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ONTOLOGY REPORT - ANNOTATIONS


Term:programmed necrotic cell death
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Accession:GO:0097300 term browser browse the term
Definition:A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
Comment:This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples.
Synonyms:exact_synonym: programmed cell death by necrosis
 broad_synonym: regulated necrosis



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programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3583691|PMID:16429160)
Ensembl
RGD
PMID:16429160 GO_REF:0000107 MGI:3583691 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Irf3 interferon regulatory factor 3 acts_upstream_of_or_within ISO MGI:3577601 (MGI:5502260|PMID:23770239) RGD PMID:23770239 MGI:5502260 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A acts_upstream_of_or_within ISO (MGI:3583691|PMID:16429160) RGD PMID:16429160 MGI:3583691 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Traf2 Tnf receptor-associated factor 2 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (MGI:6434626|PMID:32296175), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907) RGD PMID:27321907 PMID:32200799 PMID:32296175 MGI:6434626 MGI:6436412 MGI:6436434 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)
UniProt
RGD
PMID:27746097 PMID:27917412 GO_REF:0000024 MGI:6436445 MGI:6442612 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104798|MGI:108212|MGI:1261423|MGI:2154952 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5824599|PMID:27545878)
RGD PMID:21052097 PMID:22037414 PMID:27545878 PMID:21873635 MGI:5306844 MGI:5315337 MGI:5824599, RGD:13792537 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Dnm1l dynamin 1-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5516181|PMID:22265414)
(PMID:22265414)
UniProt
RGD
PMID:22265414 GO_REF:0000024 MGI:5516181 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Ipmk inositol polyphosphate multikinase involved_in ISO
ISS
(PMID:29883610)
GO_REF:0000024
RGD
UniProt
PMID:29883610 GO_REF:0000024 NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase involved_in ISO (PMID:29883610) RGD PMID:29883610 NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO
ISS
(PMID:22265414), (PMID:24316671), (PMID:29883610)
(MGI:5532892|PMID:24012422), (MGI:5532894|PMID:23835476)
GO_REF:0000024
RGD
UniProt
PMID:22265414 PMID:23835476 PMID:24012422 PMID:24316671 PMID:29883610 GO_REF:0000024 MGI:5532892 MGI:5532894 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6453663|PMID:30248149)
GO_REF:0000107
RGD
Ensembl
PMID:30248149 GO_REF:0000107 MGI:6453663 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in ISO
IEA
ISS
(PMID:22265414)
(MGI:5516181|PMID:22265414)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22265414 GO_REF:0000024 GO_REF:0000107 MGI:5516181 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO MGI:98834 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Pygl glycogen phosphorylase L acts_upstream_of_or_within ISO MGI:2154952 (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:104798|MGI:1921506|MGI:2154952|MGI:95484 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
(MGI:5912943|PMID:28701375), (MGI:5926457|PMID:28842570), (MGI:6120592|PMID:29440439), (MGI:6362112|PMID:31519886), (MGI:6362574|PMID:31519887), (MGI:6369186|PMID:30867408)
(PMID:21737330), (PMID:22265414), (PMID:29440439)
UniProt
RGD
PMID:19498109 PMID:21052097 PMID:21737330 PMID:22037414 PMID:22265414 More... GO_REF:0000024 MGI:5306844 MGI:5315337 MGI:5510543 MGI:5912943 MGI:5926457 MGI:6120592 MGI:6362112 MGI:6362574 MGI:6369186 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:5532892|PMID:24012422)
MGI:104798|MGI:108212|MGI:109324|MGI:1261423|MGI:1336166|MGI:1921506 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5486419|PMID:22675671), (MGI:5510543|PMID:19498109)
(PMID:21737330), (PMID:29883609)
UniProt
RGD
PMID:19498109 PMID:21368763 PMID:21402742 PMID:21737330 PMID:22037414 More... GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5486419 MGI:5510543 MGI:5532892 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Spata2 spermatogenesis associated 2 acts_upstream_of ISO (MGI:5824599|PMID:27545878) RGD PMID:27545878 MGI:5824599 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2145814 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24316671)
UniProt
Ensembl
RGD
PMID:24316671 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
necroptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:16507998)
MGI:108212 (MGI:5315337|PMID:21052097)
PMID:21873635
RGD PMID:16507998 PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (PMID:22265413)
(MGI:5516182|PMID:22265413)
RGD PMID:22265413 MGI:5516182 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5291865|PMID:21876153), (MGI:6401044|PMID:31827281)
(PMID:11101870), (PMID:16507998), (PMID:22265413), (PMID:22817896), (PMID:31827280)
UniProt
RGD
PMID:11101870 PMID:16507998 PMID:21876153 PMID:22265413 PMID:22817896 More... GO_REF:0000024 MGI:5291865 MGI:6401044 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (PMID:22265413), (PMID:22817896) RGD PMID:22265413 PMID:22817896 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:11101870), (PMID:22265413), (PMID:22265414), (PMID:22817896)
MGI:108212|MGI:1197009|MGI:1261423|MGI:1336166|MGI:1346877|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
GO_REF:0000024
RGD
UniProt
PMID:11101870 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414 More... GO_REF:0000024 MGI:4947443 MGI:5306844 MGI:5315337 MGI:5510543 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprs ADP-ribosylserine hydrolase involved_in ISO
IEA
(MGI:6445044|PMID:30830864)
GO_REF:0000107
RGD
Ensembl
PMID:30830864 GO_REF:0000107 MGI:6445044 NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104798 (MGI:5315337|PMID:21052097)
RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in IBA
ISO
PMID:21873635
(MGI:5315337|PMID:21052097)
RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Casp2 caspase 2 involved_in ISO (PMID:30025878) RGD PMID:30025878 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:31827280)
