FGF10 (fibroblast growth factor 10) - Rat Genome Database

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Gene: FGF10 (fibroblast growth factor 10) Homo sapiens
Analyze
Symbol: FGF10
Name: fibroblast growth factor 10
RGD ID: 734330
HGNC Page HGNC:3666
Description: Enables heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including exocrine system development; lung development; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; lung development; and positive regulation of urothelial cell proliferation. Located in several cellular components, including cell surface; extracellular space; and nucleus. Implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FGF-10; keratinocyte growth factor 2; KGF-2; LADD3; produced by fibroblasts of urinary bladder lamina propria
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38544,300,247 - 44,389,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl544,300,247 - 44,389,706 (-)Ensemblhg38GRCh38
GRCh37544,300,349 - 44,389,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36544,340,854 - 44,424,541 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34544,340,853 - 44,424,541NCBI
Celera544,197,375 - 44,281,044 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef544,258,055 - 44,341,703 (-)NCBIHuRef
CHM1_1544,306,497 - 44,390,196 (-)NCBICHM1_1
T2T-CHM13v2.0544,553,832 - 44,642,982 (-)NCBIT2T-CHM13v2.0
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
asbestos  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
carbon nanotube  (EXP)
CGP 52608  (EXP)
CHIR 99021  (EXP)
chondroitin sulfate  (EXP)
colforsin daropate hydrochloride  (EXP)
dermatan sulfate  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethyl malate  (ISO)
ethylparaben  (EXP)
flavonoids  (ISO)
folic acid  (ISO)
heparan sulfate  (ISO)
heparin  (EXP)
indometacin  (ISO)
lipopolysaccharide  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nitrofen  (ISO)
okadaic acid  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sunitinib  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA)
angiogenesis  (IEA,ISO)
animal organ formation  (IEA)
animal organ morphogenesis  (IEA)
blood vessel morphogenesis  (IEA)
blood vessel remodeling  (IEA)
branch elongation involved in salivary gland morphogenesis  (IEA)
branching involved in salivary gland morphogenesis  (IEA)
branching morphogenesis of an epithelial tube  (IDA)
bronchiole morphogenesis  (IEA)
bud elongation involved in lung branching  (IEA)
bud outgrowth involved in lung branching  (IDA)
cell differentiation  (IEA,ISO)
cell population proliferation  (IEA)
cell-cell signaling  (IEA)
chemotaxis  (IEA)
determination of left/right symmetry  (IEA)
digestive tract development  (IEA)
embryonic camera-type eye development  (IEA)
embryonic digestive tract development  (IEA)
embryonic digestive tract morphogenesis  (IEA)
embryonic genitalia morphogenesis  (IEA)
embryonic pattern specification  (IEA)
endothelial cell proliferation  (IEA)
epidermis development  (IEA)
epidermis morphogenesis  (IEA)
epithelial cell differentiation  (IEA,ISO)
epithelial cell proliferation  (IDA,IEA)
epithelial cell proliferation involved in salivary gland morphogenesis  (IEA)
epithelial tube branching involved in lung morphogenesis  (IEA)
ERK1 and ERK2 cascade  (IDA,IEA)
establishment of mitotic spindle orientation  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
female genitalia morphogenesis  (IEA)
fibroblast growth factor receptor apoptotic signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IBA,IDA)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IEA)
fibroblast proliferation  (IEA)
hair follicle morphogenesis  (IEA)
Harderian gland development  (IEA)
induction of positive chemotaxis  (IEA)
inner ear morphogenesis  (IEA)
keratinocyte proliferation  (IEA)
lacrimal gland development  (IEA,IMP)
limb bud formation  (IEA)
limb development  (IEA)
limb morphogenesis  (IEA)
lung alveolus development  (IEA)
lung development  (IEA)
lung epithelium development  (IDA)
lung morphogenesis  (IEA)
lung proximal/distal axis specification  (IEA)
lung saccule development  (IMP)
male genitalia morphogenesis  (IEA)
mammary gland bud formation  (IEA)
mammary gland specification  (IEA)
mesenchymal cell differentiation involved in lung development  (IEA)
mesenchymal-epithelial cell signaling involved in lung development  (IEA)
mesonephros development  (IEP)
metanephros development  (IEP)
metanephros morphogenesis  (IEA)
mitotic cell cycle  (IEA)
muscle cell fate commitment  (IEA)
negative regulation of epithelial cell differentiation  (IEA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of stem cell proliferation  (IEA)
neurogenesis  (IBA)
odontogenesis of dentin-containing tooth  (IEA)
organ growth  (IEA)
organ induction  (IEA)
otic vesicle formation  (IEA)
pancreas development  (IEA)
pituitary gland development  (IEA)
positive chemotaxis  (IBA,IDA,IEA)
positive regulation of ATP-dependent activity  (IDA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell population proliferation  (IBA)
positive regulation of DNA repair  (IDA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell migration  (IDA,IEA)
positive regulation of epithelial cell proliferation  (IDA,IEA)
positive regulation of epithelial cell proliferation involved in wound healing  (NAS)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of G1/S transition of mitotic cell cycle  (IDA)
positive regulation of hair follicle cell proliferation  (IDA)
positive regulation of keratinocyte migration  (IDA)
positive regulation of keratinocyte proliferation  (IDA,IEA)
positive regulation of lymphocyte proliferation  (IDA)
positive regulation of MAPK cascade  (IBA,IDA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of Ras protein signal transduction  (IDA)
positive regulation of stem cell proliferation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of urothelial cell proliferation  (IDA)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA)
