SHH (sonic hedgehog signaling molecule) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SHH (sonic hedgehog signaling molecule) Homo sapiens
Analyze
Symbol: SHH
Name: sonic hedgehog signaling molecule
RGD ID: 736829
HGNC Page HGNC:10848
Description: Enables calcium ion binding activity; patched binding activity; and zinc ion binding activity. Involved in several processes, including hemopoiesis; positive regulation of sclerotome development; and positive regulation of smoothened signaling pathway. Acts upstream of or within epithelial-mesenchymal signaling involved in prostate gland development. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Biomarker of several diseases, including autism spectrum disorder; biliary atresia; gastrointestinal system cancer (multiple); glomerulonephritis (multiple); and multiple sclerosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7155,799,980 - 155,812,463 (-)EnsemblGRCh38hg38GRCh38
GRCh377155,592,674 - 155,605,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36Build 36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,604,000 - 155,613,409 (-)NCBICHM1_1
T2T-CHM13v2.07156,983,127 - 156,995,607 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acrocallosal syndrome  (IAGP)
Anorectal Malformations  (IDA,IEP,ISO)
atrioventricular septal defect  (ISO)
autism spectrum disorder  (IEP)
autistic disorder  (IAGP)
basal cell carcinoma  (IDA)
biliary atresia  (IEP)
brachydactyly type A1  (ISO)
chronic kidney disease  (ISO)
cleft palate  (ISO)
colorectal cancer  (IEP)
Congenital Limb Deformities  (ISO)
demyelinating disease  (ISO)
esophageal atresia/tracheoesophageal fistula  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Eye Abnormalities  (EXP)
Facial Dysmorphism with Multiple Malformations  (EXP)
Failure to Thrive  (IAGP)
Fluoride Poisoning  (ISO)
focal segmental glomerulosclerosis  (IEP)
gastrointestinal stromal tumor  (IEP)
genetic disease  (IAGP)
hepatocellular carcinoma  (EXP)
Hirschsprung's disease  (IAGP)
holoprosencephaly  (EXP,IAGP,ISO)
holoprosencephaly 3  (IAGP)
Hyperoxic Lung Injury  (ISO)
hypoplastic or aplastic tibia with polydactyly  (IAGP)
hypothyroidism  (ISO)
IgA glomerulonephritis  (IEP)
Isolated Microphthalmia with Coloboma 5  (IAGP)
Kidney Reperfusion Injury  (ISO)
membranous glomerulonephritis  (IEP)
microphthalmia  (EXP)
middle cerebral artery infarction  (IDA)
multiple sclerosis  (IEP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neurodevelopmental Disorder with Dysmorphic Facies and Distal Limb Anomalies  (IAGP)
nevoid basal cell carcinoma syndrome  (ISO,ISS)
ocular hypertension  (ISO)
pancreatic cancer  (TAS)
Parkinsonism  (ISO)
Partial Agenesis of Corpus Callosum  (IAGP)
Patterson Stevenson Syndrome  (IAGP)
Peripheral Nerve Injuries  (ISO)
Persistent Cloaca  (IEP,ISO)
polydactyly  (IAGP,ISO)
pre-malignant neoplasm  (ISO)
Preaxial Polydactyly II  (IAGP)
primary progressive multiple sclerosis  (IEP)
Schizencephaly  (IAGP)
secondary Parkinson disease  (EXP)
septooptic dysplasia  (IAGP)
solitary median maxillary central incisor  (IAGP)
Spinal Cord Injuries  (ISO)
stomach cancer  (IEP)
Subarachnoid Hemorrhage  (ISO)
syndactyly type 4  (IAGP)
temporal lobe epilepsy  (IEP,ISO)
ureteral obstruction  (ISO)
VACTERL association  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP,ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP,ISO)
actinomycin D  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
ammonium chloride  (ISO)
apomorphine  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
captopril  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
curcumin  (ISO)
Cyclopamine  (EXP,ISO)
D-glucose  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP,ISO)
ethanol  (ISO)
Ethylenethiourea  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
gemcitabine  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
goralatide  (EXP,ISO)
hydrogen peroxide  (ISO)
ipriflavone  (EXP,ISO)
isotretinoin  (EXP)
lansoprazole  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
melittin  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nitrofen  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
ochratoxin A  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenytoin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
saccharin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP)
tolnaftate  (EXP,ISO)
trans-piceid  (ISO)
triadimefon  (ISO)
triptonide  (EXP)
udenafil  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vismodegib  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IEA,ISO)
alpha-tubulin acetylation  (IEA)
anatomical structure development  (IEA,ISO)
anatomical structure formation involved in morphogenesis  (IEA,ISO)
androgen metabolic process  (IEA,ISO,ISS)
angiogenesis  (IEA,ISO)
animal organ development  (IEA)
