cornification - Ontology Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	cornification	go back to main search page
Accession:	GO:0070268	browse the term
Definition:	A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).

show annotations for term's descendants Sort by:
Rat (4) Mouse (4) Human (9) Chinchilla (4) Bonobo (4) Dog (4) Squirrel (4) Pig (4) Green Monkey (4) Naked Mole-rat (4) All
Genes (4)

cornification

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ceramide synthase 3

involved_in

(MGI:5303015|PMID:22038835)

NCBI chr 1:120,316,930...120,422,926
Ensembl chr 1:120,318,212...120,422,902

G

cytochrome P450, family 26, subfamily b, polypeptide 1

acts_upstream_of_or_within

MGI:3039046 (MGI:5466369|PMID:22366455)

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

transmembrane protein 79

acts_upstream_of_or_within

MGI:1856947 (MGI:5519142|PMID:24084074)

NCBI chr 2:173,798,267...173,803,151
Ensembl chr 2:173,798,267...173,803,046

negative regulation of cornification

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

corneodesmosin

involved_in

(PMID:26014679)

NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250

Term paths to the root

Path 1
Term	Annotations
biological_process	19527
multicellular organismal process	9158
keratinization	62
cornification	4
negative regulation of cornification	1
positive regulation of cornification	0
regulation of cornification +	1
Path 2
Term	Annotations
biological_process	19527
developmental process	6898
anatomical structure development	6425
tissue development	2268
epithelium development	1418
epithelial cell differentiation	833
epidermal cell differentiation	250
keratinocyte differentiation	160
keratinization	62
cornification	4
negative regulation of cornification	1
positive regulation of cornification	0
regulation of cornification +	1

paths to the root