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ONTOLOGY REPORT - ANNOTATIONS

Term:ferroptosis
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Accession:GO:0097707 term browser browse the term
Definition:A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
Synonyms:related_synonym: iron-dependent programmed cell death


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negative regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm2 apoptosis inducing factor, mitochondria associated 2 involved_in ISO (PMID:31634899), (PMID:31634900), (PMID:35922516) RGD PMID:31634899 PMID:31634900 PMID:35922516 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Gpx4 glutathione peroxidase 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5615528|PMID:25402683), (MGI:6114953|PMID:29290465)		 UniProt
RGD		 PMID:25402683 PMID:29290465 GO_REF:0000024 MGI:5615528 MGI:6114953 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 involved_in ISO (PMID:35245456) RGD PMID:35245456 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
positive regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir23a microRNA 23a IMP RGD PMID:33403590 RGD:155882539 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Tmem164 transmembrane protein 164 involved_in ISO (PMID:35947500) RGD PMID:35947500 NCBI chr  X:106,288,019...106,448,642
Ensembl chr  X:106,289,371...106,448,640 		JBrowse link
regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a7 solute carrier family 39 member 7 involved_in ISO
ISS		 (PMID:33608508)
GO_REF:0000024		 RGD
UniProt		 PMID:33608508 GO_REF:0000024 NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19748
    cellular process 18161
      cell death 2222
        programmed cell death 2100
          ferroptosis 6
            negative regulation of ferroptosis 3
            positive regulation of ferroptosis 2
            regulation of ferroptosis + 6
paths to the root