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ONTOLOGY REPORT - ANNOTATIONS

Term:programmed cell death in response to reactive oxygen species
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Accession:GO:0097468 term browser browse the term
Definition:Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
Synonyms:exact_synonym: PCD in response to reactive oxygen species;   reactive oxygen species-mediated PCD;   reactive oxygen species-mediated programmed cell death
 broad_synonym: PCD in response to oxidative stress;   programmed cell death in response to oxidative stress


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programmed cell death in response to reactive oxygen species term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pjvk pejvakin involved_in ISO (MGI:6294584|PMID:30936319) RGD PMID:30936319 MGI:6294584 NCBI chr 3:61,594,644...61,605,051
Ensembl chr 3:61,596,641...61,605,045 		JBrowse link
intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd10 programmed cell death 10 involved_in ISO UniProtKB:O00506 (PMID:22652780) RGD PMID:22652780 NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018 		JBrowse link
G Stk25 serine/threonine kinase 25 involved_in ISO UniProtKB:Q9BUL8 (PMID:22652780) RGD PMID:22652780 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244 		JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO (MGI:5613479|PMID:14652021)
UniProtKB:Q99LX0 (PMID:14652021)		 RGD PMID:14652021 MGI:5613479 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:21177249), (PMID:23261939) RGD PMID:21177249 PMID:23261939 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
negative regulation of hydrogen peroxide-mediated programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr2 discoidin domain receptor tyrosine kinase 2 IMP RGD PMID:32412792 RGD:150429761 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Glrx glutaredoxin IMP RGD PMID:19938943 RGD:9686063 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Hgf hepatocyte growth factor involved_in ISO (PMID:20655899) RGD PMID:20655899 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hk3 hexokinase 3 involved_in IDA PMID:21072205 CACAO PMID:21072205 RGD:10047370 NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO
IEA		 (PMID:20655899)
GO_REF:0000107		 RGD
Ensembl		 PMID:20655899 GO_REF:0000107 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mir132 microRNA 132 IMP RGD PMID:23585551 RGD:7327146 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir21 microRNA 21 IMP RGD PMID:19336275 RGD:41404719 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir212 microRNA 212 IMP RGD PMID:23585551 RGD:7327146 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Mirlet7b microRNA let-7b involved_in ISO (PMID:26296645) RGD PMID:26296645 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsph1 heat shock protein family H (Hsp110) member 1 acts_upstream_of_or_within ISO (MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:3822965 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in IMP
ISO		 PMID:17579517
(PMID:17579517)		 RGD PMID:17579517 PMID:17579517 RGD:8693356 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Trap1 TNF receptor-associated protein 1 involved_in IMP PMID:17579517 ParkinsonsUK-UCL PMID:17579517 RGD:8693356 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
positive regulation of hydrogen peroxide-mediated programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase IMP hippocampal neurons RGD PMID:21715626 RGD:8693407 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Endog endonuclease G IMP RGD PMID:20594982 RGD:9685387 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:23585551 RGD:7327146 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Foxa1 forkhead box A1 IMP RGD PMID:19649697 RGD:151665511 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxo3 forkhead box O3 IMP RGD PMID:23585551 RGD:7327146 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxp1 forkhead box P1 IMP cardiac muscle cell RGD PMID:26333362 RGD:11561912 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:18606987) RGD PMID:18606987 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (MGI:5648604|PMID:25472717) RGD PMID:25472717 MGI:5648604 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    cellular process 18159
      cell death 2233
        cell death in response to oxidative stress 102
          programmed cell death in response to reactive oxygen species 24
            hydrogen peroxide-mediated programmed cell death + 23
            singlet oxygen-mediated programmed cell death 0
Path 2
Term Annotations click to browse term
  biological_process 19746
    response to stimulus 10448
      cellular response to stimulus 8828
        cellular response to stress 2129
          cellular response to chemical stress 446
            cellular response to oxidative stress 372
              cell death in response to oxidative stress 102
                programmed cell death in response to reactive oxygen species 24
                  hydrogen peroxide-mediated programmed cell death + 23
                  singlet oxygen-mediated programmed cell death 0
paths to the root