Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:anoikis
go back to main search page
Accession:GO:0043276 term browser browse the term
Definition:Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
Synonyms:exact_synonym: detachment induced cell death;   suspension induced apoptosis
 xref: Wikipedia:Anoikis


show annotations for term's descendants           Sort by:
anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmf Bcl2 modifying factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11546872)
GO_REF:0000107		 RGD
Ensembl		 PMID:11546872 GO_REF:0000107 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Dapk2 death-associated protein kinase 2 involved_in ISO (PMID:18957423) RGD PMID:18957423 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567 		JBrowse link
G E2f1 E2F transcription factor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3028362|PMID:14667810)
GO_REF:0000107		 RGD
Ensembl		 PMID:14667810 GO_REF:0000107 MGI:3028362 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (MGI:5819337|PMID:23778976) RGD PMID:23778976 MGI:5819337 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5819337|PMID:23778976) RGD PMID:23778976 MGI:5819337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISO
IEA		 (MGI:4887544|PMID:19622832)
GO_REF:0000107		 RGD
Ensembl		 PMID:19622832 GO_REF:0000107 MGI:4887544 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:19622832) RGD PMID:19622832 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tfdp1 transcription factor Dp-1 acts_upstream_of_or_within ISO (MGI:3028362|PMID:14667810) RGD PMID:14667810 MGI:3028362 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5819337|PMID:23778976)
UniProtKB:Q61037 (PMID:23778976)		 Ensembl
RGD		 PMID:23778976 GO_REF:0000107 MGI:5819337 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
negative regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA		 (PMID:15006356)
GO_REF:0000107		 RGD
Ensembl		 PMID:15006356 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Cav1 caveolin 1 involved_in ISO
IEA		 (PMID:22277751)
(MGI:5437406|PMID:22277751)
GO_REF:0000107		 RGD
Ensembl		 PMID:22277751 GO_REF:0000107 MGI:5437406 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 involved_in ISO (PMID:10910050), (PMID:14724575) RGD PMID:10910050 PMID:14724575 NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668 		JBrowse link
G Itga5 integrin subunit alpha 5 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO (PMID:22277751) RGD PMID:22277751 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:17984306) RGD PMID:17984306 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5306312|PMID:15329723)		 Ensembl
RGD		 PMID:15329723 GO_REF:0000107 MGI:5306312 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO
IEA		 (PMID:21852536)
GO_REF:0000107		 RGD
Ensembl		 PMID:21852536 GO_REF:0000107 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 involved_in ISO
IBA		 (PMID:21383007)
PMID:21873635		 RGD PMID:21383007 PMID:21873635 RGD:13792537 NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:17984306) RGD PMID:17984306 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor involved_in ISO (PMID:15006356), (PMID:22952044) RGD PMID:15006356 PMID:22952044 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774 		JBrowse link
positive regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brms1 BRMS1, transcriptional repressor and anoikis regulator involved_in ISO
ISS		 (PMID:17000776)
GO_REF:0000024		 RGD
UniProt		 PMID:17000776 GO_REF:0000024 NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028 		JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:21834075 RGD:10401645 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726 		JBrowse link
G Mybbp1a MYB binding protein 1a involved_in ISO
IEA		 (PMID:23388179)
GO_REF:0000107		 RGD
Ensembl		 PMID:23388179 GO_REF:0000107 NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255 		JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 involved_in ISO
IBA		 (PMID:15006356), (PMID:22952044)
PMID:21873635		 RGD PMID:15006356 PMID:22952044 PMID:21873635 RGD:13792537 NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398 		JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISO
IEA		 (PMID:19622832)
GO_REF:0000107		 RGD
Ensembl		 PMID:19622832 GO_REF:0000107 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Tle5 TLE family member 5, transcriptional modulator involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 7:8,143,357...8,150,295
Ensembl chr 7:8,143,357...8,150,113 		JBrowse link
regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd13c ankyrin repeat domain 13C involved_in ISO (PMID:20959461) RGD PMID:20959461 NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    cellular process 18233
      cell death 2119
        programmed cell death 2119
          apoptotic process 2039
            anoikis 31
              negative regulation of anoikis 16
              positive regulation of anoikis 7
              regulation of anoikis + 23
paths to the root