positive regulation of white fat cell proliferation  (IEA)
positive regulation of Wnt signaling pathway  (IEA)
prostatic bud formation  (IEA)
protein localization to cell surface  (IDA)
radial glial cell differentiation  (IEA,ISS)
regulation of activin receptor signaling pathway  (IEA)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA)
regulation of cell migration  (IBA)
regulation of gene expression  (IEA)
regulation of saliva secretion  (IMP)
regulation of smoothened signaling pathway  (IEA)
respiratory system development  (IEA)
response to estradiol  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
salivary gland development  (IMP)
salivary gland morphogenesis  (IEA)
secretion by lung epithelial cell involved in lung growth  (IDA)
semicircular canal fusion  (IEA)
semicircular canal morphogenesis  (IEA)
signal transduction  (IEA)
smooth muscle cell differentiation  (IEA)
somatic stem cell population maintenance  (IEA)
spleen development  (IEA)
stem cell proliferation  (IEA)
submandibular salivary gland formation  (IEA)
tear secretion  (IMP)
thymus development  (IDA)
thyroid gland development  (IEA)
tissue regeneration  (IEA,ISO)
type II pneumocyte differentiation  (IEA)
urothelial cell proliferation  (IDA)
vascular endothelial growth factor receptor signaling pathway  (IEA)
white fat cell differentiation  (IEA)
white fat cell proliferation  (IEA)
Wnt signaling pathway  (IEA)
wound healing  (IBA,IDA)

Cellular Component
cell surface  (IDA,NAS)
cytoplasm  (IBA)
extracellular region  (IEA,TAS)
extracellular space  (IBA,IDA,IEA)
nucleus  (IDA)
plasma membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal dental enamel morphology  (IAGP)
Abnormal digit morphology  (IAGP)
Abnormal facial shape  (IAGP)
Abnormal lacrimal duct morphology  (IAGP)
Abnormal lacrimal gland morphology  (IAGP)
Abnormal pinna morphology  (IAGP)
Abnormal salivary gland morphology  (IAGP)
Abnormal thumb morphology  (IAGP)
Abnormality of the dentition  (IAGP)
Abnormality of the eye  (IAGP)
Absent eyelashes  (IAGP)
Absent lacrimal punctum  (IAGP)
Absent thumb  (IAGP)
Alacrima  (IAGP)
Anosmia  (IAGP)
Arthritis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Bicornuate uterus  (IAGP)
Bifid uvula  (IAGP)
Carious teeth  (IAGP)
Choanal atresia  (IAGP)
Clinodactyly  (IAGP)
Conductive hearing impairment  (IAGP)
Congenital onset  (IAGP)
Corneal neovascularization  (IAGP)
Corneal ulceration  (IAGP)
Cryptorchidism  (IAGP)
Cupped ear  (IAGP)
Decreased corneal sensation  (IAGP)
Duplication of thumb phalanx  (IAGP)
Dysphagia  (IAGP)
Enamel hypoplasia  (IAGP)
Epicanthus  (IAGP)
Epiphora  (IAGP)
Esotropia  (IAGP)
Exotropia  (IAGP)
Feeding difficulties  (IAGP)
Finger syndactyly  (IAGP)
Global developmental delay  (IAGP)
Hearing impairment  (IAGP)
Hydronephrosis  (IAGP)
Hypodontia  (IAGP)
Hypoplasia of the epiglottis  (IAGP)
Hypoplasia of the lacrimal punctum  (IAGP)
Hypoplasia of the radius  (IAGP)
Increased corneal thickness  (IAGP)
Keratoconjunctivitis  (IAGP)
Keratoconjunctivitis sicca  (IAGP)
Lacrimal duct aplasia  (IAGP)
Lacrimal gland aplasia  (IAGP)
Lacrimal gland hypoplasia  (IAGP)
Limbal stem cell deficiency  (IAGP)
Low-set ears  (IAGP)
Lung adenocarcinoma  (IAGP)
Microdontia  (IAGP)
Micrognathia  (IAGP)
Microtia  (IAGP)
Mixed hearing impairment  (IAGP)
Nail dysplasia  (IAGP)
Open angle glaucoma  (IAGP)
Orofacial cleft  (IAGP)
Partial duplication of thumb phalanx  (IAGP)
Patent ductus arteriosus  (IAGP)
Ptosis  (IAGP)
Recurrent corneal erosions  (IAGP)
Renal hypoplasia  (IAGP)
Scoliosis  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Short thumb  (IAGP)
Syndactyly  (IAGP)
Toe syndactyly  (IAGP)
Vesicoureteral reflux  (IAGP)
Widely spaced teeth  (IAGP)
Xerostomia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and High-Fat Diet Alter the Generation of Newborn Neurons Expressing Estrogen Receptor α. Bless EP, etal., eNeuro. 2016 Sep 22;3(4). pii: eN-NWR-0027-16. doi: 10.1523/ENEURO.0027-16.2016. eCollection 2016 Jul-Aug.
2. Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin. Gambichler T, etal., BMC Dermatol. 2002 Apr 12;2:6. doi: 10.1186/1471-5945-2-6.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Novel xylan-controlled delivery of therapeutic proteins to inflamed colon by the human anaerobic commensal bacterium. Hamady ZZ, Ann R Coll Surg Engl. 2013 May;95(4):235-40. doi: 10.1308/003588413X13511609958217.
5. Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Hamady ZZ, etal., Gut. 2010 Apr;59(4):461-9. doi: 10.1136/gut.2008.176131. Epub 2009 Sep 7.
6. Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. Hertzler-Schaefer K, etal., Cell Rep. 2014 Mar 13;6(5):818-26. doi: 10.1016/j.celrep.2014.01.045. Epub 2014 Feb 27.
7. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
8. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Kelly RG, etal., Dev Cell 2001 Sep;1(3):435-40.
9. Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis. Miceli R, etal., J Pharmacol Exp Ther. 1999 Jul;290(1):464-71.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. Quantius J, etal., PLoS Pathog. 2016 Jun 20;12(6):e1005544. doi: 10.1371/journal.ppat.1005544. eCollection 2016 Jun.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
16. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
17. Fgf10 is essential for limb and lung formation. Sekine K, etal., Nat Genet 1999 Jan;21(1):138-41.
18. In vivo characterization of keratinocyte growth factor-2 as a potential wound healing agent. Soler PM, etal., Wound Repair Regen. 1999 May-Jun;7(3):172-8. doi: 10.1046/j.1524-475x.1999.00172.x.
19. Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. Suzuki K, etal., FEBS Lett 2000 Sep 8;481(1):53-6.
20. MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10. Wu J, etal., J Biol Chem. 2019 Oct 11;294(41):15052-15067. doi: 10.1074/jbc.RA119.007404. Epub 2019 Aug 20.
21. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5.
