SHH (sonic hedgehog signaling molecule) - Rat Genome Database

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Gene: SHH (sonic hedgehog signaling molecule) Homo sapiens
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Symbol: SHH
Name: sonic hedgehog signaling molecule
RGD ID: 736829
HGNC Page HGNC:10848
Description: Enables calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including hemopoiesis; positive regulation of sclerotome development; and positive regulation of smoothened signaling pathway. Acts upstream of or within epithelial-mesenchymal cell signaling. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Biomarker of several diseases, including autism spectrum disorder; biliary atresia; gastrointestinal system cancer (multiple); glomerulonephritis (multiple); and multiple sclerosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7155,799,980 - 155,812,463 (-)EnsemblGRCh38hg38GRCh38
GRCh377155,592,674 - 155,605,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36Build 36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,604,000 - 155,613,409 (-)NCBICHM1_1
T2T-CHM13v2.07156,983,127 - 156,995,607 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model