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Ontology Browser

Parent Terms Term With Siblings Child Terms
apoptotic process +   
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
autophagic cell death +   
cornification +   
ferroptosis +   
granzyme-mediated programmed cell death signaling pathway +   
mitochondrial outer membrane permeabilization involved in programmed cell death +   
negative regulation of programmed cell death +   
positive regulation of programmed cell death +   
programmed cell death in response to reactive oxygen species +   
programmed cell death in response to retinoic acid 
programmed cell death involved in cell development +   
programmed necrotic cell death +   
pyroptosis +   
regulation of programmed cell death +   
symbiont-induced defense-related programmed cell death +   

Exact Synonyms: apoptotic cell death ;   apoptotic programmed cell death ;   programmed cell death by apoptosis
Narrow Synonyms: activation of apoptosis ;   apoptosis ;   apoptosis signaling ;   apoptotic program ;   type I programmed cell death
Broad Synonyms: cell suicide ;   cellular suicide
Related Synonyms: apoptosis activator activity ;   caspase-dependent programmed cell death ;   commitment to apoptosis ;   induction of apoptosis ;   induction of apoptosis by p53 ;   signaling (initiator) caspase activity
Alternate IDs: GO:0006917 ;   GO:0008632
Xrefs: Wikipedia:Apoptosis
Never In Taxon: NCBITaxon:2 ! Bacteria
Only In Taxon: NCBITaxon:33154 ! Opisthokonta
Never In Taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe
Definition Sources: GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263

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