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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   mitochondrion outer membrane permeabilization involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death


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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F involved_in ISO
ISS
(PMID:26387735)
GO_REF:0000024
RGD
UniProt
PMID:26387735 GO_REF:0000024 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin involved_in IMP PMID:26387735 UniProt PMID:26387735 RGD:13441202 NCBI chr19:55,880,549...55,914,729
Ensembl chr19:55,880,561...55,915,502
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO MGI:1929260 (MGI:5566519|PMID:20436477) RGD PMID:20436477 MGI:5566519 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
ISS
IEA
(PMID:18188704)
GO_REF:0000107
RGD
Ensembl
PMID:18188704, PMID:18188704 GO_REF:0000107, RGD:8553738 NCBI chr 1:263,913,901...263,920,989
Ensembl chr 1:263,913,854...263,920,962
JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IBA
ISO
PMID:21873635
(PMID:18371312)
RGD PMID:18371312, PMID:21873635 RGD:13792537 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) RGD PMID:11700312 MGI:2158099 NCBI chr 3:162,285,275...162,470,642
Ensembl chr 3:162,346,490...162,470,065
JBrowse link
G LOC102548901 protein Bop-like involved_in ISO (PMID:23055042) RGD PMID:23055042 NCBI chr12:6,230,524...6,231,398 JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) RGD PMID:12482879 NCBI chr10:67,559,277...67,640,622
Ensembl chr10:67,532,030...67,640,555
JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISS
ISO
GO_REF:0000024
(PMID:12482879)
UniProt
RGD
PMID:12482879 GO_REF:0000024 NCBI chr10:15,205,943...15,211,739
Ensembl chr10:15,205,534...15,211,325
JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO
ISS
(PMID:31015432)
GO_REF:0000024
RGD
UniProt
PMID:31015432 GO_REF:0000024 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18371312)
Ensembl
UniProt
RGD
PMID:18371312 GO_REF:0000024 GO_REF:0000107 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:4437986 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:3,321,488...3,359,219
Ensembl chr10:3,321,476...3,357,470
JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:19154410)
UniProt
RGD
PMID:19154410 GO_REF:0000024 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc35f6 solute carrier family 35, member F6 involved_in ISS
ISO
GO_REF:0000024
(PMID:19154410)
UniProt
RGD
PMID:19154410 GO_REF:0000024 NCBI chr 6:27,095,144...27,106,982
Ensembl chr 6:27,095,141...27,107,030
JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO
IBA
(PMID:21723035)
PMID:21873635
RGD PMID:21723035, PMID:21873635 RGD:13792537 NCBI chr 9:27,333,956...27,345,612
Ensembl chr 9:27,343,853...27,345,070
Ensembl chr 9:27,343,853...27,345,070
JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS
(PMID:22304920)
GO_REF:0000024
RGD
UniProt
PMID:22304920 GO_REF:0000024 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1197519 (MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:3581932 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l11 BCL2 like 11 acts_upstream_of_or_within ISO MGI:99702 (MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:3581932 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Stpg1 sperm-tail PG-rich repeat containing 1 involved_in IBA
ISO
PMID:21873635
(PMID:23028632)
RGD PMID:23028632, PMID:21873635 RGD:13792537 NCBI chr 5:153,834,263...153,888,510
Ensembl chr 5:153,835,821...153,888,506
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:4437986 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5796067|PMID:26949185)
UniProt
RGD
PMID:26949185 GO_REF:0000024 MGI:5796067 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) RGD PMID:26666268 PMID:30092269 NCBI chr20:13,665,046...13,666,845
Ensembl chr20:13,665,031...13,667,333
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
ISO
GO_REF:0000024
(MGI:5514334|PMID:16543145)
UniProt
RGD
PMID:16543145 GO_REF:0000024 MGI:5514334 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO
GO_REF:0000024
(MGI:5514334|PMID:16543145)
UniProt
RGD
PMID:16543145 GO_REF:0000024 MGI:5514334 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO UniProtKB:Q9HD36 (PMID:19255499) RGD PMID:19255499 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:137,209,999...137,214,379
Ensembl chr 6:137,210,052...137,214,388
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,908,643...12,916,784
Ensembl chr10:12,908,643...12,916,784
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2681654 (MGI:3804133|PMID:16705087)
(PMID:17024184)
RGD PMID:16705087 PMID:17024184, PMID:21873635 MGI:3804133, RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) RGD PMID:16227588 MGI:3607027 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857429 (MGI:2675761|PMID:12952892)
Ensembl
RGD
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18591963) RGD PMID:18591963 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) RGD PMID:17828305 NCBI chr10:56,410,898...56,413,154
Ensembl chr10:56,410,918...56,412,544
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      cell death 2128
        programmed cell death 1944
          mitochondrial outer membrane permeabilization involved in programmed cell death 38
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 36
Path 2
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      cellular component organization or biogenesis 6727
        cellular component organization 6482
          organelle organization 4058
            mitochondrion organization 551
              mitochondrial membrane organization 109
                regulation of mitochondrial membrane permeability 59
                  positive regulation of mitochondrial membrane permeability 41
                    mitochondrial outer membrane permeabilization involved in programmed cell death 38
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 36
paths to the root