Additional References at PubMed
PMID:8622701   PMID:9287324   PMID:9582367   PMID:9740653   PMID:9927546   PMID:10541313   PMID:10579907   PMID:10629055   PMID:10951499   PMID:11286634   PMID:11294897   PMID:11896977  
PMID:11923311   PMID:12477932   PMID:12591959   PMID:12804770   PMID:12818887   PMID:14702039   PMID:14726452   PMID:14975937   PMID:15199049   PMID:15208658   PMID:15489334   PMID:15632068  
PMID:15654336   PMID:15679583   PMID:15690149   PMID:15806171   PMID:16086254   PMID:16323074   PMID:16344560   PMID:16501574   PMID:16597614   PMID:16597617   PMID:16630169   PMID:17071719  
PMID:17133345   PMID:17188682   PMID:17213838   PMID:17264867   PMID:17360555   PMID:17449030   PMID:17471512   PMID:17496316   PMID:17500053   PMID:17609292   PMID:17682060   PMID:17944804  
PMID:17959718   PMID:17969154   PMID:18081024   PMID:18199118   PMID:18329286   PMID:18437684   PMID:18454440   PMID:18587586   PMID:18594526   PMID:18773495   PMID:18990706   PMID:19102732  
PMID:19115389   PMID:19152659   PMID:19224135   PMID:19727229   PMID:19915940   PMID:20036575   PMID:20083228   PMID:20424473   PMID:20544801   PMID:20634891   PMID:20705941   PMID:21048031  
PMID:21310815   PMID:21696361   PMID:21742743   PMID:21743467   PMID:21873635   PMID:22303449   PMID:22877940   PMID:22965740   PMID:23169889   PMID:23328208   PMID:23599340   PMID:23774963  
PMID:23949615   PMID:23949743   PMID:24002438   PMID:24004862   PMID:24265547   PMID:24320134   PMID:24667918   PMID:24865969   PMID:25241761   PMID:25446127   PMID:26186194   PMID:26268776  
PMID:26511927   PMID:27339175   PMID:27411850   PMID:27503909   PMID:27640304   PMID:28514442   PMID:29053399   PMID:29372690   PMID:30021884   PMID:30639323   PMID:31021460   PMID:31574782  
PMID:31718875   PMID:32296183   PMID:32664970   PMID:32807901   PMID:33492380   PMID:33620261   PMID:33626352   PMID:33961781   PMID:33967277   PMID:34383782   PMID:34731724   PMID:34755840  
PMID:36183124   PMID:37369494   PMID:37956773   PMID:39247826  


Genomics

Comparative Map Data
FGF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38544,300,247 - 44,389,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl544,300,247 - 44,389,706 (-)Ensemblhg38GRCh38
GRCh37544,300,349 - 44,389,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36544,340,854 - 44,424,541 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34544,340,853 - 44,424,541NCBI
Celera544,197,375 - 44,281,044 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef544,258,055 - 44,341,703 (-)NCBIHuRef
CHM1_1544,306,497 - 44,390,196 (-)NCBICHM1_1
T2T-CHM13v2.0544,553,832 - 44,642,982 (-)NCBIT2T-CHM13v2.0
Fgf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913118,851,199 - 118,928,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13118,806,327 - 118,928,651 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3813118,714,699 - 118,792,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13118,669,791 - 118,792,115 (+)Ensemblmm10GRCm38
MGSCv3713119,503,506 - 119,581,380 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613119,833,907 - 119,910,988 (+)NCBIMGSCv36mm8
Celera13123,161,950 - 123,245,519 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.14NCBI
Fgf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8252,533,939 - 52,610,980 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl252,533,939 - 52,610,980 (+)EnsemblGRCr8
mRatBN7.2250,801,171 - 50,878,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl250,800,992 - 50,876,866 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx257,899,752 - 57,973,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0255,958,474 - 56,031,945 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0250,887,932 - 50,961,398 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0251,673,480 - 51,747,533 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)Ensemblrn6Rnor6.0
Rnor_5.0270,046,331 - 70,120,384 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4250,866,799 - 50,940,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera246,463,913 - 46,537,376 (+)NCBICelera
RGSC_v3.1250,795,031 - 50,868,552 (+)NCBI
Cytogenetic Map2q14NCBI
Fgf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,163,117 - 18,245,199 (+)Ensembl
ChiLan1.0NW_00495544618,163,117 - 18,244,840 (+)NCBIChiLan1.0ChiLan1.0
FGF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2465,933,753 - 66,021,682 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1564,085,283 - 64,175,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0565,979,443 - 66,069,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,028,324 - 71,111,713 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,028,187 - 71,111,706 (+)EnsemblpanPan2panpan1.1
FGF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1465,851,130 - 65,930,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl465,851,069 - 65,928,192 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha465,597,673 - 65,676,839 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0466,343,407 - 66,423,104 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,343,839 - 66,423,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,096,317 - 66,176,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,218,509 - 66,297,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0466,768,760 - 66,848,396 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,177,124 - 209,259,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,114,204 - 18,195,898 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,114,231 - 18,195,884 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,695,470 - 28,777,509 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,234,658 - 30,317,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1443,080,387 - 43,163,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl443,081,831 - 43,163,432 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607133,710,353 - 33,794,576 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475910,904,989 - 10,983,574 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475910,904,626 - 10,983,509 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF10
96 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004465.2(FGF10):c.267dup (p.Leu90fs) duplication not provided [RCV000523783] Chr5:44388415..44388416 [GRCh38]