animal organ formation  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISS)
artery development  (IEA,ISO)
astrocyte differentiation  (IEA,ISO)
axon guidance  (IEA,ISO,ISS)
Bergmann glial cell differentiation  (IEA,ISO)
blood coagulation  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO,ISS)
branching involved in prostate gland morphogenesis  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
branching morphogenesis of an epithelial tube  (IEA,ISO,ISS)
bud outgrowth involved in lung branching  (IEA,ISO)
camera-type eye development  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (IDA,IEA)
cell development  (IEA,ISO,ISS)
cell fate commitment  (IEA,ISO)
cell fate specification  (IBA,IEA,ISO,ISS)
cell migration  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell proliferation in external granule layer  (IEA,ISO)
cell-cell signaling  (IEA,ISO,ISS)
cellular response to lithium ion  (IEA,ISO)
central nervous system development  (IEA,ISO,ISS)
cerebellar granule cell precursor proliferation  (IEA,ISO,ISS)
commissural neuron axon guidance  (ISO)
determination of left/right asymmetry in lateral mesoderm  (IEA,ISS)
determination of left/right symmetry  (IEA,ISO)
developmental growth  (IEA,ISO)
digestive tract mesoderm development  (ISO)
digestive tract morphogenesis  (IEA,ISO)
dopaminergic neuron differentiation  (TAS)
dorsal/ventral neural tube patterning  (IEA,ISO)
dorsal/ventral pattern formation  (IEA,ISO,ISS)
ectoderm development  (IEA,ISO)
embryonic digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO,ISS)
embryonic foregut morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO,ISS)
embryonic morphogenesis  (IEA,ISO)
embryonic organ development  (IEA,ISO)
embryonic pattern specification  (TAS)
embryonic skeletal system development  (IEA,ISO)
endocytosis  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
epithelial-mesenchymal cell signaling  (IEA,ISO)
epithelial-mesenchymal signaling involved in prostate gland development  (IDA,IEA)
establishment of cell polarity  (IEA)
establishment of epithelial cell polarity  (IEA,ISO)
forebrain development  (IEA,ISO,ISS)
forebrain regionalization  (IEA,ISO)
formation of anatomical boundary  (IEA,ISO)
fungiform papilla development  (ISO)
fungiform papilla formation  (ISO)
fungiform papilla morphogenesis  (ISO)
gene expression  (IEA)
hair follicle development  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
heart development  (IEA,ISO,ISS)
heart looping  (IEA,ISO,ISS)
hindbrain development  (IEA,ISO,ISS)
hindgut morphogenesis  (IEA,ISO)
inner ear development  (IEA,ISO)
intein-mediated protein splicing  (IEA)
intermediate filament organization  (IEA,ISO)
kidney development  (IEA,ISO)
left lung development  (IEA,ISO)
limb bud formation  (IEA,ISO)
limb development  (IEA,ISO)
liver regeneration  (ISO)
lung development  (IEA,ISO,ISS)
lung epithelium development  (IEA,ISO)
lung lobe morphogenesis  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
lung-associated mesenchyme development  (IEA,ISO)
lymphoid progenitor cell differentiation  (IEA,IMP)
male genitalia development  (IEA,ISO,ISS)
male genitalia morphogenesis  (ISO)
mesenchymal cell apoptotic process  (IEA,ISO)
mesenchymal cell proliferation  (IEA,ISO)
mesenchymal cell proliferation involved in lung development  (IEA,ISO)
mesenchymal smoothened signaling pathway involved in prostate gland development  (IEA,ISO)
metanephric collecting duct development  (IEP)
metanephric mesenchymal cell proliferation involved in metanephros development  (IEA,ISS)
metanephros development  (IEA,ISS)
midbrain development  (IEA,ISO,ISS)
myoblast differentiation  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of alpha-beta T cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell differentiation  (ISS)
negative regulation of cell migration  (IEA,ISO,ISS)
negative regulation of cholesterol efflux  (IEA,ISS)
negative regulation of dopaminergic neuron differentiation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of kidney smooth muscle cell differentiation  (IEA,ISS)
negative regulation of mesenchymal cell apoptotic process  (IEA,ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of T cell differentiation in thymus  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
negative regulation of ureter smooth muscle cell differentiation  (IEA,ISS)
negative regulation of Wnt signaling pathway  (IEA,ISO)
negative thymic T cell selection  (IEA,ISS)
neural crest cell migration  (IEA,ISO,ISS)
neural tube formation  (ISO)
neuroblast proliferation  (IEA,ISO,ISS)
neuron differentiation  (IEA,ISO)
neuron fate commitment  (IEA,ISO,ISS)
odontogenesis  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
oligodendrocyte development  (IEA,ISO)
oligodendrocyte differentiation  (IBA,IEA,ISO)
osteoblast development  (IEA,ISO)
pancreas development  (IEA,ISO)
