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ONTOLOGY REPORT - ANNOTATIONS

Term:salivary gland development
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Accession:GO:0007431 term browser browse the term
Definition:The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.


show annotations for term's descendants           Sort by:
salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL3 achaete-scute family bHLH transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:8,937,578...8,943,016
Ensembl chr11:8,937,578...8,943,016 		JBrowse link
G CST3 cystatin C ISO Submandibular gland RGD PMID:10075146 RGD:2306516 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473 		JBrowse link
G FGF10 fibroblast growth factor 10 involved_in IMP (PMID:17213838) UniProt PMID:17213838 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G MUC19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) MGI PMID:37475871 NCBI chr12:40,393,394...40,570,757
Ensembl chr12:40,393,395...40,570,832 		JBrowse link
G NKX3-1 NK3 homeobox 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:10906459) UniProt
MGI
Ensembl		 PMID:10906459 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938 		JBrowse link
G TFCP2L1 transcription factor CP2 like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17079272) Ensembl
MGI		 PMID:17079272 GO_REF:0000107 NCBI chr 2:121,216,587...121,285,202
Ensembl chr 2:121,216,587...121,285,202 		JBrowse link
branch elongation involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15972105) Ensembl
MGI		 PMID:15972105 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:15972105) UniProt
MGI		 PMID:15972105 GO_REF:0000024 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
branching involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP7 bone morphogenetic protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11731698) Ensembl
MGI		 PMID:11731698 GO_REF:0000107 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G DAG1 dystroglycan 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11798066) Ensembl
MGI		 PMID:11798066 GO_REF:0000107 NCBI chr 3:49,468,948...49,535,615
Ensembl chr 3:49,468,713...49,535,618 		JBrowse link
G ESRP1 epithelial splicing regulatory protein 1 acts_upstream_of_or_within ISO (PMID:26371508) MGI PMID:26371508 NCBI chr 8:94,641,174...94,707,466
Ensembl chr 8:94,641,074...94,707,466 		JBrowse link
G ESRP2 epithelial splicing regulatory protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26371508) Ensembl
MGI		 PMID:26371508 GO_REF:0000107 NCBI chr16:68,229,033...68,236,127
Ensembl chr16:68,229,033...68,238,102 		JBrowse link
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15972105)
(PMID:18559345)		 Ensembl
MGI		 PMID:15972105 PMID:18559345 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G FGF7 fibroblast growth factor 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18559345) Ensembl
MGI		 PMID:18559345 GO_REF:0000107 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775 		JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15042696)
(PMID:15063181)		 Ensembl
MGI		 PMID:15042696 PMID:15063181 GO_REF:0000107 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12421715), (PMID:18559345) Ensembl
MGI		 PMID:12421715 PMID:18559345 GO_REF:0000107 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:11731698) UniProt
MGI		 PMID:11731698 GO_REF:0000024 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:11275690) MGI PMID:11275690 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LAMA1 laminin subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11798066) Ensembl
MGI		 PMID:11798066 GO_REF:0000107 NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797 		JBrowse link
G LAMA5 laminin subunit alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14568553) Ensembl
MGI		 PMID:14568553 GO_REF:0000107 NCBI chr20:62,309,065...62,367,312
Ensembl chr20:62,307,955...62,367,312 		JBrowse link
G PDGFB platelet derived growth factor subunit B acts_upstream_of_or_within ISO (PMID:18559345) MGI PMID:18559345 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15042696) Ensembl
MGI		 PMID:15042696 GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G TGM2 transglutaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15970210) Ensembl
MGI		 PMID:15970210 GO_REF:0000107 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
cell differentiation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11976342) Ensembl
MGI		 PMID:11976342 GO_REF:0000107 NCBI chr 3:184,346,185...184,361,605
Ensembl chr 3:184,346,185...184,361,650 		JBrowse link
G MUC19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:12847143)
(PMID:23580649)		 MGI PMID:12847143 PMID:23580649 NCBI chr12:40,393,394...40,570,757
Ensembl chr12:40,393,395...40,570,832 		JBrowse link
G NFIB nuclear factor I B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25403566) Ensembl
MGI		 PMID:25403566 GO_REF:0000107 NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983 		JBrowse link
dichotomous subdivision of terminal units involved in salivary gland branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRP1 neuropilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17626059) Ensembl
MGI		 PMID:17626059 GO_REF:0000107 NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262 		JBrowse link
G PLXNA1 plexin A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17626059) Ensembl
MGI		 PMID:17626059 GO_REF:0000107 NCBI chr 3:126,983,115...127,037,389
Ensembl chr 3:126,982,693...127,037,389 		JBrowse link
G PLXND1 plexin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17626059) Ensembl
MGI		 PMID:17626059 GO_REF:0000107 NCBI chr 3:129,555,214...129,606,676
Ensembl chr 3:129,555,214...129,606,676 		JBrowse link
G SEMA3A semaphorin 3A acts_upstream_of_or_within ISO (PMID:17626059) MGI PMID:17626059 NCBI chr 7:83,955,777...84,492,725
Ensembl chr 7:83,955,777...84,492,724 		JBrowse link
G SEMA3C semaphorin 3C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17626059) Ensembl
MGI		 PMID:17626059 GO_REF:0000107 NCBI chr 7:80,742,538...80,922,389
Ensembl chr 7:80,742,538...80,922,359 		JBrowse link
epithelial cell differentiation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNND1 catenin delta 1 acts_upstream_of_or_within ISO (PMID:16399075) MGI PMID:16399075 NCBI chr11:57,761,802...57,819,540
Ensembl chr11:57,753,243...57,819,546 		JBrowse link
epithelial cell maturation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XBP1 X-box binding protein 1 acts_upstream_of_or_within ISO (PMID:16362047) MGI PMID:16362047 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
epithelial cell proliferation involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15972105) Ensembl
