Gene: FGF10 (fibroblast growth factor 10) Homo sapiens
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Symbol:
FGF10
Name:
fibroblast growth factor 10
Description:
Exhibits heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Localizes to several cellular components, including cell surface; extracellular space; and nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in LADD syndrome and aplasia of lacrimal and salivary glands.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
FGF-10; keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Fgf10 (fibroblast growth factor 10) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Fgf10 (fibroblast growth factor 10) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Fgf10 (fibroblast growth factor 10) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
FGF10 (fibroblast growth factor 10) NCBI
Ortholog
Canis lupus familiaris (dog):
FGF10 (fibroblast growth factor 10) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Fgf10 (fibroblast growth factor 10) NCBI
Ortholog
Sus scrofa (pig):
FGF10 (fibroblast growth factor 10) HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):
FGF10 (fibroblast growth factor 10) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Fgf10 (fibroblast growth factor 10) NCBI
Ortholog
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Fgf10 (fibroblast growth factor 10)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Fgf10 (fibroblast growth factor 10)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Danio rerio (zebrafish):
fgf10a (fibroblast growth factor 10a)
Alliance
DIOPT (PANTHER|ZFIN|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Danio rerio (zebrafish):
fgf10b (fibroblast growth factor 10b)
Alliance
DIOPT (ZFIN|Roundup|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
bnl
Alliance
DIOPT (PANTHER|OrthoInspector|OrthoFinder|Ensembl Compara)
Caenorhabditis elegans (roundworm):
let-756
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|Ensembl Compara)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 5 44,300,247 - 44,389,706 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 Ensembl 5 44,303,544 - 44,389,706 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 5 44,300,247 - 44,389,706 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 5 44,305,004 - 44,389,808 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 5 44,340,854 - 44,424,541 (-) NCBI NCBI36 hg18 NCBI36 Build 34 5 44,340,853 - 44,424,541 NCBI Celera 5 44,197,375 - 44,281,044 (-) NCBI Cytogenetic Map 5 p12 NCBI HuRef 5 44,258,055 - 44,341,703 (-) NCBI HuRef CHM1_1 5 44,306,497 - 44,390,196 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
aplasia of lacrimal and salivary glands IAGP RGD:11649037 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:10049451 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:28492532 aplasia of lacrimal and salivary glands IAGP RGD:28904262 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:28904260 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11588063 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:28492532 aplasia of lacrimal and salivary glands IAGP RGD:11580500 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:28492532 aplasia of lacrimal and salivary glands IAGP RGD:8559990 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:17213838 , PMID:25741868 aplasia of lacrimal and salivary glands IAGP RGD:11646708 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11584946 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11649392 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11589752 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11666098 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:11591102 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar aplasia of lacrimal and salivary glands IAGP RGD:8559986 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:15654336 aplasia of lacrimal and salivary glands IAGP RGD:8559985 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:15654336 aplasia of lacrimal and salivary glands IAGP RGD:8559991 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:17213838 aplasia of lacrimal and salivary glands IAGP RGD:8559989 8554872 ClinVar Annotator: match by term: Aplasia of lacrimal and salivary glands