pattern specification process  (IEA,ISO,ISS)
polarity specification of anterior/posterior axis  (IEA,ISS)
positive regulation of alpha-beta T cell differentiation  (IEA,ISS)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of cell division  (IDA)
positive regulation of cell population proliferation  (IDA,IEA,ISO,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of hh target transcription factor activity  (IEA,ISO,ISS)
positive regulation of immature T cell proliferation in thymus  (IEA,ISS)
positive regulation of kidney smooth muscle cell differentiation  (IEA,ISS)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of mesenchymal cell proliferation involved in ureter development  (IEA,ISS)
positive regulation of neuroblast proliferation  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neurotrophin production  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of oligodendrocyte progenitor proliferation  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of photoreceptor cell differentiation  (ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of sclerotome development  (IDA)
positive regulation of skeletal muscle cell proliferation  (IEA,ISO)
positive regulation of skeletal muscle tissue development  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IDA,IEA,ISS)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of striated muscle cell differentiation  (IEA,ISO)
positive regulation of T cell differentiation in thymus  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of ureter smooth muscle cell differentiation  (IEA,ISS)
positive regulation of Wnt signaling pathway  (IEA,ISO)
positive thymic T cell selection  (IEA,ISS)
primary prostatic bud elongation  (IEA,ISO)
prostate epithelial cord elongation  (IEA,ISO)
prostate gland development  (IEA,ISO,ISS)
prostatic bud formation  (ISO)
protein autoprocessing  (IEA)
protein import into nucleus  (IEA,ISO)
protein localization to nucleus  (IEA,ISO)
proteolysis  (IEA)
regulation of cell population proliferation  (ISO,ISS)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
regulation of gene expression  (IBA,IEA,ISO)
regulation of glial cell proliferation  (IEA,ISO)
regulation of mesenchymal cell proliferation involved in prostate gland development  (IEA,ISO)
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (NAS)
regulation of odontogenesis  (IEA,ISS)
regulation of prostatic bud formation  (IEA,ISO)
regulation of protein localization to nucleus  (IDA)
regulation of proteolysis  (IEA,ISO,ISS)
regulation of stem cell proliferation  (IEA,ISO)
respiratory tube development  (IEA,ISO)
response to axon injury  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to organonitrogen compound  (ISO)
response to retinoic acid  (ISO)
right lung development  (IEA,ISO)
roof of mouth development  (IEA,ISO)
salivary gland cavitation  (IEA,ISO)
self proteolysis  (IEA,ISS)
skeletal muscle cell proliferation  (IEA,ISO)
skeletal muscle fiber differentiation  (IEA,ISO)
skeletal muscle tissue development  (IEA,ISO)
skin development  (IEA,ISO)
smooth muscle tissue development  (IEP)
smoothened signaling pathway  (IBA,IDA,IEA,IEP,ISO,ISS)
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation  (IEA,ISO)
somite development  (IEA,ISS)
spinal cord dorsal/ventral patterning  (IEA,ISO)
spinal cord motor neuron differentiation  (IEA,ISO)
stem cell development  (IEA,ISS)
stem cell proliferation  (IEA,ISO)
striated muscle cell differentiation  (IEA,ISO)
striated muscle tissue development  (IEA,ISO)
system development  (IEA)
T cell differentiation in thymus  (IEA,ISO,ISS)
T cell proliferation  (IEA,ISO)
telencephalon regionalization  (IEA,ISO)
thalamus development  (IEA,ISO)
thymus development  (IEA,ISS)
thyroid gland development  (IEA,ISO)
tongue development  (ISO)
tongue morphogenesis  (ISO)
trachea development  (IEA,ISO)
trachea morphogenesis  (IEA,ISO)
tracheoesophageal septum formation  (IEA,ISO)
trunk neural crest cell migration  (IEA,ISO)
vasculature development  (IEA,ISO)
vasculogenesis  (IEA,ISO,ISS)
ventral midline development  (TAS)
ventral spinal cord interneuron specification  (ISO)
zona limitans intrathalamica formation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
1-5 finger syndactyly  (IAGP)
6 metacarpals  (IAGP)
Abnormal brainstem morphology  (IAGP)
Abnormal corpus callosum morphology  (IAGP)
Abnormal heart morphology  (IAGP)
Abnormal heart rate variability  (IAGP)
Abnormal hypothalamus physiology  (IAGP)
Abnormal midbrain morphology  (IAGP)
Abnormal morphology of the olfactory bulb  (IAGP)
Abnormal nasopharynx morphology  (IAGP)
Abnormal rib morphology  (IAGP)
Abnormal septum pellucidum morphology  (IAGP)
Abnormal vertebral morphology  (IAGP)
Abnormality of chromosome segregation  (IAGP)
Abnormality of fibula morphology  (IAGP)
Abnormality of the autonomic nervous system  (IAGP)
