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Term:apoptotic process
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Accession:GO:0006915 term browser browse the term
Definition:A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Synonyms:exact_synonym: apoptotic cell death;   apoptotic programmed cell death;   programmed cell death by apoptosis
 narrow_synonym: activation of apoptosis;   apoptosis;   apoptosis signaling;   apoptotic program;   type I programmed cell death
 broad_synonym: cell suicide;   cellular suicide
 related_synonym: apoptosis activator activity;   caspase-dependent programmed cell death;   commitment to apoptosis;   induction of apoptosis;   induction of apoptosis by p53;   signaling (initiator) caspase activity
 alt_id: GO:0006917;   GO:0008632
 xref: Wikipedia:Apoptosis
 never_in_taxon: NCBITaxon:2 ! Bacteria
 only_in_taxon: NCBITaxon:33154 ! Opisthokonta
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe

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      biological_process 19903
        cellular process 18297
          cell death 2271
            programmed cell death 2075
              apoptotic process 2016
                anoikis + 31
                apoptotic mitochondrial changes + 124
                apoptotic process in bone marrow cell + 7
                apoptotic process in response to mitochondrial fragmentation 0
                apoptotic process involved in development + 49
                apoptotic signaling pathway + 639
                epithelial cell apoptotic process + 172
                execution phase of apoptosis + 79
                fat cell apoptotic process + 2
                fibroblast apoptotic process + 35
                glial cell apoptotic process + 24
                hepatoblast apoptotic process 0
                inflammatory cell apoptotic process + 30
                leukocyte apoptotic process + 153
                melanocyte apoptotic process 2
                mesenchymal cell apoptotic process + 18
                muscle cell apoptotic process + 129
                myeloid cell apoptotic process + 51
                myofibroblast cell apoptotic process + 1
                negative regulation of apoptotic process + 1043
                neuron apoptotic process + 350
                positive regulation of apoptotic process + 662
                regulation of apoptotic process + 1669
                retinal cell apoptotic process + 8
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