ClinVar PMID:16630169 LADD syndrome IAGP RGD:8559987 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:15654336 , PMID:16501574 LADD syndrome IAGP RGD:11588063 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:28492532 LADD syndrome IAGP RGD:11580500 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:28492532 LADD syndrome IAGP RGD:13703618 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:13703617 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:8559990 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:17213838 , PMID:25741868 LADD syndrome IAGP RGD:13703626 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:13703620 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:13703625 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:13703622 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:13703614 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:25741868 LADD syndrome IAGP RGD:8559988 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:16630169 LADD syndrome IAGP RGD:11646708 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:11584946 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:11649392 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:11589752 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:11666098 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:11591102 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar LADD syndrome IAGP RGD:8559989 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar PMID:16630169 LADD syndrome IAGP RGD:11649037 8554872 ClinVar Annotator: match by term: Levy-Hollister syndrome ClinVar Neurodevelopmental Disorders IAGP RGD:14698291 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
Breast Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18438407 cleft lip EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17963255 cleft palate EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17963255 Prostatic Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21743467 Imported Annotations - MGI
intestinal atresia ISS RGD:10578 13592920 MouseDO Imported Annotations - OMIM
aplasia of lacrimal and salivary glands IAGP 7240710 OMIM LADD syndrome IAGP 7240710 OMIM
(S)-amphetamine increases expression ISO RGD:10578 6480464 Dextroamphetamine results in increased expression of FGF10 mRNA CTD PMID:12205029 (S)-amphetamine multiple interactions ISO RGD:10578 6480464 SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FGF10 mRNA] CTD PMID:12205029 1,3,5-trinitro-1,3,5-triazinane decreases expression ISO RGD:2606 6480464 cyclonite results in decreased expression of FGF10 mRNA CTD PMID:25559034 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression ISO RGD:2606 6480464 chlorcyclizine results in increased expression of FGF10 mRNA CTD PMID:21058326 17beta-estradiol decreases expression ISO RGD:2606 6480464 Estradiol results in decreased expression of FGF10 mRNA, Estradiol results in decreased expression of FGF10 protein CTD PMID:15680359 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10578 6480464 Tetrachlorodibenzodioxin results in decreased expression of FGF10 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10578 6480464 Tetrachlorodibenzodioxin results in increased expression of FGF10 mRNA CTD PMID:26139165 2,3,7,8-tetrachlorodibenzodioxine decreases response to substance ISO RGD:10578 6480464 Tetrachlorodibenzodioxin results in decreased susceptibility to FGF10 protein CTD PMID:19805408 3-methylcholanthrene multiple interactions ISO RGD:10578 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA CTD PMID:23519560 4,4'-diaminodiphenylmethane affects expression ISO RGD:10578 6480464 4, 4'-diaminodiphenylmethane affects the expression of FGF10 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:10578 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of FGF10 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide decreases expression ISO RGD:10578 6480464 Fenretinide results in decreased expression of FGF10 mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression ISO RGD:2606 6480464 Propylthiouracil results in decreased expression of FGF10 mRNA CTD PMID:24780913 8-Br-cAMP increases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FGF10 mRNA CTD PMID:20147733 acrolein decreases expression