Chr5:44388517..44388518 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.577C>T (p.Arg193Ter) single nucleotide variant Congenital absence of salivary gland [RCV000007964]|not provided [RCV000760468] Chr5:44305045 [GRCh38]
Chr5:44305147 [GRCh37]
Chr5:5p12		 pathogenic|likely pathogenic
NC_000005.10:g.(44304226_44304232)_(44357318_44357323)del deletion Congenital absence of salivary gland [RCV000007965] Chr5:44304232..44357318 [GRCh38]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.317G>T (p.Cys106Phe) single nucleotide variant Lacrimoauriculodentodigital syndrome 3 [RCV003151710] Chr5:44388366 [GRCh38]
Chr5:44388468 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.467T>G (p.Ile156Arg) single nucleotide variant Lacrimoauriculodentodigital syndrome 3 [RCV003151711] Chr5:44305155 [GRCh38]
Chr5:44305257 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.409A>T (p.Lys137Ter) single nucleotide variant Congenital absence of salivary gland [RCV000007968]|Lacrimoauriculodentodigital syndrome 3 [RCV003151712] Chr5:44310447 [GRCh38]
Chr5:44310549 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.240A>C (p.Arg80Ser) single nucleotide variant Congenital absence of salivary gland [RCV000007970]|Inborn genetic diseases [RCV004619187]|Levy-Hollister syndrome [RCV000659642] Chr5:44388443 [GRCh38]
Chr5:44388545 [GRCh37]
Chr5:5p12		 pathogenic|uncertain significance
NM_004465.2(FGF10):c.413G>A (p.Gly138Glu) single nucleotide variant Congenital absence of salivary gland [RCV000007971] Chr5:44310443 [GRCh38]
Chr5:44310545 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.526del (p.Met176fs) deletion not provided [RCV000522239] Chr5:44305096 [GRCh38]
Chr5:44305198 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.1(FGF10):c.325+33027A>G single nucleotide variant Lung cancer [RCV000095973] Chr5:44355331 [GRCh38]
Chr5:44355433 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.1(FGF10):c.325+581C>T single nucleotide variant Lung cancer [RCV000095974] Chr5:44387777 [GRCh38]
Chr5:44387879 [GRCh37]
Chr5:5p12		 uncertain significance
GRCh38/hg38 5p14.1-q11.1(chr5:26593632-50288555)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051834]|See cases [RCV000051834] Chr5:26593632..50288555 [GRCh38]
Chr5:26593741..49584389 [GRCh37]
Chr5:26629498..49620146 [NCBI36]
Chr5:5p14.1-q11.1		 pathogenic
GRCh38/hg38 5p13.2-12(chr5:35700480-45260029)x3 copy number gain See cases [RCV000051835] Chr5:35700480..45260029 [GRCh38]
Chr5:35700582..45260131 [GRCh37]
Chr5:35736339..45295888 [NCBI36]
Chr5:5p13.2-12		 pathogenic
GRCh38/hg38 5p13.2-q11.1(chr5:36374107-51103841)x3 copy number gain See cases [RCV000051836] Chr5:36374107..51103841 [GRCh38]
Chr5:36374209..50399675 [GRCh37]
Chr5:36409966..50435432 [NCBI36]
Chr5:5p13.2-q11.1		 pathogenic
GRCh38/hg38 5p15.33-12(chr5:54839-45649861)x3 copy number gain See cases [RCV000051810] Chr5:54839..45649861 [GRCh38]
Chr5:54954..45649963 [GRCh37]
Chr5:107954..45685720 [NCBI36]
Chr5:5p15.33-12		 pathogenic
NM_004465.2(FGF10):c.356del (p.Gly119fs) deletion Levy-Hollister syndrome [RCV000659644] Chr5:44310500 [GRCh38]
Chr5:44310602 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.232del (p.Arg78fs) deletion Levy-Hollister syndrome [RCV000659641] Chr5:44388451 [GRCh38]
Chr5:44388553 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.541A>C (p.Asn181His) single nucleotide variant FGF10-related disorder [RCV003403519]|Levy-Hollister syndrome [RCV000659646] Chr5:44305081 [GRCh38]
Chr5:44305183 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.97G>A (p.Val33Ile) single nucleotide variant Congenital absence of salivary gland [RCV001152456]|FGF10-related disorder [RCV003927583]|not provided [RCV000888690]|not specified [RCV000173344] Chr5:44388586 [GRCh38]
Chr5:44388688 [GRCh37]
Chr5:5p12		 benign|likely benign
GRCh38/hg38 5p15.33-11(chr5:49978-46114984)x3 copy number gain See cases [RCV000135453] Chr5:49978..46114984 [GRCh38]
Chr5:50093..46115086 [GRCh37]
Chr5:103093..46150843 [NCBI36]
Chr5:5p15.33-11		 pathogenic
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3 copy number gain See cases [RCV000137302] Chr5:35201559..61903141 [GRCh38]
Chr5:35201661..61198968 [GRCh37]
Chr5:35237418..61234725 [NCBI36]
Chr5:5p13.2-q12.1		 pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3		 pathogenic
GRCh37/hg19 5p15.2-12(chr5:13461664-46098927)x3 copy number gain See cases [RCV000239779] Chr5:13461664..46098927 [GRCh37]
Chr5:5p15.2-12		 pathogenic
NM_004465.2(FGF10):c.620A>C (p.His207Pro) single nucleotide variant Congenital absence of salivary gland [RCV000335259]|Congenital absence of salivary gland [RCV002502145]|FGF10-related disorder [RCV003967784]|not provided [RCV000960252]|not specified [RCV000398550] Chr5:44305002 [GRCh38]
Chr5:44305104 [GRCh37]
Chr5:5p12		 benign|likely benign
NM_004465.2(FGF10):c.426C>T (p.Gly142=) single nucleotide variant Congenital absence of salivary gland [RCV000277744] Chr5:44310430 [GRCh38]
Chr5:44310532 [GRCh37]
Chr5:5p12		 likely benign|uncertain significance
NM_004465.2(FGF10):c.591C>T (p.Thr197=) single nucleotide variant Congenital absence of salivary gland [RCV000299866]|not provided [RCV000970124] Chr5:44305031 [GRCh38]
Chr5:44305133 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.261G>A (p.Lys87=) single nucleotide variant Congenital absence of salivary gland [RCV000364753] Chr5:44388422 [GRCh38]
Chr5:44388524 [GRCh37]
Chr5:5p12		 benign|likely benign
NM_004465.2(FGF10):c.430-15G>C single nucleotide variant Congenital absence of salivary gland [RCV000312899]|not provided [RCV002061287] Chr5:44305207 [GRCh38]
Chr5:44305309 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.186C>A (p.Ser62Arg) single nucleotide variant Congenital absence of salivary gland [RCV000320633]|FGF10-related disorder [RCV003950253]|not provided [RCV004695871] Chr5:44388497 [GRCh38]
Chr5:44388599 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.355G>A (p.Gly119Arg) single nucleotide variant Orofacial cleft 1 [RCV003321462] Chr5:44310501 [GRCh38]
Chr5:44310603 [GRCh37]
Chr5:5p12		 likely pathogenic
NC_000005.10:g.44304990T>A single nucleotide variant Congenital absence of salivary gland [RCV000315768]|Levy-Hollister syndrome [RCV000361118]|not provided [RCV001692088] Chr5:44304990 [GRCh38]
Chr5:44305092 [GRCh37]
Chr5:5p12		 benign|likely benign
NM_004465.2(FGF10):c.144G>A (p.Glu48=) single nucleotide variant Congenital absence of salivary gland [RCV000377629] Chr5:44388539 [GRCh38]
