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ONTOLOGY REPORT - ANNOTATIONS

Term:apoptotic mitochondrial changes
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Accession:GO:0008637 term browser browse the term
Definition:The morphological and physiological alterations undergone by mitochondria during apoptosis.
Comment:This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.


show annotations for term's descendants           Sort by:
apoptotic mitochondrial changes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Aifm2 AIF family member 2 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		(PMID:11980907)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11980907 GO_REF:0000033 GO_REF:0000107 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 acts_upstream_of_or_within ISO
IEA 		(PMID:12869584)
GO_REF:0000107 		RGD
Ensembl		 PMID:12869584 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member IEP RGD PMID:30131474 RGD:15036798 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO
IEA 		(PMID:19061639)
GO_REF:0000107 		RGD
Ensembl		 PMID:19061639 GO_REF:0000107 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within 		ISO
IEA
ISS 		(PMID:9843949)
GO_REF:0000107
(PMID:12925707)
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:9843949 PMID:12925707 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO (PMID:14707049) RGD PMID:14707049 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000104 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:9525867) 		GO_Central
RGD		 PMID:9525867 GO_REF:0000033 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO (PMID:14707049) RGD PMID:14707049 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Dap3 death associated protein 3 acts_upstream_of_or_within ISO
IEA 		(PMID:11017876)
GO_REF:0000107 		RGD
Ensembl		 PMID:11017876 GO_REF:0000107 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461 		JBrowse link
G ENSRNOG00000065699 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr14:100,606,613...100,607,588 JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 acts_upstream_of_or_within ISO
IEA 		(PMID:38693257)
GO_REF:0000107 		RGD
Ensembl		 PMID:38693257 GO_REF:0000107 NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO
IEA 		MGI:104990 (PMID:15288121)
GO_REF:0000107 		RGD
Ensembl		 PMID:15288121 GO_REF:0000107 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hk2 hexokinase 2 acts_upstream_of_or_within ISO
IEA 		(PMID:18350175)
GO_REF:0000107
MGI:1353495|MGI:2145814 (PMID:18350175) 		RGD
Ensembl		 PMID:18350175 GO_REF:0000107 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in IMP
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:21854881 GO_REF:0000033, RGD:10402841 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Hspd1l1 heat shock protein family D (Hsp60) member 1 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:1,587,931...1,590,330
Ensembl chr18:1,588,008...1,590,314 		JBrowse link
G Jtb jumping translocation breakpoint acts_upstream_of_or_within ISO (PMID:17369841) RGD PMID:17369841 NCBI chr 2:175,685,392...175,689,609
Ensembl chr 2:175,684,993...175,690,108 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 acts_upstream_of_or_within ISO (PMID:15882989) RGD PMID:15882989 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mir361 microRNA 361 acts_upstream_of_or_within ISO (PMID:25057983) RGD PMID:25057983 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO
IEA 		(PMID:12869584)
GO_REF:0000107 		RGD
Ensembl		 PMID:12869584 GO_REF:0000107 NCBI chr  X:17,289,509...17,294,778
Ensembl chr  X:14,617,582...14,622,851 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO MGI:1315197|MGI:1353495 (PMID:18350175) RGD PMID:18350175 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of_or_within ISO
IEA 		(PMID:16717086)
GO_REF:0000107 		RGD
Ensembl		 PMID:16717086 GO_REF:0000107 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Rnf7 ring finger protein 7 acts_upstream_of_or_within ISO (PMID:10082581) RGD PMID:10082581 NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 acts_upstream_of_or_within ISO
IEA 		MGI:1315197|MGI:2145814 (PMID:18350175)
GO_REF:0000107 		RGD
Ensembl		 PMID:18350175 GO_REF:0000107 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857344 (PMID:11226230)
GO_REF:0000107 		RGD
Ensembl		 PMID:11226230 GO_REF:0000107 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