ISO RGD:10578 6480464 Acrolein results in decreased expression of FGF10 mRNA CTD PMID:18515264 all-trans-retinoic acid affects expression ISO RGD:10578 6480464 Tretinoin affects the expression of FGF10 CTD PMID:10862743 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of FGF10 mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression ISO RGD:2606 6480464 Tretinoin results in increased expression of FGF10 mRNA CTD PMID:15328022 all-trans-retinoic acid increases expression ISO RGD:10578 6480464 Tretinoin results in increased expression of FGF10 mRNA CTD PMID:15328022 ammonium chloride affects expression ISO RGD:2606 6480464 Ammonium Chloride affects the expression of FGF10 mRNA CTD PMID:16483693 antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of FGF10 mRNA CTD PMID:24449571 arsane affects methylation EXP 6480464 Arsenic affects the methylation of FGF10 gene CTD PMID:25304211 arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of FGF10 gene CTD PMID:25304211 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of FGF10 mRNA CTD PMID:26705709 asbestos multiple interactions ISO RGD:2606 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF10 protein inhibits the reaction [Asbestos results in increased activity of CASP9 protein]] more ... CTD PMID:15618436 asbestos decreases expression EXP 6480464 Asbestos results in decreased expression of FGF10 mRNA CTD PMID:22076105 atrazine multiple interactions EXP 6480464 [Atrazine co-treated with Arsenates] results in increased expression of FGF10 mRNA CTD PMID:18585445 bisphenol A decreases expression ISO RGD:2606 6480464 bisphenol A results in decreased expression of FGF10 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:10578 6480464 bisphenol A results in increased expression of FGF10 mRNA CTD PMID:25594700 , PMID:30951980 bisphenol F increases expression ISO RGD:10578 6480464 bisphenol F results in increased expression of FGF10 mRNA CTD PMID:30951980 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon results in decreased expression of FGF10 mRNA CTD PMID:22076105 chondroitin sulfate affects binding EXP 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein, Chondroitin Sulfates analog binds to FGF10 protein CTD PMID:12221095 , PMID:15385557 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein], Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12533312 , PMID:14975937 dermatan sulfate affects binding EXP 6480464 [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:15385557 dexamethasone increases expression ISO RGD:10578 6480464 Dexamethasone results in increased expression of FGF10 mRNA CTD PMID:22733784 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of FGF10 mRNA CTD PMID:26705709 dibutyl phthalate increases expression ISO RGD:2606 6480464 Dibutyl Phthalate results in increased expression of FGF10 mRNA CTD PMID:15829613 dibutyl phthalate decreases expression ISO RGD:2606 6480464 Dibutyl Phthalate results in decreased expression of FGF10 mRNA, Dibutyl Phthalate results in decreased expression of FGF10 protein CTD PMID:19464577 more ... dichlorine decreases expression ISO RGD:2606 6480464 Chlorine results in decreased expression of FGF10 mRNA CTD PMID:18636392 dichlorine multiple interactions ISO RGD:2606 6480464 [Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA CTD PMID:18636392 diethyl malate affects expression ISO RGD:10578 6480464 diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 flavonoids increases expression ISO RGD:2606 6480464 Flavonoids results in increased expression of FGF10 mRNA CTD PMID:18035473 heparan sulfate affects activity ISO RGD:10578 6480464 Heparitin Sulfate affects the activity of FGF10 protein CTD PMID:12781692 , PMID:12818887 heparin multiple interactions EXP 6480464 Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein] CTD PMID:15632068 indometacin decreases response to substance ISO RGD:2606 6480464 FGF10 protein results in decreased susceptibility to Indomethacin CTD PMID:11052999 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:2606 6480464 Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA CTD PMID:15120970 nitrofen decreases expression ISO RGD:10578 6480464 nitrofen results in decreased expression of FGF10 mRNA CTD PMID:11404268 nitrofen decreases expression ISO