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ONTOLOGY REPORT - ANNOTATIONS


Term:autophagic cell death
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Accession:GO:0048102 term browser browse the term
Definition:A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
Comment:The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
Synonyms:exact_synonym: programmed cell death by autophagy;   programmed cell death by macroautophagy
 broad_synonym: autophagic death
 related_synonym: autosis;   type II programmed cell death
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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autophagic cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp2 acid phosphatase 2, lysosomal JBrowse link 3 80,020,346 80,030,365 RGD:4892631
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:5128797
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:1624291
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:2315590
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:4892631
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1600115
RGD:1624291
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 JBrowse link 5 24,402,895 24,419,651 RGD:1600115
RGD:1624291
induction by virus of host autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
negative regulation of autophagic cell death term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v0c ATPase H+ transporting V0 subunit C JBrowse link 10 13,537,031 13,543,407 RGD:14700553
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
suppression by virus of host autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291

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  biological_process 19332
    cellular process 17237
      cell death 2118
        programmed cell death 1940
          autophagic cell death 12
            negative regulation of autophagic cell death 3
            positive regulation of autophagic cell death 0
            regulation of autophagic cell death + 5
            salivary gland cell autophagic cell death + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.