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ONTOLOGY REPORT - ANNOTATIONS


Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:A series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway



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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:9396766) RGD PMID:9396766 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940) RGD PMID:31953257 PMID:32188940 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G Gzmb granzyme B involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:31953257), (PMID:32188940)
MGI:1857156 (MGI:3531039|PMID:15454490), (MGI:3665503|PMID:16618603)
GO_REF:0000024
RGD
UniProt
PMID:15454490 PMID:16618603 PMID:31953257 PMID:32188940 GO_REF:0000024 MGI:3531039 MGI:3665503 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA
(PMID:23632890)
GO_REF:0000107
RGD
Ensembl
PMID:23632890 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Nkg7 natural killer cell granule protein 7 acts_upstream_of_or_within ISO (PMID:33911019) RGD PMID:33911019 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983
JBrowse link
G Srgn serglycin involved_in ISO
ISS
(PMID:11911826)
GO_REF:0000024
RGD
UniProt
PMID:11911826 GO_REF:0000024 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406
JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO (PMID:11802788) RGD PMID:11802788 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    signaling 7490
      signal transduction 6908
        granzyme-mediated programmed cell death signaling pathway 8
          granzyme-mediated apoptotic signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        regulation of cellular process 12336
          signal transduction 6908
            granzyme-mediated programmed cell death signaling pathway 8
              granzyme-mediated apoptotic signaling pathway 1
paths to the root