RGD:2606 6480464 nitrofen results in decreased expression of FGF10 mRNA CTD PMID:12861530 oxidopamine increases expression ISO RGD:2606 6480464 Oxidopamine results in increased expression of FGF10 mRNA CTD PMID:15303306 ozone multiple interactions ISO RGD:2606 6480464 [Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA CTD PMID:18636392 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10578 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA CTD PMID:23519560 resveratrol decreases expression ISO RGD:10578 6480464 resveratrol results in decreased expression of FGF10 mRNA CTD PMID:23525482 , PMID:25338179 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of FGF10 mRNA CTD PMID:29301061 sodium chlorate affects activity ISO RGD:10578 6480464 sodium chlorate affects the activity of FGF10 protein CTD PMID:12818887 sunitinib increases expression EXP 6480464 Sunitinib results in increased expression of FGF10 mRNA CTD PMID:31533062 tetrachloromethane decreases expression ISO RGD:2606 6480464 Carbon Tetrachloride results in decreased expression of FGF10 mRNA CTD PMID:16644059 tetrachloromethane increases expression ISO RGD:2606 6480464 Carbon Tetrachloride results in increased expression of FGF10 mRNA CTD PMID:17805973 trichostatin A increases expression ISO RGD:10578 6480464 trichostatin A results in increased expression of FGF10 mRNA CTD PMID:23463510 triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of FGF10 mRNA CTD PMID:30510588 trimellitic anhydride decreases expression ISO RGD:10578 6480464 trimellitic anhydride results in decreased expression of FGF10 mRNA CTD PMID:19042947 vinclozolin decreases expression ISO RGD:2606 6480464 vinclozolin results in decreased expression of FGF10 mRNA CTD PMID:18629315
Biological Process actin cytoskeleton reorganization IDA 2290271 (PMID:17449030) UniProtKB PMID:17449030 activation of MAPK activity IDA 2290271 (PMID:14975937) UniProtKB PMID:14975937 angiogenesis IEA UniProtKB:P70492 , ensembl:ENSRNOP000000164852290271 Ensembl GO_REF:0000107 animal organ formation ISO MGI:MGI:1859647 9068941 (MGI:MGI:3688470, PMID:11062007) MGI MGI:MGI:3688470 , PMID:11062007 animal organ morphogenesis ISO MGI:MGI:1859647 9068941 (MGI:MGI:2653666, PMID:12615071) MGI MGI:MGI:2653666 , PMID:12615071 animal organ morphogenesis ISO MGI:MGI:1927833 9068941 (MGI:MGI:1889108 more ... MGI MGI:MGI:1889108 more ... animal organ morphogenesis ISO RGD:10578 9068941 (MGI:MGI:2682159, PMID:14651921) MGI MGI:MGI:2682159 , PMID:14651921 blood vessel morphogenesis ISO MGI:MGI:3629660 9068941 (MGI:MGI:3716020, PMID:17560563) MGI MGI:MGI:3716020 , PMID:17560563 blood vessel remodeling IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 branch elongation involved in salivary gland morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 branching involved in salivary gland morphogenesis ISO RGD:10578 9068941 (MGI:MGI:3813176, PMID:18559345) MGI MGI:MGI:3813176 , PMID:18559345 branching involved in salivary gland morphogenesis ISO MGI:MGI:95523 9068941 (MGI:MGI:3703378, PMID:15972105) MGI MGI:MGI:3703378 , PMID:15972105 branching morphogenesis of an epithelial tube IDA 2290271 (PMID:17959718) UniProtKB PMID:17959718 bronchiole morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 bud elongation involved in lung branching IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 bud outgrowth involved in lung branching IDA 2290271 (PMID:9740653) MGI PMID:9740653 cell differentiation ISO RGD:2606 9068941 RGD PMID:12565793 , REF_RGD_ID:727503 cell-cell signaling ISO MGI:MGI:1927833 9068941 (MGI:MGI:3045497, PMID:15199404) MGI MGI:MGI:3045497 , PMID:15199404 cell-cell signaling ISO RGD:10578 9068941 (MGI:MGI:1101385, PMID:9428423) MGI MGI:MGI:1101385 , PMID:9428423 chemotaxis ISO RGD:10578 9068941 (MGI:MGI:3609523, PMID:16169547) MGI MGI:MGI:3609523 , PMID:16169547 determination of left/right symmetry IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 digestive tract development ISO MGI:MGI:1859647 9068941 (MGI:MGI:3052435, PMID:15234214) MGI MGI:MGI:3052435 , PMID:15234214 embryonic camera-type eye development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 embryonic digestive tract development ISO MGI:MGI:1927833 9068941 (MGI:MGI:3611702, PMID:16308329) MGI MGI:MGI:3611702 , PMID:16308329 