mitochondrial fragmentation involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg3 autophagy related 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:20723759)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:20723759 GO_REF:0000024 GO_REF:0000107 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
ISS 		(PMID:12499352)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:12499352 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IEA 		(PMID:20436456)
GO_REF:0000107 		RGD
Ensembl		 PMID:20436456 GO_REF:0000107 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO
IEA 		(PMID:15824730)
GO_REF:0000107 		RGD
Ensembl		 PMID:15824730 GO_REF:0000107 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
G Dnm1l dynamin 1-like involved_in IMP
ISO
IBA 		(PMID:12499352)
GO_REF:0000033 		RGD
GO_Central		 PMID:12499352 PMID:17443673 GO_REF:0000033, RGD:12738363 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in ISO
IEA
ISS 		(PMID:16778220)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:16778220 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fis1 fission, mitochondrial 1 IMP RGD PMID:18940801 RGD:2314538 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Nptx1 neuronal pentraxin 1 IMP RGD PMID:22279230 RGD:6903322 NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta IMP RGD PMID:18940801 RGD:2314538 NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,653,721...35,081,025 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:28761318 RGD:13432138 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26618722) RGD PMID:26618722 NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO
IEA 		MGI:1929260 (PMID:20436477)
GO_REF:0000107 		RGD
Ensembl		 PMID:20436477 GO_REF:0000107 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
IEA
ISS 		(PMID:18188704)
GO_REF:0000107 		RGD
Ensembl		 PMID:18188704 PMID:18188704 GO_REF:0000107, RGD:8553738 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IEA
IBA 		(PMID:18371312)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:18371312 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3-ps3 BCL2 interacting protein 3, pseudogene 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:41,782,256...41,782,924
Ensembl chr  X:41,782,209...41,782,898
Ensembl chr  X:41,782,209...41,782,898 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO
IEA 		(PMID:11700312)
GO_REF:0000107 		RGD
Ensembl		 PMID:11700312 GO_REF:0000107 NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793 		JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) RGD PMID:12482879 NCBI chr10:65,198,700...65,262,807
Ensembl chr10:65,170,560...65,262,804 		JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:12482879) 		UniProt
RGD		 PMID:12482879 GO_REF:0000024 NCBI chr10:14,858,954...14,864,751
Ensembl chr10:14,858,956...14,864,751 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO
ISS 		(PMID:31015432)
GO_REF:0000024 		RGD
UniProt		 PMID:31015432 GO_REF:0000024 NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
negative regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO
IEA 		(PMID:18371312)
GO_REF:0000107 		RGD
Ensembl		 PMID:18371312 GO_REF:0000107 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IMP RGD PMID:17980495 RGD:11561965 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO (PMID:24312627) RGD PMID:24312627 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 IDA RGD PMID:22564366 RGD:9681467 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:18371312) 		Ensembl
UniProt
RGD		 PMID:18371312 GO_REF:0000024 GO_REF:0000107 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO
IEA 		(PMID:15901672)
GO_REF:0000107 		RGD
Ensembl		 PMID:15901672 GO_REF:0000107 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15901672), (PMID:9393856)
GO_REF:0000114 		RGD
ComplexPortal		 PMID:9393856 PMID:15901672 GO_REF:0000114 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO
IEA 		(PMID:27098698)
GO_REF:0000107 		RGD
Ensembl		 PMID:27098698 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G ENSRNOG00000063076 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 7:88,803,047...88,804,403 JBrowse link
G ENSRNOG00000063289 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr10:100,153,638...100,154,558 JBrowse link
G ENSRNOG00000066174 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:201,787,072...201,792,824 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO
IEA 		MGI:104995 (PMID:15288121)
GO_REF:0000107 		RGD
Ensembl		 PMID:15288121 GO_REF:0000107 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO
IEA 		(PMID:19096392)
GO_REF:0000107 		RGD
Ensembl		 PMID:19096392 GO_REF:0000107 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:1,988,451...2,025,300
Ensembl chr10:1,988,136...2,007,649 		JBrowse link
G Slc25a31 solute carrier family 25 member 31 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:125,623,331...125,639,155
Ensembl chr 2:123,695,408...123,710,795 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:19154410) 		UniProt
GO_Central
RGD		 PMID:19154410 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc25a5-ps9 solute carrier family 25 member 5, pseudogene 9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:96,656,145...96,657,368
Ensembl chr 3:96,656,151...96,657,400 		JBrowse link
G Slc35f6 solute carrier family 35, member F6 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19154410) 		UniProt
Ensembl
RGD		 PMID:19154410 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:25,725,822...25,737,720
Ensembl chr 6:25,725,819...25,737,730 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) RGD PMID:21723035 NCBI chr 9:23,640,594...23,652,379
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463 		JBrowse link
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:18977203) 		UniProt
Ensembl
RGD		 PMID:18977203 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Arrb2 arrestin, beta 2 IMP RGD PMID:19171933 RGD:5510006 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO
IEA 		(PMID:15901672)
GO_REF:0000107 		RGD
Ensembl		 PMID:15901672 GO_REF:0000107 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in ISO (PMID:15901672), (PMID:9393856)
GO_REF:0000114 		RGD
ComplexPortal		 PMID:9393856 PMID:15901672 GO_REF:0000114 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l2 Bcl2-like 2 IDA RGD PMID:10724126 RGD:14394498 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Fxn frataxin involved_in ISO (PMID:16608849) RGD PMID:16608849 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein involved_in ISO (PMID:18417609) RGD PMID:18417609 NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in ISO
IEA 		(PMID:12221075)
GO_REF:0000107 		RGD
Ensembl		 PMID:12221075 GO_REF:0000107 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hgf hepatocyte growth factor involved_in ISO
IEA 		(PMID:20655899)
GO_REF:0000107 		RGD
Ensembl		 PMID:20655899 GO_REF:0000107 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A acts_upstream_of_or_within ISO
IEA 		(PMID:21856340)
GO_REF:0000107 		RGD
Ensembl		 PMID:21856340 GO_REF:0000107 NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:121,514,156...121,523,443 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B IMP RGD PMID:16397188 RGD:1626654 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:18977203) 		UniProt
RGD		 PMID:18977203 GO_REF:0000024 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Lmna lamin A/C acts_upstream_of_or_within ISO (PMID:21151901) RGD PMID:21151901 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Matcap1 microtubule associated tyrosine carboxypeptidase 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:33,158,053...33,166,784
Ensembl chr19:33,158,056...33,166,445 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:18006463 RGD:12738362 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IDA
IBA
ISO 		PMID:10590251
GO_REF:0000033
(PMID:15004034) 		GO_Central
RGD		 PMID:15004034 PMID:10590251 GO_REF:0000033, RGD:10047155 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:16839884)
(PMID:21149567) 		ParkinsonsUK-UCL
Ensembl
RGD		 PMID:16839884 PMID:21149567 GO_REF:0000024 GO_REF:0000107 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pam16 presequence translocase associated motor 16 IDA RGD PMID:24069394 RGD:13462066 NCBI chr10:10,942,534...10,950,654
Ensembl chr10:10,943,001...10,950,649 		JBrowse link
G Parl presenilin associated, rhomboid-like involved_in ISS
ISO 		GO_REF:0000024
(PMID:16839884) 		ParkinsonsUK-UCL
RGD		 PMID:16839884 GO_REF:0000024 NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISS
ISO 		GO_REF:0000024
(PMID:19228691) 		UniProt