Chr5:44388641 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.624A>G (p.Ser208=) single nucleotide variant Congenital absence of salivary gland [RCV000287224]|Levy-Hollister syndrome [RCV000398807]|not provided [RCV002520376] Chr5:44304998 [GRCh38]
Chr5:44305100 [GRCh37]
Chr5:5p12		 likely benign|uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p14.2-11(chr5:24281195-46389339)x3 copy number gain See cases [RCV000512120] Chr5:24281195..46389339 [GRCh37]
Chr5:5p14.2-11		 likely pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_004465.2(FGF10):c.1A>G (p.Met1Val) single nucleotide variant Levy-Hollister syndrome [RCV000659640] Chr5:44388682 [GRCh38]
Chr5:44388784 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.256del (p.Thr86fs) deletion Levy-Hollister syndrome [RCV000659643] Chr5:44388427 [GRCh38]
Chr5:44388529 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.401T>A (p.Met134Lys) single nucleotide variant Levy-Hollister syndrome [RCV000659645] Chr5:44310455 [GRCh38]
Chr5:44310557 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.550G>A (p.Gly184Arg) single nucleotide variant Levy-Hollister syndrome [RCV000659647] Chr5:44305072 [GRCh38]
Chr5:44305174 [GRCh37]
Chr5:5p12		 likely pathogenic
GRCh37/hg19 5p14.1-12(chr5:27227243-45685844)x3 copy number gain not provided [RCV000682542] Chr5:27227243..45685844 [GRCh37]
Chr5:5p14.1-12		 pathogenic
NM_004465.2(FGF10):c.429+210del deletion not provided [RCV001566814] Chr5:44310217 [GRCh38]
Chr5:44310319 [GRCh37]
Chr5:5p12		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_004465.2(FGF10):c.430-80G>A single nucleotide variant not provided [RCV001541753] Chr5:44305272 [GRCh38]
Chr5:44305374 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.430-221A>T single nucleotide variant not provided [RCV001681473] Chr5:44305413 [GRCh38]
Chr5:44305515 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.155C>A (p.Ser52Tyr) single nucleotide variant Inborn genetic diseases [RCV003268479] Chr5:44388528 [GRCh38]
Chr5:44388630 [GRCh37]
Chr5:5p12		 uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5p13.2-11(chr5:34453883-46389339)x3 copy number gain not provided [RCV000848003] Chr5:34453883..46389339 [GRCh37]
Chr5:5p13.2-11		 pathogenic
NM_004465.2(FGF10):c.430-93_430-92del deletion not provided [RCV001552123] Chr5:44305284..44305285 [GRCh38]
Chr5:44305386..44305387 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.429+37T>A single nucleotide variant not provided [RCV001685911] Chr5:44310390 [GRCh38]
Chr5:44310492 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.-294del deletion not provided [RCV001619751] Chr5:44388976 [GRCh38]
Chr5:44389078 [GRCh37]
Chr5:5p12		 benign
GRCh37/hg19 5p13.2-11(chr5:36053583-46389339)x3 copy number gain musculoskeletal system issues [RCV002284293] Chr5:36053583..46389339 [GRCh37]
Chr5:5p13.2-11		 pathogenic
NM_004465.2(FGF10):c.610A>G (p.Met204Val) single nucleotide variant Congenital absence of salivary gland [RCV001157920]|Congenital absence of salivary gland [RCV005394772]|not provided [RCV002275300] Chr5:44305012 [GRCh38]
Chr5:44305114 [GRCh37]
Chr5:5p12		 benign|likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_004465.2(FGF10):c.102T>G (p.Pro34=) single nucleotide variant not provided [RCV000934660] Chr5:44388581 [GRCh38]
Chr5:44388683 [GRCh37]
Chr5:5p12		 likely benign
GRCh37/hg19 5p13.2-11(chr5:34984696-46405042)x3 copy number gain not provided [RCV001537930] Chr5:34984696..46405042 [GRCh37]
Chr5:5p13.2-11		 pathogenic
NM_004465.2(FGF10):c.429+280C>T single nucleotide variant not provided [RCV001540336] Chr5:44310147 [GRCh38]
Chr5:44310249 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.-33G>A single nucleotide variant not provided [RCV001652260] Chr5:44388715 [GRCh38]
Chr5:44388817 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.116C>A (p.Ala39Asp) single nucleotide variant Levy-Hollister syndrome [RCV001196292] Chr5:44388567 [GRCh38]
Chr5:44388669 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.423T>C (p.Tyr141=) single nucleotide variant Congenital absence of salivary gland [RCV001157921]|not provided [RCV003769756] Chr5:44310433 [GRCh38]
Chr5:44310535 [GRCh37]
Chr5:5p12		 likely benign|uncertain significance
GRCh37/hg19 5p13.1-q11.1(chr5:38432180-49441945)x3 copy number gain not provided [RCV001005674] Chr5:38432180..49441945 [GRCh37]
Chr5:5p13.1-q11.1		 pathogenic
GRCh37/hg19 5p13.3-12(chr5:29081195-45294031)x3 copy number gain See cases [RCV001310288] Chr5:29081195..45294031 [GRCh37]
Chr5:5p13.3-12		 pathogenic
NC_000005.9:g.(?_44305097)_(45696195_?)dup duplication Developmental and epileptic encephalopathy [RCV001346561] Chr5:44305097..45696195 [GRCh37]
Chr5:5p12		 uncertain significance
NC_000005.9:g.44300489_44312646del deletion Levy-Hollister syndrome [RCV001726492] Chr5:44300489..44312646 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.190G>T (p.Gly64Ter) single nucleotide variant Levy-Hollister syndrome [RCV002471161]|not provided [RCV001783273] Chr5:44388493 [GRCh38]
Chr5:44388595 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.198_199insA (p.Val67fs) insertion not provided [RCV001874304] Chr5:44388484..44388485 [GRCh38]
Chr5:44388586..44388587 [GRCh37]
Chr5:5p12		 pathogenic
GRCh37/hg19 5p14.1-11(chr5:26382110-46389339) copy number gain not specified [RCV002053485] Chr5:26382110..46389339 [GRCh37]
Chr5:5p14.1-11		 pathogenic
GRCh37/hg19 5p12-11(chr5:43855245-46389339) copy number loss not specified [RCV002053493] Chr5:43855245..46389339 [GRCh37]
Chr5:5p12-11		 pathogenic
GRCh37/hg19 5p12-11(chr5:43972062-46101844) copy number loss not specified [RCV002053494] Chr5:43972062..46101844 [GRCh37]
Chr5:5p12-11		 pathogenic
NC_000005.9:g.(?_42688972)_(44388784_?)del deletion not provided [RCV001956361] Chr5:42688972..44388784 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.10T>C (p.Trp4Arg) single nucleotide variant not provided [RCV002026873] Chr5:44388673 [GRCh38]
Chr5:44388775 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.216C>T (p.His72=) single nucleotide variant not provided [RCV002218750] Chr5:44388467 [GRCh38]
Chr5:44388569 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.325+15C>A single nucleotide variant not provided [RCV002122826] Chr5:44388343 [GRCh38]
Chr5:44388445 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.325+3045C>T single nucleotide variant not provided [RCV002117806] Chr5:44385313 [GRCh38]