Abnormality of the genitourinary system  (IAGP)
Abnormality of the scaphoid  (IAGP)
Abnormality of the trapezium  (IAGP)
Abnormality of vision  (IAGP)
Absent speech  (IAGP)
Agenesis of corpus callosum  (IAGP)
Ambiguous genitalia  (IAGP)
Anophthalmia  (IAGP)
Anosmia  (IAGP)
Anterior hypopituitarism  (IAGP)
Anteriorly placed anus  (IAGP)
Anteverted nares  (IAGP)
Anxiety  (IAGP)
Apathy  (IAGP)
Aplasia of the 1st metacarpal  (IAGP)
Aplasia of the falx cerebri  (IAGP)
Aplasia/Hypoplasia of the radius  (IAGP)
Aplasia/Hypoplasia of the thumb  (IAGP)
Aplasia/Hypoplasia of the tibia  (IAGP)
Aspiration pneumonia  (IAGP)
Asthma  (IAGP)
Attention deficit hyperactivity disorder  (IAGP)
Autism  (IAGP)
Autosomal dominant inheritance  (IAGP)
Bifid uvula  (IAGP)
Bilateral microphthalmos  (IAGP)
Camptodactyly of finger  (IAGP)
Central apnea  (IAGP)
Central diabetes insipidus  (IAGP)
Central hypothyroidism  (IAGP)
Cerebral cortical atrophy  (IAGP)
Cerebral visual impairment  (IAGP)
Choanal atresia  (IAGP)
Chorioretinal coloboma  (IAGP)
Chronic lung disease  (IAGP)
Cleft lip  (IAGP)
Cleft palate  (IAGP)
Cleft upper lip  (IAGP)
Coarctation of aorta  (IAGP)
Coloboma  (IAGP)
Constipation  (IAGP)
Cyclopia  (IAGP)
Decreased response to growth hormone stimulation test  (IAGP)
Depressed nasal bridge  (IAGP)
Depressed nasal ridge  (IAGP)
Depression  (IAGP)
Deviation of the hand or of fingers of the hand  (IAGP)
Diabetes insipidus  (IAGP)
Duodenal atresia  (IAGP)
Dysphagia  (IAGP)
EMG: myopathic abnormalities  (IAGP)
Ethmoidal encephalocele  (IAGP)
Expressive language delay  (IAGP)
Failure to thrive  (IAGP)
Flexion contracture  (IAGP)
Foot polydactyly  (IAGP)
Gastroesophageal reflux  (IAGP)
Gastrostomy tube feeding in infancy  (IAGP)
Generalized hypotonia  (IAGP)
Global developmental delay  (IAGP)
Hand polydactyly  (IAGP)
Hemangioma  (IAGP)
High palate  (IAGP)
Hip dislocation  (IAGP)
Holoprosencephaly  (IAGP)
Hydrocephalus  (IAGP)
Hydronephrosis  (IAGP)
Hypoplasia of penis  (IAGP)
Hypoplasia of the pons  (IAGP)
Hypotelorism  (IAGP)
Hypothyroidism  (IAGP)
Impulsivity  (IAGP)
Inability to walk  (IAGP)
Infantile axial hypotonia  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, mild  (IAGP)
Intrauterine growth retardation  (IAGP)
Iris coloboma  (IAGP)
Irritability  (IAGP)
Lethargy  (IAGP)
Limb dystonia  (IAGP)
Limitation of joint mobility  (IAGP)
Macrocephaly  (IAGP)
Malar flattening  (IAGP)
Maternal diabetes  (IAGP)
Median cleft lip  (IAGP)
Megalencephaly  (IAGP)
Microcephaly  (IAGP)
Microphthalmia  (IAGP)
Midface retrusion  (IAGP)
Midnasal stenosis  (IAGP)
Morphological abnormality of the gastrointestinal tract  (IAGP)
Narrow nasal bridge  (IAGP)
Neural tube defect  (IAGP)
Oral cleft  (IAGP)
Oromotor apraxia  (IAGP)
Panhypopituitarism  (IAGP)
Partial agenesis of the corpus callosum  (IAGP)
Patellar aplasia  (IAGP)
Perisylvian polymicrogyria  (IAGP)
Poor speech  (IAGP)
Poor suck  (IAGP)
Precocious puberty  (IAGP)
Premature birth  (IAGP)
Proboscis  (IAGP)
Prominent median palatal raphe  (IAGP)
Proptosis  (IAGP)
Pyriform aperture stenosis  (IAGP)
Renal agenesis  (IAGP)
Rhombencephalosynapsis  (IAGP)
Schizencephaly  (IAGP)
Scoliosis  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Septo-optic dysplasia  (IAGP)
Short attention span  (IAGP)
Short columella  (IAGP)
Short nose  (IAGP)
Short philtrum  (IAGP)
Short stature  (IAGP)
Short tibia  (IAGP)
Single naris  (IAGP)
Sleep-wake cycle disturbance  (IAGP)
Solitary median maxillary central incisor  (IAGP)
Spasticity  (IAGP)
Specific learning disability  (IAGP)
Strabismus  (IAGP)
Synostosis of carpal bones  (IAGP)
Temperature instability  (IAGP)
Tented upper lip vermilion  (IAGP)
Tetralogy of Fallot  (IAGP)
Toe syndactyly  (IAGP)
Torus palatinus  (IAGP)
Triphalangeal thumb  (IAGP)
Typified by incomplete penetrance  (IAGP)
Variable expressivity  (IAGP)
Ventriculomegaly  (IAGP)
Vomiting  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. Ahmed RP, etal., PLoS One. 2010 Jan 5;5(1):e8576. doi: 10.1371/journal.pone.0008576.
2. Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Al-Ayadhi LY, Neurochem Res. 2012 Feb;37(2):394-400. doi: 10.1007/s11064-011-0624-x. Epub 2011 Oct 9.
3. A novel mutation in the SHH long-range regulator (ZRS) is associated with preaxial polydactyly, triphalangeal thumb, and severe radial ray deficiency. Al-Qattan MM, etal., Am J Med Genet A. 2012 Oct;158A(10):2610-5. doi: 10.1002/ajmg.a.35584. Epub 2012 Aug 17.
4. Identification of two novel mutations in Shh long-range regulator associated with familial pre-axial polydactyly. Albuisson J, etal., Clin Genet. 2011 Apr;79(4):371-7. doi: 10.1111/j.1399-0004.2010.01465.x.
5. Sonic hedgehog is neuroprotective in the cavernous nerve with crush injury. Angeloni N, etal., J Sex Med. 2013 May;10(5):1240-50. doi: 10.1111/j.1743-6109.2012.02930.x. Epub 2012 Sep 20.