RGD		 PMID:19228691 GO_REF:0000024 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Prelid1 PRELI domain containing 1 involved_in ISO (PMID:23931759) RGD PMID:23931759 NCBI chr17:9,310,471...9,313,511
Ensembl chr17:9,305,361...9,308,407 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA
ISS 		(PMID:19880420), (PMID:23453807)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
ParkinsonsUK-UCL		 PMID:19880420 PMID:23453807 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 involved_in ISO
IEA
ISS 		(PMID:19729910)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:19729910 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:109,445,291...109,453,605
Ensembl chr  X:104,656,812...104,665,097 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO
IEA 		(PMID:23931759)
GO_REF:0000107 		RGD
Ensembl		 PMID:23931759 GO_REF:0000107 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
ISS 		(PMID:22304920)
GO_REF:0000024 		RGD
UniProt		 PMID:22304920 GO_REF:0000024 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO
IEA 		MGI:1197519 (PMID:15967824)
GO_REF:0000107 		RGD
Ensembl		 PMID:15967824 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:99702 (PMID:15967824) RGD PMID:15967824 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:17893612 RGD:408346749 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:20041405) RGD PMID:20041405 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Stpg1 sperm-tail PG-rich repeat containing 1 involved_in ISO
IBA
IEA 		(PMID:23028632)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:23028632 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:147,717,084...147,769,792
Ensembl chr 5:147,726,646...147,769,788 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) RGD PMID:19096392 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:26949185) 		UniProt
Ensembl
RGD		 PMID:26949185 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) RGD PMID:26666268 PMID:30092269 NCBI chr20:12,725,839...12,727,638
Ensembl chr20:12,725,842...12,732,763 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:16543145) 		UniProt
RGD		 PMID:16543145 GO_REF:0000024 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO 		GO_REF:0000024
(PMID:16543145) 		UniProt
RGD		 PMID:16543145 GO_REF:0000024 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO
IEA 		UniProtKB:Q9HD36 (PMID:19255499)
GO_REF:0000107 		RGD
Ensembl		 PMID:19255499 GO_REF:0000107 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:21370995) RGD PMID:21370995 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO
IEA 		(PMID:22306510)
GO_REF:0000107 		RGD
Ensembl		 PMID:22306510 GO_REF:0000107 NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISO (PMID:17289999) RGD PMID:17289999 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP RGD PMID:12485416 RGD:2317097 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
ISS 		(PMID:14963330), (PMID:21262771)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:14963330 PMID:21262771 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO
IEA
IBA 		UniProtKB:P70444 (PMID:21041309)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:21041309 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2l11 Bcl2-like 11 involved_in ISO UniProtKB:P70444 (PMID:17289999), (PMID:21041309) RGD PMID:17289999 PMID:21041309 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISS
IBA
IMP
ISO
IEA 		GO_REF:0000024
GO_REF:0000033
UniProtKB:O08734|UniProtKB:P70444 (PMID:10950869), (PMID:21041309)
GO_REF:0000107
(PMID:32029622)
UniProtKB:P70444 (PMID:17289999), (PMID:21041309), (PMID:21262771) 		UniProt
GO_Central
RGD
Ensembl		 PMID:10950869 PMID:17289999 PMID:21041309 PMID:21262771 PMID:32029622 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:408345233 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer involved_in ISO (PMID:21041309) RGD PMID:21041309 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Bmf Bcl2 modifying factor involved_in ISO UniProtKB:P70444 (PMID:21041309) RGD PMID:21041309 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO
IEA 		(PMID:20436456)
GO_REF:0000107 		RGD
Ensembl		 PMID:20436456 GO_REF:0000107 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Fam162a family with sequence similarity 162, member A involved_in ISS
ISO
IBA 		GO_REF:0000024
(PMID:15082785)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:15082785 GO_REF:0000024 GO_REF:0000033 NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in IDA PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hrk harakiri, BCL2 interacting protein involved_in ISO