Chr5:44385415 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.325+22915G>T single nucleotide variant not provided [RCV002200573] Chr5:44365443 [GRCh38]
Chr5:44365545 [GRCh37]
Chr5:5p12		 benign
NM_004465.2(FGF10):c.626A>G (p.Ter209Trp) single nucleotide variant Interstitial lung disease specific to childhood [RCV004776552] Chr5:44304996 [GRCh38]
Chr5:44305098 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.*1093A>G single nucleotide variant Lung adenocarcinoma [RCV003129628] Chr5:44303902 [GRCh38]
Chr5:44304004 [GRCh37]
Chr5:5p12		 pathogenic
Single allele duplication not specified [RCV002286366] Chr5:44375961..44815730 [GRCh38]
Chr5:5p12		 uncertain significance
GRCh37/hg19 5p13.3-11(chr5:29348753-46389339)x3 copy number gain not provided [RCV002474514] Chr5:29348753..46389339 [GRCh37]
Chr5:5p13.3-11		 pathogenic
NM_004465.2(FGF10):c.553G>A (p.Ala185Thr) single nucleotide variant Inborn genetic diseases [RCV002997387] Chr5:44305069 [GRCh38]
Chr5:44305171 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.53GCT[5] (p.Cys23del) microsatellite not provided [RCV002904672] Chr5:44388613..44388615 [GRCh38]
Chr5:44388715..44388717 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.374C>A (p.Ala125Asp) single nucleotide variant Congenital absence of salivary gland [RCV002463401] Chr5:44310482 [GRCh38]
Chr5:44310584 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.101del (p.Pro34fs) deletion not provided [RCV002842650] Chr5:44388582 [GRCh38]
Chr5:44388684 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.130A>G (p.Met44Val) single nucleotide variant Inborn genetic diseases [RCV002659763]|not provided [RCV003730246] Chr5:44388553 [GRCh38]
Chr5:44388655 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.354C>T (p.Ile118=) single nucleotide variant not provided [RCV003080976] Chr5:44310502 [GRCh38]
Chr5:44310604 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.133G>C (p.Val45Leu) single nucleotide variant Inborn genetic diseases [RCV002738159] Chr5:44388550 [GRCh38]
Chr5:44388652 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.539T>C (p.Leu180Ser) single nucleotide variant not provided [RCV002893912] Chr5:44305083 [GRCh38]
Chr5:44305185 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.41C>T (p.Pro14Leu) single nucleotide variant not provided [RCV003089330] Chr5:44388642 [GRCh38]
Chr5:44388744 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.367G>A (p.Val123Ile) single nucleotide variant Congenital absence of salivary gland [RCV005034635]|not provided [RCV003061017] Chr5:44310489 [GRCh38]
Chr5:44310591 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.64T>C (p.Cys22Arg) single nucleotide variant Congenital absence of salivary gland [RCV005034702]|Inborn genetic diseases [RCV003161840]|not provided [RCV003087064] Chr5:44388619 [GRCh38]
Chr5:44388721 [GRCh37]
Chr5:5p12		 likely benign|uncertain significance
NM_004465.2(FGF10):c.613G>A (p.Val205Met) single nucleotide variant Congenital absence of salivary gland [RCV005042894]|not provided [RCV002608305] Chr5:44305009 [GRCh38]
Chr5:44305111 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.48G>A (p.Leu16=) single nucleotide variant not provided [RCV002943200] Chr5:44388635 [GRCh38]
Chr5:44388737 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.325+8A>G single nucleotide variant not provided [RCV002612420] Chr5:44388350 [GRCh38]
Chr5:44388452 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.453G>C (p.Lys151Asn) single nucleotide variant Inborn genetic diseases [RCV003287088] Chr5:44305169 [GRCh38]
Chr5:44305271 [GRCh37]
Chr5:5p12		 uncertain significance
GRCh38/hg38 5p13.3-12(chr5:29299893-45899898)x3 copy number gain See cases [RCV003482191] Chr5:29299893..45899898 [GRCh38]
Chr5:5p13.3-12		 likely pathogenic
GRCh37/hg19 5p12(chr5:43680944-45642977)x3 copy number gain not provided [RCV003484609] Chr5:43680944..45642977 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.16C>A (p.Leu6Met) single nucleotide variant FGF10-related disorder [RCV003412278] Chr5:44388667 [GRCh38]
Chr5:44388769 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.109T>C (p.Cys37Arg) single nucleotide variant FGF10-related disorder [RCV003416890] Chr5:44388574 [GRCh38]
Chr5:44388676 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.237G>A (p.Trp79Ter) single nucleotide variant Lacrimoauriculodentodigital syndrome 3 [RCV003445414] Chr5:44388446 [GRCh38]
Chr5:44388548 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.581G>A (p.Arg194Lys) single nucleotide variant not provided [RCV003693890] Chr5:44305041 [GRCh38]
Chr5:44305143 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.112C>G (p.Gln38Glu) single nucleotide variant not provided [RCV003715102] Chr5:44388571 [GRCh38]
Chr5:44388673 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.234dup (p.Trp79fs) duplication Lacrimoauriculodentodigital syndrome 3 [RCV003493405] Chr5:44388448..44388449 [GRCh38]
Chr5:44388550..44388551 [GRCh37]
Chr5:5p12		 pathogenic
NM_004465.2(FGF10):c.60C>T (p.Cys20=) single nucleotide variant not provided [RCV003579781] Chr5:44388623 [GRCh38]
Chr5:44388725 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.191G>T (p.Gly64Val) single nucleotide variant not provided [RCV003832965] Chr5:44388492 [GRCh38]
Chr5:44388594 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.325+12A>C single nucleotide variant not provided [RCV003861309] Chr5:44388346 [GRCh38]
Chr5:44388448 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.527T>C (p.Met176Thr) single nucleotide variant not provided [RCV003685934] Chr5:44305095 [GRCh38]
Chr5:44305197 [GRCh37]
Chr5:5p12		 uncertain significance
GRCh37/hg19 5p12-11(chr5:43949281-46116307)x1 copy number loss not specified [RCV003986550] Chr5:43949281..46116307 [GRCh37]
Chr5:5p12-11		 pathogenic
NM_004465.2(FGF10):c.-10T>A single nucleotide variant FGF10-related disorder [RCV003971882] Chr5:44388692 [GRCh38]
Chr5:44388794 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.48G>T (p.Leu16=) single nucleotide variant FGF10-related disorder [RCV003969433] Chr5:44388635 [GRCh38]
Chr5:44388737 [GRCh37]
Chr5:5p12		 likely benign
NC_000005.9:g.(?_42688972)_(45303961_?)dup duplication Developmental and epileptic encephalopathy [RCV004578960] Chr5:42688972..45303961 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.1_31delinsGCAGCCTTTCAGTTTCAG (p.Met1fs) indel Congenital absence of salivary gland [RCV004594805] Chr5:44388652..44388682 [GRCh38]