MGI		 PMID:15972105 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:15972105) UniProt
MGI		 PMID:15972105 GO_REF:0000024 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:11275690) MGI PMID:11275690 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NKX3-1 NK3 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 (PMID:10906459) Ensembl
MGI
UniProt		 PMID:10906459 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938 		JBrowse link
G PDGFB platelet derived growth factor subunit B acts_upstream_of_or_within ISO (PMID:18559345) MGI PMID:18559345 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15042696) Ensembl
MGI		 PMID:15042696 GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11241200) Ensembl
MGI		 PMID:11241200 GO_REF:0000107 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
regulation of branching involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTBD7 BTB domain containing 7 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:20671187) Ensembl
GO_Central
MGI		 PMID:20671187 GO_REF:0000033 GO_REF:0000107 NCBI chr14:93,237,550...93,333,036
Ensembl chr14:93,237,550...93,333,092 		JBrowse link
G CDH1 cadherin 1 acts_upstream_of_or_within ISO (PMID:18816447) MGI PMID:18816447 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20671187) Ensembl
MGI		 PMID:20671187 GO_REF:0000107 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11241200) Ensembl
MGI		 PMID:11241200 GO_REF:0000107 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFA platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:18559345) UniProt
MGI		 PMID:18559345 GO_REF:0000024 NCBI chr 7:497,258...520,700
Ensembl chr 7:497,258...520,296 		JBrowse link
regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTN4 netrin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17588941) Ensembl
MGI		 PMID:17588941 GO_REF:0000107 NCBI chr12:95,657,807...95,791,155
Ensembl chr12:95,657,807...95,791,189 		JBrowse link
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18559345) Ensembl
MGI		 PMID:18559345 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G FGF7 fibroblast growth factor 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18559345) Ensembl
MGI		 PMID:18559345 GO_REF:0000107 NCBI chr15:49,423,242...49,488,775
Ensembl chr15:49,423,237...49,488,775 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18559345) Ensembl
MGI		 PMID:18559345 GO_REF:0000107 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G HGF hepatocyte growth factor acts_upstream_of_or_within
involved_in		 IDA
IEA		 (PMID:14517989) MGI
Ensembl		 PMID:14517989 GO_REF:0000107 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:14517989) MGI PMID:14517989 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
salivary gland cavitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH1 cadherin 1 acts_upstream_of_or_within ISO (PMID:18816447) MGI PMID:18816447 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G EDA ectodysplasin A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12629675) Ensembl
MGI		 PMID:12629675 GO_REF:0000107 NCBI chr  X:69,616,113...70,039,472
Ensembl chr  X:69,616,067...70,039,472 		JBrowse link
G EDAR ectodysplasin A receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12629675) Ensembl
MGI		 PMID:12629675 GO_REF:0000107 NCBI chr 2:108,894,471...108,989,220
Ensembl chr 2:108,894,471...108,989,372 		JBrowse link
G NFIB nuclear factor I B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25403566) Ensembl
MGI		 PMID:25403566 GO_REF:0000107 NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16332353) Ensembl
MGI		 PMID:16332353 GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G TGM2 transglutaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15970210) Ensembl
MGI		 PMID:15970210 GO_REF:0000107 NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578 		JBrowse link
salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP7 bone morphogenetic protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11731698) Ensembl
MGI		 PMID:11731698 GO_REF:0000107 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G CTNND1 catenin delta 1 acts_upstream_of_or_within ISO (PMID:16399075) MGI PMID:16399075 NCBI chr11:57,761,802...57,819,540
Ensembl chr11:57,753,243...57,819,546 		JBrowse link
G EGFR epidermal growth factor receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10521784) Ensembl
MGI		 PMID:10521784 GO_REF:0000107 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15654336) Ensembl
MGI		 PMID:15654336 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12421715) Ensembl
MGI		 PMID:12421715 GO_REF:0000107 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G PAX6 paired box 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11731698) Ensembl
MGI		 PMID:11731698 GO_REF:0000107 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24388753) Ensembl
MGI		 PMID:24388753 GO_REF:0000107 NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IEP (PMID:18080134) BHF-UCL PMID:18080134 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEP (PMID:18080134) BHF-UCL PMID:18080134 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in IEP (PMID:18080134) BHF-UCL PMID:18080134 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16289463) Ensembl
MGI		 PMID:16289463 GO_REF:0000107 NCBI chr18:9,334,773...9,402,420
Ensembl chr18:9,334,767...9,402,420 		JBrowse link
submandibular salivary gland formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC42 cell division cycle 42 involved_in ISO
IEA		 RGD
Ensembl		 PMID:18784978 GO_REF:0000107 RGD:5688282 NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360 		JBrowse link
G FGF10 fibroblast growth factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11062007) Ensembl
MGI		 PMID:11062007 GO_REF:0000107 NCBI chr 5:44,300,247...44,389,420
Ensembl chr 5:44,300,247...44,389,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    multicellular organismal process 8483
      multicellular organism development 5649
        system development 4923
          exocrine system development 61
            salivary gland development 47
              cell differentiation involved in salivary gland development + 5
              salivary gland boundary specification + 0
              salivary gland morphogenesis + 41
Path 2
Term Annotations click to browse term
  biological_process 19770
    developmental process 7625
      anatomical structure development 7039
        multicellular organism development 5649
          system development 4923
            exocrine system development 61
              salivary gland development 47
                cell differentiation involved in salivary gland development + 5
                salivary gland boundary specification + 0
                salivary gland morphogenesis + 41
paths to the root