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Gene: PDGFA (platelet derived growth factor subunit A) Homo sapiens
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Symbol: PDGFA
Name: platelet derived growth factor subunit A
Description: Exhibits several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of cell migration; and regulation of phosphate metabolic process. Localizes to cell surface and extracellular space. Implicated in malignant glioma. Biomarker of Leydig cell tumor; breast cancer; leiomyoma; and prostate adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PDGF A-chain; PDGF subunit A; PDGF-1; PDGF-A; PDGF1; platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A
Orthologs:
Mus musculus (house mouse) : Pdgfa (platelet derived growth factor, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdgfa (platelet derived growth factor subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfa (platelet derived growth factor subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFA (platelet derived growth factor subunit A)
Canis lupus familiaris (dog) : PDGFA (platelet derived growth factor subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfa (platelet derived growth factor subunit A)
Sus scrofa (pig) : PDGFA (platelet derived growth factor subunit A)
Chlorocebus sabaeus (African green monkey) : PDGFA (platelet derived growth factor subunit A)
Heterocephalus glaber (naked mole-rat) : Pdgfa (platelet derived growth factor subunit A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7497,258 - 520,296 (-)EnsemblGRCh38hg38GRCh38
GRCh387497,245 - 520,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377536,895 - 559,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367503,421 - 526,007 (-)NCBINCBI36hg18NCBI36
Celera7505,832 - 559,337 (-)NCBI
Cytogenetic Map7p22.3NCBI
HuRef7455,023 - 477,393 (-)NCBIHuRef
CHM1_17535,640 - 589,379 (-)NCBICHM1_1
CRA_TCAGchr7v27598,080 - 651,496 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDGFA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736070
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.