IEA 		(PMID:21041309)
GO_REF:0000107 		RGD
Ensembl		 PMID:21041309 GO_REF:0000107 NCBI chr12:44,048,402...44,070,561 JBrowse link
G LOC120095320 protein FAM162A-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:36,389,447...36,391,357
Ensembl chr10:36,390,113...36,390,613 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in ISS
IEA
IBA
ISO 		GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:18852119) 		UniProt
Ensembl
GO_Central
RGD		 PMID:18852119 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA 		(PMID:22984561)
GO_REF:0000107 		RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643
Ensembl chr17:121,882,366...121,898,643 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO
IEA 		(PMID:19880420)
GO_REF:0000107 		RGD
Ensembl		 PMID:19880420 GO_REF:0000107 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pla2g6 phospholipase A2 group VI IDA RGD PMID:18936091 RGD:6482750 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO
IEA 		(PMID:22984561)
GO_REF:0000107 		RGD
Ensembl		 PMID:22984561 GO_REF:0000107 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:14500711), (PMID:14699081), (PMID:15705586), (PMID:17289999) RGD PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO
IEA 		(PMID:14730312)
GO_REF:0000107 		RGD
Ensembl		 PMID:14730312 GO_REF:0000107 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in ISO (PMID:22266862) RGD PMID:22266862 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA 		(PMID:14963330)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:23289926 RGD:11553920 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO
IEA 		MGI:108093|MGI:1929260|MGI:98834 (PMID:14963330), (PMID:23744079)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 PMID:23744079 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO
IEA 		MGI:1929260|MGI:99702 (PMID:14963330), (PMID:23744079)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 PMID:23744079 GO_REF:0000107 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha involved_in
acts_upstream_of_or_within 		ISS
ISO 		GO_REF:0000024
(PMID:23051746) 		ParkinsonsUK-UCL
RGD		 PMID:23051746 GO_REF:0000024 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:108093|MGI:99702 (PMID:20436477), (PMID:23744079) RGD PMID:20436477 PMID:23744079 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189 		JBrowse link
G Naif1 nuclear apoptosis inducing factor 1 involved_in ISO
IEA 		(PMID:16378748)
GO_REF:0000107 		RGD
Ensembl		 PMID:16378748 GO_REF:0000107 NCBI chr 3:15,741,239...15,747,672
Ensembl chr 3:15,742,919...15,747,669 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K involved_in ISO
IEA 		(PMID:17374715)
GO_REF:0000107 		RGD
Ensembl		 PMID:17374715 GO_REF:0000107 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152 		JBrowse link
G Them4 thioesterase superfamily member 4 involved_in ISO
ISS 		(PMID:19168129)
GO_REF:0000024 		RGD
UniProt		 PMID:19168129 GO_REF:0000024 NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA 		MGI:99702 (PMID:14963330)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO
IEA 		(PMID:18591963)
GO_REF:0000107 		RGD
Ensembl		 PMID:18591963 GO_REF:0000107 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO
IEA 		(PMID:17828305)
GO_REF:0000107 		RGD
Ensembl		 PMID:17828305 GO_REF:0000107 NCBI chr10:54,523,901...54,525,997
Ensembl chr10:54,523,585...54,525,990 		JBrowse link
regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr3 phospholipid scramblase 3 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:14573790), (PMID:18358005) 		UniProt
Ensembl
RGD		 PMID:14573790 PMID:18358005 GO_REF:0000024 GO_REF:0000107 NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709 		JBrowse link
release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856098 (PMID:11311799) RGD PMID:11311799 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Bad BCL2-associated agonist of cell death involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:3029528 (PMID:12431371) 		GO_Central
RGD		 PMID:12431371 GO_REF:0000033 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in IMP
IEA
ISO
IBA 		positive regulation
GO_REF:0000107
(PMID:10950869)
GO_REF:0000033
UniProtKB:O08734 (PMID:16199525), (PMID:21041309), (PMID:9843949) 		Ensembl
RGD
