Prkn (parkin RBR E3 ubiquitin protein ligase) - Rat Genome Database

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Pathways
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Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Chinchilla lanigera
Analyze
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
RGD ID: 8883716
Description: ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cullin family protein binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); aggresome assembly (ortholog); cellular response to hydrogen sulfide (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN aggresome (ortholog); axon (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase parkin; Park2; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543918,664,379 - 19,951,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543918,664,230 - 19,953,358 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
aggresome assembly  (ISO)
cellular response to hydrogen sulfide  (ISO)
cellular response to L-glutamate  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to manganese ion  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to toxic substance  (ISO)
dopamine metabolic process  (ISO)
dopamine uptake involved in synaptic transmission  (ISO)
free ubiquitin chain polymerization  (ISO)
learning  (ISO)
locomotory behavior  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrion localization  (ISO)
mitochondrion to lysosome vesicle-mediated transport  (ISO)
mitophagy  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation by host of viral genome replication  (ISO)
negative regulation of actin filament bundle assembly  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of exosomal secretion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of intralumenal vesicle formation  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of spontaneous neurotransmitter secretion  (ISO)
negative regulation of synaptic transmission, glutamatergic  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
norepinephrine metabolic process  (ISO)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of mitochondrial fusion  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitophagy  (ISO)
positive regulation of mitophagy in response to mitochondrial depolarization  (ISO)
positive regulation of neurotransmitter uptake  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein linear polyubiquitination  (ISO)
positive regulation of protein localization to membrane  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
proteasomal protein catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein autoubiquitination  (ISO)
protein catabolic process  (ISO)
protein destabilization  (ISO)
protein K11-linked ubiquitination  (ISO)
protein K48-linked ubiquitination  (ISO)
protein K6-linked ubiquitination  (ISO)
protein K63-linked ubiquitination  (ISO)
protein localization to mitochondrion  (ISO)
protein metabolic process  (ISO)
protein monoubiquitination  (ISO)
protein polyubiquitination  (ISO)
protein stabilization  (ISO)
protein ubiquitination  (ISO)
regulation of autophagy  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of dopamine metabolic process  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of postsynaptic membrane neurotransmitter receptor levels  (ISO)
regulation of protein stability  (ISO)
regulation of protein ubiquitination  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation protein catabolic process at presynapse  (ISO)
response to corticosterone  (ISO)
response to curcumin  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to muscle activity  (ISO)
response to unfolded protein  (ISO)
response to xenobiotic stimulus  (ISO)
startle response  (ISO)
synaptic transmission, dopaminergic  (ISO)
synaptic transmission, glutamatergic  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543918,664,379 - 19,951,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543918,664,230 - 19,953,358 (+)NCBIChiLan1.0ChiLan1.0
PRKN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386161,347,417 - 162,727,766 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6161,347,417 - 162,727,775 (-)EnsemblGRCh38hg38GRCh38
GRCh376161,768,449 - 163,148,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,689,661 - 163,068,793 (-)NCBINCBI36Build 36hg18NCBI36
Build 346161,740,081 - 163,119,211NCBI
Celera6162,497,923 - 163,878,436 (-)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6159,224,034 - 160,600,983 (-)NCBIHuRef
CHM1_16162,031,091 - 163,411,071 (-)NCBICHM1_1
T2T-CHM13v2.06162,705,911 - 164,090,895 (-)NCBIT2T-CHM13v2.0
Prkn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391711,059,227 - 12,282,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1711,059,271 - 12,282,248 (+)EnsemblGRCm39 Ensembl
GRCm381710,840,359 - 12,063,370 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,840,384 - 12,063,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv371711,033,250 - 12,256,227 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361710,683,742 - 11,906,719 (+)NCBIMGSCv36mm8
Celera1710,880,667 - 12,092,859 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.8NCBI
Prkn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8151,236,410 - 52,430,242 (-)NCBIGRCr8
mRatBN7.2148,688,651 - 49,882,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,690,556 - 49,882,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,387,875 - 50,601,445 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,372,640 - 56,585,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,463,372 - 50,676,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBICelera
Cytogenetic Map1q11NCBI
PRKN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,523,208 - 182,914,092 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,428,720 - 180,815,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06159,293,016 - 160,679,106 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16164,498,420 - 165,678,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6164,314,990 - 165,678,770 (-)Ensemblpanpan1.1panPan2
PRKN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,886,887 - 51,201,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,889,005 - 51,201,764 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,729,328 - 52,042,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0150,071,882 - 51,381,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl150,071,597 - 51,381,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,954,154 - 51,268,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,824,568 - 51,126,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,440,798 - 51,751,574 (-)NCBIUU_Cfam_GSD_1.0
Prkn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,866,545 - 145,855,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648912,120,678 - 13,327,872 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648912,118,538 - 12,913,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15,465,312 - 6,730,872 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115,698,508 - 6,731,132 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.217,649,954 - 8,260,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.217,197,051 - 7,562,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,856,056 - 90,329,379 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604061,183,625 - 62,136,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624855430,260 - 1,989,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624855430,148 - 1,992,121 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005390686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005390687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005390688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005390689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01036062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01036096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDF01253845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000012145   ⟹   ENSCLAP00000012004
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543918,664,379 - 19,951,152 (+)Ensembl
RefSeq Acc Id: XM_005390686   ⟹   XP_005390743
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543918,664,230 - 19,953,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390687   ⟹   XP_005390744
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543918,664,230 - 19,922,686 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390688   ⟹   XP_005390745
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543918,664,230 - 19,863,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005390689   ⟹   XP_005390746
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543918,664,230 - 19,773,172 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390743 (Get FASTA)   NCBI Sequence Viewer  
  XP_005390744 (Get FASTA)   NCBI Sequence Viewer  
  XP_005390745 (Get FASTA)   NCBI Sequence Viewer  
  XP_005390746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012004
  ENSCLAP00000012004.1
Reference Protein Sequences
RefSeq Acc Id: XP_005390743   ⟸   XM_005390686
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VAC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005390745   ⟸   XM_005390688
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005390744   ⟸   XM_005390687
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005390746   ⟸   XM_005390689
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000012004   ⟸   ENSCLAT00000012145
Protein Domains
RING-type   Ubiquitin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008284 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012145 ENTREZGENE
  ENSCLAT00000012145.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1750 UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/TrEMBL
InterPro BRcat_RBR_parkin UniProtKB/TrEMBL
  E3_UB_ligase_RBR UniProtKB/TrEMBL
  IBR_dom UniProtKB/TrEMBL
  Parkin UniProtKB/TrEMBL
  Parkin_Znf-RING UniProtKB/TrEMBL
  Rcat_RBR_parkin UniProtKB/TrEMBL
  RING-HC_RBR_parkin UniProtKB/TrEMBL
  TRIAD_supradom UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  Znf-RING_14 UniProtKB/TrEMBL
NCBI Gene Park2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE PARKIN UniProtKB/TrEMBL
  RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
  zf-RING_12 UniProtKB/TrEMBL
  zf-RING_14 UniProtKB/TrEMBL
PIRSF Parkin UniProtKB/TrEMBL
PRINTS PARKIN UniProtKB/TrEMBL
PROSITE TRIAD UniProtKB/TrEMBL
  UBIQUITIN_2 UniProtKB/TrEMBL
SMART IBR UniProtKB/TrEMBL
  UBQ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8C2VAC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-28 Prkn  parkin RBR E3 ubiquitin protein ligase  Park2    Symbol and/or name change 5135510 APPROVED
2015-08-25 Park2  parkin RBR E3 ubiquitin protein ligase    parkinson protein 2, E3 ubiquitin protein ligase (parkin)  Symbol and/or name change 5135510 APPROVED