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Term:autophagic cell death
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Accession:GO:0048102 term browser browse the term
Definition:A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
Comment:The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
Synonyms:exact_synonym: programmed cell death by autophagy;   programmed cell death by macroautophagy
 broad_synonym: autophagic death
 related_synonym: autosis;   type II programmed cell death
 only_in_taxon: NCBITaxon:2759 ! Eukaryota

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autophagic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal IDA RGD PMID:18690537 RGD:4892631 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
JBrowse link
G Bnip3 BCL2 interacting protein 3 IMP RGD PMID:19539716 RGD:5128797 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B involved_in ISO (PMID:12698196) RGD PMID:12698196 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D involved_in ISO (PMID:16322758) RGD PMID:16322758 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Ctsl cathepsin L IEP RGD PMID:16176344 RGD:2315590 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 IDA RGD PMID:18690537 RGD:4892631 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 involved_in ISO (PMID:17891140)
RGD PMID:17891140 MGI:3770552 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 involved_in ISO
PMID:22421968 GO_REF:0000024 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
negative regulation of autophagic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 acts_upstream_of_or_within
PMID:19273585 GO_REF:0000107 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C IMP RGD PMID:17845832 RGD:14700553 NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500
JBrowse link
G Bmf Bcl2 modifying factor involved_in ISO (MGI:5490676|PMID:23629966) RGD PMID:23629966 MGI:5490676 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:19787053) RGD PMID:19787053 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:5906931|PMID:28802038) RGD PMID:28802038 MGI:5906931 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
positive regulation of autophagic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO (PMID:11980920) ComplexPortal PMID:11980920 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:11980920) ComplexPortal PMID:11980920 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:11980920) ComplexPortal PMID:11980920 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Dapk1 death associated protein kinase 1 involved_in ISO (PMID:11980920) RGD PMID:11980920 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link

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  biological_process 19746
    cellular process 18159
      cell death 2233
        programmed cell death 2100
          autophagic cell death 17
            negative regulation of autophagic cell death 5
            positive regulation of autophagic cell death 4
            regulation of autophagic cell death + 9
            salivary gland cell autophagic cell death + 0
paths to the root