Chr5:44388754..44388784 [GRCh37]
Chr5:5p12		 likely pathogenic
NM_004465.2(FGF10):c.134T>A (p.Val45Glu) single nucleotide variant Inborn genetic diseases [RCV004623253] Chr5:44388549 [GRCh38]
Chr5:44388651 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.193_225del (p.Arg65_Gly75del) deletion not provided [RCV004772386] Chr5:44388458..44388490 [GRCh38]
Chr5:44388560..44388592 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.484A>C (p.Asn162His) single nucleotide variant not provided [RCV004762641] Chr5:44305138 [GRCh38]
Chr5:44305240 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.429+4A>G single nucleotide variant not provided [RCV004722198] Chr5:44310423 [GRCh38]
Chr5:44310525 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.70T>C (p.Phe24Leu) single nucleotide variant Congenital absence of salivary gland [RCV005045433] Chr5:44388613 [GRCh38]
Chr5:44388715 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.452A>T (p.Lys151Met) single nucleotide variant Congenital absence of salivary gland [RCV005045432] Chr5:44305170 [GRCh38]
Chr5:44305272 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.52G>A (p.Gly18Ser) single nucleotide variant Inborn genetic diseases [RCV004975062] Chr5:44388631 [GRCh38]
Chr5:44388733 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.326G>A (p.Ser109Asn) single nucleotide variant Inborn genetic diseases [RCV004975061] Chr5:44310530 [GRCh38]
Chr5:44310632 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.299G>A (p.Gly100Glu) single nucleotide variant Inborn genetic diseases [RCV004975063] Chr5:44388384 [GRCh38]
Chr5:44388486 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.179C>T (p.Pro60Leu) single nucleotide variant Inborn genetic diseases [RCV004975060] Chr5:44388504 [GRCh38]
Chr5:44388606 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.386A>G (p.Asn129Ser) single nucleotide variant Congenital absence of salivary gland [RCV005037621] Chr5:44310470 [GRCh38]
Chr5:44310572 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.367G>T (p.Val123Phe) single nucleotide variant Congenital absence of salivary gland [RCV005037622] Chr5:44310489 [GRCh38]
Chr5:44310591 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.325+6T>C single nucleotide variant Congenital absence of salivary gland [RCV005037623] Chr5:44388352 [GRCh38]
Chr5:44388454 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.156TTC[1] (p.Ser56del) microsatellite Congenital absence of salivary gland [RCV005037624] Chr5:44388522..44388524 [GRCh38]
Chr5:44388624..44388626 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.17T>C (p.Leu6Pro) single nucleotide variant Congenital absence of salivary gland [RCV005037625] Chr5:44388666 [GRCh38]
Chr5:44388768 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.389A>G (p.Tyr130Cys) single nucleotide variant not provided [RCV005065535] Chr5:44310467 [GRCh38]
Chr5:44310569 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.349G>C (p.Glu117Gln) single nucleotide variant not provided [RCV005073582] Chr5:44310507 [GRCh38]
Chr5:44310609 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.358G>A (p.Val120Ile) single nucleotide variant not provided [RCV005157632] Chr5:44310498 [GRCh38]
Chr5:44310600 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.344C>T (p.Ser115Leu) single nucleotide variant not provided [RCV005134292] Chr5:44310512 [GRCh38]
Chr5:44310614 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.186C>T (p.Ser62=) single nucleotide variant not provided [RCV005181532] Chr5:44388497 [GRCh38]
Chr5:44388599 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.212A>G (p.Asn71Ser) single nucleotide variant Inborn genetic diseases [RCV005344357] Chr5:44388471 [GRCh38]
Chr5:44388573 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.146C>T (p.Ala49Val) single nucleotide variant Inborn genetic diseases [RCV005344355] Chr5:44388537 [GRCh38]
Chr5:44388639 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.206G>A (p.Ser69Asn) single nucleotide variant Inborn genetic diseases [RCV005344358] Chr5:44388477 [GRCh38]
Chr5:44388579 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.127G>T (p.Asp43Tyr) single nucleotide variant not specified [RCV005406695] Chr5:44388556 [GRCh38]
Chr5:44388658 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.577C>G (p.Arg193Gly) single nucleotide variant Inborn genetic diseases [RCV005327871] Chr5:44305045 [GRCh38]
Chr5:44305147 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.325+8A>C single nucleotide variant not specified [RCV005406696] Chr5:44388350 [GRCh38]
Chr5:44388452 [GRCh37]
Chr5:5p12		 likely benign
NM_004465.2(FGF10):c.58T>A (p.Cys20Ser) single nucleotide variant Congenital absence of salivary gland [RCV005045434] Chr5:44388625 [GRCh38]
Chr5:44388727 [GRCh37]
Chr5:5p12		 uncertain significance
NM_004465.2(FGF10):c.*723C>A single nucleotide variant Lung adenocarcinoma [RCV003129707] Chr5:44304272 [GRCh38]
Chr5:44304374 [GRCh37]
Chr5:5p12		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:775
Count of miRNA genes:551
Interacting mature miRNAs:640
Transcripts:ENST00000264664, ENST00000513107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406943137GWAS592113_Hforced expiratory volume QTL GWAS592113 (human)3e-13lung capacity (VT:0001942)forced expiratory volume (CMO:0000254)54436711944367120Human
407040064GWAS689040_Hprostate carcinoma QTL GWAS689040 (human)4e-08prostate integrity trait (VT:0010571)54436544344365444Human
597060242GWAS1156316_Hvital capacity QTL GWAS1156316 (human)2e-19lung capacity (VT:0001942)54434903944349040Human
597291868GWAS1387942_Hgastroesophageal reflux disease, vital capacity QTL GWAS1387942 (human)1e-10lung capacity (VT:0001942)54434702944347030Human
597175229GWAS1271303_Hacne QTL GWAS1271303 (human)2e-08acne54436203244362033Human
596962673GWAS1082192_Hforced expiratory volume, gastroesophageal reflux disease QTL GWAS1082192 (human)2e-09forced expiratory volume, gastroesophageal reflux disease54437156744371568Human
406942023GWAS590999_Hvital capacity QTL GWAS590999 (human)9e-17lung capacity (VT:0001942)54436711944367120Human
597325405GWAS1421479_Hvital capacity QTL GWAS1421479 (human)3e-28lung capacity (VT:0001942)54435224244352243Human