GO_Central		 PMID:9843949 PMID:10950869 PMID:16199525 PMID:21041309 PMID:18252800 GO_REF:0000033 GO_REF:0000107, RGD:2313987 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within 		IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
MGI:108093|MGI:98834 (PMID:12925707), (PMID:14614769), (PMID:14623868), (PMID:14963330), (PMID:17052454), (PMID:9560217)
(PMID:16199525), (PMID:17052454), (PMID:25609812), (PMID:9843949) 		Ensembl
GO_Central
RGD		 PMID:9560217 PMID:9843949 PMID:12925707 PMID:14614769 PMID:14623868 More... GO_REF:0000033 GO_REF:0000107, RGD:14394498 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO
IBA 		(PMID:11463392)
GO_REF:0000033 		RGD
GO_Central		 PMID:11463392 GO_REF:0000033 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in ISS
ISO
IBA 		PMID:9843949
(PMID:9843949)
GO_REF:0000033 		RGD
GO_Central		 PMID:9843949 PMID:9843949 GO_REF:0000033, RGD:8554139 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 involved_in
acts_upstream_of_or_within 		ISO
IBA 		(PMID:9843949)
GO_REF:0000033
MGI:99702 (PMID:17052454) 		RGD
GO_Central		 PMID:9843949 PMID:17052454 GO_REF:0000033 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l10 Bcl2-like 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Bcl2l2 Bcl2-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within 		IDA
ISO
IEA 		(PMID:18084238)
MGI:2158671 (PMID:11369777)
GO_REF:0000107
(PMID:17052454) 		RGD
Ensembl		 PMID:11369777 PMID:17052454 PMID:18084238 PMID:18252800 GO_REF:0000107, RGD:2313987 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO
IEA
IBA 		(PMID:27505430)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:27505430 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:11964411 RGD:625521 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ggct gamma-glutamyl cyclotransferase involved_in ISO
IEA 		(PMID:16765912)
GO_REF:0000107 		RGD
Ensembl		 PMID:16765912 GO_REF:0000107 NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IMP induces release following removal of NGF from sympathetic neurons RGD PMID:11301023 RGD:2290592 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:15504737 RGD:2298783 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:2678372 (PMID:12952892)
GO_REF:0000002
(PMID:14699081) 		RGD
InterPro		 PMID:12952892 PMID:14699081 GO_REF:0000002 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Sfn stratifin involved_in ISO (PMID:11574543) RGD PMID:11574543 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Smad3 SMAD family member 3 IMP RGD PMID:11839804 RGD:2301029 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857344|MGI:1857480 (PMID:10212301), (PMID:15642323)
GO_REF:0000107 		RGD
Ensembl		 PMID:10212301 PMID:15642323 GO_REF:0000107 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 acts_upstream_of_or_within ISO
IEA 		(PMID:15044455)
GO_REF:0000107 		RGD
Ensembl		 PMID:15044455 GO_REF:0000107 NCBI chr 1:92,702,437...92,710,311
Ensembl chr 1:83,556,757...83,582,793 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA 		MGI:99702 (PMID:14963330), (PMID:15483136)
GO_REF:0000107 		RGD
Ensembl		 PMID:14963330 PMID:15483136 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
release of matrix enzymes from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
IEA
ISS 		(PMID:9843949)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:9843949 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell death 2200
        programmed cell death 2200
          apoptotic process 2122
            apoptotic mitochondrial changes 129
              mitochondrial fragmentation involved in apoptotic process 11
              regulation of mitochondrial membrane permeability involved in apoptotic process + 50
              release of cytochrome c from mitochondria + 63
              release of matrix enzymes from mitochondria 1
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular component organization or biogenesis 7114
        cellular component organization 6827
          organelle organization 3713
            mitochondrion organization 484
              apoptotic mitochondrial changes 129
                mitochondrial fragmentation involved in apoptotic process 11
                regulation of mitochondrial membrane permeability involved in apoptotic process + 50
                release of cytochrome c from mitochondria + 63
                release of matrix enzymes from mitochondria 1
paths to the root