embryonic digestive tract morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 embryonic genitalia morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 embryonic pattern specification IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 epidermis development ISO MGI:MGI:1859647 9068941 (MGI:MGI:1889413, PMID:10984614) MGI MGI:MGI:1889413 , PMID:10984614 epidermis morphogenesis ISO MGI:MGI:1927833 9068941 (MGI:MGI:2676027, PMID:14530295) MGI MGI:MGI:2676027 , PMID:14530295 epithelial cell differentiation ISO MGI:MGI:1927833 9068941 (MGI:MGI:3722952, PMID:16618415) MGI MGI:MGI:3722952 , PMID:16618415 epithelial cell proliferation IDA 2290271 (PMID:19224135) UniProtKB PMID:19224135 epithelial cell proliferation involved in salivary gland morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 epithelial tube branching involved in lung morphogenesis ISO MGI:MGI:3629660 , MGI:MGI:1859647 9068941 (MGI:MGI:3578606, PMID:15800000) MGI MGI:MGI:3578606 , PMID:15800000 epithelial tube branching involved in lung morphogenesis ISO MGI:MGI:3629660 9068941 (MGI:MGI:3716020, PMID:17560563) MGI MGI:MGI:3716020 , PMID:17560563 epithelial tube branching involved in lung morphogenesis ISO RGD:10578 9068941 (MGI:MGI:1101385 more ... MGI MGI:MGI:1101385 more ... epithelial tube branching involved in lung morphogenesis ISO MGI:MGI:1927833 9068941 (MGI:MGI:1309706, PMID:9784490) MGI MGI:MGI:1309706 , PMID:9784490 epithelial tube branching involved in lung morphogenesis ISO MGI:MGI:1859647 9068941 (MGI:MGI:1327513, PMID:9916808) MGI MGI:MGI:1327513 , PMID:9916808 ERK1 and ERK2 cascade IDA 2290271 (PMID:17959718) UniProtKB PMID:17959718 establishment of mitotic spindle orientation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 female genitalia morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 fibroblast growth factor receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-190370 more ... fibroblast growth factor receptor signaling pathway IEA InterPro:IPR028252 2290271 InterPro GO_REF:0000002 fibroblast growth factor receptor signaling pathway involved in mammary gland specification IDA 2290271 (PMID:11923311) MGI PMID:11923311 hair follicle morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 Harderian gland development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 induction of positive chemotaxis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 inner ear morphogenesis ISO MGI:MGI:1347464 9068941 (MGI:MGI:3654570, PMID:16691564) MGI MGI:MGI:3654570 , PMID:16691564 inner ear morphogenesis ISO MGI:MGI:1859647 9068941 (MGI:MGI:3688470, PMID:11062007) MGI MGI:MGI:3688470 , PMID:11062007 lacrimal gland development IMP 2290271 (PMID:17213838) UniProtKB PMID:17213838 limb bud formation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 limb development ISO MGI:MGI:1859647 9068941 (MGI:MGI:1855908, PMID:10804187) MGI MGI:MGI:1855908 , PMID:10804187 limb morphogenesis ISO MGI:MGI:1859647 9068941 (MGI:MGI:1327513, PMID:9916808) MGI MGI:MGI:1327513 , PMID:9916808 lung alveolus development ISO MGI:MGI:95523 9068941 (MGI:MGI:3688953, PMID:16989802) MGI MGI:MGI:3688953 , PMID:16989802 lung alveolus development ISO MGI:MGI:3629660 9068941 (MGI:MGI:3716020, PMID:17560563) MGI MGI:MGI:3716020 , PMID:17560563 lung development ISO MGI:MGI:3629660 9068941 (MGI:MGI:3716020, PMID:17560563) MGI MGI:MGI:3716020 , PMID:17560563 lung development ISO MGI:MGI:1859647 9068941 (MGI:MGI:1327513, PMID:9916808) MGI MGI:MGI:1327513 , PMID:9916808 lung development ISO RGD:10578 9068941 (MGI:MGI:1101385 more ... MGI MGI:MGI:1101385 more ... lung epithelium development IDA 2290271 (PMID:9740653) MGI PMID:9740653 lung morphogenesis ISO MGI:MGI:3629660 , MGI:MGI:1859647 9068941 (MGI:MGI:3578606, PMID:15800000) MGI MGI:MGI:3578606 , PMID:15800000 lung proximal/distal axis specification IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 lung saccule development IMP 2290271 (PMID:17071719) UniProtKB PMID:17071719 male genitalia morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 mammary gland bud formation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 mammary gland specification ISO MGI:MGI:95729 9068941 (MGI:MGI:3629001, PMID:16720875) MGI MGI:MGI:3629001 , PMID:16720875 MAPK cascade TAS 2290271 Reactome