6. Fetal ethanol exposure activates protein kinase A and impairs Shh expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly. Aoto K, etal., Birth Defects Res A Clin Mol Teratol. 2008 Apr;82(4):224-31. doi: 10.1002/bdra.20447.
7. Improvement of neurological recovery and stimulation of neural progenitor cell proliferation by intrathecal administration of Sonic hedgehog. Bambakidis NC, etal., J Neurosurg. 2012 May;116(5):1114-20. doi: 10.3171/2012.1.JNS111285. Epub 2012 Feb 10.
8. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
9. Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components. Brinkhuizen T, etal., PLoS One. 2012;7(12):e51710. doi: 10.1371/journal.pone.0051710. Epub 2012 Dec 17.
10. Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions. Cai D, etal., J Cell Physiol. 2019 Jul;234(7):10827-10834. doi: 10.1002/jcp.27908. Epub 2018 Dec 7.
11. Upregulation of Shh and Ptc1 in hyperoxia-induced acute lung injury in neonatal rats. Dang H, etal., Mol Med Rep. 2012 Aug;6(2):297-302. doi: 10.3892/mmr.2012.929. Epub 2012 May 28.
12. Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis. Ding H, etal., J Am Soc Nephrol. 2012 May;23(5):801-13. doi: 10.1681/ASN.2011060614. Epub 2012 Feb 2.
13. Increased expression of sonic hedgehog in temporal lobe epileptic foci in humans and experimental rats. Fang M, etal., Neuroscience. 2011 May 19;182:62-70. doi: 10.1016/j.neuroscience.2011.02.060. Epub 2011 Mar 3.
14. Abnormal Sonic hedgehog signaling in the lung of rats with esophageal atresia induced by adriamycin. Fragoso AC, etal., Pediatr Res. 2014 Oct;76(4):355-62. doi: 10.1038/pr.2014.105. Epub 2014 Jul 8.
15. A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb. Furniss D, etal., Hum Mol Genet. 2008 Aug 15;17(16):2417-23. doi: 10.1093/hmg/ddn141. Epub 2008 May 7.
16. [Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease]. Gao H, etal., Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Oct;13(10):758-61.
17. Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association. Gillick J, etal., J Pediatr Surg. 2003 Mar;38(3):469-73; discussion 469-73.
18. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
19. Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD). Halepoto DM, etal., J Coll Physicians Surg Pak. 2015 Dec;25(12):882-5. doi: 12.2015/JCPSP.882885.
20. Expression of sonic hedgehog regulates morphological changes of rat developing cerebellum in hypothyroidism. Hasebe M, etal., J Toxicol Sci. 2008 Oct;33(4):473-7.
21. Extreme variability of expression of a Sonic Hedgehog mutation: attention difficulties and holoprosencephaly. Heussler HS, etal., Arch Dis Child. 2002 Apr;86(4):293-6.
22. Left cardiac isomerism in the Sonic hedgehog null mouse. Hildreth V, etal., J Anat. 2009 Jun;214(6):894-904. doi: 10.1111/j.1469-7580.2009.01087.x.
23. Hypermethylation of SHH in the pathogenesis of congenital anorectal malformations. Huang Y, etal., J Pediatr Surg. 2014 Sep;49(9):1400-4. doi: 10.1016/j.jpedsurg.2014.03.007.
24. Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart. Hwang JM, etal., Mol Cell Biochem. 2008 Apr;311(1-2):179-87. Epub 2008 Jan 29.
25. Bone marrow-derived mesenchymal stem cells expressing the Shh transgene promotes functional recovery after spinal cord injury in rats. Jia Y, etal., Neurosci Lett. 2014 Jun 24;573:46-51. doi: 10.1016/j.neulet.2014.05.010. Epub 2014 May 15.
26. Sonic hedgehog (SHH) and glioblastoma-2 (Gli-2) expressions are associated with poor jaundice-free survival in biliary atresia. Jung HY, etal., J Pediatr Surg. 2015 Mar;50(3):371-6. doi: 10.1016/j.jpedsurg.2014.08.025. Epub 2014 Dec 20.
27. Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Krebs O, etal., Development. 2003 Dec;130(24):6037-47.
28. Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis. Li R, etal., J Inflamm (Lond). 2015 Mar 28;12:24. doi: 10.1186/s12950-015-0072-5. eCollection 2015.
29. The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats. Li T, etal., Neurosci Lett. 2013 Sep 27;552:81-6. doi: 10.1016/j.neulet.2013.07.042. Epub 2013 Aug 7.
30. Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Maity T, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17026-31. Epub 2005 Nov 10.
31. Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. Mandhan P, etal., J Pediatr Surg. 2006 Dec;41(12):2041-5.
32. Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. Mastronardi FG, etal., J Immunol. 2004 May 15;172(10):6418-26.
33. The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient. Mastronardi FG, etal., Mult Scler. 2003 Aug;9(4):362-71.
34. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
35. Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation. Nicot A, etal., J Neurosci 2002 Nov 1;22(21):9244-54.
36. An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. Niedermaier M, etal., J Clin Invest. 2005 Apr;115(4):900-9.
37. Expression of the Sonic hedgehog (SHH ) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly. Odent S, etal., Hum Mol Genet. 1999 Sep;8(9):1683-9.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Basal cell carcinomas in mice overexpressing sonic hedgehog. Oro AE, etal., Science. 1997 May 2;276(5313):817-21.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
45. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Roessler E, etal., Nat Genet. 1996 Nov;14(3):357-60.
46. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Runck LA, etal., Dis Model Mech. 2014 Apr;7(4):483-93. doi: 10.1242/dmm.014530. Epub 2014 Feb 13.
47. Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Sagai T, etal., Development. 2005 Feb;132(4):797-803.
48. Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos. Sasaki Y, etal., Arch Oral Biol. 2007 Mar;52(3):260-7. Epub 2006 Nov 13.
49. Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer. Saze Z, etal., Dig Surg. 2012;29(2):115-23. doi: 10.1159/000336949. Epub 2012 Mar 27.
50. Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis. Seifert T, etal., J Neuropathol Exp Neurol. 2005 May;64(5):404-11.
51. Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch. Sharpe J, etal., Curr Biol. 1999 Jan 28;9(2):97-100.
52. Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer. Sun M, etal., J Med Genet. 2008 Sep;45(9):589-95. doi: 10.1136/jmg.2008.057646. Epub 2008 Apr 16.
53. Expression and clinical significance of hedgehog signaling pathway related components in colorectal cancer. Wang H, etal., Asian Pac J Cancer Prev. 2012;13(5):2319-24. doi: 10.7314/apjcp.2012.13.5.2319.
54. Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosis. Wang Y, etal., Ann Neurol. 2008 Oct;64(4):417-27. doi: 10.1002/ana.21457.
55. A specific mutation in the distant sonic hedgehog (SHH) cis-regulator (ZRS) causes Werner mesomelic syndrome (WMS) while complete ZRS duplications underlie Haas type polysyndactyly and preaxial polydactyly (PPD) with or without triphalangeal thumb. Wieczorek D, etal., Hum Mutat. 2010 Jan;31(1):81-9. doi: 10.1002/humu.21142.
56. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
57. Neuroprotective effect of up-regulated Sonic hedgehog in retinal ganglion cells following chronic ocular hypertension. Wu J, etal., Invest Ophthalmol Vis Sci. 2010 Jan 13.
58. Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis. Yoshizaki A, etal., World J Gastroenterol. 2006 Sep 21;12(35):5687-91. doi: 10.3748/wjg.v12.i35.5687.
59. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. Zhang J, etal., J Int Med Res. 2009 Nov-Dec;37(6):1842-50.
60. Lentivirus-mediated delivery of sonic hedgehog into the striatum stimulates neuroregeneration in a rat model of Parkinson disease. Zhang Y, etal., Neurol Sci. 2014 Dec;35(12):1931-40. doi: 10.1007/s10072-014-1866-6. Epub 2014 Jul 17.
61. [Expression of sonic hedgehog signaling pathw ay and its inhibition by cyclopamine in rat liver with chronic fluorosis]. Zhao L, etal., Zhonghua Bing Li Xue Za Zhi. 2014 Dec;43(12):814-9.
62. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. Zhou D, etal., J Am Soc Nephrol. 2014 Oct;25(10):2187-200. doi: 10.1681/ASN.2013080893. Epub 2014 Apr 17.
Additional References at PubMed
PMID:7590746   PMID:7720571   PMID:8012391   PMID:8012392   PMID:8269518   PMID:8647801   PMID:8896571   PMID:8906787   PMID:9302262   PMID:9593755   PMID:9811851   PMID:10050855  
PMID:10556296   PMID:10654605   PMID:11001584   PMID:11076863   PMID:11175816   PMID:11331587   PMID:11359461   PMID:11395778   PMID:11471164   PMID:11472839   PMID:11572986   PMID:11576188  
PMID:11857543   PMID:11983699   PMID:12032320   PMID:12221011   PMID:12394760   PMID:12421920   PMID:12477932   PMID:12495844   PMID:12503095   PMID:12514186   PMID:12533514   PMID:12547712  
PMID:12567406   PMID:12629553   PMID:12632368   PMID:12690205   PMID:12709790   PMID:12773389   PMID:12783258   PMID:12837695   PMID:12853948   PMID:12917489   PMID:14520411   PMID:14520413  
PMID:14691301   PMID:14727139   PMID:14733907   PMID:14764698   PMID:15128061   PMID:15170664   PMID:15221788   PMID:15238528   PMID:15249145   PMID:15249678   PMID:15292211   PMID:15314219  
PMID:15470048   PMID:15502857   PMID:15521068   PMID:15592520   PMID:15675968   PMID:15790807   PMID:15905200   PMID:15939571   PMID:15998911   PMID:16003737   PMID:16159933   PMID:16244652  
PMID:16300466   PMID:16322088   PMID:16323008   PMID:16335952   PMID:16368877   PMID:16448649   PMID:16528374   PMID:16540513   PMID:16571640   PMID:16701100   PMID:16778137   PMID:16786128  
PMID:16945339   PMID:17035233   PMID:17050669   PMID:17102592   PMID:17152067   PMID:17227833   PMID:17353904   PMID:17378681   PMID:17390043   PMID:17392427   PMID:17409199   PMID:17414057  
PMID:17461467   PMID:17507406   PMID:17611415   PMID:17628016   PMID:17761145   PMID:17850284   PMID:17895245   PMID:17914115   PMID:17927850   PMID:18063705   PMID:18156157   PMID:18174246  
