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ONTOLOGY REPORT - ANNOTATIONS


Term:anoikis
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Accession:GO:0043276 term browser browse the term
Definition:Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
Synonyms:exact_synonym: detachment induced cell death;   suspension induced apoptosis
 xref: Wikipedia:Anoikis



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anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmf Bcl2 modifying factor acts_upstream_of_or_within ISO (PMID:11546872) RGD PMID:11546872 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Dapk2 death-associated protein kinase 2 involved_in ISO (PMID:18957423) RGD PMID:18957423 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
JBrowse link
G E2f1 E2F transcription factor 1 acts_upstream_of_or_within ISO (MGI:3028362|PMID:14667810) RGD PMID:14667810 MGI:3028362 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (MGI:5819337|PMID:23778976) RGD PMID:23778976 MGI:5819337 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5819337|PMID:23778976) RGD PMID:23778976 MGI:5819337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISO (MGI:4887544|PMID:19622832) RGD PMID:19622832 MGI:4887544 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:19622832) RGD PMID:19622832 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tfdp1 transcription factor Dp-1 acts_upstream_of_or_within ISO (MGI:3028362|PMID:14667810) RGD PMID:14667810 MGI:3028362 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5819337|PMID:23778976)
UniProtKB:Q61037 (PMID:23778976)
Ensembl
RGD
PMID:23778976 GO_REF:0000107 MGI:5819337 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
negative regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:22277751)
(MGI:5437406|PMID:22277751)
RGD PMID:22277751 MGI:5437406 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 involved_in ISO (PMID:10910050), (PMID:14724575) RGD PMID:10910050 PMID:14724575 NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668
JBrowse link
G Itga5 integrin subunit alpha 5 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO (PMID:22277751) RGD PMID:22277751 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:17984306) RGD PMID:17984306 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5306312|PMID:15329723)
Ensembl
RGD
PMID:15329723 GO_REF:0000107 MGI:5306312 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in ISO (PMID:21852536) RGD PMID:21852536 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 involved_in ISO
IBA
(PMID:21383007)
PMID:21873635
RGD PMID:21383007 PMID:21873635 RGD:13792537 NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398
JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:17984306) RGD PMID:17984306 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:22402981) RGD PMID:22402981 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor involved_in ISO (PMID:15006356), (PMID:22952044) RGD PMID:15006356 PMID:22952044 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
JBrowse link
positive regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brms1 BRMS1, transcriptional repressor and anoikis regulator involved_in ISO
IEA
ISS
(PMID:17000776)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17000776 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028
JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:21834075 RGD:10401645 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726
JBrowse link
G Mybbp1a MYB binding protein 1a involved_in ISO (PMID:23388179) RGD PMID:23388179 NCBI chr10:57,056,913...57,067,263
Ensembl chr10:57,056,874...57,067,255
JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 involved_in ISO
IBA
(PMID:15006356), (PMID:22952044)
PMID:21873635
RGD PMID:15006356 PMID:22952044 PMID:21873635 RGD:13792537 NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398
JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISO (PMID:19622832) RGD PMID:19622832 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Tle5 TLE family member 5, transcriptional modulator involved_in ISO (PMID:15006356) RGD PMID:15006356 NCBI chr 7:8,143,357...8,150,295
Ensembl chr 7:8,143,357...8,150,113
JBrowse link
regulation of anoikis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd13c ankyrin repeat domain 13C involved_in ISO (PMID:20959461) RGD PMID:20959461 NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20094
    cellular process 18691
      cell death 2260
        programmed cell death 2066
          apoptotic process 2009
            anoikis 31
              negative regulation of anoikis 16
              positive regulation of anoikis 7
              regulation of anoikis + 23
paths to the root