Reactome:R-HSA-5673001 mesenchymal cell differentiation involved in lung development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 mesenchymal-epithelial cell signaling involved in lung development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 mesonephros development IEP 2290271 (PMID:18437684) UniProtKB PMID:18437684 metanephros development IEP 2290271 (PMID:18437684) UniProtKB PMID:18437684 metanephros morphogenesis IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 muscle cell fate commitment IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 negative regulation of cell cycle arrest IDA 2290271 (PMID:17188682) UniProtKB PMID:17188682 negative regulation of cell differentiation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 negative regulation of cell population proliferation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 odontogenesis of dentin-containing tooth IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 organ growth ISO MGI:MGI:1927833 9068941 (MGI:MGI:3722952, PMID:16618415) MGI MGI:MGI:3722952 , PMID:16618415 organ induction IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 organ induction IEA UniProtKB:P70492 , ensembl:ENSRNOP000000164852290271 Ensembl GO_REF:0000107 otic vesicle formation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 pancreas development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 pituitary gland development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive chemotaxis IDA 2290271 (PMID:17449030), (PMID:9740653) MGI PMID:17449030 , PMID:9740653 positive regulation of ATPase activity IDA 2290271 (PMID:12804770) UniProtKB PMID:12804770 positive regulation of canonical Wnt signaling pathway IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of cell population proliferation ISO RGD:10578 9068941 (MGI:MGI:1101385 more ... MGI MGI:MGI:1101385 more ... positive regulation of DNA repair IDA 2290271 (PMID:14975937) UniProtKB PMID:14975937 positive regulation of epithelial cell migration IDA 2290271 (PMID:17500053) UniProtKB PMID:17500053 positive regulation of epithelial cell proliferation IDA 2290271 (PMID:15690149) UniProtKB PMID:15690149 positive regulation of epithelial cell proliferation involved in wound healing NAS 2290271 (PMID:19152659) UniProtKB PMID:19152659 positive regulation of ERK1 and ERK2 cascade IDA 2290271 (PMID:14975937) UniProtKB PMID:14975937 positive regulation of fibroblast proliferation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of G1/S transition of mitotic cell cycle IDA 2290271 (PMID:17188682) UniProt PMID:17188682 positive regulation of hair follicle cell proliferation IDA 2290271 (PMID:16086254) UniProtKB PMID:16086254 positive regulation of keratinocyte migration IDA 2290271 (PMID:17449030), (PMID:19152659) UniProtKB PMID:17449030 , PMID:19152659 positive regulation of keratinocyte proliferation IDA 2290271 (PMID:17449030) UniProtKB PMID:17449030 positive regulation of lymphocyte proliferation IDA 2290271 (PMID:19152659) UniProtKB PMID:19152659 positive regulation of MAPK cascade IDA 2290271 (PMID:12804770) UniProtKB PMID:12804770 positive regulation of mitotic cell cycle ISO MGI:MGI:1859647 9068941 (MGI:MGI:3690587, PMID:16956603) MGI MGI:MGI:3690587 , PMID:16956603 positive regulation of Notch signaling pathway IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of peptidyl-tyrosine phosphorylation IDA 2290271 (PMID:17449030) UniProtKB PMID:17449030 positive regulation of protein kinase B signaling TAS 2290271 Reactome Reactome:R-HSA-2316434 positive regulation of Ras protein signal transduction IDA 2290271 (PMID:12804770) UniProtKB PMID:12804770 positive regulation of transcription by RNA polymerase II IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:10578 9068941 (MGI:MGI:3708201, PMID:17394208) CACAO MGI:MGI:3708201 , PMID:17394208 positive regulation of urothelial cell proliferation IDA 2290271 (PMID:11923311) MGI PMID:11923311 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of white fat cell proliferation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 positive regulation of Wnt signaling pathway ISO MGI:MGI:3629660 9068941 (MGI:MGI:3716020, PMID:17560563) MGI MGI:MGI:3716020 , PMID:17560563 prostatic bud formation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 