MGI:104798|MGI:1336166|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5521568|PMID:22089168)
(MGI:6378798|PMID:31511692), (MGI:6401035|PMID:31748744), (MGI:6401044|PMID:31827281)
GO_REF:0000024
RGD
UniProt
PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 PMID:31511692 More... GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5521568 MGI:6378798 MGI:6401035 MGI:6401044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5464050|PMID:23049990)
Ensembl
RGD
PMID:23049990 GO_REF:0000107 MGI:5464050 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator acts_upstream_of_or_within ISO MGI:104798|MGI:1261423|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:21368763 PMID:22089168 PMID:22675671 MGI:4947443 MGI:5486419 MGI:5521568 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO MGI:104798|MGI:2154952 (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:22089168 PMID:22675671 MGI:5486419 MGI:5521568 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mutyh mutY DNA glycosylase involved_in IEA
ISO
GO_REF:0000107
(MGI:6378777|PMID:28059467)
Ensembl
RGD
PMID:28059467 GO_REF:0000107 MGI:6378777 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (PMID:29883609)
(MGI:6163945|PMID:29883609)
RGD PMID:29883609 MGI:6163945 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104798 (MGI:5521568|PMID:22089168)
Ensembl
RGD
PMID:22089168 GO_REF:0000107 MGI:5521568 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681) RGD PMID:24813849 PMID:24813850 PMID:27819681 PMID:27819682 MGI:5602910 MGI:5602911 MGI:5907398 MGI:5907399 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Rnf31 ring finger protein 31 acts_upstream_of_or_within ISO MGI:104798 (MGI:5521568|PMID:22089168) RGD PMID:22089168 MGI:5521568 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16507998)
Ensembl
RGD
PMID:16507998 GO_REF:0000107 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Ybx3 Y box binding protein 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:22711822)
Ensembl
RGD
PMID:22711822 GO_REF:0000107 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
JBrowse link
negative regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISO
ISS
(PMID:30451898)
GO_REF:0000024
RGD
UniProt
PMID:30451898 GO_REF:0000024 NCBI chr 1:181,213,292...181,215,327 JBrowse link
negative regulation of ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
positive regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp6 caspase 6 involved_in ISO
IEA
ISS
(PMID:32298652)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:32298652 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Gzmb granzyme B IMP RGD PMID:19895873 RGD:2325193 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IMP
ISO
(PMID:22028622), (PMID:22274400), (PMID:22817896) RGD PMID:22028622 PMID:22274400 PMID:22817896 PMID:22372834 RGD:7777172 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS
(PMID:22265414), (PMID:22817896)
(MGI:5315337|PMID:21052097), (MGI:5516181|PMID:22265414), (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907)
GO_REF:0000024
RGD
UniProt
PMID:21052097 PMID:22265414 PMID:22423968 PMID:22817896 PMID:24813849 More... GO_REF:0000024 MGI:5315337 MGI:5516181 MGI:5602910 MGI:5602911 MGI:6434626 MGI:6436371 MGI:6436412 MGI:6436434 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISO
ISS
(PMID:32200799)
(MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681), (MGI:6095612|PMID:29073079), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436393|PMID:30050136), (MGI:6436412|PMID:32200799), (MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609)
GO_REF:0000024
RGD
UniProt
PMID:22423968 PMID:27746097 PMID:27819681 PMID:27819682 PMID:27917412 More... GO_REF:0000024 MGI:5907398 MGI:5907399 MGI:6095612 MGI:6434626 MGI:6436371 MGI:6436393 MGI:6436412 MGI:6436445 MGI:6442612 MGI:6453154 MGI:6490907 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
JBrowse link
positive regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh7 alkB homolog 7 involved_in ISO (PMID:23666923) RGD PMID:23666923 NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3589203 (MGI:5319417|PMID:22493254)
Ensembl
RGD
PMID:22493254 GO_REF:0000107 MGI:5319417 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:3576003|PMID:15800626), (MGI:3603054|PMID:16103352), (MGI:5431269|PMID:22726440)
PMID:21873635
(PMID:22726440)
UniProt
RGD
PMID:15800626 PMID:16103352 PMID:22726440 PMID:21873635 GO_REF:0000024 MGI:3576003 MGI:3603054 MGI:5431269, RGD:13792537 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IEA
ISO
GO_REF:0000107
(MGI:5912943|PMID:28701375)
(PMID:27458237)
Ensembl
RGD
PMID:27458237 PMID:28701375 GO_REF:0000107 MGI:5912943 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Fadd Fas associated via death domain IMP RGD PMID:26038570 RGD:11341801 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Spata2 spermatogenesis associated 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5912943|PMID:28701375)
PMID:21873635
(PMID:27307491), (PMID:27458237), (PMID:27545878)
UniProt
RGD
PMID:27307491 PMID:27458237 PMID:27545878 PMID:28701375 PMID:21873635 GO_REF:0000024 MGI:5912943, RGD:13792537 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705
JBrowse link
regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6275115|PMID:10974027)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:10974027 GO_REF:0000024 GO_REF:0000107 MGI:6275115 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5306844|PMID:22037414) RGD PMID:22037414 MGI:5306844 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO MGI:104798|MGI:1197009|MGI:1346877 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    cellular process 18637
      cell death 2173
        necrotic cell death 68
          programmed necrotic cell death 48
            necroptotic process + 38
            negative regulation of programmed necrotic cell death + 19
            positive regulation of programmed necrotic cell death + 6
            programmed necrotic cell death in response to starvation 0
            regulation of mitochondrial membrane permeability involved in programmed necrotic cell death 3
            regulation of programmed necrotic cell death + 27
paths to the root