW_004955468:83,679...95,113 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:14963330)
(PMID:15483136)		 MGI PMID:14963330 PMID:15483136 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
release of matrix enzymes from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:9843949) HGNC-UCL PMID:9843949 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12571
    cellular process 12010
      cell death 1748
        programmed cell death 1748
          apoptotic process 1682
            apoptotic mitochondrial changes 103
              mitochondrial fragmentation involved in apoptotic process 11
              regulation of mitochondrial membrane permeability involved in apoptotic process + 38
              release of cytochrome c from mitochondria + 52
              release of matrix enzymes from mitochondria 1
Path 2
Term Annotations click to browse term
  biological_process 12571
    cellular process 12010
      cellular component organization or biogenesis 5435
        cellular component organization 5307
          organelle organization 2923
            mitochondrion organization 416
              apoptotic mitochondrial changes 103
                mitochondrial fragmentation involved in apoptotic process 11
                regulation of mitochondrial membrane permeability involved in apoptotic process + 38
                release of cytochrome c from mitochondria + 52
                release of matrix enzymes from mitochondria 1
paths to the root