protein localization to cell surface IDA 2290271 (PMID:17449030) UniProtKB PMID:17449030 radial glial cell differentiation ISS UniProtKB:O35565 2290271 UniProtKB GO_REF:0000024 regulation of activin receptor signaling pathway IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 regulation of gene expression ISO MGI:MGI:1859647 9068941 (MGI:MGI:3588480, PMID:15958512) MGI MGI:MGI:3588480 , PMID:15958512 regulation of saliva secretion IMP 2290271 (PMID:19102732) UniProtKB PMID:19102732 regulation of smoothened signaling pathway IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 respiratory system development ISO RGD:10578 9068941 (MGI:MGI:1934408, PMID:11287183) MGI MGI:MGI:1934408 , PMID:11287183 response to estradiol IEA UniProtKB:P70492 , ensembl:ENSRNOP000000164852290271 Ensembl GO_REF:0000107 response to lipopolysaccharide IEA UniProtKB:P70492 , ensembl:ENSRNOP000000164852290271 Ensembl GO_REF:0000107 response to organic cyclic compound ISO RGD:2606 9068941 di-n-butyl phthalate RGD PMID:19464577 , REF_RGD_ID:2314151 salivary gland development IMP 2290271 (PMID:17213838) UniProtKB PMID:17213838 salivary gland morphogenesis ISO MGI:MGI:1859647 9068941 (MGI:MGI:3530190, PMID:15654336) MGI MGI:MGI:3530190 , PMID:15654336 secretion by lung epithelial cell involved in lung growth IDA 2290271 (PMID:10541313) UniProtKB PMID:10541313 semicircular canal fusion IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 semicircular canal morphogenesis ISO MGI:MGI:95517 9068941 (MGI:MGI:3720541, PMID:17601531) MGI MGI:MGI:3720541 , PMID:17601531 smooth muscle cell differentiation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 somatic stem cell population maintenance IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 spleen development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 submandibular salivary gland formation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 tear secretion IMP 2290271 (PMID:19102732) UniProtKB PMID:19102732 thymus development IDA 2290271 (PMID:17969154) UniProtKB PMID:17969154 thyroid gland development IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 tissue regeneration IEA UniProtKB:P70492 , ensembl:ENSRNOP000000164852290271 Ensembl GO_REF:0000107 type II pneumocyte differentiation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 urothelial cell proliferation IDA 2290271 (PMID:11923311) UniProtKB PMID:11923311 white fat cell differentiation IEA UniProtKB:O35565 , ensembl:ENSMUSP000000222462290271 Ensembl GO_REF:0000107 wound healing IDA 2290271 (PMID:11896977), (PMID:19152659) UniProtKB PMID:11896977 , PMID:19152659 Cellular Component cell surface NAS 2290271 (PMID:11923311) UniProtKB PMID:11923311 cell surface IDA 2290271 (PMID:16597614) UniProtKB PMID:16597614 collagen-containing extracellular matrix colocalizes_with IDA 2290271 (PMID:17959718) UniProt PMID:17959718 extracellular region TAS 2290271 Reactome Reactome:R-HSA-109699 more ... extracellular region IEA InterPro:IPR028252 2290271 InterPro GO_REF:0000002 extracellular space IDA 2290271 (PMID:16597614) UniProtKB PMID:16597614 nucleus IDA 2290271 (PMID:11923311), (PMID:16597614), (PMID:17471512) UniProtKB PMID:11923311 more ... plasma membrane IDA 2290271 (PMID:16597614) UniProtKB PMID:16597614 Molecular Function chemoattractant activity IDA 2290271 (PMID:17449030), (PMID:9740653) UniProtKB PMID:17449030 , PMID:9740653 fibroblast growth factor receptor binding IDA 2290271 (PMID:11923311) UniProtKB PMID:11923311 fibroblast growth factor receptor binding IEA InterPro:IPR028252 2290271 InterPro GO_REF:0000002 growth factor activity IDA 2290271 (PMID:11923311), (PMID:15690149) UniProtKB PMID:11923311 , PMID:15690149 growth factor activity IEA InterPro:IPR002209 2290271 InterPro GO_REF:0000002 heparin binding IDA 2290271 (PMID:11923311) UniProtKB PMID:11923311 protein binding IPI UniProtKB:P21802 2290271 (PMID:12591959), (PMID:25241761) IntAct PMID:12591959 , PMID:25241761 protein binding IPI UniProtKB:Q9NVV9 2290271 (PMID:32296183) IntAct PMID:32296183 protein binding IPI UniProtKB:Q8N9Q2 2290271 (PMID:32296183) IntAct PMID:32296183 type 2 fibroblast growth factor receptor binding IPI UniProtKB:P21802-18 2290271 (PMID:19224135) UniProtKB PMID:19224135
Gene-Chemical Interaction Annotations