597050044GWAS1146118_Hprostate carcinoma QTL GWAS1146118 (human)1e-08prostate integrity trait (VT:0010571)54436544344365444Human
597120476GWAS1216550_Hvital capacity QTL GWAS1216550 (human)5e-17lung capacity (VT:0001942)54436497644364977Human
597121084GWAS1217158_Hforced expiratory volume QTL GWAS1217158 (human)6e-21lung capacity (VT:0001942)forced expiratory volume (CMO:0000254)54436840444368405Human
597291062GWAS1387136_Hforced expiratory volume, gastroesophageal reflux disease QTL GWAS1387136 (human)2e-09stomach integrity trait (VT:0010603)forced expiratory volume (CMO:0000254)54437156744371568Human
597099526GWAS1195600_Hprostate carcinoma QTL GWAS1195600 (human)0.0000004prostate integrity trait (VT:0010571)54436840444368405Human
597138467GWAS1234541_Hvital capacity QTL GWAS1234541 (human)3e-08lung capacity (VT:0001942)54436553144365532Human
597092067GWAS1188141_HAlzheimer disease, age at onset QTL GWAS1188141 (human)0.0000003Alzheimer disease, age at onset54430106544301066Human
597024044GWAS1120118_Hbreast carcinoma QTL GWAS1120118 (human)5e-15mammary gland integrity trait (VT:0010552)54430207544302076Human
597169508GWAS1265582_Hacne QTL GWAS1265582 (human)1e-15acne54436645044366451Human
596962602GWAS1082121_Hgastroesophageal reflux disease, vital capacity QTL GWAS1082121 (human)1e-10gastroesophageal reflux disease, vital capacity54434702944347030Human
597076073GWAS1172147_Hhigh altitude adaptation QTL GWAS1172147 (human)2e-08wellness/fitness trait (VT:1000152)54432522044325221Human
597175431GWAS1271505_Hacne QTL GWAS1271505 (human)2e-08acne54436645044366451Human

Markers in Region
SHGC-82302  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37544,360,164 - 44,360,475UniSTSGRCh37
Build 36544,395,921 - 44,396,232RGDNCBI36
Celera544,252,423 - 44,252,734RGD
Cytogenetic Map5p13-p12UniSTS
HuRef544,313,076 - 44,313,387UniSTS
SHGC-110572  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37544,364,108 - 44,364,389UniSTSGRCh37
Build 36544,399,865 - 44,400,146RGDNCBI36
Celera544,256,367 - 44,256,648RGD
Cytogenetic Map5p13-p12UniSTS
HuRef544,317,020 - 44,317,301UniSTS
G16001  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37544,388,533 - 44,388,753UniSTSGRCh37
Build 36544,424,290 - 44,424,510RGDNCBI36
Celera544,280,793 - 44,281,013RGD
Cytogenetic Map5p13-p12UniSTS
HuRef544,341,452 - 44,341,672UniSTS
SHGC-100998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37544,383,257 - 44,383,537UniSTSGRCh37
Build 36544,419,014 - 44,419,294RGDNCBI36
Celera544,275,517 - 44,275,797RGD
Cytogenetic Map5p13-p12UniSTS
HuRef544,336,176 - 44,336,456UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2309 2782 2195 4393 1486 1904 3 426 638 265 2143 5479 5113 17 3282 651 1573 1371 164 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB002097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF508782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX591263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX591285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX591408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX591430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY604046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX955123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ897310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA795795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR003252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ351295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000264664   ⟹   ENSP00000264664
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl544,300,247 - 44,389,420 (-)Ensembl
Ensembl Acc Id: ENST00000513107   ⟹   ENSP00000426406
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl544,388,485 - 44,389,706 (-)Ensembl
RefSeq Acc Id: NM_004465   ⟹   NP_004456
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38544,300,247 - 44,389,420 (-)NCBI
GRCh37544,305,004 - 44,389,808 (-)NCBI
Build 36544,340,854 - 44,424,541 (-)NCBI Archive
HuRef544,258,055 - 44,341,703 (-)ENTREZGENE
CHM1_1544,306,497 - 44,390,196 (-)NCBI
T2T-CHM13v2.0544,553,832 - 44,642,982 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005248264   ⟹   XP_005248321
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38544,300,247 - 44,389,420 (-)NCBI
Sequence:
RefSeq Acc Id: NP_004456   ⟸   NM_004465
- Peptide Label: precursor
- UniProtKB: Q6FHT6 (UniProtKB/Swiss-Prot),   Q6FHR3 (UniProtKB/Swiss-Prot),   C7FDY0 (UniProtKB/Swiss-Prot),   Q96P59 (UniProtKB/Swiss-Prot),   O15520 (UniProtKB/Swiss-Prot),   A0A7U3JW18 (UniProtKB/TrEMBL),   Q8NFI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005248321   ⟸   XM_005248264
- Peptide Label: isoform X1
- UniProtKB: Q6FHT6 (UniProtKB/Swiss-Prot),   Q6FHR3 (UniProtKB/Swiss-Prot),   C7FDY0 (UniProtKB/Swiss-Prot),   Q96P59 (UniProtKB/Swiss-Prot),   O15520 (UniProtKB/Swiss-Prot),   A0A7U3JW18 (UniProtKB/TrEMBL),   Q8NFI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000426406   ⟸   ENST00000513107
Ensembl Acc Id: ENSP00000264664   ⟸   ENST00000264664

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15520-F1-model_v2 AlphaFold O15520 1-208 view protein structure

Promoters
RGD ID:6869550
Promoter ID:EPDNEW_H7940
Type:initiation region
Name:FGF10_1
Description:fibroblast growth factor 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38544,388,817 - 44,388,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3666 AgrOrtholog
COSMIC FGF10 COSMIC
Ensembl Genes ENSG00000070193 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264664 ENTREZGENE
  ENST00000264664.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
GTEx ENSG00000070193 GTEx
HGNC ID HGNC:3666 ENTREZGENE
Human Proteome Map FGF10 Human Proteome Map
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report hsa:2255 UniProtKB/Swiss-Prot
NCBI Gene 2255 ENTREZGENE
OMIM 602115 OMIM
PANTHER PTHR11486 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot
PharmGKB PA28106 PharmGKB
PRINTS HBGFFGF UniProtKB/Swiss-Prot
  IL1HBGF UniProtKB/Swiss-Prot
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt A0A7U3JW18 ENTREZGENE, UniProtKB/TrEMBL
  C7FDY0 ENTREZGENE
  D6RG33_HUMAN UniProtKB/TrEMBL
  FGF10_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FHR3 ENTREZGENE
  Q6FHT6 ENTREZGENE
  Q8NFI9 ENTREZGENE, UniProtKB/TrEMBL
  Q96P59 ENTREZGENE
UniProt Secondary C7FDY0 UniProtKB/Swiss-Prot
  Q6FHR3 UniProtKB/Swiss-Prot
  Q6FHT6 UniProtKB/Swiss-Prot
  Q96P59 UniProtKB/Swiss-Prot