Nol3 (nucleolar protein 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nol3 (nucleolar protein 3) Chinchilla lanigera
Analyze
Symbol: Nol3
Name: nucleolar protein 3
RGD ID: 8878023
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); caspase binding (ortholog); cysteine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cardiac muscle cell apoptotic process (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); cataract 5 multiple types (ortholog); Chromosome 16q12 Duplication Syndrome (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleolar protein 3 (apoptosis repressor with CARD domain)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
mRNA splice site recognition  (ISO)
myoblast differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of death-inducing signaling complex assembly  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of mitochondrial calcium ion concentration  (ISO)
negative regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
negative regulation of muscle atrophy  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of programmed necrotic cell death  (ISO)
negative regulation of protein targeting to mitochondrion  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of striated muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein complex oligomerization  (ISO)
regulation of gene expression  (ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
response to hypoxia  (ISO)
response to injury involved in regulation of muscle adaptation  (ISO)
response to ischemia  (ISO)
smooth muscle cell proliferation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nol3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBIChiLan1.0ChiLan1.0
NOL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,170,538 - 67,175,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,170,154 - 67,175,737 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,204,441 - 67,209,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,765,371 - 65,767,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 341665,765,370 - 65,767,125NCBI
Celera1651,712,649 - 51,717,887 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,077,589 - 53,082,828 (+)NCBIHuRef
CHM1_11668,611,732 - 68,616,967 (+)NCBICHM1_1
T2T-CHM13v2.01672,964,831 - 72,970,031 (+)NCBIT2T-CHM13v2.0
Nol3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,002,777 - 106,008,571 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,002,772 - 106,008,571 (+)EnsemblGRCm39 Ensembl
GRCm388105,276,145 - 105,281,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,276,140 - 105,281,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,800,347 - 107,805,839 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,165,576 - 108,171,068 (+)NCBIMGSCv36mm8
Celera8109,499,596 - 109,505,088 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Nol3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,066,493 - 50,068,175 (+)NCBIGRCr8
mRatBN7.21933,154,061 - 33,158,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,154,062 - 33,158,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1939,972,172 - 39,973,839 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,625,491 - 40,627,158 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01942,914,430 - 42,916,067 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,232,567 - 37,236,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,235,001 - 37,236,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,098,203 - 48,102,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,094,345 - 35,096,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,099,225 - 35,100,893 (+)NCBI
Celera1932,585,344 - 32,587,011 (+)NCBICelera
Cytogenetic Map19q11NCBI
NOL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,700,244 - 76,705,501 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,612,801 - 82,618,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,516,156 - 47,521,441 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,904,738 - 66,909,956 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,904,738 - 66,909,956 (+)Ensemblpanpan1.1panPan2
Nol3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,940,899 - 41,944,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,644,653 - 17,648,211 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,644,299 - 17,648,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,281,492 - 60,286,865 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604723,033,169 - 23,039,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000015945   ⟹   ENSCLAP00000015782
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554849,443,090 - 9,447,095 (-)Ensembl
RefSeq Acc Id: XM_013503986   ⟹   XP_013359440
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554849,443,090 - 9,445,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503987   ⟹   XP_013359441
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554849,443,090 - 9,447,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503988   ⟹   XP_013359442
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554849,443,090 - 9,447,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503989   ⟹   XP_013359443
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554849,443,090 - 9,447,140 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503990   ⟹   XP_013359444
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554849,443,090 - 9,447,142 (-)NCBI
Sequence:
RefSeq Acc Id: XP_013359444   ⟸   XM_013503990
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YQG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359443   ⟸   XM_013503989
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YQG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359442   ⟸   XM_013503988
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YQG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359441   ⟸   XM_013503987
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YQG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013359440   ⟸   XM_013503986
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000015782   ⟸   ENSCLAT00000015945
Protein Domains
CARD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010849 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015945 ENTREZGENE
  ENSCLAT00000015945.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro Apoptosis_Repressor_CARD UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Nol3 ENTREZGENE
PANTHER CARD6/NUCLEOLAR PROTEIN 3 UniProtKB/TrEMBL
  NUCLEOLAR PROTEIN 3 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A8C2YQG4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Nol3  nucleolar protein 3    nucleolar protein 3 (apoptosis repressor with CARD domain)  Symbol and/or name change 5135510 APPROVED