PMID:18178630   PMID:18308861   PMID:18332216   PMID:18410549   PMID:18422746   PMID:18425375   PMID:18524848   PMID:18534984   PMID:18629868   PMID:18655123   PMID:18661269   PMID:18691547  
PMID:18701018   PMID:18772349   PMID:18776754   PMID:18776995   PMID:18787206   PMID:18788453   PMID:18829478   PMID:18836447   PMID:18953259   PMID:18974107   PMID:18997815   PMID:19004543  
PMID:19055941   PMID:19057928   PMID:19074837   PMID:19177589   PMID:19219074   PMID:19240184   PMID:19244133   PMID:19254376   PMID:19291772   PMID:19363151   PMID:19398181   PMID:19407245  
PMID:19431187   PMID:19432668   PMID:19453261   PMID:19460624   PMID:19540662   PMID:19548265   PMID:19561609   PMID:19564910   PMID:19577569   PMID:19593328   PMID:19603532   PMID:19622100  
PMID:19629560   PMID:19633682   PMID:19662327   PMID:19730683   PMID:19738389   PMID:19784071   PMID:19788370   PMID:19801637   PMID:19834598   PMID:19836325   PMID:19856079   PMID:19862523  
PMID:19901516   PMID:19906872   PMID:19920144   PMID:19952108   PMID:19996099   PMID:20015350   PMID:20026066   PMID:20053908   PMID:20087349   PMID:20137639   PMID:20186790   PMID:20200556  
PMID:20218977   PMID:20219995   PMID:20301552   PMID:20301702   PMID:20336604   PMID:20425842   PMID:20440271   PMID:20508033   PMID:20512148   PMID:20526338   PMID:20531442   PMID:20538960  
PMID:20561215   PMID:20564213   PMID:20578145   PMID:20619754   PMID:20634891   PMID:20643644   PMID:20720195   PMID:20842831   PMID:20854074   PMID:20938369   PMID:21039988   PMID:21059263  
PMID:21110116   PMID:21129534   PMID:21172305   PMID:21190179   PMID:21338440   PMID:21357747   PMID:21372638   PMID:21424326   PMID:21434830   PMID:21441223   PMID:21496866   PMID:21498615  
PMID:21520153   PMID:21537345   PMID:21597001   PMID:21633164   PMID:21646478   PMID:21649559   PMID:21685941   PMID:21707705   PMID:21720384   PMID:21732818   PMID:21824197   PMID:21861243  
PMID:21873635   PMID:21940735   PMID:21940988   PMID:21945071   PMID:21953141   PMID:21975935   PMID:22020162   PMID:22049079   PMID:22052462   PMID:22056874   PMID:22114142   PMID:22123293  
PMID:22125638   PMID:22130025   PMID:22144466   PMID:22240607   PMID:22241722   PMID:22262830   PMID:22264144   PMID:22264356   PMID:22310223   PMID:22350753   PMID:22354771   PMID:22388744  
PMID:22407314   PMID:22432023   PMID:22461522   PMID:22486854   PMID:22513293   PMID:22535603   PMID:22543708   PMID:22554932   PMID:22559324   PMID:22581926   PMID:22609357   PMID:22677152  
PMID:22679015   PMID:22683912   PMID:22786669   PMID:22791840   PMID:22797776   PMID:22811598   PMID:22875023   PMID:22897141   PMID:22902404   PMID:22941587   PMID:22948179   PMID:22995914  
PMID:23023967   PMID:23027863   PMID:23027964   PMID:23041623   PMID:23091001   PMID:23112049   PMID:23172661   PMID:23249701   PMID:23322567   PMID:23336661   PMID:23340176   PMID:23395608  
PMID:23410206   PMID:23468532   PMID:23476075   PMID:23493353   PMID:23504944   PMID:23551431   PMID:23596255   PMID:23667589   PMID:23709101   PMID:23835807   PMID:23867461   PMID:23867465  
PMID:23894369   PMID:23934731   PMID:23935859   PMID:23967143   PMID:23998958   PMID:24004862   PMID:24058673   PMID:24072710   PMID:24076665   PMID:24095799   PMID:24174682   PMID:24224878  
PMID:24342078   PMID:24344235   PMID:24366871   PMID:24431302   PMID:24456159   PMID:24522195   PMID:24682719   PMID:24694877   PMID:24710823   PMID:24733827   PMID:24740159   PMID:24741597  
PMID:24742993   PMID:24768363   PMID:24867209   PMID:24910992   PMID:24915900   PMID:24925370   PMID:24927541   PMID:24947933   PMID:24954133   PMID:24991722   PMID:25017332   PMID:25049282  
PMID:25056824   PMID:25060182   PMID:25068457   PMID:25140582   PMID:25141859   PMID:25146370   PMID:25197388   PMID:25204354   PMID:25215859   PMID:25256290   PMID:25288466   PMID:25296753  
PMID:25432698   PMID:25501422   PMID:25552484   PMID:25595896   PMID:25682950   PMID:25693592   PMID:25713298   PMID:25728352   PMID:25740074   PMID:25756958   PMID:25782671   PMID:25794996  
PMID:25811359   PMID:25824057   PMID:25843803   PMID:25990213   PMID:26171876   PMID:26212257   PMID:26276718   PMID:26281688   PMID:26286140   PMID:26290227   PMID:26317501   PMID:26317547  
PMID:26334609   PMID:26371509   PMID:26446020   PMID:26465952   PMID:26483188   PMID:26499980   PMID:26563370   PMID:26586670   PMID:26592459   PMID:26676748   PMID:26689865   PMID:26725322  
PMID:26727947   PMID:26762695   PMID:26773496   PMID:26815504   PMID:26825960   PMID:26867642   PMID:26934446   PMID:26943330   PMID:26988754   PMID:26997450   PMID:27039174   PMID:27082974  
PMID:27086929   PMID:27108756   PMID:27120089   PMID:27146893   PMID:27199253   PMID:27246849   PMID:27289556   PMID:27325696   PMID:27333788   PMID:27453577   PMID:27614115   PMID:27647915  
PMID:27657189   PMID:27662839   PMID:27694322   PMID:27730468   PMID:27731925   PMID:27779682   PMID:27810405   PMID:28058596   PMID:28127823   PMID:28137592   PMID:28263766   PMID:28284480  
PMID:28292438   PMID:28344315   PMID:28370639   PMID:28389227   PMID:28496132   PMID:28551328   PMID:28574612   PMID:28645738   PMID:28652022   PMID:28739739   PMID:28747625   PMID:28754309  
PMID:28839461   PMID:28870814   PMID:28870922   PMID:28877722   PMID:28881358   PMID:28886265   PMID:28886322   PMID:29054489   PMID:29088246   PMID:29088375   PMID:29128669   PMID:29158396  
PMID:29187450   PMID:29222038   PMID:29313231   PMID:29321670   PMID:29358407   PMID:29483508   PMID:29492654   PMID:29498412   PMID:29517209   PMID:29551561   PMID:29572896   PMID:29587601  
PMID:29715275   PMID:29734730   PMID:29867080   PMID:29954986   PMID:29995851   PMID:29996106   PMID:30124781   PMID:30139912   PMID:30187971   PMID:30235038   PMID:30347228   PMID:30361899  
PMID:30453796   PMID:30483764   PMID:30539521   PMID:30544841   PMID:30568656   PMID:30598432   PMID:30670636   PMID:30747231   PMID:30761741   PMID:30841515   PMID:30895425   PMID:31018591  
PMID:31072042   PMID:31080015   PMID:31087761   PMID:31092427   PMID:31127104   PMID:31147463   PMID:31163988   PMID:31167533   PMID:31253779   PMID:31279575   PMID:31364136   PMID:31395945  
PMID:31411078   PMID:31442607   PMID:31445709   PMID:31465935   PMID:31503551   PMID:31590919   PMID:31634481   PMID:31638600   PMID:31647783   PMID:31692471   PMID:31702025   PMID:31744214  
PMID:31782614   PMID:31851932   PMID:32030915   PMID:32044884   PMID:32061952   PMID:32084300   PMID:32130032   PMID:32186749   PMID:32358063   PMID:32377291   PMID:32403133   PMID:32404987  
PMID:32440000   PMID:32526259   PMID:32540122   PMID:32542401   PMID:32575925   PMID:32576942   PMID:32670287   PMID:32682910   PMID:32814794   PMID:32929330   PMID:32939873   PMID:32957513  
PMID:33000351   PMID:33047712   PMID:33070227   PMID:33199907   PMID:33206287   PMID:33218077   PMID:33291316   PMID:33390589   PMID:33418093   PMID:33438046   PMID:33589929   PMID:33599359  
PMID:33630857   PMID:33741928   PMID:33749384   PMID:33817723   PMID:33863273   PMID:33885911   PMID:33906647   PMID:33948856   PMID:34112694   PMID:34129846   PMID:34260267   PMID:34275739  
PMID:34290270   PMID:34314869   PMID:34371011   PMID:34399854   PMID:34440799   PMID:34576017   PMID:34667228   PMID:34732409   PMID:34830484   PMID:34845226   PMID:34887403   PMID:34944004  
PMID:35184473   PMID:35245826   PMID:35271396   PMID:35501487   PMID:35704688   PMID:35768071   PMID:35785032   PMID:35974013   PMID:36014865   PMID:36346167  


Genomics

Comparative Map Data
SHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,799,980 - 155,812,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7155,799,980 - 155,812,463 (-)EnsemblGRCh38hg38GRCh38
GRCh377155,592,674 - 155,605,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367155,288,319 - 155,297,728 (-)NCBINCBI36Build 36hg18NCBI36
Build 347155,095,033 - 155,104,443NCBI
Celera7150,021,217 - 150,030,626 (-)NCBICelera
Cytogenetic Map7q36.3NCBI
HuRef7149,327,101 - 149,336,513 (-)NCBIHuRef
CHM1_17155,604,000 - 155,613,409 (-)NCBICHM1_1
T2T-CHM13v2.07156,983,127 - 156,995,607 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27154,827,119 - 154,836,528 (-)NCBI
Shh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39528,661,838 - 28,672,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl528,661,813 - 28,672,254 (-)EnsemblGRCm39 Ensembl
GRCm38528,456,840 - 28,467,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl528,456,815 - 28,467,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv37528,783,380 - 28,793,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36528,787,627 - 28,797,875 (-)NCBIMGSCv36mm8
Celera525,997,895 - 26,008,156 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map514.39NCBI
Shh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl